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Combined Training (Strength and Endurance) and the Serum Levels of Myostatin and Hormone-sensitive Lipase in Overweight and Obese Men

14 de junio de 2026 actualizado por: Arya Habibi

Effect of Upper Body and Lower Body Combined Training (Strength and Endurance) on the Serum Levels of Myostatin and Hormone-sensitive Lipase in Overweight and Obese Men

This randomized controlled trial investigated the effects of upper body-based and lower body-based combined training on serum levels of myostatin (MSTN) and hormone-sensitive lipase (HSL) in overweight and obese men. Myostatin is a myokine involved in the regulation of skeletal muscle growth and adipose tissue metabolism, while HSL is a key enzyme involved in lipolysis and fat mobilization.

Thirty-six overweight and obese men were assigned to either an upper body combined training group, a lower body combined training group, or a non-exercising control group. The intervention consisted of 10 weeks of combined resistance and aerobic training performed three times per week. Serum levels of MSTN and HSL were measured before and after the intervention to determine whether upper body-focused and lower body-focused combined training produce different effects on markers associated with muscle growth and lipid metabolism.

Descripción general del estudio

Estado

Terminado

Condiciones

Intervención / Tratamiento

Tipo de estudio

Intervencionista

Inscripción (Actual)

36

Fase

  • No aplica

Contactos y Ubicaciones

Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.

Ubicaciones de estudio

  • Irán
    • Tehran Province
      • Tehran, Tehran Province, Irán
        • Faculty of Sports and Health Sciences of the University of Tehran

Criterios de participación

Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.

Criterio de elegibilidad

Edades elegibles para estudiar

  • Adulto

Acepta Voluntarios Saludables

Sí

Descripción

Inclusion Criteria:

  • Male participants aged 20 to 45 years.
  • Body mass index (BMI) ≥25 kg/m².
  • Overweight or obese status.
  • No participation in regular resistance or aerobic exercise during the previous 6 months.
  • Willingness to participate and provide written informed consent.

Exclusion Criteria:

  • Presence of metabolic diseases, including diabetes mellitus.
  • Presence of cardiovascular or respiratory diseases.
  • Musculoskeletal or joint injuries that could interfere with exercise participation.
  • Use of anti-obesity medications.
  • Use of anabolic steroids, sports supplements, or fat-burning supplements.
  • Regular alcohol consumption or tobacco use.
  • Absence from more than two training sessions during the intervention period.
  • Withdrawal of consent or unwillingness to continue participation.

Plan de estudios

Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.

¿Cómo está diseñado el estudio?

Detalles de diseño

  • Propósito principal: Tratamiento
  • Asignación: Aleatorizado
  • Modelo Intervencionista: Asignación paralela
  • Enmascaramiento: Ninguno (etiqueta abierta)

Armas e Intervenciones

Grupo de participantes/brazo
Intervención / Tratamiento
Experimental: Upper Body Combined Training
Participants completed a 10-week upper body-focused combined training program three times per week. Each session consisted of upper body resistance exercises followed by aerobic exercise performed on a hand ergometer. Resistance training included chest press, rowing machine, biceps curl, triceps extension, shoulder press, and abdominal exercises.
Conductual: Upper Body Combined Training
Participants completed a 10-week upper body-focused combined training program performed three times per week. Each session included six upper body resistance exercises (chest press, rowing machine, biceps curl, triceps extension, shoulder press, and abdominal machine exercises) followed by aerobic exercise on a hand ergometer. Resistance training was performed for 3 sets during the first 5 weeks and 4 sets during weeks 6-10, with 8-12 repetitions per set. Aerobic exercise began at 20 minutes and increased by 1 minute each week, reaching 29 minutes in the final week. Exercise intensity was maintained at approximately 57-66% of maximum heart rate during aerobic training.
Otros nombres:
  • Upper Body Resistance and Aerobic Training
Experimental: Lower Body Combined Training
Participants completed a 10-week lower body-focused combined training program three times per week. Each session consisted of lower body resistance exercises followed by aerobic exercise performed on a leg ergometer. Resistance training included leg press, leg extension, leg flexion, leg abduction, leg adduction, and calf raise exercises.
Conductual: Lower Body Combined Training
Participants completed a 10-week lower body-focused combined training program performed three times per week. Each session included six lower body resistance exercises (leg press, leg extension, leg flexion, leg abduction, leg adduction, and calf raise exercises) followed by aerobic exercise on a leg ergometer. Resistance training was performed for 3 sets during the first 5 weeks and 4 sets during weeks 6-10, with 8-12 repetitions per set. Aerobic exercise began at 20 minutes and increased by 1 minute each week, reaching 29 minutes in the final week. Exercise intensity was maintained at approximately 57-66% of maximum heart rate during aerobic training.
Otros nombres:
  • Lower Body Resistance and Aerobic Training
Sin intervención: Control
Participants in the control group did not participate in the exercise intervention and were instructed to maintain their usual daily activities throughout the 10-week study period.

¿Qué mide el estudio?

Medidas de resultado primarias

Medida de resultado
Medida Descripción
Periodo de tiempo
Change in serum myostatin (MSTN) concentration
Periodo de tiempo: Baseline and 10 weeks
Serum myostatin concentration measured by enzyme-linked immunosorbent assay (ELISA). The outcome was assessed before the intervention and 48 hours after completion of the 10-week training program.
Baseline and 10 weeks
Change in serum hormone-sensitive lipase (HSL) concentration
Periodo de tiempo: Baseline and 10 weeks
Serum hormone-sensitive lipase concentration measured by enzyme-linked immunosorbent assay (ELISA). The outcome was assessed before the intervention and 48 hours after completion of the 10-week training program.
Baseline and 10 weeks

Colaboradores e Investigadores

Aquí es donde encontrará personas y organizaciones involucradas en este estudio.

Patrocinador

Arya Habibi

Fechas de registro del estudio

Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados ​​por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.

Fechas importantes del estudio

Inicio del estudio (Actual)

1 de mayo de 2024

Finalización primaria (Actual)

1 de mayo de 2024

Finalización del estudio (Actual)

15 de diciembre de 2024

Fechas de registro del estudio

Enviado por primera vez

14 de junio de 2026

Primero enviado que cumplió con los criterios de control de calidad

14 de junio de 2026

Publicado por primera vez (Actual)

18 de junio de 2026

Actualizaciones de registros de estudio

Última actualización publicada (Actual)

18 de junio de 2026

Última actualización enviada que cumplió con los criterios de control de calidad

14 de junio de 2026

Última verificación

1 de junio de 2026

Más información

Términos relacionados con este estudio

Términos MeSH relevantes adicionales

Otros números de identificación del estudio

  • IR.UT.SPORT.REC.1403.064

Plan de datos de participantes individuales (IPD)

¿Planea compartir datos de participantes individuales (IPD)?

NO

Descripción del plan IPD

Individual participant data (IPD) will not be made publicly available. The study was not originally designed with a formal data-sharing plan, and participant-level data contain information that could potentially compromise participant confidentiality.

Información sobre medicamentos y dispositivos, documentos del estudio

Estudia un producto farmacéutico regulado por la FDA de EE. UU.

No

Estudia un producto de dispositivo regulado por la FDA de EE. UU.

No

Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .

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