Costruire la Resilienza Cognitiva contro la Disinformazione sui Vaccini utilizzando l'IA in Europa
Costruire la resilienza cognitiva alla disinformazione sui vaccini utilizzando l'IA conversazionale: evidenze da uno studio randomizzato multi-paese europeo
This multi-country trial evaluates an AI chatbot designed to counter cognitive biases and inoculate parents against vaccine misinformation, embedded within a large survey across five European countries (n=5,000). Scaled from a 2026 single-country study, outcomes compare behavioural and attitudinal responses against standard-of-care materials (e.g., UNICEF infographics) to identify effective, scalable misinformation interventions.
Panoramica dello studio
Stato
Condizioni
Intervento / Trattamento
Descrizione dettagliata
The aim of this multi-country trial is to identify and quantify the effectiveness of inoculation strategies against vaccine-related misinformation. Building on a single-country study implemented in early 2026 [NCT07488962], the study evaluates an AI chatbot designed to counter cognitive biases, embedded within a larger survey to enable integrated assessment of engagement, behavioural responses, and system performance at scale.
The study will be conducted across five European countries-the United Kingdom, the Netherlands, Croatia, Latvia, and Slovakia-with a total sample of 5,000 parents or caregivers (n=1,000 per country). Participants will complete a structured survey assessing childhood vaccination behaviours, vaccine confidence, trust in information sources, exposure to misinformation, and relevant psychological and sociodemographic factors.
Participants will be randomly assigned to either the intervention or control arm. The intervention arm will receive the AI-based chatbot, while the control arm will receive standard-of-care materials-such as national or international health institute communications (e.g., UNICEF infographics)-that address the same misinformation messages, enabling a direct and rigorous comparison.
The primary outcome is parents' ability to correctly distinguish true from false childhood vaccine statements. Quantitative analyses will include pooled and country-specific models to identify determinants of vaccine confidence and estimate intervention effects. Findings will clarify drivers of declining vaccine confidence and assess whether a scalable AI-based chatbot can reduce vulnerability to misinformation and support informed vaccination decisions.
Tipo di studio
Iscrizione (Stimato)
Fase
- Non applicabile
Contatti e Sedi
Contatto studio
- Nome: Leesa Lin, PhD
- Numero di telefono: +44 (0)20 7636 8636
- Email: Leesa.Lin@lshtm.ac.uk
Backup dei contatti dello studio
- Nome: Kana Kobayashi, MSPH
- Email: Kana.Kobayashi@lshtm.ac.uk
Luoghi di studio
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London, Regno Unito
- Reclutamento
- London School of Hygiene and Tropical Medicine
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Contatto:
- Leesa Lin
- Numero di telefono: +44 20 7927 2555
- Email: Leesa.Lin@lshtm.ac.uk
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Criteri di partecipazione
Criteri di ammissibilità
Età idonea allo studio
Accetta volontari sani
Sessi ammissibili allo studio
Descrizione
Inclusion Criteria:
- Parents or caregivers with children under 18 years old in the five target countries (UK, Netherlands, Croatia, Latvia, and Slovakia); and
- Those who have regular access to a digital device and the internet
Exclusion Criteria:
- Participants who do not meet the inclusion criteria.
Piano di studio
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Ricerca sui servizi sanitari
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Doppio
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
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Sperimentale: AI-driven chatbot
An interactive, web-based, AI-driven chatbot intervention designed to counter vaccine misinformation. It can be accessed via a personal computer, tablet, or mobile device through a web- browser link. |
A tailored AI-driven chatbot designed to counter vaccine misinformation. |
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Comparatore attivo: Social media infographic
A UNICEF social media infographic with three "myth vs. fact" statements on vaccination that correspond to the same misinformation tactics explained by the MindShield chatbot. |
A UNICEF social media infographic with three "myth vs. fact" statements on vaccination. |
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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Parental susceptibility to misinformation about childhood vaccination
Lasso di tempo: Through study completion, an average of 20-30 minutes
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The primary outcome of this study will assess parental susceptibility to misinformation about childhood vaccination, defined as parents' ability to accurately distinguish between true and false vaccine-related information. This will be measured using ten statements on childhood vaccines, including four true and six false, rumour-related statements. Two of the rumour-related statements correspond to each of the three misinformation tactics introduced by the chatbot and the UNICEF infographic. This measure reflects parents' ability to identify misinformation containing manipulation tactics they were inoculated against and to distinguish true from false information regarding childhood vaccination. Responses will be recorded as "True", "False", or "Don't know". A composite misinformation susceptibility score will be calculated based on the number of correct responses, with higher scores indicating greater ability to identify vaccine misinformation accurately. |
Through study completion, an average of 20-30 minutes
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Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
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Vaccine confidence
Lasso di tempo: Through study completion, an average of 20-30 minutes
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Vaccine confidence will be assessed using three statements addressing whether childhood vaccines are important, safe, and effective. Responses will range from "Strongly agree" to "Strongly disagree", with a "Don't know" option. A composite score ranging from 0 to 100 will be calculated, with higher scores indicating greater vaccine confidence. |
Through study completion, an average of 20-30 minutes
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Collaboratori e investigatori
Investigatori
- Investigatore principale: Leesa Lin, PhD, London School of Hygiene and Tropical Medicine
Studiare le date dei record
Studia le date principali
Inizio studio (Effettivo)
Completamento primario (Stimato)
Completamento dello studio (Stimato)
Date di iscrizione allo studio
Primo inviato
Primo inviato che soddisfa i criteri di controllo qualità
Primo Inserito (Effettivo)
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo verificato
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Altri numeri di identificazione dello studio
- LSHTM32877
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .