Immune Response to Anti COVID-19 Vaccine in Immunocompromised Patients: a Cohort Study

General Inclusion Criteria:

• Eastern Cooperative Oncology Group < 3
• Vaccination with 2 doses of Coronavac vaccine

General Exclusion Criteria:

• Previous SARS-CoV-2 infection
• Vaccination with Coronavac more than 12 weeks before informed consent
• Intravenous immunoglobulin therapy 60 days before informed consent
• Any condition, that could interfere with the participant's participation during the study in the opinion of the treating investigator.

Cancer Cohort

Inclusion Criteria:

• Diagnosis of cancer in the previous 5 years (consistent biopsy is required).
• Life expectancy more than 12 weeks

Exclusion Criteria:

• Bone marrow transplant, solid organ recipient, HIV, immunosuppressant treatment for other condition.

Bone Marrow Transplant Cohort

Inclusion Criteria:

• Bone marrow transplant between January 2019 and December 2020

Exclusion Criteria:

• Other cancer diagnosis during the last 5 years, solid organ recipient, HIV, immunosuppressant treatment for other condition.

Solid Organ Recipient Cohort:

Inclusion Criteria:

• Liver, kidney or heart transplant between January 2019 and December 2020
• Active immunosuppressant treatment

Exclusion Criteria:

- Cancer diagnosis during the last 5 years, bone marrow transplant, immunosuppressant treatment for other condition, HIV

HIV Cohort:

Inclusion Criteria:

• CD4 <= 500 cels/mm3 documented one year before study enrollment
• Active antiretroviral therapy
• Viral load < 200 copies/ml

Exclusion Criteria:

• Cancer diagnosis during the last 5 years, bone marrow transplant or solid organ recipient, immunosuppressant treatment.

Rheumatic Disease Cohort

Inclusion Criteria:

• Diagnosis of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, relapsing polychondritis, Behcet disease or juvenile idiopathic arthritis
• Chronic immunomodulatory treatment with anti-TNF, anti-IL6 or anti-IL17 agents

Exclusion Criteria:

• Treatment with more than one biological agent.
• Cancer diagnosis during the last 5 years, bone marrow transplant or solid organ recipient, HIV diagnosis.