Opfølgningsbesøg af højrisikobørn (FU)
7. november 2023 opdateret af: NICHD Neonatal Research Network
NICHD Neonatal Research Networks opfølgningsstudie er en multicenterkohorte, hvor overlevende spædbørn med ekstrem lav fødselsvægt, født i deltagende netværkscentre, modtager neuroudviklingsmæssige, neurosensoriske og funktionelle vurderinger i 22-26 måneders korrigeret alder (spædbørn født før 1. juli , 2012 blev set ved 18-22 måneders korrigeret alder).
Data vedrørende graviditet og neonatal udfald indsamles prospektivt.
Målet er at identificere potentielle moder- og neonatale risikofaktorer, der kan påvirke spædbørns neuroudvikling.
Studieoversigt
Status
Rekruttering
Detaljeret beskrivelse
NICHD Neonatal Research Networks opfølgningsstudie er et multicenter kohortestudie, hvor overlevende spædbørn med ekstrem lav fødselsvægt gennemgår neuroudviklingsmæssige, neurosensoriske og funktionelle vurderinger i 22-26 måneders korrigeret alder (spædbørn født før 1. juli 2012 blev set ved 18-22 måneders korrigeret alder). Målet med undersøgelsen er at identificere potentielle maternelle og neonatale risikofaktorer, der kan påvirke spædbarns neuroudvikling, herunder:
- Evaluering af udvikling af motoriske færdigheder, kognitive færdigheder, sprog og adfærd
- Bestemmelse af dødelighed og forekomsten af specifikke medicinske tilstande
- Vurdering af forholdet mellem vækst og neuroudviklingsresultat
- Vurdering af sammenhængen mellem den socioøkonomiske status og udviklingsresultater
- Vurdering af denne befolknings brug af særlige støttetjenester og programmer for tidlig indsats
- Evaluering af behovet for opfølgning i skolealderen.
De planlagte evalueringer indsamler: demografiske oplysninger; socioøkonomisk status; medicinsk historie; medicin; påkrævet medicinsk udstyr; vækstdata; en detaljeret neurologisk undersøgelse; Bayley Scales of Infant Development (mental, motorisk, spædbarnsadfærd); Tjekliste for børns adfærd.
Et delstudie vil vurdere en referencegruppe bestående af et begrænset antal raske terminsbørn født i netværkscentre for at opfylde følgende tre mål: 1) at undgå potentielle konstateringsforstyrrelser på grund af eksaminatorforventninger, når det kun er ekstremt for tidligt fødte eller andre højrisikobørn. vurderes 2) i mangel af veludviklede normer for Bayley-skalaen for at definere tærskler for svækkelse baseret på data for et repræsentativt udsnit af raske børn født til termin i vores centre og samtidigt vurderet af de samme eksaminatorer som for vores høj- risiko spædbørn; og 3) at hjælpe med at identificere og adressere, når "afdrift" opstår over tid ved udførelse og scoring af Bayley-vurderinger.
Undersøgelsestype
Observationel
Tilmelding (Anslået)
68000
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Susan R Hintz, MD, MS Epi
- E-mail: srhintz@stanford.edu
Undersøgelse Kontakt Backup
- Navn: Abhik Das, PhD
- Telefonnummer: 301 230 4640
- E-mail: adas@rti.org
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- Rekruttering
- University of Alabama at Birmingham
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Kontakt:
- Waldemar A. Carlo, MD
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Ledende efterforsker:
- Myriam Peralta-Carcelen, MD MPH
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Ledende efterforsker:
- Waldemar A. Carlo, MD
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California
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Los Angeles, California, Forenede Stater, 90025
- Rekruttering
- University of California - Los Angeles
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Kontakt:
- Uday Devaskar, MD
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Ledende efterforsker:
- Uday Devaskar, MD
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Ledende efterforsker:
- Isabell Purdy, MD
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Palo Alto, California, Forenede Stater, 94304
- Rekruttering
- Stanford University
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Kontakt:
- Krisa P. Van Meurs, MD
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Ledende efterforsker:
- Krisa P. Van Meurs, MD
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Ledende efterforsker:
- Susan R. Hintz, MD
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San Diego, California, Forenede Stater, 92123
- Ikke rekrutterer endnu
- Sharp Mary Birch Hospital for Women & Newborns
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Kontakt:
- Anup Katheria, MD
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Ledende efterforsker:
- Anup Katheria, MD
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San Diego, California, Forenede Stater, 92103-8774
- Afsluttet
- University of California at San Diego
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Connecticut
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New Haven, Connecticut, Forenede Stater, 06504
- Afsluttet
- Yale University
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20052
- Afsluttet
- George Washington University
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Florida
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Miami, Florida, Forenede Stater, 33136
- Afsluttet
- University of Miami
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Georgia
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Atlanta, Georgia, Forenede Stater, 30303
- Rekruttering
- Emory University
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Kontakt:
- David P. Carlton, MD
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Ledende efterforsker:
- David P. Carlton, MD
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Ledende efterforsker:
- Ira Adams-Chapman, MD
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Illinois
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Chicago, Illinois, Forenede Stater, 60611
- Ikke rekrutterer endnu
- Northwestern Lurie Children's Hospital of Chicago
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Kontakt:
- Aaron Hamvas, MD
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Ledende efterforsker:
- Aaron Hamvas, MD
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Indiana
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Indianapolis, Indiana, Forenede Stater, 46202
- Rekruttering
- Indiana University
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Ledende efterforsker:
- Greg Sokol, MD
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Ledende efterforsker:
- Heidi Harmon, MD
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Kontakt:
- Greg Sokol, MD
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Iowa
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Iowa City, Iowa, Forenede Stater, 52242
- Rekruttering
- University of Iowa
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Kontakt:
- Edward F. Bell, MD
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Ledende efterforsker:
- Edward F. Bell, MD
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Ledende efterforsker:
- Jane E. Brumbaugh, MD
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Massachusetts
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Boston, Massachusetts, Forenede Stater, 02111
- Afsluttet
- Tufts Medical Center
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Cambridge, Massachusetts, Forenede Stater, 02138
- Afsluttet
- Harvard University
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Michigan
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Detroit, Michigan, Forenede Stater, 48201
- Rekruttering
- Wayne State University
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Kontakt:
- Seetha Shankaran, MD
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Ledende efterforsker:
- Seetha Shankaran, MD
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Mississippi
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Jackson, Mississippi, Forenede Stater, 39216
- Ikke rekrutterer endnu
- University of Mississippi Medical Center - Children's of Mississippi
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Ledende efterforsker:
- Abhay Bhatt, MD
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Kontakt:
- Abhay Bhatt, MD
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Missouri
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Kansas City, Missouri, Forenede Stater, 64108
- Rekruttering
- Children's Mercy Hospital
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Kontakt:
- William Truog, MD
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Ledende efterforsker:
- William Truog, MD
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Ledende efterforsker:
- Howard Kilbride, MD
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New Mexico
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Albuquerque, New Mexico, Forenede Stater, 87131
- Rekruttering
- University of New Mexico
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Kontakt:
- Kristi L. Watterberg, MD
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Ledende efterforsker:
- Kristi L. Watterberg, MD
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Ledende efterforsker:
- Janell Fuller, MD
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Ledende efterforsker:
- Jean Lowe, MD
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New York
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Rochester, New York, Forenede Stater, 14642
- Aktiv, ikke rekrutterende
- University of Rochester
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North Carolina
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Charlotte, North Carolina, Forenede Stater, 27157
- Afsluttet
- Wake Forest University
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Durham, North Carolina, Forenede Stater, 27710
- Rekruttering
- Duke University
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Kontakt:
- C. Michael Cotten, MD
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Ledende efterforsker:
- C. Michael Cotten, MD
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Ledende efterforsker:
- William F. Malcolm, MD
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Durham, North Carolina, Forenede Stater, 27705
- Aktiv, ikke rekrutterende
- RTI International
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Ohio
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Cincinnati, Ohio, Forenede Stater, 45267
- Rekruttering
- Cincinnati Children's Medical Center
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Ledende efterforsker:
- Stephanie Merhar, MD
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Kontakt:
- Brenda Poindexter, MD,MS
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Ledende efterforsker:
- Brenda Poindexter, MD
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Ledende efterforsker:
- Kimberly Yolton, PhD
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Cleveland, Ohio, Forenede Stater, 44106
- Rekruttering
- Case Western Reserve University, Rainbow Babies and Children's Hospital
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Kontakt:
- Michele C. Walsh, MD MS
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Ledende efterforsker:
- Michele C. Walsh, MD MS
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Ledende efterforsker:
- Deanne E. Wilson, MD
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Columbus, Ohio, Forenede Stater, 43205
- Aktiv, ikke rekrutterende
- Research Institute at Nationwide Children's Hospital
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Pennsylvania
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Philadelphia, Pennsylvania, Forenede Stater, 19104
- Rekruttering
- University of Pennsylvania
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Kontakt:
- Eric Eichenwald, MD
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Ledende efterforsker:
- Eric Eichenwald, MD
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Ledende efterforsker:
- Sara DeMauro, MD
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Rhode Island
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Providence, Rhode Island, Forenede Stater, 02905
- Aktiv, ikke rekrutterende
- Brown University, Women & Infants Hospital of Rhode Island
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Tennessee
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Memphis, Tennessee, Forenede Stater, 38163
- Afsluttet
- University of Tennessee
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Texas
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Dallas, Texas, Forenede Stater, 75235
- Rekruttering
- University of Texas Southwestern Medical Center at Dallas
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Kontakt:
- Myra H Wyckoff, MD
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Ledende efterforsker:
- Myra H. Wyckfoff, MD
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Ledende efterforsker:
- Roy J. Heyne, MD
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Houston, Texas, Forenede Stater, 77030
- Rekruttering
- University of Texas Health Science Center at Houston
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Kontakt:
- Jon Tyson, MD MPH
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Ledende efterforsker:
- Jon E. Tyson, MD MPH
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Ledende efterforsker:
- Andrea F. Duncan, MD
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Utah
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Salt Lake City, Utah, Forenede Stater, 84108
- Rekruttering
- University of Utah
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Kontakt:
- Bradley Yoder, MD
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Ledende efterforsker:
- Sara Winter, MD
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Ledende efterforsker:
- Bradley Yoder, MD
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
1 år til 2 år (Barn)
Tager imod sunde frivillige
Ingen
Prøveudtagningsmetode
Sandsynlighedsprøve
Studiebefolkning
Spædbørn født ved 401-1000 gram fødselsvægt og/eller <29 ugers svangerskabsalder
Beskrivelse
- Spædbørn født på NRN-centre
- <27 ugers svangerskabsalder
- Spædbørn, der er tilmeldt en eller flere yderligere NICHD NRN-opfølgningsundersøgelser. For spædbørn, der ikke opfylder inklusionskriterierne ovenfor, bestemmes inklusions- og eksklusionskriterierne af kriterierne for det eller de yderligere forsøg. I disse tilfælde kan spædbørn, der er større end 1.000 gram og/eller ældre end 27 uger, indgå i FU-undersøgelsen.
Bemærk: Disse inklusionskriterier blev ændret pr. 1/1/2008. Før denne dato var spædbørn med fødselsvægte mellem 401 og 1500 gram, som blev indlagt på NRN NICU'er inden for 14 dage efter fødslen, inkluderet i databasen.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
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At opretholde et register over baseline- og resultatdata for VLBW-spædbørn med data indsamlet på en ensartet måde
Tidsramme: Længdegående database finansieret i øjeblikket indtil 31/3/2016
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Længdegående database finansieret i øjeblikket indtil 31/3/2016
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Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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At undersøge sammenhængen mellem baseline karakteristika og resultat
Tidsramme: Længdegående database finansieret i øjeblikket indtil 31/3/2016
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Længdegående database finansieret i øjeblikket indtil 31/3/2016
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At levere data til hypoteseformulering og beregning af stikprøvestørrelse til netværks multicenterundersøgelser
Tidsramme: Længdegående database finansieret i øjeblikket indtil 31/3/2016
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Længdegående database finansieret i øjeblikket indtil 31/3/2016
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: C. Michael Cotten, MD, MHS, Duke University
- Ledende efterforsker: David P. Carlton, MD, Emory University
- Ledende efterforsker: Brenda B. Poindexter, MD, Children's Hospital Medical Center, Cincinnati
- Ledende efterforsker: Myra H. Wyckoff, MD, University of Texas, Southwestern Medical Center at Dallas
- Ledende efterforsker: Bradley A. Yoder, MD, University of Utah
- Ledende efterforsker: William E. Truog, MD, Children's Mercy Hospital Kansas City
- Ledende efterforsker: Pablo J. Sanchez, MD, Research Institute at Nationwide Children's Hospital
- Ledende efterforsker: Eric C Eichenwald, MD, University of Pennsylvania
- Ledende efterforsker: Seetha Shankaran, MD, Wayne State University
- Ledende efterforsker: Abbot R. Laptook, MD, Brown University, Women & Infants Hospital of Rhode Island
- Ledende efterforsker: Michele C. Walsh, MD MS, Case Western Reserve University, Rainbow Babies and Children's Hospital
- Ledende efterforsker: Greg M. Sokol, MD, Indiana University
- Ledende efterforsker: Abhik Das, PhD, RTI International
- Ledende efterforsker: Krisa P. Van Meurs, MD, Stanford University
- Ledende efterforsker: Waldemar A. Carlo, MD, University of Alabama at Birmingham
- Ledende efterforsker: Edward F. Bell, MD, University of Iowa
- Ledende efterforsker: Kristi L. Watterberg, MD, University of New Mexico
- Ledende efterforsker: Jon E Tyson, MD, MPH, The University of Texas Health Science Center, Houston
- Ledende efterforsker: Uday Devaskar, MD, University of California, Los Angeles
- Ledende efterforsker: Carl T D'Angio, MD, University of Rochester
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Malcolm WF, Gantz M, Martin RJ, Goldstein RF, Goldberg RN, Cotten CM; National Institute of Child Health and Human Development Neonatal Research Network. Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants. Pediatrics. 2008 Jan;121(1):22-7. doi: 10.1542/peds.2007-0381.
- Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R; NICHD Research Network. Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics. 2008 May;121(5):e1167-77. doi: 10.1542/peds.2007-0423. Epub 2008 Apr 7.
- Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R; National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92. doi: 10.1542/peds.2004-2292.
- Broitman E, Ambalavanan N, Higgins RD, Vohr BR, Das A, Bhaskar B, Murray K, Hintz SR, Carlo WA; National Institute of Child Health and Human Development Neonatal Research Network. Clinical data predict neurodevelopmental outcome better than head ultrasound in extremely low birth weight infants. J Pediatr. 2007 Nov;151(5):500-5, 505.e1-2. doi: 10.1016/j.jpeds.2007.04.013. Epub 2007 Jul 12.
- Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10. doi: 10.1542/peds.114.2.404.
- Cole CR, Hansen NI, Higgins RD, Ziegler TR, Stoll BJ; Eunice Kennedy Shriver NICHD Neonatal Research Network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months. Pediatrics. 2008 Sep;122(3):e573-82. doi: 10.1542/peds.2007-3449.
- Da Costa D, Bann CM, Hansen NI, Shankaran S, Delaney-Black V; National Institute of Child Health and Human Development Neonatal Research Network. Validation of the Functional Status II questionnaire in the assessment of extremely-low-birthweight infants. Dev Med Child Neurol. 2009 Jul;51(7):536-44. doi: 10.1111/j.1469-8749.2009.03318.x.
- Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, Wrage LA, Poole K; National Institutes of Child Health and Human Development Neonatal Research Network. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics. 2005 Dec;116(6):1353-60. doi: 10.1542/peds.2005-0249.
- Gargus RA, Vohr BR, Tyson JE, High P, Higgins RD, Wrage LA, Poole K. Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months. Pediatrics. 2009 Jul;124(1):112-21. doi: 10.1542/peds.2008-2742.
- Heller CD, O'Shea M, Yao Q, Langer J, Ehrenkranz RA, Phelps DL, Poole WK, Stoll B, Duara S, Oh W, Lemons J, Poindexter B; NICHD Neonatal Research Network. Human milk intake and retinopathy of prematurity in extremely low birth weight infants. Pediatrics. 2007 Jul;120(1):1-9. doi: 10.1542/peds.2006-1465.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhood. Arch Pediatr Adolesc Med. 2008 Aug;162(8):748-55. doi: 10.1001/archpedi.162.8.748.
- Hintz SR, Kendrick DE, Stoll BJ, Vohr BR, Fanaroff AA, Donovan EF, Poole WK, Blakely ML, Wright L, Higgins R; NICHD Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics. 2005 Mar;115(3):696-703. doi: 10.1542/peds.2004-0569.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999. Pediatrics. 2005 Jun;115(6):1645-51. doi: 10.1542/peds.2004-2215.
- Hintz SR, Kendrick DE, Vohr BR, Kenneth Poole W, Higgins RD; Nichd Neonatal Research Network. Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants. Acta Paediatr. 2006 Oct;95(10):1239-48. doi: 10.1080/08035250600599727.
- Lainwala S, Perritt R, Poole K, Vohr B; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants who are transferred from neonatal intensive care units to level I or II nurseries. Pediatrics. 2007 May;119(5):e1079-87. doi: 10.1542/peds.2006-0899. Epub 2007 Apr 2.
- Laptook AR, O'Shea TM, Shankaran S, Bhaskar B; NICHD Neonatal Network. Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents. Pediatrics. 2005 Mar;115(3):673-80. doi: 10.1542/peds.2004-0667.
- Lowe J, Woodward B, Papile LA. Emotional regulation and its impact on development in extremely low birth weight infants. J Dev Behav Pediatr. 2005 Jun;26(3):209-13. doi: 10.1097/00004703-200506000-00008.
- Madan JC, Kendrick D, Hagadorn JI, Frantz ID 3rd; National Institute of Child Health and Human Development Neonatal Research Network. Patent ductus arteriosus therapy: impact on neonatal and 18-month outcome. Pediatrics. 2009 Feb;123(2):674-81. doi: 10.1542/peds.2007-2781.
- Morris BH, Gard CC, Kennedy K; NICHD Neonatal Research Network. Rehospitalization of extremely low birth weight (ELBW) infants: are there racial/ethnic disparities? J Perinatol. 2005 Oct;25(10):656-63. doi: 10.1038/sj.jp.7211361.
- Oh W, Tyson JE, Fanaroff AA, Vohr BR, Perritt R, Stoll BJ, Ehrenkranz RA, Carlo WA, Shankaran S, Poole K, Wright LL; National Institute of Child Health and Human Development Neonatal Research Network. Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics. 2003 Oct;112(4):773-9. doi: 10.1542/peds.112.4.773.
- Shankaran S, Johnson Y, Langer JC, Vohr BR, Fanaroff AA, Wright LL, Poole WK. Outcome of extremely-low-birth-weight infants at highest risk: gestational age < or =24 weeks, birth weight < or =750 g, and 1-minute Apgar < or =3. Am J Obstet Gynecol. 2004 Oct;191(4):1084-91. doi: 10.1016/j.ajog.2004.05.032.
- Stephens BE, Bann CM, Poole WK, Vohr BR. NEURODEVELOPMENTAL IMPAIRMENT: PREDICTORS OF ITS IMPACT ON THE FAMILIES OF EXTREMELY LOW BIRTH WEIGHT INFANTS AT 18 MONTHS. Infant Ment Health J. 2008 Nov 1;29(6):570-587. doi: 10.1002/imhj.20196.
- Stoll BJ, Hansen NI, Adams-Chapman I, Fanaroff AA, Hintz SR, Vohr B, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA. 2004 Nov 17;292(19):2357-65. doi: 10.1001/jama.292.19.2357.
- Tyson JE, Younes N, Verter J, Wright LL. Viability, morbidity, and resource use among newborns of 501- to 800-g birth weight. National Institute of Child Health and Human Development Neonatal Research Network. JAMA. 1996 Nov 27;276(20):1645-51.
- Tyson JE, Parikh NA, Langer J, Green C, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Intensive care for extreme prematurity--moving beyond gestational age. N Engl J Med. 2008 Apr 17;358(16):1672-81. doi: 10.1056/NEJMoa073059.
- Vohr BR, Msall ME, Wilson D, Wright LL, McDonald S, Poole WK. Spectrum of gross motor function in extremely low birth weight children with cerebral palsy at 18 months of age. Pediatrics. 2005 Jul;116(1):123-9. doi: 10.1542/peds.2004-1810.
- Vohr BR, O'Shea M, Wright LL. Longitudinal multicenter follow-up of high-risk infants: why, who, when, and what to assess. Semin Perinatol. 2003 Aug;27(4):333-42. doi: 10.1016/s0146-0005(03)00045-4.
- Vohr BR, Wright LL, Dusick AM, Mele L, Verter J, Steichen JJ, Simon NP, Wilson DC, Broyles S, Bauer CR, Delaney-Black V, Yolton KA, Fleisher BE, Papile LA, Kaplan MD. Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994. Pediatrics. 2000 Jun;105(6):1216-26. doi: 10.1542/peds.105.6.1216.
- Vohr BR, Wright LL, Poole WK, McDonald SA. Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks' gestation between 1993 and 1998. Pediatrics. 2005 Sep;116(3):635-43. doi: 10.1542/peds.2004-2247.
- Vohr BR, Tyson JE, Wright LL, Perritt RL, Li L, Poole WK; NICHD Neonatal Research Network. Maternal age, multiple birth, and extremely low birth weight infants. J Pediatr. 2009 Apr;154(4):498-503.e2. doi: 10.1016/j.jpeds.2008.10.044. Epub 2008 Dec 25.
- Vohr BR, Wright LL, Dusick AM, Perritt R, Poole WK, Tyson JE, Steichen JJ, Bauer CR, Wilson-Costello DE, Mayes LC; Neonatal Research Network. Center differences and outcomes of extremely low birth weight infants. Pediatrics. 2004 Apr;113(4):781-9. doi: 10.1542/peds.113.4.781.
- Wadhawan R, Oh W, Perritt RL, McDonald SA, Das A, Poole WK, Vohr BR, Higgins RD. Twin gestation and neurodevelopmental outcome in extremely low birth weight infants. Pediatrics. 2009 Feb;123(2):e220-7. doi: 10.1542/peds.2008-1126. Epub 2009 Jan 12.
- Wadhawan R, Vohr BR, Fanaroff AA, Perritt RL, Duara S, Stoll BJ, Goldberg R, Laptook A, Poole K, Wright LL, Oh W. Does labor influence neonatal and neurodevelopmental outcomes of extremely-low-birth-weight infants who are born by cesarean delivery? Am J Obstet Gynecol. 2003 Aug;189(2):501-6. doi: 10.1067/s0002-9378(03)00360-0.
- Walden RV, Taylor SC, Hansen NI, Poole WK, Stoll BJ, Abuelo D, Vohr BR; National Institute of Child Health and Human Development Neonatal Research Network. Major congenital anomalies place extremely low birth weight infants at higher risk for poor growth and developmental outcomes. Pediatrics. 2007 Dec;120(6):e1512-9. doi: 10.1542/peds.2007-0354. Epub 2007 Nov 5.
- Walsh MC, Morris BH, Wrage LA, Vohr BR, Poole WK, Tyson JE, Wright LL, Ehrenkranz RA, Stoll BJ, Fanaroff AA; National Institutes of Child Health and Human Development Neonatal Research Network. Extremely low birthweight neonates with protracted ventilation: mortality and 18-month neurodevelopmental outcomes. J Pediatr. 2005 Jun;146(6):798-804. doi: 10.1016/j.jpeds.2005.01.047.
- Rysavy MA, Bell EF, Iams JD, Carlo WA, Li L, Mercer BM, Hintz SR, Stoll BJ, Vohr BR, Shankaran S, Walsh MC, Brumbaugh JE, Colaizy TT, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Discordance in Antenatal Corticosteroid Use and Resuscitation Following Extremely Preterm Birth. J Pediatr. 2019 May;208:156-162.e5. doi: 10.1016/j.jpeds.2018.12.063. Epub 2019 Feb 6.
- Boghossian NS, Do BT, Bell EF, Dagle JM, Brumbaugh JE, Stoll BJ, Vohr BR, Das A, Shankaran S, Sanchez PJ, Wyckoff MH, Bethany Ball M; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Efficacy of pharmacologic closure of patent ductus arteriosus in small-for-gestational-age extremely preterm infants. Early Hum Dev. 2017 Oct;113:10-17. doi: 10.1016/j.earlhumdev.2017.07.011. Epub 2017 Jul 8.
- Younge N, Goldstein RF, Bann CM, Hintz SR, Patel RM, Smith PB, Bell EF, Rysavy MA, Duncan AF, Vohr BR, Das A, Goldberg RN, Higgins RD, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med. 2017 Feb 16;376(7):617-628. doi: 10.1056/NEJMoa1605566.
- Boghossian NS, Hansen NI, Bell EF, Brumbaugh JE, Stoll BJ, Laptook AR, Shankaran S, Wyckoff MH, Colaizy TT, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Outcomes of Extremely Preterm Infants Born to Insulin-Dependent Diabetic Mothers. Pediatrics. 2016 Jun;137(6):e20153424. doi: 10.1542/peds.2015-3424. Epub 2016 May 13.
- Shankaran S, Papile LA, Wright LL, Ehrenkranz RA, Mele L, Lemons JA, Korones SB, Stevenson DK, Donovan EF, Stoll BJ, Fanaroff AA, Oh W. The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants. N Engl J Med. 1997 Aug 14;337(7):466-71. doi: 10.1056/NEJM199708143370705.
- Shankaran S, Papile LA, Wright LL, Ehrenkranz RA, Mele L, Lemons JA, Korones SB, Stevenson DK, Donovan EF, Stoll BJ, Fanaroff AA, Oh W, Verter J. Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure. Am J Obstet Gynecol. 2002 Jul;187(1):171-7. doi: 10.1067/mob.2002.122445.
- Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps DL, O'Shea TM, McDavid GE, Perritt RL, Van Meurs KP, Vohr BR, Grisby C, Yao Q, Pedroza C, Das A, Poole WK, Carlo WA, Duara S, Laptook AR, Salhab WA, Shankaran S, Poindexter BB, Fanaroff AA, Walsh MC, Rasmussen MR, Stoll BJ, Cotten CM, Donovan EF, Ehrenkranz RA, Guillet R, Higgins RD; NICHD Neonatal Research Network. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008 Oct 30;359(18):1885-96. doi: 10.1056/NEJMoa0803024.
- Oh W, Stevenson DK, Tyson JE, Morris BH, Ahlfors CE, Bender GJ, Wong RJ, Perritt R, Vohr BR, Van Meurs KP, Vreman HJ, Das A, Phelps DL, O'Shea TM, Higgins RD; NICHD Neonatal Research Network Bethesda MD. Influence of clinical status on the association between plasma total and unbound bilirubin and death or adverse neurodevelopmental outcomes in extremely low birth weight infants. Acta Paediatr. 2010 May;99(5):673-678. doi: 10.1111/j.1651-2227.2010.01688.x. Epub 2010 Jan 25. Erratum In: Acta Paediatr. 2013 Mar;102(3):326.
- Poindexter BB, Langer JC, Dusick AM, Ehrenkranz RA; National Institute of Child Health and Human Development Neonatal Research Network. Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome. J Pediatr. 2006 Mar;148(3):300-305. doi: 10.1016/j.jpeds.2005.10.038.
- Vohr BR, Poindexter BB, Dusick AM, McKinley LT, Wright LL, Langer JC, Poole WK; NICHD Neonatal Research Network. Beneficial effects of breast milk in the neonatal intensive care unit on the developmental outcome of extremely low birth weight infants at 18 months of age. Pediatrics. 2006 Jul;118(1):e115-23. doi: 10.1542/peds.2005-2382.
- Vohr BR, Poindexter BB, Dusick AM, McKinley LT, Higgins RD, Langer JC, Poole WK; National Institute of Child Health and Human Development National Research Network. Persistent beneficial effects of breast milk ingested in the neonatal intensive care unit on outcomes of extremely low birth weight infants at 30 months of age. Pediatrics. 2007 Oct;120(4):e953-9. doi: 10.1542/peds.2006-3227.
- Peralta-Carcelen M, Moses M, Adams-Chapman I, Gantz M, Vohr BR; NICHD Neonatal Research Network; National Institutes of Health. Stability of neuromotor outcomes at 18 and 30 months of age after extremely low birth weight status. Pediatrics. 2009 May;123(5):e887-95. doi: 10.1542/peds.2008-0135.
- Schmidt B, Davis P, Moddemann D, Ohlsson A, Roberts RS, Saigal S, Solimano A, Vincer M, Wright LL; Trial of Indomethacin Prophylaxis in Preterms Investigators. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med. 2001 Jun 28;344(26):1966-72. doi: 10.1056/NEJM200106283442602.
- Ambalavanan N, Baibergenova A, Carlo WA, Saigal S, Schmidt B, Thorpe KE; Trial of Indomethacin Prophylaxis in Preterms (TIPP) Investigators. Early prediction of poor outcome in extremely low birth weight infants by classification tree analysis. J Pediatr. 2006 Apr;148(4):438-444. doi: 10.1016/j.jpeds.2005.11.042.
- Schmidt B, Roberts RS, Fanaroff A, Davis P, Kirpalani HM, Nwaesei C, Vincer M; TIPP Investigators. Indomethacin prophylaxis, patent ductus arteriosus, and the risk of bronchopulmonary dysplasia: further analyses from the Trial of Indomethacin Prophylaxis in Preterms (TIPP). J Pediatr. 2006 Jun;148(6):730-734. doi: 10.1016/j.jpeds.2006.01.047.
- Bassler D, Stoll BJ, Schmidt B, Asztalos EV, Roberts RS, Robertson CM, Sauve RS; Trial of Indomethacin Prophylaxis in Preterms Investigators. Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infection. Pediatrics. 2009 Jan;123(1):313-8. doi: 10.1542/peds.2008-0377.
- Inhaled nitric oxide in term and near-term infants: neurodevelopmental follow-up of the neonatal inhaled nitric oxide study group (NINOS). J Pediatr. 2000 May;136(5):611-7. doi: 10.1067/mpd.2000.104826.
- Van Meurs KP, Wright LL, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK, Perritt R, Higgins RD, Oh W, Hudak ML, Laptook AR, Shankaran S, Finer NN, Carlo WA, Kennedy KA, Fridriksson JH, Steinhorn RH, Sokol GM, Konduri GG, Aschner JL, Stoll BJ, D'Angio CT, Stevenson DK; Preemie Inhaled Nitric Oxide Study. Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med. 2005 Jul 7;353(1):13-22. doi: 10.1056/NEJMoa043927.
- Hintz SR, Van Meurs KP, Perritt R, Poole WK, Das A, Stevenson DK, Ehrenkranz RA, Lemons JA, Vohr BR, Heyne R, Childers DO, Peralta-Carcelen M, Dusick A, Johnson YR, Morris B, Dillard R, Vaucher Y, Steichen J, Adams-Chapman I, Konduri G, Myers GJ, de Ungria M, Tyson JE, Higgins RD; NICHD Neonatal Research Network. Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxide. J Pediatr. 2007 Jul;151(1):16-22, 22.e1-3. doi: 10.1016/j.jpeds.2007.03.017.
- Chock VY, Van Meurs KP, Hintz SR, Ehrenkranz RA, Lemons JA, Kendrick DE, Stevenson DK; NICHD Neonatal Research Network. Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia. Am J Perinatol. 2009 Apr;26(4):317-22. doi: 10.1055/s-0028-1104743. Epub 2008 Dec 9.
- Lee BH, Stoll BJ, McDonald SA, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental outcomes of extremely low birth weight infants exposed prenatally to dexamethasone versus betamethasone. Pediatrics. 2008 Feb;121(2):289-96. doi: 10.1542/peds.2007-1103.
- Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH; National Institute of Child Health and Human Development Neonatal Research Network. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005 Oct 13;353(15):1574-84. doi: 10.1056/NEJMcps050929.
- Ambalavanan N, Carlo WA, Shankaran S, Bann CM, Emrich SL, Higgins RD, Tyson JE, O'Shea TM, Laptook AR, Ehrenkranz RA, Donovan EF, Walsh MC, Goldberg RN, Das A; National Institute of Child Health and Human Development Neonatal Research Network. Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics. 2006 Nov;118(5):2084-93. doi: 10.1542/peds.2006-1591.
- Oh W, Perritt R, Shankaran S, Merritts M, Donovan EF, Ehrenkranz RA, O'Shea TM, Tyson JE, Laptook AR, Das A, Higgins RD. Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathy. J Pediatr. 2008 Sep;153(3):375-8. doi: 10.1016/j.jpeds.2008.03.041. Epub 2008 May 9.
- Laptook A, Tyson J, Shankaran S, McDonald S, Ehrenkranz R, Fanaroff A, Donovan E, Goldberg R, O'Shea TM, Higgins RD, Poole WK; National Institute of Child Health and Human Development Neonatal Research Network. Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. Pediatrics. 2008 Sep;122(3):491-9. doi: 10.1542/peds.2007-1673.
- Shankaran S, Pappas A, Laptook AR, McDonald SA, Ehrenkranz RA, Tyson JE, Walsh M, Goldberg RN, Higgins RD, Das A; NICHD Neonatal Research Network. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics. 2008 Oct;122(4):e791-8. doi: 10.1542/peds.2008-0456.
- Sood BG, Madan A, Saha S, Schendel D, Thorsen P, Skogstrand K, Hougaard D, Shankaran S, Carlo W; NICHD neonatal research network. Perinatal systemic inflammatory response syndrome and retinopathy of prematurity. Pediatr Res. 2010 Apr;67(4):394-400. doi: 10.1203/PDR.0b013e3181d01a36.
- Bhandari V, Finer NN, Ehrenkranz RA, Saha S, Das A, Walsh MC, Engle WA, VanMeurs KP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomes. Pediatrics. 2009 Aug;124(2):517-26. doi: 10.1542/peds.2008-1302. Epub 2009 Jul 27.
- Wilson-Costello D, Walsh MC, Langer JC, Guillet R, Laptook AR, Stoll BJ, Shankaran S, Finer NN, Van Meurs KP, Engle WA, Das A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. Pediatrics. 2009 Mar;123(3):e430-7. doi: 10.1542/peds.2008-1928. Epub 2009 Feb 9.
- Ambalavanan N, Tyson JE, Kennedy KA, Hansen NI, Vohr BR, Wright LL, Carlo WA; National Institute of Child Health and Human Development Neonatal Research Network. Vitamin A supplementation for extremely low birth weight infants: outcome at 18 to 22 months. Pediatrics. 2005 Mar;115(3):e249-54. doi: 10.1542/peds.2004-1812. Epub 2005 Feb 15.
- Blakely ML, Tyson JE, Lally KP, McDonald S, Stoll BJ, Stevenson DK, Poole WK, Jobe AH, Wright LL, Higgins RD; NICHD Neonatal Research Network. Laparotomy versus peritoneal drainage for necrotizing enterocolitis or isolated intestinal perforation in extremely low birth weight infants: outcomes through 18 months adjusted age. Pediatrics. 2006 Apr;117(4):e680-7. doi: 10.1542/peds.2005-1273. Epub 2006 Mar 20.
- Dusick AM, Poindexter BB, Ehrenkranz RA, Lemons JA. Growth failure in the preterm infant: can we catch up? Semin Perinatol. 2003 Aug;27(4):302-10. doi: 10.1016/s0146-0005(03)00044-2.
- Ehrenkranz RA, Dusick AM, Vohr BR, Wright LL, Wrage LA, Poole WK. Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants. Pediatrics. 2006 Apr;117(4):1253-61. doi: 10.1542/peds.2005-1368.
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- Konduri GG, Vohr B, Robertson C, Sokol GM, Solimano A, Singer J, Ehrenkranz RA, Singhal N, Wright LL, Van Meurs K, Stork E, Kirpalani H, Peliowski A, Johnson Y; Neonatal Inhaled Nitric Oxide Study Group. Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: neurodevelopmental follow-up. J Pediatr. 2007 Mar;150(3):235-40, 240.e1. doi: 10.1016/j.jpeds.2006.11.065.
- Ohls RK, Ehrenkranz RA, Das A, Dusick AM, Yolton K, Romano E, Delaney-Black V, Papile LA, Simon NP, Steichen JJ, Lee KG; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental outcome and growth at 18 to 22 months' corrected age in extremely low birth weight infants treated with early erythropoietin and iron. Pediatrics. 2004 Nov;114(5):1287-91. doi: 10.1542/peds.2003-1129-L.
- Shankaran S. Neonatal encephalopathy: treatment with hypothermia. J Neurotrauma. 2009 Mar;26(3):437-43. doi: 10.1089/neu.2008.0678.
- Duncan AF, Watterberg KL, Nolen TL, Vohr BR, Adams-Chapman I, Das A, Lowe J; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Effect of ethnicity and race on cognitive and language testing at age 18-22 months in extremely preterm infants. J Pediatr. 2012 Jun;160(6):966-71.e2. doi: 10.1016/j.jpeds.2011.12.009. Epub 2012 Jan 23.
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- Salas AA, Carlo WA, Ambalavanan N, Nolen TL, Stoll BJ, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Gestational age and birthweight for risk assessment of neurodevelopmental impairment or death in extremely preterm infants. Arch Dis Child Fetal Neonatal Ed. 2016 Nov;101(6):F494-F501. doi: 10.1136/archdischild-2015-309670. Epub 2016 Feb 19.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. januar 1993
Primær færdiggørelse (Anslået)
31. marts 2030
Studieafslutning (Anslået)
31. marts 2030
Datoer for studieregistrering
Først indsendt
1. februar 2001
Først indsendt, der opfyldte QC-kriterier
2. februar 2001
Først opslået (Anslået)
5. februar 2001
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Anslået)
8. november 2023
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
7. november 2023
Sidst verificeret
1. marts 2023
Mere information
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Nøgleord
Yderligere relevante MeSH-vilkår
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