- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT02201095
Active Warming During Elective Caesearean Section
Active Warming for Elective Caesarean Section - a RCT
During anaesthesia for caesarean section it is common to lose heat and become hypothermic, (<36 degrees C). In order to try and avoid this all women are given warmed intravenous fluid and insulated from cold surfaces. There are also 2 types of machine available to actively warm women;
- Forced Air Warming - that uses a disposable sheet the woman lies upon with lots of air pockets that have warm air blown into them continuously by a fan.
- Conduction Warming Mattress - a thin mattress which covers the operating table and the woman lies on top. The padded mattress has strips of material that heat up when electricity passes through it, similar to a normal electric blanket.
We plan to carry out a randomised controlled trial to compare these 2 methods with the current practice of no active warming.
The hypothesis for this study is that active warming women during elective caesarean section prevents women's temperature from dropping and keeps them more comfortable than if active warming were not used.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
When a baby is delivered by a surgical procedure (a caesarean section) the woman will usually have a "spinal" anaesthetic. With a "spinal", local anaesthetic is injected into the spinal fluid to make the woman numb from her chest to her feet, allowing her to be comfortable but awake during the birth. During this type of anaesthetic it is common to lose heat and become cold or "hypothermic" measured as less than 36 degrees Celsius. Becoming this cold can be uncomfortable for the woman but also causes other problems. It can make blood clotting less effective, alter the way wounds heal afterwards and make the woman more likely to develop infections or problems related to her heart and lungs.
To help keep their temperature stable, the investigators give all women fluid into the veins that is already warm and ensure that they are well insulated from any cold surfaces. There are two machines that the investigators can also use to actively warm patients but these are not yet used in every case. The first method is called "Forced Air Warming" and uses a special disposable sheet the woman lies upon with lots of air pockets that have warm air blown into them continuously by a fan. The woman is surrounded by these pockets of warm air, which help to warm her and also insulate against heat loss. The second method is called a "Conduction Warming Mattress" and uses a thin mattress which covers the operating table and the woman lies on top. The padded mattress has strips of material that heat up when electricity passes through it, similar to a normal electric blanket.
The investigators have already looked at the records of some women having caesarean sections in our hospital and found that both forced air warming and conduction mattress warming seem to help them stay warm. However, the investigators would like to study this in more detail and prove scientifically whether these methods are effective. Our aim in this study is to see if warming machines can help prevent women getting too cold, and prove scientifically whether one is more effective.
The hypothesis for this study is that active warming women during elective caesarean section prevents women's temperature from dropping and keeps them more comfortable than if active warming were not used.
The women will have exactly the same anaesthetic as they would have had if they were not in the study. If a woman agrees to be in the study she will be chosen randomly to receive either, normal care (including warmed fluids but no warming machines), additional warming with forced air or additional warming by conduction mattress. Her temperature will be measured at regular intervals before, during and after the caesarean section, at the same time she will be asked to score herself on a thermal comfort scale. The results will be analysed to compare the temperature changes in each group.
The investigators hope that the active warming machines will keep body temperature stable and prevent hypothermia. If the investigators find out that these machines prevent women getting cold, they can ensure that the most effective methods of warming during caesarean section operations are used and minimise problems due to becoming cold.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiesteder
-
-
South Yorkshire
-
Sheffield, South Yorkshire, Det Forenede Kongerige, S10 2JF
- Sheffield Teaching Hospitals NHS Trust
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Patients with a singleton, uncomplicated pregnancy, presenting for elective caesarean section under spinal anaesthesia, where surgery and anaesthesia are expected to be uncomplicated. Patients scheduled for tubal ligation surgery (sterilisation) as part of the caesarean section may also be included.
Exclusion Criteria:
- Age under 18
- BMI <19 or >30
- Diseases of pregnancy: e.g. pregnancy induced hypertension
- Grand Multiparity - ie parity of 5 or greater
- Pre-operative pyrexia (temperature of 37.5 degrees C or greater)
- Pre-operative hypothermia (temperature 36.0 degrees or cooler)
- Significant co-existing maternal disease - e.g. congenital heart disease
- Co-existing maternal disease that could impact on temperature- e.g. hypo/hyperthyroid
- Coagulation abnormalities or anticipated excessive blood loss including any form of abnormal placentation
- Surgical procedure expected not to be routine/deviation from normal practice
- Condition preventing full, informed consent.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Forebyggelse
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Dobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Ingen indgriben: Normal care
Normal care - no active warming
|
|
|
Aktiv komparator: Forced air warming
Underbody forced air warming blanket
|
Andre navne:
|
|
Aktiv komparator: Conduction warming mattress
Underbody conduction warming mattress
|
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Mean temperature on arrival in recovery
Tidsramme: Temperature will be measured on arrival in recovery.
|
The primary outcome of the study is to find whether there is a clinically significant statistical difference between the mean temperatures on arrival in recovery of the control and conduction mattress groups; the control and forced air warming groups; and the conduction mattress and forced air warming groups.
|
Temperature will be measured on arrival in recovery.
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Peri-operative hypothermia
Tidsramme: Temperature will be measured evry 15 minutes throughout the duration of the procedure and in recovery room. The investigators anticipate that this will be over approximately a 2 hour period.
|
To find whether these active warming devices significantly reduce the incidence of peri-operative hypothermia during spinal anaesthesia for caesarean section
|
Temperature will be measured evry 15 minutes throughout the duration of the procedure and in recovery room. The investigators anticipate that this will be over approximately a 2 hour period.
|
Andre resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Thermal comfort scores
Tidsramme: Thermal comfort will be assessed and scored at 15 minute intervals during surgery and in recovery. We anticipate that this will occur over approximately 2 hours.
|
To assess whether active warming makes patients too hot and assess maternal thermal comfort and satisfaction during active warming.
|
Thermal comfort will be assessed and scored at 15 minute intervals during surgery and in recovery. We anticipate that this will occur over approximately 2 hours.
|
Samarbejdspartnere og efterforskere
Efterforskere
- Ledende efterforsker: Melanie J Woolnough, Mb ChB, Sheffield Teaching Hospitals NHS Foundation Trust
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- STH18196
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Preoperative Hypothermia
-
University of ValenciaAfsluttet
-
Jiangsu HengRui Medicine Co., Ltd.Afsluttet
-
Cairo UniversityIkke rekrutterer endnuPræoperativ angst | Preoperativ angst oplevet af den pædiatriske patientEgypten
-
Liaquat National Hospital & Medical CollegeIkke rekrutterer endnuSedation | Sedation og analgesi | Preoperativ angst oplevet af den pædiatriske patient | Anxiolytisk effekt
-
Istinye UniversityRekrutteringPostdural punktering hovedpine | Preoperativ neutrofil-til-lymfocytforhold (NLR)Kalkun
-
Konya City HospitalAfsluttetPREOPERATIV SOVEKVALITET PÅ POSTOPERATIVT DELIRIUMKalkun
-
Bozok UniversityRekrutteringPostoperative komplikationer | Pædiatriske patienter | Preoperativ angst (Ameliyat Öncesi Anksiyete) | Emergence Delirium (Derlenme Deliryumu)Tyrkiet (Türkiye)
-
Qun ZhaoFirst Hospital of Shijiazhuang City; Baoding First Central Hospital; Hengshui...Tilmelding efter invitationMavekræft | Lymfemetastase | Kunstig intelligens | Radiomik | Para-aorta lymfeknude metastase | Preoperativ billeddannelsesvurderingKina
Kliniske forsøg med Forced air warming
-
Virginia Commonwealth UniversityAfsluttet
-
Stanford UniversityAfsluttetHypotermiForenede Stater
-
Indus Hospital and Health NetworkUkendtForceret luftopvarmningseffekt på hypotermiPakistan
-
University of MinnesotaAfsluttetKirurgi | Temperaturændring, kropForenede Stater
-
Michael Garron HospitalAfsluttetHypotermi | Ændringer i kropstemperaturen | Hypotermi efter anæstesi | Hypotermi, utilsigtet | Hypotermi på grund af bedøvelseCanada
-
Massachusetts General HospitalAfsluttetPerinatal asfyksi | Asphyxia Neonatorum | Fødselsasfyksi
-
AIRNA CorporationRekrutteringAlpha 1 Antitrypsin mangelDet Forenede Kongerige, Australien, Georgien
-
The Cleveland ClinicThe Surgical CompanyAfsluttetVarmeoverførsel med kliniske opvarmningsanordningerForenede Stater
-
Nimbic Systems, LLCAfsluttet
-
Riphah International UniversityAfsluttetKronisk obstruktiv lungesygdomPakistan