"Cryptogenic Stroke and Atrial Fibrillation Detection Through Implantable Loop Recorder (ILR)" (CRYPTONITE)

Inclusion Criteria:

• All patients included must meet one of these two conditions:

  • Patient presenting with an episode of transient ischemic attack (TIA) of cryptogenic origin with neurological symptoms of less than 24h of evolution and negative neuroimaging.
  • First episode of ischaemic stroke with cryptogenic etiology following TOAST criteria

• All patients must meet all of the following:

  • The patient has been implanted an ILR within 30 days after qualifying event
  • Age between 45-85 years
  • No stenosis >50% in any arterial vessel corresponding to the affected territory
  • Normal Echocardiography
  • Normal 24 hours EKG Holter recording
  • Absence of Patent Foramen Ovale through transcranial doppler (or transesophageal echocardiography)
  • Acceptance and signature of Patient Informed Consent.

Exclusion Criteria:

• All patients included cannot meet any of the following conditions:

  • Recurrent stroke or TIA
  • Stroke or TIA with determined etiology according to TOAST criteria.
  • Anticoagulation indication at the time of enrollment in the study.
  • Total contraindication for anticoagulation therapy
  • Atrial fibrillation detection prior to enrollment
  • Severe cognitive impairment or dementia
  • Patient unable to be followed up
  • Patients enrolled in another clinical trial
  • Patients with life expectancy of less than 1 year
  • Pregnancy