Forskelle i EKG- versus forlænget hjertemonitor-detekteret atrieflimren hos STROKE-patienter (DELIMIT AF-STROKE)
Forskelle i EKG- vs. forlænget hjertemonitor-detekteret atrieflimren hos patienter med slagtilfælde
The present study is an investigator-initiated, single-center, retrospective study based on data from the London Ontario Stroke Registry (LOSR), aiming to compare the characteristics and outcomes of ECG-detected and Device-Detected atrial fibrillation in patients with ischemic stroke and transient ischemic attack.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Patients with ischemic stroke and transient ischemic attack (TIA) without known atrial fibrillation (AF) are investigated with Prolonged Cardiac Monitoring (PCM) to detect AF. It is unclear if AF detected on 12-lead ECG after stroke occurrence bears the same risk of stroke as Device-detected AF. The investigators hypothesize, that Device-detected AF has a lower risk of ischemic stroke recurrence. The investigators will conduct a retrospective analysis of prospectively collected data from consecutive patients enrolled in the London Ontario Stroke Registry, (Ontario, Canada). The primary outcome will be a recurrent ischemic stroke at the end of the available follow-up window. The investigators will include ischemic stroke and TIA patients with ECG-detected AF and those with Device-detected AF on at least 7 days of Holter monitoring.
Undersøgelsestype
Tilmelding (Anslået)
Kontakter og lokationer
Studiesteder
-
-
Ontario
-
London, Ontario, Canada, N6A 5A5
- Heart & Brain Lab, Western University
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Patients with an acute ischemic stroke or TIA in the London Ontario Stroke Registry without known AF, who are newly diagnosed with AF on a 12-lead ECG or a ≥7-day external cardiac monitor.
Beskrivelse
Inclusion Criteria:
- Age ≥18 years
- Patient with a diagnosis of ischemic stroke or TIA.
- ECG-diagnosed AF or PCM-detected AF post ischemic stroke or TIA
Exclusion Criteria:
- Individuals younger than18 years-old
- Patients without IS or TIA diagnosis
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: COHORT
- Tidsperspektiver: RETROSPECTIVE
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
|
ECG-Detected AF
Patients with atrial fibrillation detected on 12-lead ECGs done post-stroke |
Electrocardiogram |
|
Device-Detected AF
Patients with atrial fibrillation detected on prolonged Holter monitoring lasting at least 7 days. |
Prolonged cardiac monitoring |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Number of Participants with Recurrent Ischemic Stroke at End of available Follow-up Time
Tidsramme: Duration of follow-up - minimum of 3 months after the first encounter with the stroke team
|
Documented recurrent ischemic stroke |
Duration of follow-up - minimum of 3 months after the first encounter with the stroke team
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Death
Tidsramme: Duration of follow-up - minimum of 3 months after the first encounter with the stroke team
|
Number of patients dead at the end of the available follow-up |
Duration of follow-up - minimum of 3 months after the first encounter with the stroke team
|
|
Readmission for decompensated AF or heart failure
Tidsramme: Duration of follow-up - minimum of 3 months after the first encounter with the stroke team
|
Prevalence of readmission for decompensated AF or heart failure (HF) in each group |
Duration of follow-up - minimum of 3 months after the first encounter with the stroke team
|
|
Prevalence of risk factors, cardiovascular comorbidities, and structural heart disease
Tidsramme: Documented at baseline.
|
Proportion with vascular risk factors, cardiovascular comorbidities, and structural heart disease in each group |
Documented at baseline.
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Ledende efterforsker: Luciano Sposato, MD, MBA (PI), London Health Sciences Centre, Western University (London, ON. Canada)
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Cerebrovaskulære lidelser
- Hjernesygdomme
- Sygdomme i centralnervesystemet
- Sygdomme i nervesystemet
- Karsygdomme
- Hjerte-kar-sygdomme
- Patologiske processer
- Hjertesygdomme
- Arytmier, hjerte
- Patologiske tilstande, tegn og symptomer
- Slag
- Atrieflimren
- Diagnostiske teknikker og procedurer
- Diagnose
- Diagnostiske teknikker, kardiovaskulær
- Hjertefunktionstest
- Elektrodiagnose
- Elektrokardiografi
Andre undersøgelses-id-numre
- ReDA ID 13446
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
IPD-planbeskrivelse
Individual patients data will be made available upon reasonable request, conditional to approval from Western University Ethics Review Board
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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