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NET-TIME: Inflammatory Tumor Microenvironment in Pituitary Neoplasm (NET-TIME)

14. maj 2026 opdateret af: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Inflammatory Tumor Microenvironment in Pituitary Neoplasm

Over the past twenty years, a progressively increasing number of markers biochemical, clinical, imaging, histopathological or genetic have been suggested to attempt to predict aggression and therapeutic outcome, both in secretory PitNETs and in non-secretory PitNETs. In recent years, the microenvironment tumor (TEM) has been extensively studied in different malignancies, promoting the development of therapies target and immunotherapy with checkpoint inhibitors immune system (ICI). Data on TIME in PitNETs are scarce today and derive from studies conducted mainly on heterogeneous cases for type of PitNET. Therefore, the purpose of this research project is to investigate the TIME in PitNET, to identify immune biomarkers and new molecular pathways that can promote the use of ICI and target therapies in Aggressive PitNETs.

Studieoversigt

Status

Rekruttering

Betingelser

Detaljeret beskrivelse

Pituitary adenomas are currently recognized such as pituitary neuroendocrine tumors (PitNETs), as originating from the neuroendocrine cells of the pituitary gland and represent about 10% of all intracranial tumors. Over the past twenty years, a progressively increasing number of markers biochemical, clinical, imaging, histopathological or genetic have been suggested to attempt to predict aggression and therapeutic outcome, both in secretory PitNETs and in non-secretory PitNETs, such as concentration blood tests of secreted hormones, the patient's gender, the age at onset of the disease, the size of the tumor, signs of local invasiveness, tumor indices of proliferation and mitotic indices. However, unique and reproducible markers of tumor aggressiveness and outcome have been identified therapeutic. In recent years, the microenvironment tumor (TEM) has been extensively studied in different malignancies, promoting the development of therapies target and immunotherapy with checkpoint inhibitors immune system (ICI). Data on TIME in PitNETs are scarce today and derive from studies conducted mainly on heterogeneous cases for type of PitNET. Plus most of the studies on TIME in PitNETs they were focused on study of the inflammatory cellular infiltrate and in particular on lymphocyte populations, showing a heterogeneous phenotype during the different phases of the natural history of neoplastic pathology. Therefore, the purpose of this research project is to investigate the TIME in PitNET, to identify immune biomarkers and new molecular pathways that can promote the use of ICI and target therapies in Aggressive PitNETs.

Undersøgelsestype

Observationel

Tilmelding (Anslået)

60

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiesteder

  • Italien
    • Lazio
      • Rome, Lazio, Italien, 00168
        • Rekruttering
        • Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC ENDOCRINOLOGIA
        • Ledende efterforsker:
          • Sabrina Chiloiro
        • Kontakt:

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Prøveudtagningsmetode

Sandsynlighedsprøve

Studiebefolkning

Patients with pituitary adenomas

Beskrivelse

Inclusion Criteria:

  • indication as per clinical practice and in agreement to current guidelines for surgical removal of the PitNET0;
  • patient naïve to medical therapy before surgical removal of PitNET;
  • Diagnosis of PitNET confirmed through the study pathological/histological;
  • over 18 years of age;
  • acceptance of participation in the study, by signing an informed consent.

Exclusion Criteria:

  • History of medical therapy with analogs of somatostatin or dopamine agonist, previous the removal of the pituitary adenoma;
  • history of radiotherapy of the head and neck region earlier than 10 years after resection of the adenoma pituitary;
  • history of autoimmune diseases.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Cells immune systems
Tidsramme: 24 months
Quantify and locate cells immune systems (lymphocytes CD3, CD4, CD8, CD20, CD138, CD68+ macrophages) associated with the various PitNET subtypes in the study
24 months

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Chemokines in PitNETS samples
Tidsramme: 24 months
Identify cytokines and chemokines in PitNETS samples, through Human Cytokine antibody Array ab 133997
24 months
Chemokines in PitNETS samples
Tidsramme: 24 months
Quantify cytokines and chemokines in PitNETS samples, through Human Cytokine antibody Array ab 133997
24 months
pituitary antibodies in PitNET
Tidsramme: 24 months
Quantify plasma pituitary antibodies associated with the various subtypes of PitNET under study
24 months
Identify the biomarkers associated with the various PitNET subtypes, anatomical-pathological and morphological characteristics, surgical outcome and response to medical therapy in PitNET
Tidsramme: 24 months
Identify the biomarkers associated with the various PitNET subtypes, anatomical-pathological and morphological characteristics, surgical outcome and response to medical therapy, through statistical software R. We will use clinical parameters for the measurement.
24 months

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Efterforskere

  • Ledende efterforsker: Sabrina Chiloiro, Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

3. juni 2023

Primær færdiggørelse (Anslået)

1. september 2026

Studieafslutning (Anslået)

31. marts 2027

Datoer for studieregistrering

Først indsendt

19. september 2024

Først indsendt, der opfyldte QC-kriterier

14. maj 2026

Først opslået (Faktiske)

18. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

18. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

14. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 5116

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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