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Optimering af excentriske øvelser (OPTIMEX)

5. november 2026 opdateret af: University Hospital, Clermont-Ferrand

Karakterisering af den endokrine respons på træning: Virkningen af ​​muskelkontraktionsmodaliteten

Regular physical activity is an important public health lever and is recognised as an alternative in the management of certain long-term conditions. To achieve beneficial effects on the body, exercise recommendations are based on several parameters such as duration, intensity and continuous or intermittent nature of the activity. However, the mode of muscle contraction during exercise is generally little considered or poorly defined in these recommendations, which can lead to prescribing errors. In particular, the eccentric contraction modality, which can be found in actions designed to slow down movement (e.g. walking downhill), represents an interesting strategy, but its prescription modalities are still poorly understood.

The beneficial effects of physical activity are based in part on the release of molecules (myokines) by the skeletal muscles during exercise, which improve the functioning of the body. However, the effect of downhill walking on the release of myokines by the muscle has been little studied. The lack of knowledge of this effect is therefore an obstacle to the use of this exercise modality to try to optimise physical activity recommendations for health or performance improvement.

The aim of this study is therefore to better understand how downhill walking (eccentric muscle contraction) affects the production of molecules by muscles (myokines) during exercise.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

After being informed of the aims, nature and possible risks of the study, written informed consent will be obtained from the subjects.

Prior to enrolment, volunteers will undergo a medical evaluation that includes a review of personal and family medical history, any current medications, and a standard physical examination. Compliance with the inclusion/exclusion criteria will be checked during this examination.

After enrolment, subjects will perform a treadmill familiarization session.

Experimental days:

  • Subjects will complete a 45-minute walking exercise on a negative gradient treadmill (6 km/h) in a randomised 2-way cross-over design with either a -10% or -20% gradient.
  • Blood will be sampled immediately pre-exercise, 1-h and 24-h post-exercise for the analysis of muscle myokines.
  • Exercise-induced muscle fatigue in lower limbs will be evaluated using squat and counter-movement jumps immediately before and post-exercise.
  • Heart-rate variability will be measured during the eccentric exercise session.
  • Thigh muscle volume will be measured immediately before and post-exercise.
  • Exercise-induced myalgia at 24-, 48-, 72- and 96h will be assessed using a visual analogue scale.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

20

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Frankrig
      • Clermont-Ferrand, Frankrig
        • Chu Clermont Ferrand

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 40 år (Voksen)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Han

Beskrivelse

Inclusion Criteria:

  • Body Mass Index between 18.5 and 24.9 kg/m² (18.5 ≤ BMI ≤ 24.9)
  • Non-smoker
  • No treatment (background or at the time of the examination)
  • Physical check up considered compatible with study participation (no bones, articular or muscular problems in lower limbs)
  • Subjects considered healthy by investigator based on medical questioning and clinical examination
  • Affiliation to the French Social Security system
  • Person who has read and understood the research-related information, and signed the consent forms

Exclusion Criteria:

  • Smoking
  • Subjects with heart or respiratory failure
  • Participants with lower extremity injury in the past three months
  • Contraindication to the application of a magnetic field (wearing a pacemaker, presence of prosthetic material or ferromagnetic foreign bodies, presence of cochlear implants or ocular prosthetic material)
  • Participant that does not wish to participate (refusal to sign the consent form)
  • Patients under guardianship, trusteeship, deprived of liberty or safeguard of justice

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Forebyggelse
  • Tildeling: Randomiseret
  • Interventionel model: Crossover opgave
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: downhill treadmill walking -10% gradient

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% incline)
Enhed: Experimental: downhill treadmill walking at -10% and -20% gradient

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% or -20% incline)
Eksperimentel: downhill treadmill walking -20% gradient

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-20% incline)
Enhed: Experimental: downhill treadmill walking at -10% and -20% gradient

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% or -20% incline)

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Effect of eccentric exercise on myokine concentrations
Tidsramme: Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise

Changes in systemic myokine levels following submaximal downhill treadmill exercise at different inclines, at the same speed and for the same duration.
Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise
Effect of treadmill inclination on myokine concentrations
Tidsramme: Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise

Differences in systemic myokine levels concentrations following -10 and -20% gradient submaximal downhill treadmill exercises, at the same speed and for the same duration.
Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Assessment of exercise-induced muscle fatigue in lower limbs
Tidsramme: Baseline (prior exercise) and 15 seconds post-exercise

squat jump
Baseline (prior exercise) and 15 seconds post-exercise
Assessment of exercise-induced muscle fatigue in lower limbs
Tidsramme: Baseline (prior exercise) and 15 seconds post-exercise

counter-movement jump
Baseline (prior exercise) and 15 seconds post-exercise
Assessment of autonomic nervous system function
Tidsramme: During treadmill exercise

Heart rate variability (HRV) analysis Temporal and spectral analyses of cardiac variability
During treadmill exercise
Effect of treadmill exercise on muscle volume
Tidsramme: Baseline (prior exercise) and 15 seconds post-exercise

Measurement of thigh and calf circumferences
Baseline (prior exercise) and 15 seconds post-exercise
Effect of treadmill exercise on muscle pain
Tidsramme: Baseline (prior exercise) and 15 seconds post-exercise

Measurement of muscle pain induced by a half-squat movement (self-measurement by the subject using a visual analogic scale, 0-10)
Baseline (prior exercise) and 15 seconds post-exercise
Effect of treadmill exercise on delayed onset muscle soreness
Tidsramme: Baseline (prior exercise) and Hour 24, Hour 48, Hour 72, Hour 96 post-exercise

Measurement of muscle pain induced by eccentric exercise (self-measurement by the subject using a visual analogic scale, 0-10)
Baseline (prior exercise) and Hour 24, Hour 48, Hour 72, Hour 96 post-exercise

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

University Hospital, Clermont-Ferrand

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

4. maj 2023

Primær færdiggørelse (Faktiske)

16. september 2023

Studieafslutning (Faktiske)

16. november 2023

Datoer for studieregistrering

Først indsendt

23. juni 2023

Først indsendt, der opfyldte QC-kriterier

21. december 2023

Først opslået (Faktiske)

5. januar 2024

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

9. november 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

5. november 2026

Sidst verificeret

1. maj 2023

Mere information

Begreber relateret til denne undersøgelse

Andre undersøgelses-id-numre

  • RBHP 2022 RANNOU

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

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