Building Cognitive Resilience to Vaccine Misinformation Using AI in Europe
Renforcer la résilience cognitive face à la désinformation sur les vaccins grâce à une IA conversationnelle : résultats d'un essai randomisé multi-pays européen
This multi-country trial evaluates an AI chatbot designed to counter cognitive biases and inoculate parents against vaccine misinformation, embedded within a large survey across five European countries (n=5,000). Scaled from a 2026 single-country study, outcomes compare behavioural and attitudinal responses against standard-of-care materials (e.g., UNICEF infographics) to identify effective, scalable misinformation interventions.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
The aim of this multi-country trial is to identify and quantify the effectiveness of inoculation strategies against vaccine-related misinformation. Building on a single-country study implemented in early 2026 [NCT07488962], the study evaluates an AI chatbot designed to counter cognitive biases, embedded within a larger survey to enable integrated assessment of engagement, behavioural responses, and system performance at scale.
The study will be conducted across five European countries-the United Kingdom, the Netherlands, Croatia, Latvia, and Slovakia-with a total sample of 5,000 parents or caregivers (n=1,000 per country). Participants will complete a structured survey assessing childhood vaccination behaviours, vaccine confidence, trust in information sources, exposure to misinformation, and relevant psychological and sociodemographic factors.
Participants will be randomly assigned to either the intervention or control arm. The intervention arm will receive the AI-based chatbot, while the control arm will receive standard-of-care materials-such as national or international health institute communications (e.g., UNICEF infographics)-that address the same misinformation messages, enabling a direct and rigorous comparison.
The primary outcome is parents' ability to correctly distinguish true from false childhood vaccine statements. Quantitative analyses will include pooled and country-specific models to identify determinants of vaccine confidence and estimate intervention effects. Findings will clarify drivers of declining vaccine confidence and assess whether a scalable AI-based chatbot can reduce vulnerability to misinformation and support informed vaccination decisions.
Type d'étude
Inscription (Estimé)
Phase
- N'est pas applicable
Contacts et emplacements
Coordonnées de l'étude
- Nom: Leesa Lin, PhD
- Numéro de téléphone: +44 (0)20 7636 8636
- E-mail: Leesa.Lin@lshtm.ac.uk
Sauvegarde des contacts de l'étude
- Nom: Kana Kobayashi, MSPH
- E-mail: Kana.Kobayashi@lshtm.ac.uk
Lieux d'étude
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London, Royaume-Uni
- Recrutement
- London School of Hygiene and Tropical Medicine
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Contact:
- Leesa Lin
- Numéro de téléphone: +44 20 7927 2555
- E-mail: Leesa.Lin@lshtm.ac.uk
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
- Parents or caregivers with children under 18 years old in the five target countries (UK, Netherlands, Croatia, Latvia, and Slovakia); and
- Those who have regular access to a digital device and the internet
Exclusion Criteria:
- Participants who do not meet the inclusion criteria.
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Recherche sur les services de santé
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Double
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
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Expérimental: AI-driven chatbot
An interactive, web-based, AI-driven chatbot intervention designed to counter vaccine misinformation. It can be accessed via a personal computer, tablet, or mobile device through a web- browser link. |
A tailored AI-driven chatbot designed to counter vaccine misinformation. |
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Comparateur actif: Social media infographic
A UNICEF social media infographic with three "myth vs. fact" statements on vaccination that correspond to the same misinformation tactics explained by the MindShield chatbot. |
A UNICEF social media infographic with three "myth vs. fact" statements on vaccination. |
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Parental susceptibility to misinformation about childhood vaccination
Délai: Through study completion, an average of 20-30 minutes
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The primary outcome of this study will assess parental susceptibility to misinformation about childhood vaccination, defined as parents' ability to accurately distinguish between true and false vaccine-related information. This will be measured using ten statements on childhood vaccines, including four true and six false, rumour-related statements. Two of the rumour-related statements correspond to each of the three misinformation tactics introduced by the chatbot and the UNICEF infographic. This measure reflects parents' ability to identify misinformation containing manipulation tactics they were inoculated against and to distinguish true from false information regarding childhood vaccination. Responses will be recorded as "True", "False", or "Don't know". A composite misinformation susceptibility score will be calculated based on the number of correct responses, with higher scores indicating greater ability to identify vaccine misinformation accurately. |
Through study completion, an average of 20-30 minutes
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Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Vaccine confidence
Délai: Through study completion, an average of 20-30 minutes
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Vaccine confidence will be assessed using three statements addressing whether childhood vaccines are important, safe, and effective. Responses will range from "Strongly agree" to "Strongly disagree", with a "Don't know" option. A composite score ranging from 0 to 100 will be calculated, with higher scores indicating greater vaccine confidence. |
Through study completion, an average of 20-30 minutes
|
Collaborateurs et enquêteurs
Les enquêteurs
- Chercheur principal: Leesa Lin, PhD, London School of Hygiene and Tropical Medicine
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Estimé)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Autres numéros d'identification d'étude
- LSHTM32877
Informations sur les médicaments et les dispositifs, documents d'étude
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