Protectivity and Safety of Quadrivalent Influenza HA Vaccine in Indonesian Population

Inclusion Criteria for Subjects 9 - 40 Years of Age:

• Healthy
• Properly informed about the study and having signed the informed consent form
• Subject/Parent will commit themselves to comply with the instructions of the investigator and the schedule of the trial.

Inclusion Criteria for Subjects 6 Months - 8 Years of Age:

• Healthy
• Parents have been informed properly regarding the study and signed the informed consent form
• Parents will commit themselves to comply with the instructions of the investigator and the schedule of the trial

Exclusion Criteria:

• Subject concomitantly enrolled or scheduled to be enrolled in another trial
• Evolving mild, moderate or severe illness, especially infectious diseases or fever (axillary temperature >= 37.5 C )
• Known history of allergy to egg and or chicken protein or any component of the vaccines
• History of uncontrolled coagulopathy or blood disorders contraindicating intramuscular injection
• Subject who has received in the previous 4 weeks a treatment likely to alter the immune response (intravenous immunoglobulins, blood-derived products or long term corticotherapy (> 2 weeks).
• Pregnancy & Lactation (Adult)
• Any abnormality or chronic disease which according to the investigator might interfere with the assessment of the trial objectives
• Subject already immunized with influenza vaccine within 1 year.
• Subjects receive any vaccination within 1 month before and after immunization of Quadrivalent Influenza Vaccine.