- ICH GCP
- USA klinikai vizsgálatok nyilvántartása
- Klinikai vizsgálat NCT00953342
Impact of Aerobic Exercise on Asthma Morbidity (Ex-Asthma)
A tanulmány áttekintése
Állapot
Körülmények
Beavatkozás / kezelés
Részletes leírás
Introduction: Asthma is a chronic respiratory disorder primarily driven by increased airway inflammation. It is one of the most prevalent chronic conditions affecting Canadians. It is the most common chronic illness affecting children and the fourth most common disorders affecting adults. In 2001, nearly 2.2 million (8.4%) Canadians were diagnosed as having asthma. More importantly, asthma is an escalating medical problem in Canada, e.g., between 1994 and 2001, there was a 40% increase in the number of Canadians with asthma. Not only is the prevalence of asthma increasing, but there has been a rapid rise in the morbidity and costs associated with asthma and its poor control. The WHO estimated that the global cost of caring for asthma exceeds that of AIDS/HIV and tuberculosis combined. Though recent guidelines have emphasized the importance of improving asthma control and quality of life, leading to huge amounts of resource being dedicated to this, more than 50% of adult patients with asthma remain poorly controlled. As current treatment strategies appear to be failing, it is important to target simple, cost effective interventions that are applicable for most patients with asthma and will increase overall levels of control and decrease asthma morbidity. There is evidence to suggest that aerobic exercise may improve asthma symptoms and control in children. In addition, there is evidence that exercise directly improves inflammatory and immune profiles in non-asthma patients, which may provide the mechanism by which exercise could improve asthma. However, there are no known studies that have systematically assessed the effects of aerobic exercise on asthma control, quality of life or immune function in adult asthma populations.
Objective: The primary objective of the current application is to assess the efficacy of aerobic exercise as an intervention to improve asthma control and quality of life in adult patients with asthma. The results of this study will provide data that will inform physicians and members of the Thoracic community about the benefits of exercise for asthma. The study will also assess potential inflammatory pathways by which exercise may elicit improvements in asthma morbidity. The results of this study should be available for the next Canadian Thoracic Society Canadian Adult Consensus Guidelines.
Methodology: The current proposal is for a study of aerobic exercise in sedentary patients with poorly controlled asthma. In addition to usual care, 52 patients will undertake supervised aerobic exercise. The exercise program will consist of 3 X 1hr sessions of supervised exercise per week for 12 weeks. The exercise routine, under medical supervision, will consist of 10 minutes of warm up exercises, 40 minutes of biking and/or walking (and eventually jogging), and 10 minutes of cool down exercises. These patients will be compared to a group of 52 patients who will follow their usual regimen, this group will be offered the exercise programme once they have completed the post assessments. For the primary outcomes (asthma control [Asthma Control Questionnaire], quality of life [Asthma Quality of Life Questionnaire]) and secondary outcomes (inflammatory profile) will be evaluated at baseline and after 12 weeks (the length of the treatment). To check the efficacy of the intervention both lung function, ambulatory peak flow, and exercise tolerance data will also be collected. Repeated measures analysis of covariance-type models with time (pre, post intervention) as the within subject factor, group (exercise, usual care) as the between factor, and sex, age, and asthma severity as the covariates will be used for the primary outcome variables. To assess the potential mechanistic role of inflammation on the exercise-asthma relationship a series of regression-like GLMs will be conducted.
It is hypothesized that: (1) The exercise intervention will result in clinically and statistically significant improvements in levels of asthma control and asthma quality of life; (2) The exercise intervention will result in clinically and statistically significant improvements in inflammatory profiles, with reductions in Th2 cytokines, and activation of inflammatory cells, and increases in Th1 cytokines; and (3) Changes in inflammatory profile will be directly linked to improvements in asthma measures.
We believe that the proposal will have great clinical significance for patient management. This project will be the first to systematically evaluate the benefits of exercise training on asthma control and quality of life in adult asthma patients. We anticipate that the results of this study will form the basis for new national and international guidelines and will provide an evidence-based background for physicians to prescribe aerobic exercise for patients with asthma.
Tanulmány típusa
Beiratkozás (Tényleges)
Fázis
- 3. fázis
Kapcsolatok és helyek
Tanulmányi helyek
-
-
Quebec
-
Montreal, Quebec, Kanada, H3T 1E2
- Jewish General Hospital
-
Montreal, Quebec, Kanada, H4J 1C5
- Hôpital du Sacré-Coeur de Montréal
-
Montreal, Quebec, Kanada, H2X 2P4
- Montreal Chest Institute
-
-
Részvételi kritériumok
Jogosultsági kritériumok
Tanulmányozható életkorok
Egészséges önkénteseket fogad
Tanulmányozható nemek
Leírás
Inclusion Criteria:
- Physician diagnosed asthma (confirmed by medical record evidence of bronchodilator reversibility of 12% or a minimum of 180 cc or PC20 methacholine <= 16 mg/ml)
- Sedentary (currently do less than 60 min of structured / planned physical activity per week)
- Taking at least 250 mg fluticasone equivalent per day
- On stable dose and regimen of asthma medications
- Mild to moderate symptomatic asthma as defined by an Asthma Control Questionnaire score of 1.25 or greater.
Exclusion Criteria:
- Diagnosed co-morbid disease for which there are already established exercise guidelines i.e., cardiac disease or COPD
- Any other medical condition that confers greater illness morbidity than asthma (e.g., active cancer) which will confirmed by physician review
- FEV1 lower than 60% of predicted
- Incapable of exercising
- A BMI > 30 kg/m2
- Unable to speak or understand either French or English
- <18 years of age
- Patients who are currently pregnant or intend to become pregnant over the course of the study.
Tanulási terv
Hogyan készül a tanulmány?
Tervezési részletek
- Elsődleges cél: Kezelés
- Kiosztás: Véletlenszerűsített
- Beavatkozó modell: Párhuzamos hozzárendelés
- Maszkolás: Egyetlen
Fegyverek és beavatkozások
Résztvevő csoport / kar |
Beavatkozás / kezelés |
---|---|
Kísérleti: Aerobic exercise
12 weeks of supervised aerobic exercise and standard care
|
12 weeks of supervised exercise, 3 x week, 1 hour sessions
|
Placebo Comparator: Usual care
12 weeks of standard care
|
Standard medical care
|
Mit mér a tanulmány?
Elsődleges eredményintézkedések
Eredménymérő |
Időkeret |
---|---|
Asthma control Questionnaire (Juniper)
Időkeret: Within 1 week of completion of the intervention (i.e., after 12 weeks)
|
Within 1 week of completion of the intervention (i.e., after 12 weeks)
|
Másodlagos eredményintézkedések
Eredménymérő |
Időkeret |
---|---|
Asthma quality of life questionnaire (Juniper)
Időkeret: Within 1 week of completion of the intervention (i.e., after 12 weeks)
|
Within 1 week of completion of the intervention (i.e., after 12 weeks)
|
Asthma control test
Időkeret: Within 1 week of completion of the intervention (i.e., after 12 weeks)
|
Within 1 week of completion of the intervention (i.e., after 12 weeks)
|
Inflammatory markers
Időkeret: Within 1 week of completion of the intervention (i.e., after 12 weeks)
|
Within 1 week of completion of the intervention (i.e., after 12 weeks)
|
Együttműködők és nyomozók
Szponzor
Együttműködők
Nyomozók
- Kutatásvezető: Simon L Bacon, PhD, Hopital du Sacre-Coeur de Montreal / Concordia University
Publikációk és hasznos linkek
Tanulmányi rekorddátumok
Tanulmány főbb dátumok
Tanulmány kezdete
Elsődleges befejezés (Tényleges)
A tanulmány befejezése (Tényleges)
Tanulmányi regisztráció dátumai
Először benyújtva
Először nyújtották be, amely megfelel a minőségbiztosítási kritériumoknak
Első közzététel (Becslés)
Tanulmányi rekordok frissítései
Utolsó frissítés közzétéve (Tényleges)
Az utolsó frissítés elküldve, amely megfelel a minőségbiztosítási kritériumoknak
Utolsó ellenőrzés
Több információ
A tanulmányhoz kapcsolódó kifejezések
További vonatkozó MeSH feltételek
Egyéb vizsgálati azonosító számok
- MOP93807
Ezt az információt közvetlenül a clinicaltrials.gov webhelyről szereztük be, változtatás nélkül. Ha bármilyen kérése van vizsgálati adatainak módosítására, eltávolítására vagy frissítésére, kérjük, írjon a következő címre: register@clinicaltrials.gov. Amint a változás bevezetésre kerül a clinicaltrials.gov oldalon, ez a webhelyünkön is automatikusan frissül. .
Klinikai vizsgálatok a Aerobic exercise
-
Boston University Charles River CampusBefejezveTérd OsteoarthritisEgyesült Államok
-
Hospital de Clinicas de Porto AlegreIsmeretlen
-
University of Sao PauloCoordenação de Aperfeiçoamento de Pessoal de Nível Superior.Befejezve
-
Uskudar UniversityBefejezve
-
Charite University, Berlin, GermanyBefejezve
-
University of Trás-os-Montes and Alto DouroBefejezveKimerültség – FiziológiaiBrazília
-
The Hospital for Sick ChildrenCanadian Institutes of Health Research (CIHR)Befejezve
-
NYU Langone HealthNew York UniversityBefejezveAlkoholfüggőség | Kábítószer-függőség
-
Instituto de Investigación Sanitaria de la Fundación...Még nincs toborzás
-
University of ValenciaEuropean Regional Development Fund; Ministerio de Ciencia e Innovación, Spain; Universitat... és más munkatársakBefejezveDiabetes mellitus, 1. típusúSpanyolország