Metabolomic Pathways and Traditional Chinese Medicine Body Constitution in Cancer-related Fatigue

March 24, 2026 updated by: Chang Gung Memorial Hospital

The Exploration of the Relationship Between Metabolomic Pathways and Traditional Chinese Medicine Body Constitution in Cancer-related Fatigue in Patients With Colorectal Cancer

The aim of this study is to integrate insights from metabolomics and TCMBC to identify biomarkers and physiological pathways associated with CRF.

Study Overview

Status

Not yet recruiting

Conditions

Colorectal Cancer

Study Type

Observational

Enrollment (Estimated)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Yun-Jen Chou, PhD
Phone Number: 3512 886-3-2118800
Email: yjchou@mail.cgu.edu.tw

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Sampling Method

Probability Sample

Study Population

Newly diagnosed with stage I to III CRC and scheduled for surgical treatment

Description

Inclusion Criteria:

Patients aged 18 years or older
Diagnosed with stage I to III CRC and scheduled for surgical treatment
Cognitively intact and able to communicate in either Mandarin or Taiwanese
Willing to participate in the study and provide written informed consent.

Exclusion Criteria:

Patients diagnosed with stage IV colorectal cancer
Patients with recurrent colorectal cancer or other concurrent cancers.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Self-report Questionnaire Time Frame: Change from baseline to 3 months after surgery.	The study utilizes two instruments. First, the Fatigue Symptom Inventory (FSI) is used to assess fatigue; total scores range from 0 to 127, with higher scores indicating greater fatigue severity. Second, the Body Constitution Questionnaire (BCQ) comprises 16 items, with total scores ranging from 16 to 80.	Change from baseline to 3 months after surgery.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chang Gung Memorial Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

April 20, 2026

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

February 28, 2029

Study Registration Dates

First Submitted

March 18, 2026

First Submitted That Met QC Criteria

March 18, 2026

First Posted (Actual)

March 24, 2026

Study Record Updates

Last Update Posted (Actual)

March 27, 2026

Last Update Submitted That Met QC Criteria