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Centro Especializado de Investigación en Enfermedades Pulmonares Inmunológicas y Ocupacionales

12 de mayo de 2016 actualizado por: National Heart, Lung, and Blood Institute (NHLBI)

El objetivo general del Centro era desarrollar una base de datos científica para el control y la prevención de lesiones pulmonares agudas y crónicas causadas por la inhalación de una variedad de agentes en el lugar de trabajo y en el medio ambiente. Hubo dos estudios epidemiológicos.

Efectos respiratorios de la exposición a gases irritantes: para recopilar datos longitudinales sobre la función pulmonar y los síntomas en trabajadores de fabricación de productos químicos que estuvieron expuestos a irritantes químicos como amoníaco, cloro, fosgeno, isocianatos, dióxido de azufre, óxido nitroso, formaldehído, ácidos orgánicos, fluoruros de ácido clorhídrico , otros aldehídos y anhídridos de ácido.

Trabajadores de la industria textil del algodón: para detectar y cuantificar el riesgo de desarrollar enfermedad obstructiva crónica de las vías respiratorias que se produjo en los trabajadores expuestos al polvo de algodón en la fabricación textil.

Descripción general del estudio

Estado

Terminado

Condiciones

Descripción detallada

FONDO:

Los dos proyectos formaban parte de un Centro Especializado de Investigación (SCOR) en Enfermedades Pulmonares Inmunológicas y Ocupacionales. Desde su creación en 1972, los investigadores del SCOR han realizado estudios epidemiológicos sobre asbestosis, silicosis en arenadoras y reacciones respiratorias en trabajadores expuestos a enzimas detergentes y vapores de películas de cloruro de polivinilo.

Los gases y vapores irritantes se utilizan en herbicidas, pesticidas, productos farmacéuticos, productos de limpieza para el hogar, explosivos, fertilizantes, refrigeración, plásticos, pinturas, fumigantes y una variedad de otros productos. Estos productos químicos se producen y utilizan inmediatamente o se envían a los usuarios finales. El potencial de accidentes químicos es grande. Un informe de la Agencia de Protección Ambiental estimó que se han producido 6.928 accidentes químicos en los Estados Unidos desde 1980, un promedio de cinco accidentes por día. Como resultado, 1.500 personas resultaron heridas y 135 muertas. Se necesitaba más información sobre las consecuencias de la lesión pulmonar aguda subletal inducida químicamente y sobre el resultado a largo plazo de la lesión específica por vapor/gas químico para tratar de manera diferente la exposición a estos productos químicos.

La bisinosis se ha reconocido como un trastorno respiratorio asociado con la exposición al polvo de algodón durante más de dos siglos. Este trastorno respiratorio se caracteriza por los síntomas clínicos de broncoconstricción con la periodicidad de la semana laboral y más tarde por una disminución de la función pulmonar durante el turno de trabajo, más marcada después de una ausencia del trabajo. El riesgo de bisinosis probablemente esté influenciado por la duración de la exposición y el tipo de fábrica, como una fábrica textil, una fábrica de trituración de aceite de semilla de algodón o una fábrica de desmotado. La prevalencia no parece estar influenciada por la edad, el sexo o la raza. Este estudio intentó responder a la pregunta de si la exposición a largo plazo al polvo textil de algodón condujo a un deterioro funcional pulmonar clínicamente importante.

NARRATIVA DE DISEÑO:

Efectos respiratorios de la exposición a gases y vapores irritantes:

Los trabajadores completaron cuestionarios respiratorios y se sometieron a pruebas de espirometría en sus plantas al inicio con seguimiento cada uno o dos años durante un período de cinco años. La IgE total inicial se midió en una muestra del 20 por ciento para determinar su capacidad para detectar cambios longitudinales en la función pulmonar y si mediaba la inmunorreactividad. En los trabajadores expuestos a derrames químicos, se determinó si la exposición química de alto nivel a corto plazo sin lesión pulmonar o la exposición química de alto nivel a corto plazo con lesión pulmonar afecta la función pulmonar longitudinalmente o afecta la adquisición de síntomas respiratorios. En los trabajadores lesionados y un grupo de control emparejado, la espirometría se realizó inmediatamente, a las dos semanas, a las seis semanas y al año después del episodio. En la semana posterior a una lesión aguda, se midieron las indicaciones bioquímicas circulantes de lesión celular y tisular. La IgE total y específica se midió después de la lesión y se comparó con las mediciones iniciales.

El estudio longitudinal tuvo dos componentes. En el primero, los investigadores de Tulane SCOR recopilaron datos de función pulmonar, salud respiratoria, inmunológica e higiene industrial de 300 trabajadores en nueve plantas textiles (seis de algodón y tres sintéticas) para compararlos con los datos de la empresa. En el segundo componente, los investigadores de Tulane trabajaron en estrecha colaboración con la empresa participante para garantizar la calidad de los datos que la empresa recopiló en su programa de vigilancia de la salud respiratoria de los trabajadores de las nueve plantas.

Se recopilaron datos sobre sexo, raza, tabaquismo, edad, estado atópico, grado de broncoconstricción en respuesta a la exposición al polvo de algodón medido por el cambio de turno del lunes en FEV1, duración del empleo, exposición pasada y actual al polvo de algodón, tipo de trabajo, grado de algodón procesado, ubicación geográfica de la planta y contaminación bacteriana del algodón. Las pruebas de función pulmonar se realizaron anualmente durante cinco años mediante la obtención de datos espirométricos antes y después del turno. Los datos estaban disponibles sobre las mediciones de polvo de la empresa durante los últimos diez años. Se realizaron mediciones de polvo durante el estudio para reconstruir un perfil de exposición completo para los diversos puestos de trabajo en cada área de producción durante el período total de empleo de los trabajadores que participaron en el estudio.

La fecha de finalización del estudio que figura en este registro se obtuvo de la "Fecha de finalización" ingresada en el registro del Sistema de registro y resultados del protocolo (PRS).

Tipo de estudio

De observación

Criterios de participación

Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.

Criterio de elegibilidad

Edades elegibles para estudiar

No mayor que 100 años (Niño, Adulto, Adulto Mayor)

Acepta Voluntarios Saludables

Géneros elegibles para el estudio

Masculino

Descripción

Sin criterios de elegibilidad

Plan de estudios

Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.

¿Cómo está diseñado el estudio?

Colaboradores e Investigadores

Aquí es donde encontrará personas y organizaciones involucradas en este estudio.

Patrocinador

National Heart, Lung, and Blood Institute (NHLBI)

Investigadores

Hans Weill, Tulane University

Publicaciones y enlaces útiles

La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.

Publicaciones Generales

Cherniack RM, Colby TV, Flint A, Thurlbeck WM, Waldron J, Ackerson L, King TE Jr. Quantitative assessment of lung pathology in idiopathic pulmonary fibrosis. The BAL Cooperative Group Steering Committee. Am Rev Respir Dis. 1991 Oct;144(4):892-900. doi: 10.1164/ajrccm/144.4.892.
Jones RN, Rando RJ, Glindmeyer HW, Foster TA, Hughes JM, O'Neil CE, Weill H. Abnormal lung function in polyurethane foam producers. Weak relationship to toluene diisocyanate exposures. Am Rev Respir Dis. 1992 Oct;146(4):871-7. doi: 10.1164/ajrccm/146.4.871.
Bozelka BE, Lehrer SB, Salvaggio JE, Hammad Y, McCants ML. Chronological assessment of asbestos exposure on cell composition in murine lung. Am J Med Sci. 1992 Jun;303(6):379-86. doi: 10.1097/00000441-199206000-00005.
Palmgren MS, deShazo RD, Carter RM, Zimny ML, Shah SV. Mechanisms of neutrophil damage to human alveolar extracellular matrix: the role of serine and metalloproteases. J Allergy Clin Immunol. 1992 Apr;89(4):905-15. doi: 10.1016/0091-6749(92)90447-a.
Glindmeyer HW, Lefante JJ, Jones RN, Rando RJ, Abdel Kader HM, Weill H. Exposure-related declines in the lung function of cotton textile workers. Relationship to current workplace standards. Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):675-83. doi: 10.1164/ajrccm/144.3_Pt_1.675.
Bronchoalveolar lavage constituents in healthy individuals, idiopathic pulmonary fibrosis, and selected comparison groups. The BAL Cooperative Group Steering Committee. Am Rev Respir Dis. 1990 May;141(5 Pt 2):S169-202. doi: 10.1164/ajrccm/141.5_Pt_2.S169. No abstract available.
Lefante JJ. The power to detect differences in average rates of change in longitudinal studies. Stat Med. 1990 Apr;9(4):437-46. doi: 10.1002/sim.4780090414.
Weill H, Waggenspack C, Bailey W, Ziskind M, Rossiter C. Radiographic and physiologic patterns among workers engaged in manufacture of asbestos cement products: a preliminary report. J Occup Med. 1973 Mar;15(3):248-52. No abstract available.
Weill H, Waggenspack C, DeRouen T, Ziskind M. Respiratory reactions to B. subtilis enzymes in detergents. J Occup Med. 1973 Mar;15(3):267-71. No abstract available.
Weill H. Pulmonary function testing in industry. J Occup Med. 1973 Sep;15(9):693-9. No abstract available.
Allen GC, Samimi B, Ziskind M, Weill H. X-ray diffraction determination of alpha-quartz in respirable and total dust samples from sand-blasting operations. Am Ind Hyg Assoc J. 1974 Nov;35(11):711-7. doi: 10.1080/0002889748507091. No abstract available.
Bailey WC, Brown M, Buechner HA, Weill H, Ichinose H, Ziskind M. Silico-mycobacterial disease in sandblasters. Am Rev Respir Dis. 1974 Aug;110(2):115-25. doi: 10.1164/arrd.1974.110.2.115. No abstract available.
Glindmeyer H, Weill H, Jones R, Ziskind M. Design and operation of a mobile pulmonary function laboratory. J Occup Med. 1974 Sep;16(9):584-8. doi: 10.1097/00043764-197409000-00002. No abstract available.
Rossiter CE, Weill H. Ethnic differences in lung function: evidence for proportional differences. Int J Epidemiol. 1974 Mar;3(1):55-61. doi: 10.1093/ije/3.1.55. No abstract available.
Rossiter CE, Weill H. Synergism between dust exposure and smoking: an artefact in the statistical analysis of lung function. Bull Physiopathol Respir (Nancy). 1974 Sep-Oct;10(5):717-25. No abstract available.
Samimi B, Weill H, Ziskind M. Respirable silica dust exposure of sandblasters and associated workers in steel fabrication yards. Arch Environ Health. 1974 Aug;29(2):61-6. doi: 10.1080/00039896.1974.10666534. No abstract available.
Weill H, Waggenspack C, DeRouen T, Ziskind M. Follow-up observations of workers exposed to enzyme detergents. Ann N Y Acad Sci. 1974;221:76-85. doi: 10.1111/j.1749-6632.1974.tb28201.x. No abstract available.
Ziskind MM, Weill H, Ellithorpe DB: The Relationship of Lung Diseases to Air Pollutants and Noxious Gases. In: Baum GL (Ed), Textbook of Pulmonary Disease, 2nd Edition. Boston: Little, Brown and Co., 1974
Enterline PE, Weill H: Asbestosis in Asbestos Cement Workers. In: Proceedings of International Conference on the Biologic Effects of Asbestos, IARC, WHO, 1974
DeRouen TA, Diem JE. The New Orleans drinking water controversy. A statistical perspective. Am J Public Health. 1975 Oct;65(10):1060-2. doi: 10.2105/ajph.65.10.1060. No abstract available.
Dharmarajan V, Thomas RL, Maddalone RF, West PW. Sulfuric acid aerosol. Sci Total Environ. 1975 Sep;4(3):279-98. doi: 10.1016/0048-9697(75)90006-6. No abstract available.
Jones RN, Weill H, Ziskind M. Pulmonary function in sandblasters' silicosis. Bull Physiopathol Respir (Nancy). 1975 Jul-Aug;11(4):589-95.
Samimi B, Neilson A, Weill H, Ziskind M. The efficiency of protective hoods used by sandblasters to reduce silica dust exposure. Am Ind Hyg Assoc J. 1975 Feb;36(2):140-8. doi: 10.1080/0002889758507222.
Weill H: Occupational Asthma. In: Proceedings of International Symposium on Asthma. In: New Directions in Asthma. 435-439, 1975
Hammad YY: Employee Exposure to Airborne Man-Made Mineral Fibers as Guideline for Testing in Animals. In: Proceedings of Workshop on Development of Protocols for Testing Man-Made Fibers in Animals. Innisbrook, Florida, 1975
Weill H, Ziskind MM, Waggenspack C, Rossiter CE. Lung function consequences of dust exposure in asbestos cement manufacturing plants. Arch Environ Health. 1975 Feb;30(2):88-97. doi: 10.1080/00039896.1975.10666650.
Weill B. Editorial: Workshop on the chest X-ray film as an epidemiologic tool. Chest. 1975 Aug;68(2):132-3. doi: 10.1378/chest.68.2.131. No abstract available.
Weill H, Salvaggio J, Neilson A, Butcher B, Ziskind M. Respiratory effects in toluene diisocyanate manufacture: a multidisciplinary approach. Environ Health Perspect. 1975 Jun;11:101-8. doi: 10.1289/ehp.7511101.
Weill H, Jones R. The chest roentgenogram as an epidemiologic tool. Report of a workshop. Arch Environ Health. 1975 Sep;30(9):435-9. doi: 10.1080/00039896.1975.10666744. No abstract available.
Weill H. Epidemiologic methods in the investigation of occupational lung disease. Am Rev Respir Dis. 1975 Jul;112(1):1-6. doi: 10.1164/arrd.1975.112.1.1. No abstract available.
Butcher BT, Jones RN, O'Neil CE, Glindmeyer HW, Diem JE, Dharmarajan V, Weill H, Salvaggio JE. Longitudinal study of workers employed in the manufacture of toluene-diisocyanate. Am Rev Respir Dis. 1977 Sep;116(3):411-21. doi: 10.1164/arrd.1977.116.3.411.
Butcher BT, Salvaggio JE, Weill H, Ziskind MM. Toluene diisocyanate (TDI) pulmonary disease: immunologic and inhalation challenge studies. J Allergy Clin Immunol. 1976 Jul;58(1 PT 1):89-100. doi: 10.1016/0091-6749(76)90110-x.
Jones RN, Turner-Warwick M, Ziskind M, Weill H. High prevalence of antinuclear antibodies in sandblasters' silicosis. Am Rev Respir Dis. 1976 Mar;113(3):393-5. doi: 10.1164/arrd.1976.113.3.393.
Ziskind M, Weill H, Anderson AE, Samimi B, Neilson A, Waggenspack C. Silicosis in shipyard sandblasters. Environ Res. 1976 Apr;11(2):237-43. doi: 10.1016/0013-9351(76)90081-5. No abstract available.
Weill H: Silicosis - Method of Hans Weill MD. In: Conn (Ed), Current Therapy, 146-147, 1976
Weill H, Diem JE, Glindmeyer HW, Waggenspack C: Longitudinal Studies of Workers Exposed to Detergent Enzyme Dust in Four US Plants. In: Proceedings of Symposium on Biological Effects of Proteolytic Enzyme Detergents. Penarth, Wales, 1976
Glindmeyer HW: An Experimental Investigation of the Errors of Spirometry. A Doctoral Thesis Presented to the Graduate Division, School of Engineering, Tulane University, 1976
Butcher BT, Salvaggio JE, O'Neil CE, Weill H, Garg O. Toluene diisocyanate pulmonary disease: immunopharmacologic and mecholyl challenge studies. J Allergy Clin Immunol. 1977 Mar;59(3):223-7. doi: 10.1016/0091-6749(77)90153-1.
Dharmarajan V. Analysis of toluene diisocyanate (TDI) and p, p1-diphenylmethane diisocyanate (MDI) in air. Am Ind Hyg Assoc J. 1977 Dec;38(12):725-6. doi: 10.1080/0002889778507685. No abstract available.
Esmen NA, Hammad YY: Log-Normality of Environmental Sampling Data. Environ Sci & Health, A12:29, 1977
Jones RN, Carr J, Glindmeyer H, Diem J, Weill H. Respiratory health and dust levels in cottonseed mills. Thorax. 1977 Jun;32(3):281-6. doi: 10.1136/thx.32.3.281.
Schuyler M, Ziskind M, Salvaggio J. Cell-mediated immunity in silicosis. Am Rev Respir Dis. 1977 Jul;116(1):147-51. doi: 10.1164/arrd.1977.116.1.147.
DeRouen TA, Diem JE: Relationship Between Cancer Mortality in Louisiana, Drinking Water Source, and Other Possible Causative Agents. In: Proceedings of Cold Spring Harbor Conference on Cell Proliferation. Origins of Human Cancer, 331-345, 1977
Weill H, Rossiter CE, Waggenspack C, Jones RN, Ziskind MM. Differences in lung effects resulting from chrysotile and crocidolite exposure. Inhaled Part. 1975 Sep;4 Pt 2:789-98.
Weill H, Diem JE: Relationships Between Cigarette Smoking and Occupational Pulmonary Disease. In: Proceedings of International Symposium on Grain Dust and Health, Saskatoon: Academic Press, 1977
Ziskind MM: Silicosis - Method of Morton M. Ziskind MD. In: Conn (Ed), Conn's Current Therapy. Philadelphia: WB Saunders Co. 145-147, 1977
Turner-Warwick M, Cole P, Weill H, Jones RN, Ziskind M: Chemical Fibrosis: The Model of Silica. Ann Rheum Dis, 36:47-50, 1977
Weill H, Sewell EM. In search of the pump handle, 1977. Am Rev Respir Dis. 1977 Jun;115(6):911-3. doi: 10.1164/arrd.1977.115.6.911. No abstract available.
Wilson MR, Gaumer HR, Salvaggio JE. Activation of the alternative complement pathway and generation of chemotactic factors by asbestos. J Allergy Clin Immunol. 1977 Oct;60(4):218-22. doi: 10.1016/0091-6749(77)90133-6. No abstract available.
Dharmarajan V, Weill H. Physical state of airborne p, p'-diphenylmethane diisocyanate (MDI) and its measurement. Am Ind Hyg Assoc J. 1978 Sep;39(9):737-44. doi: 10.1080/0002889778507843.
Dharmarajan V, Weil H, Self CW. Environmental characterization of toluene diisocyanate (TDI) in a manufacturing plant. Am Ind Hyg Assoc J. 1978 May;39(5):414-8. doi: 10.1080/0002889778507780. No abstract available. Erratum In: Am Ind Hyg Assoc J 1987 Feb;48(2):A109.
Dharmarajan V: Occupational Exposures to Methylene Diphenyl Diisocyanate (MDI) Gaseous or Aerosol? J Environ Toxicol & Pathol, 1978
Diem JE, Glindmeyer HW, Weill H: A Sensitive Procedure for Detecting the Presence of an Acute Bronchoconstrictor Response in Occupational Populations. Am Rev Respir Dis, 4:229, 1978
Glindmeyer HW, Anderson ST, Diem JE, Weill H. A comparison of the Jones and Stead-Wells spirometers. Chest. 1978 May;73(5):596-62. doi: 10.1378/chest.73.5.596.
Jones RN, Butcher BT, Diem JE, Glindmeyer H, Salvaggio JE, Weill H: Influence of Atopy on Dust Related Bronchoconstriction. Am Rev Respir Dis, 117(4):244, 1978
Jones RN, Weill H: Occupational Lung Disease. In: Basics of RD (6) 3:1-6, 1978
Jones RN, Diem JE, Glindmeyer H, Dharmarajan V, Carr J, Weill H: Byssinosis and Functional Abnormalities in Relation to Cotton Dust, Smoking and Mill Effect. Am Rev Respir Dis, 1978
Karr RM, Davies RJ, Butcher BT, Lehrer SB, Wilson MR, Dharmarajan V, Salvaggio JE. Occupational asthma. J Allergy Clin Immunol. 1978 Jan;61(1):54-65. doi: 10.1016/0091-6749(78)90474-8. No abstract available.
Karr RM, Lehrer SB, Butcher BT, Salvaggio JE. Coffee worker's asthma: a clinical appraisal using the radioallergosorbent test. J Allergy Clin Immunol. 1978 Sep;62(3):143-8. doi: 10.1016/0091-6749(78)90098-2. No abstract available.
Lehrer SB, Karr RM, Salvaggio JE. Extraction and analysis of coffee bean allergens. Clin Allergy. 1978 May;8(3):217-26. doi: 10.1111/j.1365-2222.1978.tb03217.x.
Lehrer SB, Turer E, Weill H, Salvaggio JE. Elimination of bagassosis in Louisiana paper manufacturing plant workers. Clin Allergy. 1978 Jan;8(1):15-20. doi: 10.1111/j.1365-2222.1978.tb00442.x.
Lehrer S. Isolation and preparation of antigens. J Allergy Clin Immunol. 1978 Apr;61(4):203-6. doi: 10.1016/0091-6749(78)90179-3. No abstract available.
Samimi B, Mason JW, Ziskind M, Weill H. The consistency of the gravimetric and impinger methods in evaluating hazardous dusty conditions. Am Ind Hyg Assoc J. 1978 Oct;39(10):817-20. doi: 10.1080/0002889778507861. No abstract available.
Samimi B, Ziskind M, Weill H. The relation of silica dust to accelerated silicosis. Ecotoxicol Environ Saf. 1978 Mar;1(4):429-36. doi: 10.1016/0147-6513(78)90011-8. No abstract available.
Arai DT, Kotin P, Weill H, Werchick J: Clinical Problems in Asbestos-Related Diseases. In: Preger L (Ed), Asbestos-Related Diseases. New York: Grune and Stratton, 1978
Diem JE, Jones RN, Gilson JC, Glindmeyer HW, Weill H: The Influence of Asbestos Exposure on Radiographic Progression and Functional Decline. In: Proceedings of the Fifth International Conference on Pneumoconioses. Caracas, Venezuela, 1978
Hughes JM, Waggenspack C, Weill H: Morality Study of Workers Engaged in Manufacture of Asbestos Cement Products. In: Proceedings of National Meeting of American Lung Association/American Thoracic Society, Boston, 1978
Butcher BT, Lehrer SB, O'Neil CE, Hughes JM, Salvaggio JE, Weill H: Skin Testing and RAST in Workers Engaged in Cottonseed Processing. J Allergy Clin Immunol, 63(3):213, 1979
Butcher BT. Inhalation challenge testing with toluene diisocyanate. J Allergy Clin Immunol. 1979 Dec;64(6 pt 2):655-7. doi: 10.1016/0091-6749(79)90031-9. No abstract available.
Butcher BT, Karr RM, O'Neil CE, Wilson MR, Dharmarajan V, Salvaggio JE, Weill H. Inhalation challenge and pharmacologic studies of toluene diisocyanate (TDI)-sensitive workers. J Allergy Clin Immunol. 1979 Aug;64(2):146-52. doi: 10.1016/0091-6749(79)90049-6.
Dharmarajan V, Rando RJ. A new method for the generation of standard atmospheres of organo isocyanates. Am Ind Hyg Assoc J. 1979 Oct;40(10):870-6. doi: 10.1080/15298667991430424.
Dharmarajan V, Rando RJ. A recommendation for modifying the standard analytical method for the determination of chlorine in air. Am Ind Hyg Assoc J. 1979 Feb;40(2):161-4. doi: 10.1080/15298667991429453. No abstract available.
Doll NJ, Stankus RP, Hughes J, Weill H, Gupta RC, Rodriguez M, Jones RN, Alspaugh MA, Salvaggio JE. Immune complexes and autoantibodies in silicosis. J Allergy Clin Immunol. 1981 Oct;68(4):281-5. doi: 10.1016/0091-6749(81)90152-4.
Glindmeyer HW, Anderson ST: Concepts for Comprehensive Quality Control Spirometry. Resp Ther, 1979
Hammad YY, Diem J, Weill H. Evaluation of dust exposure in asbestos cement manufacturing operations. Am Ind Hyg Assoc J. 1979 Jun;40(6):490-5. doi: 10.1080/15298667991429877.
Jones RN, Diem JE, Glindmeyer H, Dharmarajan V, Hammad YY, Carr J, Weill H. Mill effect and dose-response relationships in byssinosis. Br J Ind Med. 1979 Nov;36(4):305-13. doi: 10.1136/oem.36.4.305.
Kent RH, Butcher BT, Lehrer SB, Hughes JM, Salvaggio JE, Weill H: Comparison of Results of Skin and RAST Testing of Workers from Two Coffee Plants. Am Rev Respir Dis, 119(4):224, 1979
Schuyler MR, Ziskind MM, Salvaggio J. Function of lymphocytes and monocytes in silicosis. Chest. 1979 Mar;75(3):340-4. doi: 10.1378/chest.75.3.340.
Weill H, Hughes J, Waggenspack C. Influence of dose and fiber type on respiratory malignancy risk in asbestos cement manufacturing. Am Rev Respir Dis. 1979 Aug;120(2):345-54. doi: 10.1164/arrd.1979.120.2.345.
Butcher BT, Karr RM: Toluene Diisocyanate-Induced Asthma. In: Preger L (Ed), Induced Disease - Drug, Irradiation, Occupation. New York: Grune and Stratton, 317-327, 1979
Hughes J, Weill H. Lung cancer risk associated with manufacture of asbestos-cement products. IARC Sci Publ. 1980;(30):627-35.
Jones RN, Diem JE, Glindmeyer HW, Dharmarajan V, Hammad YY, Carr J, Weill H: Confounding of Dust Dosage and Other Variables Influencing Biologic Responses to Cotton Dust. In: Proceedings of the International Conference on Occupational Lung Diseases. San Francisco, Calif., 1979
Jones RN, Diem JE, Glindmeyer HW, Gilson JC, Weill H: Progession of Asbestos Radiographic Abnormalities: Relations to Estimates of Dust Exposure and Annual Decline in Lung Function. In: Proceedings of IARC International Symposium on Biological Effects of Mineral Fibers. Lyon, France, 1979
Jones RN: Irritant Gases. In: Fishman A (Ed), Pulmonary Diseases. New York: McGraw-Hill, 87-92, 1979
Weill H: General Discussion on Asbestos (Discussion Opener). In: Proceedings of Symposium on Biological Effects of Mineral Fibers, IARC, Lyon, France, 1979
Weill H, Butcher B, Diem JE, Dharmarajan V, Glindmeyer HW, Jones RN, Carr J, O'Neil C, Salvaggio J: Respiratory and Immunologic Evaluation of Isocyanate Exposure in a New Manufacturing Plant. Final Report, NIOSH Contract No. 210-75-0006, 1979. Published as a NIOSH Technical Document, 1979
Dharmarajan V, Rando RJ. Dynamic calibration of a continuous organo-isocyanate monitor for hexamethylene diisocyanate. Am Ind Hyg Assoc J. 1980 Jun;41(6):437-41. doi: 10.1080/15298668091424997.
Doll NJ, Salvaggio JE: Asbestos-Caused Disease: Which Patients are at Risk? J Respir Dis, 1(5):36-49, 1980
Glindmeyer HW 3rd, Anderson ST, Kern RG, Hughes J. A portable, adjustable forced vital capacity simulator for routine spirometer calibration. Am Rev Respir Dis. 1980 Mar;121(3):599-603. doi: 10.1164/arrd.1980.121.3.599. No abstract available.
Hammad YY, Weill H. Evaluation of performance of a beta absorption dust monitor. Am Ind Hyg Assoc J. 1980 Jul;41(7):501-7. doi: 10.1080/15298668091425149.
Jones RN, Butcher BT, Hammad YY, Diem JE, Glindmeyer HW 3rd, Lehrer SB, Hughes JM, Weill H. Interaction of atopy and exposure to cotton dust in the bronchoconstrictor response. Br J Ind Med. 1980 May;37(2):141-6. doi: 10.1136/oem.37.2.141.
Lehrer SB, Karr RM, Muller DJ, Salvaggio JE. Detection of castor allergens in castor wax. Clin Allergy. 1980 Jan;10(1):33-41. doi: 10.1111/j.1365-2222.1980.tb02077.x.
Schuyler MR, Gaumer HR, Stankus RP, Kaimal J, Hoffmann E, Salvaggio JE. Bronchoalveolar lavage in silicosis. Evidence of type II cell hyperplasia. Lung. 1980;157(2):95-102. No abstract available.
Glindmeyer H 3rd, Diem J, Hughes J, Jones RN, Weill H. Factors influencing the interpretation of FEV1 declines across the working shift. Chest. 1981 Apr;79(4 Suppl):71S-73S. doi: 10.1378/chest.79.4_supplement.71s.
Hammad YY, Dharmarajan V, Weill H: Sampling of Cotton Dust for Epidemiologic Investigations. In: Proceedings of International Conference on Byssinosis. Birmingham, Alabama, 1980
Hughes JM, Jones RN, Hammad YY, Doll NH, Weill H: Determinants of Progression of Sandblasters' Silicosis. Fifth International Symposium on Inhaled Particles, Cardiff, Wales, UK, September 1980
Jones RN, Hughes J, Hammad YY, Glindmeyer H 3rd, Butcher BT, Diem JE, Weill H. Respiratory health in cottonseed crushing mills. Chest. 1981 Apr;79(4 Suppl):30S-33S. doi: 10.1378/chest.79.4_supplement.30s. No abstract available.
Salvaggio JE, Butcher BT: Sensitization to Toluene Diisocyanate. In: Lavender J (Ed), Proceedings of the Tenth International Congress of Allergology. Oxford: Pergamon Press, 1980
Weill H, Ziskind MM: Occupational Pulmonary Diseases. In: Fishman A (Ed), Pulmonary Diseases and Disorders. New York: McGraw-Hill, 1980
Weill H. Basis for clinical decision making. Chest. 1980 Aug;78(2 Suppl):382-3. doi: 10.1378/chest.78.2_supplement.382. No abstract available.
Stankus RP, Doll NJ, Salvaggio JE: Humoral and Cellular Enhancement in Experimental and Human Silicosis. In: Boros D and Yoshida T (Eds), Basic and Clinical Aspects of Granulomatous Disease. New York: Elsevier Publishing Co. 305-315, 1980
Butcher BT, O'Neil CE, Reed MA, Salvaggio JE. Radioallergosorbent testing of toluene diisocyanate-reactive individuals using p-tolyl isocyanate antigen. J Allergy Clin Immunol. 1980 Sep;66(3):213-6. doi: 10.1016/0091-6749(80)90041-x.
Dharmarajan V, Rando RJ. Critical evaluation of continuous monitors for toluene diisocyanate. Am Ind Hyg Assoc J. 1980 Dec;41(12):869-78. doi: 10.1080/15298668091425798.
Hammad YY, Dharmarajan V, Corn M: Environmental Characterization. In: Weill H, Turner-Warwick M (Eds), Lenfant C (Exec Ed), Occupational Lung Diseases: Research Approaches and Methods: Lung Biology in Health and Disease. New York: Marcel Dekker Inc., 1981
Gilson JC, Jones RN: Radiography. In: Weill H, Turner-Warwick M (Eds), Lenfant C (Exec Ed), Occupational Lung Diseases: Research Approaches and Methods: Lung Biology in Health and Disease. New York: Marcel Dekker Inc., 1981
Stankus RP, Doll NJ, Salvaggio JE: Hypersensitivity Disease. In: Simmons DC (Ed), Current Pulmonology, Annual RC-756, C976, Vol III. Boston: John Wiley and Sons, 61-86, 1981
Weill H, Turner-Warwick M (Eds), Lenfant C, (Exec Ed): Occupational Lung Diseases: Research Approaches and Methods. Lung Biology in Health and Disease. New York: Marcel Dekker Inc., 1981
Hendrick DJ, Hammad YY, Salvaggio JE: Air Pollution and Asthma. In Gershwin ME (Ed), Bronchial Asthma: Principles of Diagnosis and Therapy, New York: Grune and Stratton Inc, 1981
Hendrick DJ, Jones RN, Weill H: Occupational Lung Disease. In: Simmons DH (Ed), Current Pulmonology Vol III. New York, Wiley, 205-235, 1981
Gaumer HR, Doll NJ, Kaimal J, Schuyler M, Salvaggio JE. Diminished suppressor cell function in patients with asbestosis. Clin Exp Immunol. 1981 Apr;44(1):108-16.
Lehrer SB, Karr RM, Salvaggio JE. Analysis of green coffee bean and castor bean allergens using RAST inhibition. Clin Allergy. 1981 Jul;11(4):357-66. doi: 10.1111/j.1365-2222.1981.tb01606.x.
Gardner R, Glindmeyer HW, Hankinson J: Standardization of Lung Function Measurements With Special Application to Field Testing in Occupational Lung Diseases. Research Approaches and Methods. In: Weill H, Turner-Warwick M, (Eds), Lenfant C, (Exec Ed), Occupational Lung Diseases: Research Approaches and Methods. Lung Biology in Health and Disease, Vol. 18. New York: Marcel Dekker Inc., 61-85, 1981
Glindmeyer HW: Predictable Confusion. JOM, 23:845-849, 1981
Hammad YY, Dharmarajan V, Weill H. Sampling of cotton dust for epidemiologic investigations. Chest. 1981 Apr;79(4 Suppl):108S-113S. doi: 10.1378/chest.79.4_supplement.108s. No abstract available.
Hendrick DJ, Fabbri L. Compensating occupational asthma. Thorax. 1981 Dec;36(12):881-4. doi: 10.1136/thx.36.12.881. No abstract available.
Hendrick DJ, Hammad YY, Salvaggio JE: Air Pollution and Asthma. In: Gershwin ME, (Ed), Bronchial Asthma: Principles of Diagnosis and Therapy. New York: Grune and Stratton Inc., 1981
Hendrick DJ, Weill H: Acute Respiratory Reactions to Occupational Inhalants. In: McDonald JC, (Ed), Recent Advances in Occupational Health. Edinburgh: Churchill Livingstone Inc., 39-51, 1981
Morgan JE, Stankus RP, Salvaggio JE: Silica-Induced Production of a Fibroblast Growth Promoting Factor by Alveolar Macrophages. Clin Res, 29:867, 1981
O'Neil CE, Butcher BT, Hughes JM: Studies of Total and Specific Antibodies in Workers Employed in Cottonseed Crushing Mills. In: Wakelyn PJ (Ed), Proceedings, Fifth Cotton Dust Research Conference, New Orleans (Beltwide Cotton Production Research Conferences), 1981
Rossiter CE, Jones RN: Radiographic Classifications (Chapter). In: McDonald JC (Ed), Recent Advances in Occupational Health. London: Churchill-Livingstone, 129-140, 1981
Stankus RP, Salvaggio JE. Bronchopulmonary humoral and cellular enhancement in experimental silicosis. J Reticuloendothel Soc. 1981 Feb;29(2):153-61. No abstract available.
Weill H. Occupational lung diseases. State of the art. Chest. 1981 Jul;80(1 Suppl):54-7. doi: 10.1378/chest.80.1_supplement.54s. No abstract available.
Weill H. Problem solving in occupational airways disorders. Cotton dust exposure as a case in point. Chest. 1981 Apr;79(4 Suppl):1S-2S. No abstract available.
Weill H. Risk assessment in volcano ash exposure. Chest. 1981 Jul;80(1 Suppl):87-8. doi: 10.1378/chest.80.1_supplement.87s. No abstract available.
Weill H, Butcher BT, Diem JE, Dharmarajan V, Glindmeyer H, Jones RN, Carr J, O'Neil CE, Salvaggio JE: Respiratory and Immunologic Evaluation of Isocyanate Exposure in a New Manufacturing Plant. Final Report,, NIOSH Contract No. 210-75-1979. U.S. Department of Health and Human Services, National Institute for Occupational Safety and Health, Morgantown, West Virginia, June, (DHHS [NIOSH] Publication No. 81-125), 1981
Baser Y, deShazo RD, Barkman HW Jr, Nordberg J. Lidocaine effects on immunocompetent cells. Implications for studies of cells obtained by bronchoalveolar lavage. Chest. 1982 Sep;82(3):323-8. doi: 10.1378/chest.82.3.323.
Butcher BT, O'Neil CE, Reed MA, Salvaggio JE, Weill H. Development and loss of toluene diisocyanate reactivity: immunologic, pharmacologic, and provocative challenge studies. J Allergy Clin Immunol. 1982 Oct;70(4):231-5. doi: 10.1016/0091-6749(82)90058-6.
deShazo RD. Current concepts about the pathogenesis of silicosis and asbestosis. J Allergy Clin Immunol. 1982 Jul;70(1):41-9. doi: 10.1016/0091-6749(82)90200-7.
Diem JE, Jones RN, Hendrick DJ, Glindmeyer HW, Dharmarajan V, Butcher BT, Salvaggio JE, Weill H. Five-year longitudinal study of workers employed in a new toluene diisocyanate manufacturing plant. Am Rev Respir Dis. 1982 Sep;126(3):420-8. doi: 10.1164/arrd.1982.126.3.420.
Doll NJ, Bozelka BE, Goldbach S, Anorve-Lopez E, Salvaggio JE. Asbestos-induced alteration of human peripheral blood monocyte activity. Int Arch Allergy Appl Immunol. 1982;69(4):302-5. doi: 10.1159/000233190.
Doll NJ, Stankus RP, Goldbach S, Salvaggio JE. In vitro effect of asbestos fibers on polymorphonuclear leukocyte function. Int Arch Allergy Appl Immunol. 1982;68(1):17-21. doi: 10.1159/000233061.
Fabbri L, Hendrick DJ, Weill H: Occupational Asthma and Rhinitis. In: Mediguide to Pulmonary Medicine. Vol. 3, Issue 2. New York: Della Corte Publications, 1982
Glindmeyer HW, Diem JE, Jones RN, Weill H. Noncomparability of longitudinally and cross-sectionally determined annual change in spirometry. Am Rev Respir Dis. 1982 May;125(5):544-8. doi: 10.1164/arrd.1982.125.5.544.
Glindmeyer HW, Harwood C. A compact computer printer for quality control spirometric data collection. J Occup Med. 1982 Dec;24(12):1003-8.
Hendrick DJ, Ellithorpe DB, Lyon F, Hattier P, Salvaggio JE. Allergic bronchopulmonary helminthosporiosis. Am Rev Respir Dis. 1982 Nov;126(5):935-8. doi: 10.1164/arrd.1982.126.5.935. No abstract available.
Hendrick DJ, Rando RJ, Lane DJ, Morris MJ. Formaldehyde asthma: challenge exposure levels and fate after five years. J Occup Med. 1982 Nov;24(11):893-7.
Hines WH, Banks DE: A Review of Silicosis. Practical Cardiology, 8:97-107, 1982
Hughes JM, Jones RN, Gilson JC, Hammad YY, Samimi B, Hendrick DJ, Turner-Warwick M, Doll NJ, Weill H. Determinants of progression in sandblasters' silicosis. Ann Occup Hyg. 1982;26(1-4):701-12. No abstract available.
Jones RN, Hughes JM, Lehrer SB, Butcher BT, Glindmeyer HW, Diem JE, Hammad YY, Salvaggio J, Weill H. Lung function consequences of exposure and hypersensitivity in workers who process green coffee beans. Am Rev Respir Dis. 1982 Feb;125(2):199-202. doi: 10.1164/arrd.1982.125.2.199.
Reed CE, deShazo R. Immunologic aspects of granulomatous and interstitial lung diseases. JAMA. 1982 Nov 26;248(20):2683-91. No abstract available.
Weill H: Definition of the Sensitive Worker. In: Kelley WD (Ed), Annals of the American Conference of Governmental Industrial Hygienists. Vol. 3, Protection of the Sensitive Individual. Cincinnati: American Conference of Governmental Industrial Hygienists Inc. 7-11, 1982
Weill H: Scientific Issues as Yet Unresolved. Proceedings of the World Symposium on Asbestos, Montreal, Quebec, Canada, May, 1982. Canadian Asbestos Information Center, 49-60, 1982
Weill H, Glindmeyer H, Hammad Y, Hughes J, Jones R, Sharon G: Respiratory Health of Workers Exposed to Man-Made Vitreous Fibers. Final Report to Thermal Insulation Manufacturers Association. March, 1982
Weill H, Jones RN, Hendrick DJ: Air Pollution, Energy Needs, and Occupational Lung Disease. In; Linn WS (Ed), Energy, Air Pollution, and Health: Papers From the Seminars for Physicians. New York: American Lung Association, 1982
Jones RN, Ziskind MM, Weill H: Air Pollution and Acute Exposures to Irritant Gases. In: Baum G (Ed), Textbook of Pulmonary Diseases, 3rd Edition. Boston: Little, Brown and Co., 1983
Jones RN: Silicosis. In: Rom WN (Ed), Environmental and Occupational Health, Boston: Little Brown and Company. 197-206, 1983
Banks DE, Barkman HW: Common Occupational Lung Disorders. Hosp Med, 19(6):93-110, 1983
Bozelka BE, Gaumer HR, Nordberg J, Salvaggio JE. Asbestos-induced alterations of human lymphoid cell mitogenic responses. Environ Res. 1983 Apr;30(2):281-90. doi: 10.1016/0013-9351(83)90214-1.
Bozelka BE, Jones RN, deShazo RD: Is the Immune System a Contributing Factor to the Pathogenesis of Asbestosis? An Evaluation. Sem Respir Med, 5:289, 1983
Butcher BT, Hendrick DJ. Occupational asthma. Clin Chest Med. 1983 Jan;4(1):43-53. No abstract available.
deShazo RD, Banks DE, Diem JE, Nordberg JA, Baser Y, Bevier D, Salvaggio JE. Bronchoalveolar lavage cell--lymphocyte interactions in normal nonsmokers and smokers. Analysis with a novel system. Am Rev Respir Dis. 1983 May;127(5):545-8. doi: 10.1164/arrd.1983.127.5.545.
deShazo RD, Hendrick DJ, Diem JE, Nordberg JA, Baser Y, Bevier D, Jones RN, Barkman HW, Salvaggio JE, Weill H. Immunologic aberrations in asbestos cement workers: dissociation from asbestosis. J Allergy Clin Immunol. 1983 Nov;72(5 Pt 1):454-61. doi: 10.1016/0091-6749(83)90581-x.
deShazo RD, Nordberg J, Baser Y, Bozelka B, Weill H, Salvaggio J. Analysis of depressed cell-mediated immunity in asbestos workers. J Allergy Clin Immunol. 1983 Apr;71(4):418-24. doi: 10.1016/0091-6749(83)90072-6.
Diem JE: A Statistical Assessment of the Scientific Evidence Relating Cotton Dust Exposure to Chronic Lung Disease. Amer Statistician, 38:395-403, 1983
Doll NJ, Bozelka BE. Immunologic techniques utilized in the diagnosis of occupational lung disease. Clin Chest Med. 1983 Jan;4(1):85-95.
Doll NJ, Bozelka BE, Salvaggio JE: Immunologic Techniques Used in the Diagnosis of Environmental Lung Diseases. In: Rom WN (Ed), Environmental and Occupational Medicine. Boston: Little, Brown and Company, 1983
Doll NJ, Diem JE, Jones RN, Rodriguez M, Bozelka BE, Stankus RP, Weill H, Salvaggio JE. Humoral immunologic abnormalities in workers exposed to asbestos cement dust. J Allergy Clin Immunol. 1983 Nov;72(5 Pt 1):509-12. doi: 10.1016/0091-6749(83)90589-4.
Doll NJ, Stankus RP, Barkman HW. Immunopathogenesis of asbestosis, silicosis, and coal workers' pneumoconiosis. Clin Chest Med. 1983 Jan;4(1):3-14.
Fabbri LM, Hendrick DJ, Diem JE. Effect of atropine on the bronchial response of asthmatic subjects to the inhalation of ultrasonically nebulized distilled water. J Allergy Clin Immunol. 1983 May;71(5):468-72. doi: 10.1016/0091-6749(83)90463-3.
Fabbri LM, Mapp CE, Hendrick DJ. Effect of cromolyn on carbachol-induced bronchoconstriction. Ann Allergy. 1983 Mar;50(3):195-8.
Hendrick DJ. Bronchopulmonary disease in the workplace. Challenge testing with occupational agents. Ann Allergy. 1983 Aug;51(2 Pt 1):179-84.
Hendrick DJ. Occupational asthma--problems of definition. J Occup Med. 1983 Jun;25(6):488-9. doi: 10.1097/00043764-198306000-00016. No abstract available.
Hendrick DJ: The Formaldehyde Problem - a Clinical Appraisal. Immunol and Allergy Practice, 5:97-108, 1983
Hendrick DJ: THe Formaldehyde Problem: a Clinical Appraisal (Corresp). Immunol and Allergy Practice, 5:290-291, 1983
Hendrick DJ, Salvaggio JE: The Use of Bronchial Inhalation Challenge in the Investigation of Occupational Disease. In: Spector SL (Ed), Provocative Challenge Procedures; Bronchial, Oral, Nasal, and Exercise. Boca Raton: CRC Press Inc., 1983
Jones RN, Ziskind MM, Weill H: Noxious Gases. In: Baum G (Ed), Textbook of Pulmonary Diseases. 3rd Ed. Boston: Little, Brown and Co., 833-843, 1983
Weill H. Asbestos-associated diseases. Science, public policy, and litigation. Chest. 1983 Nov;84(5):601-8. doi: 10.1378/chest.84.5.601. No abstract available.
Weill H, Hughes JM, Hammad YY, Glindmeyer HW 3rd, Sharon G, Jones RN. Respiratory health in workers exposed to man-made vitreous fibers. Am Rev Respir Dis. 1983 Jul;128(1):104-12. doi: 10.1164/arrd.1983.128.1.104. No abstract available.
Stankus RP, Salvaggio JE: Immunologic Lung Disease. In: Stankus RP, Salvaggio JE (Eds), Clinical Reviews in Allergy. Vol. 3. Elsevier Science, 1-3, 1983
Stankus RP, Salvaggio JE. The inorganic dust pneumoconioses. Clin Rev Allergy. 1985 May;3(2):235-47. doi: 10.1007/BF02992986.
Bozelka BE, Jones RN, deShazo RD: Is the Immune System a Contributing Factor to the Pathogenesis of Asbestosis? An Evaluation. Sem Respir Med, 5:289-299, 1984
Diem JE, Fischer JM, Glindmeyer HW, Abdel-Kader H, Weill H: Environmental Determinants of Across-Shift Pulmonary Function Change in Cotton Textile Workers. In: Wakelyn PJ, Jacobs RR (Eds), Cotton Dust. Proceedings of the Eighth Cotton Dust Research Conference, Beltwide Cotton Production Research Conferences, Atlanta, Georgia, January 9-10, 1984. Memphis: National Cotton Council, Raleigh, NC: Cotton Incorporated, 20-22, 1984
Glindmeyer H, Lissack T: A Network Approach to National Respiratory Health Care. In: Rubin M (Ed), Computerization and Automation in Health Facilities. Boca Raton: CRC Press Inc., 1-16, 1984
Hendrick DJ, Butcher BT, Connolly MJ: Occupational Asthma Due to Allergens of Organic Origin. In: Pepys J (Ed), Clinics in Immunology and Allergy: Occupational Respiratory Allergy. London: WB Saunders Co, 37-54, 1984
Jones RN: Aspects of the Cotton Dust Standard. In: Gee JBL, Morgan WKC, Brooks SM (Eds), Occupational Lung Disease. New York: Raven Press, 151-156. (Text of Invited address, ACCP International Conference on Occupational Lung Disease, Chicago, April, 1982), 1984
Jones RN. Cotton and chronic lung disease. Chest. 1984 May;85(5):587-9. doi: 10.1378/chest.85.5.587. No abstract available.
Jones RN. Occupational asthma. Clin Chest Med. 1984 Dec;5(4):619-22.
Jones RN, Diem JE, Ziskand MM, Rodriguez M, Weill H. Radiographic evidence of asbestos effects in American marine engineers. J Occup Med. 1984 Apr;26(4):281-4.
O'Neil CE, Butcher BT, Reed MA: Is there an Immune Component in Byssinosis? In: Wakelyn PJ, Jacobs RR (Eds), Proceedings of the Eighth Cotton Dust Research Conference, 140-142, 1984
O'Neil CE, Butcher BT, Reed MA, Salvaggio JE. In vitro effects of aqueous cotton dust extract on leucocyte cyclic adenosine monophosphate levels. Agents Actions. 1984 Feb;14(2):210-5. doi: 10.1007/BF01966644.
Rando RJ, Abdel-Kader HM, Hammad YY. Isomeric composition of airborne TDI in the polyurethane foam industry. Am Ind Hyg Assoc J. 1984 Mar;45(3):199-203. doi: 10.1080/15298668491399640.
Rowhani F, Hammad YY. Lobar deposition of fibers in the rat. Am Ind Hyg Assoc J. 1984 Jul;45(7):436-9. doi: 10.1080/15298668491400061.
Stankus R, Banks DE: Immunologic Alterations in Silicosis. In: Petty TL, Cherniak RM (Eds), Salvaggio JE, deShazo RD (Guest Eds), Seminars in Respiratory Medicine. New York: Thieme-Stratton Inc., 1984
Stankus RP, deShazo RD, Doll NJ, Salvaggio JE: Immunologic Markers of Disease Severity in Human Silicosis. Clin Res, 32:847, 1984
Stankus RP, Salvaggio JE: Interstitial Lung Disease. Interspecialty Focus, 3:1, 1984
Weill H: Natural and Man-Made Mineral Fibers. In: Heim LR (Exec Ed), Environmental Pollution and Man. Proceedings of the International Symposium, Cape Town, South Africa, April 30 - May 4, 1984. Newburgh, Indiana: Immunology Research Foundation Inc., 76-84, 1984
Weill H: Occupational Asthma: Background and Non-Particulate Pollutants. In: Heim LR (Exec Ed), Environmental Pollution and Man. Proceedings of the International Symposium, Cape Town, South Africa, April 30 - May 4, 1984. Newburgh, Indiana: Immunology Research Foundation Inc., 105-110, 1984
Weill H: Public Responsibility in Asbestos-Related Diseases. In: Edited Proceedings of the 1983 National Conference on 'Health-Related Claims: Can the Tort and Compensation Systems Cope?' Washington, D.C.: National Legal Center for the Public Interest, 40-45, 1984
Weill H: Relations Between Acute and Chronic Occupational Airway Responses. In: Gee JBL, Morgan WKC, Brooks SM (Eds), Occupational Lung Disease. Proceedings of the International Conference on Occupational Lung Disease, Chicago, March 1982. New York: Raven Press, 87-95-1984
Weill H, Diem J, Hughes J, Jones R: The Contribution of Occupational Exposures to Chronic Airways Obstruction. Chest, 85(6S):125, 1984
Fabbri LM, Mapp CE, Hendrick DJ. Comparison of ultrasonically nebulized distilled water and hyperventilation with cold air in asthma. Ann Allergy. 1984 Aug;53(2):172-7.
Butcher BT, Hammad YY, Hendrick DJ: Occupational Asthma: Identification of the Agent. In: Gee JBL Ed, Occupational Lung Disease: Contemporary Issues in Pulmonary Diseases. New York: Churchill Livingstone Inc., 1984
Hendrick DJ: Allergic Bronchopulmonary Aspergillosis. In: Salvaggio JE (Ed), Immunologic Lung Disease. Seminars in Respiratory Medicine, 1984
Hendrick DJ, Butcher BT, Conolly MJ: Occupational Asthma Due to Agents of Organic Origin. In: Pepys J (Ed), Occupational Respiratory Allergy. Clinics in Immunology and Allergy, Saunders, 1984
Banks DE: Acute Silicosis. In: NIOSH Textbook on Occupational Lung Disease (in press, 1985)
Banks DE, deShazo RD: Overview of Occupational Asthma. Immun Allergy Practice, 7:122-130, 1985
Barkman HW, Banks DE: Bronchoprovocation Testing in Occupational Asthma. Folia Aller et Immun Acta, 32:42-51, 1985
Butcher BT: Findings Suggesting that Anti-Fungal Antibodies May Play a Role in Etiology of Cotton Dust Induced Lung Disease. In: Foucard T, Dreborg S, (Eds), Mould Allergy Workshop, Uppsala, Sweden, 91-96, 1985
Butcher BT: Isocyanate-Induced Respiratory Disease. Folia Allergologica et Immunologica Clinica, 32:29-34, 1985
Butcher BT, Doll NJ. Respiratory responses to inhaled small organic molecules and related agents encountered in the workplace. Clin Rev Allergy. 1985 Jul;3(3):351-61. doi: 10.1007/BF02993000. No abstract available.
Bozelka BE, Salvaggio JE: Immunomodulation by Environmental Contaminants. Asbestos, Cadmium, and Halogenated Biphenyls. Environmental Carcinogenesis Review, C343:1, 1985
Glindmeyer HW, Weill H, Diem JE: Factors Influencing Estimates of Population Mean FEV1 Annual Change. Proceedings of the International Symposium on Health and Safety in Agriculture, October 8-11, 1985, Saskatoon, Saskatchewan, Canada, 1985
Hammad YY, Rando RJ, Abdel-Kader H: Considerations in the Design and Use of Human Inhalation Challenge Delivery Systems. Folia Allergologica et Immunologica Clinica, 32:37-44, 1985
Hendrick DJ: Pulmonary Diseases Section. In: Patient Management Problems in Internal Medicine. New York: Medical Examination Publishing Co. Inc. (in press, 1985)
Rando RJ, Hammad YY: Filter Collection of Airborne Permethrin with Determination by HPLC. J Liquid Chromatogr, 8:1869-1880, 1985
Rando RJ, Hammad YY. Modified Marcali method for the determination of total toluenediisocyanate in air. Am Ind Hyg Assoc J. 1985 Apr;46(4):206-10. doi: 10.1080/15298668591394671.
Stankus RP: Bronchopulmonary Lavage in the Diagnosis of Pulmonary Immune Disease. In: McMann E (Ed), Principles and Techniques of Human Research and Therapeutics. Futura, 37-50, 1985
Stankus RP, Salvaggio JE: Immunodiagnostic Techniques in Human Lung Research: Bronchoalveolar Lavage. In: McMann E (Ed), Principles and Techniques of Human Research and Therapeutics. Futura, 37-50, 1985
Butcher BT, Reed MA, O'Neil CE. Biochemical and immunologic characterization of cotton bract extract and its effect on in vitro cyclic AMP production. II. Green bract. Environ Res. 1986 Feb;39(1):115-23. doi: 10.1016/s0013-9351(86)80013-5.
Ayars GH, Altman LC, O'Neil CE, Butcher BT, Chi EY. Cotton dust-mediated lung epithelial injury. J Clin Invest. 1986 Dec;78(6):1579-88. doi: 10.1172/JCI112750.
Banks DE, Barkman HW Jr, Butcher BT, Hammad YY, Rando RJ, Glindmeyer HW 3rd, Jones RN, Weill H. Absence of hyperresponsiveness to methacholine in a worker with methylene diphenyl diisocyanate (MDI)-induced asthma. Chest. 1986 Mar;89(3):389-93. doi: 10.1378/chest.89.3.389.
Hendrick DJ, Fabbri LM, Hughes JM, Banks DE, Barkman HW Jr, Connolly MJ, Jones RN, Weill H. Modification of the methacholine inhalation test and its epidemiologic use in polyurethane workers. Am Rev Respir Dis. 1986 Apr;133(4):600-4. doi: 10.1164/arrd.1986.133.4.600.
Hughes JM, Weill H. Asbestos exposure--quantitative assessment of risk. Am Rev Respir Dis. 1986 Jan;133(1):5-13. doi: 10.1164/arrd.1986.133.1.5.
Jones RN, Hughes JM, Glindmeyer H, Weill H. Lung function after acute chlorine exposure. Am Rev Respir Dis. 1986 Dec;134(6):1190-5. doi: 10.1164/arrd.1986.134.6.1190.
O'Neil CE, Reed MA, Butcher BT. Biochemical and immunologic characterization of cotton bract extract and its effect on in vitro cyclic AMP production. I. Field-dried bract. Environ Res. 1986 Feb;39(1):104-14. doi: 10.1016/s0013-9351(86)80012-3.
O'Neil CE, Reed MA, Butcher BT. The effect of nonspecific binding by IgE on the radioallergosorbent test. Diagn Immunol. 1986;4(5):253-6.
Salvaggio JE, Butcher BT, O'Neil CE. Occupational asthma due to chemical agents. J Allergy Clin Immunol. 1986 Nov;78(5 Pt 2):1053-8. doi: 10.1016/0091-6749(86)90304-0. No abstract available.
Weill H, Hughes JM. Asbestos as a public health risk: disease and policy. Annu Rev Public Health. 1986;7:171-92. doi: 10.1146/annurev.pu.07.050186.001131. No abstract available.
Weissman DN, deShazo RD, Banks DE. Modulation of natural killer cell function by human alveolar macrophages. J Allergy Clin Immunol. 1986 Oct;78(4 Pt 1):571-7. doi: 10.1016/0091-6749(86)90073-4.
Weissman DN, deShazo RD, Banks DE, Baser Y. Immunomodulation by bronchial lavage cells in normal individuals and patients with bronchogenic carcinoma. Am J Med Sci. 1986 Oct;292(4):187-92. doi: 10.1097/00000441-198610000-00001.
Banks DE, Butcher BT, Salvaggio JE. Isocyanate-induced respiratory disease. Ann Allergy. 1986 Dec;57(6):389-96. No abstract available.
deShazo RD, Daul CB, Morgan JE, Diem JE, Hendrick DJ, Bozelka BE, Stankus RP, Jones R, Salvaggio JE, Weill H. Immunologic investigations in asbestos-exposed workers. Chest. 1986 Mar;89(3 Suppl):162S-165S. doi: 10.1378/chest.89.3_supplement.162s. No abstract available.
Rando RJ, Abdel-Kader H, Hughes J, Hammad YY. Toluene diisocyanate exposures in the flexible polyurethane foam industry. Am Ind Hyg Assoc J. 1987 Jun;48(6):580-5. doi: 10.1080/15298668791385246.
Rando RJ, Duvoisin PF, Abdel-Kader H, Hammad YY. A sequential tape monitor for toluene diisocyanate. Am Ind Hyg Assoc J. 1987 Jun;48(6):574-9. doi: 10.1080/15298668791385237.
Glindmeyer HW, Jones RN, Barkman HW, Weill H. Spirometry: quantitative test criteria and test acceptability. Am Rev Respir Dis. 1987 Aug;136(2):449-52. doi: 10.1164/ajrccm/136.2.449.
Glindmeyer HW, Jones RN, Diem JE, Weill H. Useful and extraneous variability in longitudinal assessment of lung function. Chest. 1987 Nov;92(5):877-82. doi: 10.1378/chest.92.5.877.
Hughes JM, Weill H, Hammad YY. Mortality of workers employed in two asbestos cement manufacturing plants. Br J Ind Med. 1987 Mar;44(3):161-74. doi: 10.1136/oem.44.3.161.
Abdel-Kader HM, Rando RJ, Hammad YY. Long-term cotton dust exposure in the textile industry. Am Ind Hyg Assoc J. 1987 Jun;48(6):545-50. doi: 10.1080/15298668791385192.
Sastre J, Banks DE, Ellis E, Barkman HW, Butcher BT, Hammad YY, Rando RJ, Glindmeyer HW: Isocyanate-Induced Asthma: Review of 62 Challenge Tests. Am Rev Respir Dis, 135:A235, (Supplement), 1987
Banks DE, Salvaggio J, Goetzel EJ: Eosinophilic Syndromes of the Lung. In: Murray FJ, Nadel JA (Eds), Textbook of Respiratory Medicine, Philadelphia: Saunders, 1988
Butcher BT, Salvaggio JE: Occupational Asthma: Immunologic Aspects. In: Daniele RP (Ed), Immunology and Immunologic Diseases of the Lung. Blackwell Scientific Publications, 1988
deShazo RD, Morgan J, Bozelka B, Chapman Y. Natural killer cell activity in asbestos workers. Interactive effects of smoking and asbestos exposure. Chest. 1988 Sep;94(3):482-5. doi: 10.1378/chest.94.3.482.
Glindmeyer HW, Hammad YY. Contributing factors to sandblasters' silicosis: inadequate respiratory protection equipment and standards. J Occup Med. 1988 Dec;30(12):917-21. doi: 10.1097/00043764-198812000-00007.
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Fechas de registro del estudio

Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.

Fechas importantes del estudio

Inicio del estudio

1 de junio de 1972

Finalización del estudio (Actual)

1 de noviembre de 1991

Fechas de registro del estudio

Enviado por primera vez

25 de mayo de 2000

Primero enviado que cumplió con los criterios de control de calidad

25 de mayo de 2000

Publicado por primera vez (Estimar)

26 de mayo de 2000

Actualizaciones de registros de estudio

Última actualización publicada (Estimar)

13 de mayo de 2016

Última actualización enviada que cumplió con los criterios de control de calidad

12 de mayo de 2016

Última verificación

1 de marzo de 2005

Más información

Términos relacionados con este estudio

Términos MeSH relevantes adicionales

Otros números de identificación del estudio

2001 (Otro número de subvención/financiamiento: Waste Connections INC)
P50HL015092 (Subvención/contrato del NIH de EE. UU.)

Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .