Vector® System vs Mini-Five Curettes in Non-Surgical Periodontal Therapy (VECTOR-RCT)

March 1, 2026 updated by: Serife Kosar, Hacettepe University

A Randomized Single-Blind Clinical Trial Comparing the Clinical and Radiographic Outcomes of the Vector® Ultrasonic System and Minimally Invasive Hand Instrumentation (Mini-Five Curettes) in Non-Surgical Periodontal Therapy

This randomized clinical trial aims to compare the clinical and radiographic outcomes of the Vector®️ ultrasonic system and mini-five curettes in non-surgical periodontal therapy. Patients diagnosed with periodontitis will be randomly assigned to either ultrasonic instrumentation or manual instrumentation. Clinical periodontal parameters and radiographic bone level changes will be evaluated at baseline, 1, 3, 6, and 12 months. The primary objective is to assess differences in clinical attachment level and probing depth reduction between the two treatment modalities.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Periodontitis is a chronic inflammatory disease leading to the destruction of supporting periodontal tissues. Non-surgical periodontal therapy is the first-line treatment and includes mechanical debridement using manual or ultrasonic instruments. The Vector®️ ultrasonic system is designed to provide minimally invasive debridement with reduced trauma to root surfaces and surrounding tissues.

This randomized, controlled, single-blind clinical trial will compare the effectiveness of the Vector®️ system and mini-five curettes in patients diagnosed with periodontitis. Participants will be randomly allocated into two groups: the ultrasonic instrumentation group (Vector®️ system) and the manual instrumentation group (mini-five curettes).

Clinical parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI) will be recorded at baseline and at 1, 3, 6, and 12 months. Standardized radiographic examinations will be performed at baseline, 6 months, and 12 months to evaluate radiographic bone level changes.

The primary outcome measure is the change in clinical attachment level at 12 months. Secondary outcomes include probing depth reduction, bleeding on probing, and radiographic bone level changes.

The study is conducted at Hacettepe University Faculty of Dentistry, Department of Periodontology. Ethical approval has been obtained from the Hacettepe University Clinical Research Ethics Committee.

Study Type

Interventional

Enrollment (Estimated)

36

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

Adults aged 18-65 years Willing to participate and provided written informed consent Presence of single-rooted teeth in both maxilla and mandible with vertical bone defects (radiographic intrabony defect ≥2 mm and probing depth ≥5 mm) Diagnosis of Stage III or Stage IV periodontitis Systemically healthy or Systemically healthy patients or American Society of Anesthesiologists (ASA) physical status I-II.

Exclusion Criteria:

Periodontal treatment within the last 6 months Teeth with furcation involvement Smoking more than 10 cigarettes per day Pregnancy Age under 18 years Patients unwilling to attend regular follow-up visits Previously endodontically treated tooth at the treatment site Poor compliance with oral hygiene instructions Single-rooted teeth with horizontal bone loss extending close to the apical third Teeth with mobility grade II or III Previous flap surgery or regenerative periodontal treatment at the study site

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Vector System Group
Participants receive non-surgical periodontal therapy using the Vector®️ ultrasonic system.
Device: Vector® Ultrasonic System
Minimally invasive ultrasonic instrumentation used for non-surgical periodontal therapy.
Active Comparator: Mini-Five Curettes Group
Participants receive non-surgical periodontal therapy using mini-five curettes.
Device: Mini-Five Curettes
Manual curette instrumentation used for non-surgical periodontal therapy.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Probing Depth(PD)
Time Frame: Baseline,1 month, 3 months, 6 months, and 12 months
Change in periodontal probing depth (in millimeters) from baseline to follow-up after non-surgical periodontal therapy using Vector®️ ultrasonic system compared with mini-five curettes.
Baseline,1 month, 3 months, 6 months, and 12 months
Change in Radiographic Vertical Bone Defect Depth
Time Frame: Baseline, 6 months, and 12 months
Change in radiographic vertical bone defect depth (mm) assessed on standardized radiographs at baseline, 6 months, and 12 months after treatment.
Baseline, 6 months, and 12 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Pain Sensitivity(VAS Score)
Time Frame: During treatment and immediately after treatment
Pain sensitivity assessed using a visual analog scale (VAS) during and immediately after the treatment session.
During treatment and immediately after treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hacettepe University

Investigators

  • Principal Investigator: Abdullah Cevdet Akman, Hacettepe University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 19, 2026

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

February 1, 2028

Study Registration Dates

First Submitted

March 1, 2026

First Submitted That Met QC Criteria

March 1, 2026

First Posted (Actual)

March 5, 2026

Study Record Updates

Last Update Posted (Actual)

March 5, 2026

Last Update Submitted That Met QC Criteria

March 1, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • THD-2026-22611

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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