- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00003931
Diagnostic Study of Gene Alterations in Patients With Acute Myeloid Leukemia
Assessment of the Partial Tandem Duplication of ALL1 (MLL) in Patients With Acute Myeloid Leukemia- A CALGB Leukemia Tissue Bank Project
RATIONALE: Diagnostic procedures, such as genetic testing, may improve the ability to detect acute myeloid leukemia and determine the extent of disease.
PURPOSE: Diagnostic study to try to detect changes in the genes of patients who have acute myeloid leukemia.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
OBJECTIVES:
- Determine the frequency of partial tandem duplication of ALL1 (MLL) in patients with acute myeloid leukemia (AML).
- Determine the predictive value of partial tandem duplication of ALL1 to identify a subset of AML patients who have a short duration of complete remission.
OUTLINE: All samples are obtained from specimens collected on CALGB-9665. No additional blood or bone marrow samples are collected.
Samples are examined by Southern blot analysis for gene rearrangement at 11q23. Samples showing evidence of ALL1 gene rearrangement are further analyzed by reverse transcription PCR amplification and/or cytogenetic analysis to detect partial tandem duplication of ALL1.
Undersøgelsestype
Tilmelding (Faktiske)
Kontakter og lokationer
Studiesteder
-
-
Alabama
-
Birmingham, Alabama, Forenede Stater, 35233-1996
- Veterans Affairs Medical Center - Birmingham
-
-
California
-
La Jolla, California, Forenede Stater, 92093-0658
- University of California San Diego Cancer Center
-
San Francisco, California, Forenede Stater, 94121
- Veterans Affairs Medical Center - San Francisco
-
San Francisco, California, Forenede Stater, 94143-0128
- UCSF Cancer Center and Cancer Research Institute
-
-
Delaware
-
Wilmington, Delaware, Forenede Stater, 19899
- CCOP - Christiana Care Health Services
-
-
District of Columbia
-
Washington, District of Columbia, Forenede Stater, 20307-5000
- Walter Reed Army Medical Center
-
Washington, District of Columbia, Forenede Stater, 20007
- Lombardi Cancer Center
-
-
Florida
-
Miami Beach, Florida, Forenede Stater, 33140
- CCOP - Mount Sinai Medical Center
-
-
Illinois
-
Chicago, Illinois, Forenede Stater, 60612
- Veterans Affairs Medical Center - Chicago (Westside Hospital)
-
Chicago, Illinois, Forenede Stater, 60637-1470
- University of Chicago Cancer Research Center
-
-
Iowa
-
Iowa City, Iowa, Forenede Stater, 52242-1009
- Holden Comprehensive Cancer Center at the University of Iowa
-
-
Maine
-
Togus, Maine, Forenede Stater, 04330
- Veterans Affairs Medical Center - Togus
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21201
- Marlene & Stewart Greenebaum Cancer Center, University of Maryland
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02115
- Dana-Farber Cancer Institute
-
Worcester, Massachusetts, Forenede Stater, 01655
- University of Massachusetts Memorial Medical Center
-
-
Minnesota
-
Minneapolis, Minnesota, Forenede Stater, 55417
- Veterans Affairs Medical Center - Minneapolis
-
Minneapolis, Minnesota, Forenede Stater, 55455
- University of Minnesota Cancer Center
-
-
Missouri
-
Columbia, Missouri, Forenede Stater, 65201
- Veterans Affairs Medical Center - Columbia (Truman Memorial)
-
Columbia, Missouri, Forenede Stater, 65203
- Ellis Fischel Cancer Center - Columbia
-
Saint Louis, Missouri, Forenede Stater, 63110
- Barnes-Jewish Hospital
-
-
Nebraska
-
Omaha, Nebraska, Forenede Stater, 68198-3330
- University of Nebraska Medical Center
-
-
Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- CCOP - Southern Nevada Cancer Research Foundation
-
-
New Hampshire
-
Lebanon, New Hampshire, Forenede Stater, 03756-0002
- Norris Cotton Cancer Center
-
-
New York
-
Buffalo, New York, Forenede Stater, 14263-0001
- Roswell Park Cancer Institute
-
Buffalo, New York, Forenede Stater, 14215
- Veterans Affairs Medical Center - Buffalo
-
Manhasset, New York, Forenede Stater, 11030
- CCOP - North Shore University Hospital
-
Manhasset, New York, Forenede Stater, 11030
- Schneider Children's Hospital at North Shore
-
New York, New York, Forenede Stater, 10021
- Memorial Sloan-Kettering Cancer Center
-
New York, New York, Forenede Stater, 10021
- New York Presbyterian Hospital - Cornell Campus
-
New York, New York, Forenede Stater, 10029
- Mount Sinai Medical Center, NY
-
Syracuse, New York, Forenede Stater, 13210
- State University of New York - Upstate Medical University
-
Syracuse, New York, Forenede Stater, 13210
- Veterans Affairs Medical Center - Syracuse
-
Syracuse, New York, Forenede Stater, 13217
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
-
-
North Carolina
-
Chapel Hill, North Carolina, Forenede Stater, 27599-7295
- Lineberger Comprehensive Cancer Center, UNC
-
Durham, North Carolina, Forenede Stater, 27705
- Veterans Affairs Medical Center - Durham
-
Durham, North Carolina, Forenede Stater, 27710
- Duke Comprehensive Cancer Center
-
Winston-Salem, North Carolina, Forenede Stater, 27104-4241
- CCOP - Southeast Cancer Control Consortium
-
Winston-Salem, North Carolina, Forenede Stater, 27157-1082
- Comprehensive Cancer Center at Wake Forest University
-
-
Ohio
-
Columbus, Ohio, Forenede Stater, 43210-1240
- Arthur G. James Cancer Hospital - Ohio State University
-
-
Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02903
- Rhode Island Hospital
-
-
Tennessee
-
Memphis, Tennessee, Forenede Stater, 38103
- University of Tennessee, Memphis Cancer Center
-
Memphis, Tennessee, Forenede Stater, 38104
- Veterans Affairs Medical Center - Memphis
-
-
Vermont
-
Burlington, Vermont, Forenede Stater, 05401-3498
- Vermont Cancer Center
-
White River Junction, Vermont, Forenede Stater, 05009
- Veterans Affairs Medical Center - White River Junction
-
-
Virginia
-
Richmond, Virginia, Forenede Stater, 23298-0037
- MBCCOP - Massey Cancer Center
-
Richmond, Virginia, Forenede Stater, 23249
- Veterans Affairs Medical Center - Richmond
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
DISEASE CHARACTERISTICS:
- Prior registration on protocol CALGB-9665
- Diagnosed with acute myeloid leukemia (AML)
- Treated on a CALGB AML treatment protocol
- Diagnostic bone marrow or blood specimen available
PATIENT CHARACTERISTICS:
Age:
- 15 and over
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
---|---|
blood or bone marrow samples
All samples are obtained from specimens collected on CALGB-9665. No additional blood or bone marrow samples are collected CALGB-9769. Samples are examined by Southern blot analysis for gene rearrangement at 11q23. Samples showing evidence of ALL1 gene rearrangement are further analyzed by reverse transcription PCR amplification and/or cytogenetic analysis to detect partial tandem duplication of ALL1. |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
frequency of partial tandem duplication of ALL1 (MLL)
Tidsramme: Up to 10 years
|
Up to 10 years
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
---|---|
predictive value of partial tandem duplication of ALL1
Tidsramme: Up to 10 years
|
Up to 10 years
|
Samarbejdspartnere og efterforskere
Samarbejdspartnere
Efterforskere
- Studiestol: Michael A. Caligiuri, MD, Ohio State University Comprehensive Cancer Center
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- CALGB-9769
- U10CA031946 (U.S. NIH-bevilling/kontrakt)
- CLB-9769
- CDR0000067123 (Registry Identifier: NCI Physician Data Query)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med omvendt transkriptase-polymerase kædereaktion
-
Assistance Publique - Hôpitaux de ParisIkke rekrutterer endnuNyretransplantation; Komplikationer | Diarré; Akut | Diarré Infektiøs
-
Fondazione Policlinico Universitario Agostino Gemelli...RekrutteringEndokarditis smitsomItalien
-
Hospices Civils de LyonUkendt
-
Fundació Institut de Recerca de l'Hospital de la...GlaxoSmithKline; Sociedad Española de Neumología y Cirugía TorácicaRekruttering
-
Seoul St. Mary's HospitalBristol-Myers SquibbRekrutteringKronisk myelocytisk leukæmiKorea, Republikken