Androgens Level in the Third Trimester of Pregnancy in Patients With Preeclampsia
Aperçu de l'étude
Statut
Les conditions
Description détaillée
Methodology:
All women in this study will be subjected to:
- All women are candidates for this study according to inclusion and exclusion criteria.
- History taking with special emphases on last menstrual period to determine the exact Gestational age.
- A reliable date is defined as the occurrence of regular menstrual cycles (28±7 days) in patients who have not taken oral contraceptives during the three months before conception and have no irregular bleeding.
- General and abdominal examination for each patient to determine those patients matching with the inclusion criteria.
- Preeclampsia refers to the new onset of hypertension (systolic blood pressure ≥140 mmHg ,or diastolic blood pressure≥ 90 mmHg ,or both, measured on two occasions > 6 hours apart) and either proteinuria or end organ dysfunction after 20 weeks of gestation in a previously normotensive woman.
- At Ain Shams University Hospitals, the investigator will use ELISA based test system intended for the quantitative measurement of total and free testosterone for patients of both groups.
Type d'étude
Inscription (Réel)
Contacts et emplacements
Lieux d'étude
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Cairo
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Cairo Governorate, Cairo, Egypte, 00202
- Ain Shams Maternity Hospital-Faculty of Medicine- Ain Shams University
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
Study Site:
Ain Shams University Maternity Hospital
Study Design:
This study is a case control study.
Study Population:
Patients will be divided into two groups:
Case group:
This group will include forty (40) preeclamptic patients at the third trimester (28-40 weeks) admitted at Ain Shams University Maternity Hospital.
Control group:
This group will include forty (40) normotensive pregnant women at term admitted at Ain Shams University Maternity Hospital.
La description
Inclusion Criteria:
- Pregnant women (primigravidas) at third trimester i.e. 28-40 weeks.
- Age between 20 and 35 years old.
- Live fetus.
- Having no history of pregestational hypertension.
- Having no history of diseases associated with hormone disorders (thyroid gland disorders, DM, hyperprolactinemia or polycystic ovary syndrome).
- During their pregnancy they did not receive antihypertensive medications.
- Nonsmoker.
Exclusion Criteria:
1- First and second trimester pregnant women. 2- Women younger than 20 years old and older than 35 years old 3- Intrauterine fetal death. 4- History of pregestational hypertension. 5- History of hormonal disorders (thyroid gland disorders and hyperprolactinemia).
6- Smoker. 7- Polycystic ovary syndrome. 8- Signs or symptoms of hyper-androgenism (hirsutism, acne, oily skin, etc.). 9- Diabetes mellitus. 10- Drug use except ordinary supplementation (iron, folic acid).
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
Cohortes et interventions
Groupe / Cohorte |
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Case group: This group will include forty (40) preeclampt
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Control group: This group will include forty (40) normoten
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Total and free testosterone level
Délai: 9 months
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Higher in preeclamptic patients than normal pregnant ladies
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9 months
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Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chaise d'étude: Noha H Rabei, Professor of Obs&Gyn, Ain Shams Maternity Hospital
- Directeur d'études: Malames M Faisal, Lecturer of Obs&Gyna, Ain Shams Maternity Hospital
- Directeur d'études: Hoda E Abd elwahab, Fellow of medical tests, Ain Shams Hospitals
Publications et liens utiles
Publications générales
- https://www.ncbi.nlm.nih.gov/pubmed/12746983
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- AinShams MH 01
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
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