Optimización de ejercicios excéntricos. (OPTIMEX)
Caracterización de la respuesta endocrina al ejercicio: impacto de la modalidad de contracción muscular
Regular physical activity is an important public health lever and is recognised as an alternative in the management of certain long-term conditions. To achieve beneficial effects on the body, exercise recommendations are based on several parameters such as duration, intensity and continuous or intermittent nature of the activity. However, the mode of muscle contraction during exercise is generally little considered or poorly defined in these recommendations, which can lead to prescribing errors. In particular, the eccentric contraction modality, which can be found in actions designed to slow down movement (e.g. walking downhill), represents an interesting strategy, but its prescription modalities are still poorly understood.
The beneficial effects of physical activity are based in part on the release of molecules (myokines) by the skeletal muscles during exercise, which improve the functioning of the body. However, the effect of downhill walking on the release of myokines by the muscle has been little studied. The lack of knowledge of this effect is therefore an obstacle to the use of this exercise modality to try to optimise physical activity recommendations for health or performance improvement.
The aim of this study is therefore to better understand how downhill walking (eccentric muscle contraction) affects the production of molecules by muscles (myokines) during exercise.
Descripción general del estudio
Estado
Condiciones
Intervención / Tratamiento
Descripción detallada
After being informed of the aims, nature and possible risks of the study, written informed consent will be obtained from the subjects.
Prior to enrolment, volunteers will undergo a medical evaluation that includes a review of personal and family medical history, any current medications, and a standard physical examination. Compliance with the inclusion/exclusion criteria will be checked during this examination.
After enrolment, subjects will perform a treadmill familiarization session.
Experimental days:
- Subjects will complete a 45-minute walking exercise on a negative gradient treadmill (6 km/h) in a randomised 2-way cross-over design with either a -10% or -20% gradient.
- Blood will be sampled immediately pre-exercise, 1-h and 24-h post-exercise for the analysis of muscle myokines.
- Exercise-induced muscle fatigue in lower limbs will be evaluated using squat and counter-movement jumps immediately before and post-exercise.
- Heart-rate variability will be measured during the eccentric exercise session.
- Thigh muscle volume will be measured immediately before and post-exercise.
- Exercise-induced myalgia at 24-, 48-, 72- and 96h will be assessed using a visual analogue scale.
Tipo de estudio
Inscripción (Actual)
Fase
- No aplica
Contactos y Ubicaciones
Ubicaciones de estudio
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Clermont-Ferrand, Francia
- Chu Clermont Ferrand
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Descripción
Inclusion Criteria:
- Body Mass Index between 18.5 and 24.9 kg/m² (18.5 ≤ BMI ≤ 24.9)
- Non-smoker
- No treatment (background or at the time of the examination)
- Physical check up considered compatible with study participation (no bones, articular or muscular problems in lower limbs)
- Subjects considered healthy by investigator based on medical questioning and clinical examination
- Affiliation to the French Social Security system
- Person who has read and understood the research-related information, and signed the consent forms
Exclusion Criteria:
- Smoking
- Subjects with heart or respiratory failure
- Participants with lower extremity injury in the past three months
- Contraindication to the application of a magnetic field (wearing a pacemaker, presence of prosthetic material or ferromagnetic foreign bodies, presence of cochlear implants or ocular prosthetic material)
- Participant that does not wish to participate (refusal to sign the consent form)
- Patients under guardianship, trusteeship, deprived of liberty or safeguard of justice
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Prevención
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación cruzada
- Enmascaramiento: Único
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
|
Experimental: downhill treadmill walking -10% gradient
The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% incline) |
The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% or -20% incline) |
|
Experimental: downhill treadmill walking -20% gradient
The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-20% incline) |
The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% or -20% incline) |
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Effect of eccentric exercise on myokine concentrations
Periodo de tiempo: Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise
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Changes in systemic myokine levels following submaximal downhill treadmill exercise at different inclines, at the same speed and for the same duration. |
Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise
|
|
Effect of treadmill inclination on myokine concentrations
Periodo de tiempo: Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise
|
Differences in systemic myokine levels concentrations following -10 and -20% gradient submaximal downhill treadmill exercises, at the same speed and for the same duration. |
Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Assessment of exercise-induced muscle fatigue in lower limbs
Periodo de tiempo: Baseline (prior exercise) and 15 seconds post-exercise
|
squat jump |
Baseline (prior exercise) and 15 seconds post-exercise
|
|
Assessment of exercise-induced muscle fatigue in lower limbs
Periodo de tiempo: Baseline (prior exercise) and 15 seconds post-exercise
|
counter-movement jump |
Baseline (prior exercise) and 15 seconds post-exercise
|
|
Assessment of autonomic nervous system function
Periodo de tiempo: During treadmill exercise
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Heart rate variability (HRV) analysis Temporal and spectral analyses of cardiac variability |
During treadmill exercise
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|
Effect of treadmill exercise on muscle volume
Periodo de tiempo: Baseline (prior exercise) and 15 seconds post-exercise
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Measurement of thigh and calf circumferences |
Baseline (prior exercise) and 15 seconds post-exercise
|
|
Effect of treadmill exercise on muscle pain
Periodo de tiempo: Baseline (prior exercise) and 15 seconds post-exercise
|
Measurement of muscle pain induced by a half-squat movement (self-measurement by the subject using a visual analogic scale, 0-10) |
Baseline (prior exercise) and 15 seconds post-exercise
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Effect of treadmill exercise on delayed onset muscle soreness
Periodo de tiempo: Baseline (prior exercise) and Hour 24, Hour 48, Hour 72, Hour 96 post-exercise
|
Measurement of muscle pain induced by eccentric exercise (self-measurement by the subject using a visual analogic scale, 0-10) |
Baseline (prior exercise) and Hour 24, Hour 48, Hour 72, Hour 96 post-exercise
|
Colaboradores e Investigadores
Patrocinador
Publicaciones y enlaces útiles
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Otros números de identificación del estudio
- RBHP 2022 RANNOU
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
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