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Sex Differences in Heart Rate Variability Responses to Eight Weeks of Circuit Training

3 ottobre 2026 aggiornato da: Marilyn Li Yin Ong, Universiti Sains Malaysia

Circuit Training and Autonomic Recovery: Sex Differences in Heart Rate Variability Among Inactive Young Adults

The main goal of this study is to find out how an 8-week circuit training exercise program affects heart health and how the body recovers in young adults who do not regularly exercise. The researchers also want to see if these responses are different between men and women.

The body's nervous system controls automatic functions like heart rate. Measuring changes in heart rate patterns-known as heart rate variability (HRV)-helps show how well the body switches between "fight-or-flight" (stress/exercise mode) and "rest-and-digest" (recovery mode). While men and women naturally have different heart rate patterns at rest, less is known about whether they recover differently after a structured exercise program.

The main questions this study aims to answer are:

  1. Does 8 weeks of circuit training improve heart rate recovery and nervous system balance in inactive young adults?
  2. Do men and women show different heart rate responses or recovery patterns after taking part in circuit training?

To answer these questions, inactive university students took part in an 8-week supervised circuit training program. Participants were considered inactive if they did less than 150 minutes of moderate exercise or less than 75 minutes of vigorous exercise per week.

Participants completed 20 exercise sessions (2 times per week) led by the study team:

  • Exercise Sessions: Each session started with a 5-minute warm-up, followed by 10 exercise stations using light weights, resistance bands, and bodyweight movements. Exercises targeted both upper and lower body muscles.
  • Workouts and Rest: Participants did each exercise for 30 seconds, rested for 1 minute between stations, and rested for 5 minutes between full sets.
  • Progression: During Weeks 1 to 4, participants did 2 sets per session. During Weeks 5 to 8, they increased to 3 sets per session.

To measure heart rate recovery, participants wore a heart rate chest monitor while resting quietly lying down:

  1. Before starting the 8-week program (Baseline)
  2. At 10 minutes after a workout at Week 8 (Short-term recovery)
  3. At 24 hours after a workout at Week 8 (Full recovery)

The researchers compared the heart rate data between men and women across these time points to see how quickly their nervous systems returned to a resting state after exercise.

Panoramica dello studio

Stato

Completato

Condizioni

Intervento / Trattamento

Descrizione dettagliata

This study evaluates the effects of an 8-week supervised circuit training program on heart rate variability (HRV) and autonomic recovery patterns among physically inactive young adults, with a specific focus on sex-related differences.

Participants undergo an 8-week exercise intervention consisting of 20 total sessions scheduled twice per week. The intervention follows a progressive volume design:

  • Weeks 1 to 4: Participants perform 2 complete sets per session (8 sessions total).
  • Weeks 5 to 8: Participants perform 3 complete sets per session (12 sessions total).

Each exercise session begins with a 5-minute dynamic warm-up. The circuit consists of 10 sequential exercise stations targeting major upper-body and lower-body muscle groups using body weight, resistance bands, and dumbbells: 1. Heel raises with dumbbells 2. Lateral raises with resistance bands 3. Leg abductions with resistance bands 4. Shoulder extensions and flexions with resistance bands 5. Jump rope 6. Triceps extensions with dumbbells 7. Half squats with resistance bands 8. Standing chest fly with dumbbells 9. Leg curls with resistance bands 10. Bicep curls with dumbbells

Participants perform each exercise station for 30 seconds, followed by a 1-minute rest interval between stations. A 5-minute rest period is provided between complete circuits. All sessions take place under direct supervision.

Autonomic function is evaluated via continuous beat-to-beat R-R interval recordings using a validated heart rate monitor while participants rest quietly in a supine position in a climate-controlled room (21 °C). Heart rate variability is assessed across three specific time points:

  1. Baseline: Pre-intervention assessment prior to beginning the 8-week training protocol.
  2. Post-10 Minutes: Immediate post-exercise recovery assessment within 10 minutes following the final training session at Week 8.
  3. Post-24 Hours: Delayed recovery assessment 24 hours following the final training session at Week 8.

Extracted frequency-domain HRV parameters include Low Frequency (LF: 0.04-0.15 Hz), High Frequency (HF: 0.15-0.40 Hz), and the LF/HF ratio, analyzed in both absolute power values (ms2) and normalized units (n.u.). Comparisons are conducted between male and female participants across time points to analyze sex-specific autonomic adaptations and recovery trajectories following circuit training.

Tipo di studio

Interventistico

Iscrizione (Effettivo)

17

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

    • Kelantan
      • Kubang Kerian, Kelantan, Malaysia, 16150
        • Exercise and Sports Science Laboratory, Universiti Sains Malaysia

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

Da 18 anni a 25 anni (Adulto)

Accetta volontari sani

Sì

Sessi ammissibili allo studio

Tutto

Descrizione

Inclusion Criteria:

  • Physically inactive, defined as engaging in less than 150 minutes of moderate-intensity aerobic activity or less than 75 minutes of vigorous-intensity activity per week.
  • Enrolled university student.
  • Willing and able to provide informed consent and attend supervised training sessions twice per week for 8 weeks.

Exclusion Criteria:

  • Regular engagement in structured exercise or training programs.
  • Current consumption of dietary supplements.
  • Inability or unwillingness to refrain from caffeine, alcohol, and vigorous physical activity for 24 hours prior to heart rate variability (HRV) testing sessions.

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Scienza basilare
  • Assegnazione: Non randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Nessuno (etichetta aperta)

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Sperimentale: Male Group

Male participants undergoing an 8-week supervised circuit training intervention (2 sessions per week; 2 sets per session for weeks 1-4, 3 sets per session for weeks 5-8).

Participants complete an 8-week supervised circuit training intervention consisting of 20 total sessions (2 sessions per week). Each session begins with a 5-minute warm-up, followed by 10 exercise stations targeting both upper-body and lower-body muscle groups using body weight, resistance bands, and dumbbells.

The 10 stations include: heel raises with dumbbells, lateral raises with resistance bands, leg abductions with resistance bands, shoulder extensions and flexions with resistance bands, jump rope, triceps extensions with dumbbells, half squats with resistance bands, standing chest fly with dumbbells, leg curls with resistance bands, and bicep curls with dumbbells.

Each exercise station is performed for 30 seconds with a 1-minute rest interval between stations, and a 5-minute rest interval between complete sets. Training volume progresses from 2 sets per session in Weeks 1-4 (8 sessions) to 3 sets per session in Weeks 5-8 (12 sessions)

Altri nomi:
  • Progressive Circuit Training Protocol
Sperimentale: Female Group

Female participants undergoing the identical 8-week supervised circuit training intervention (2 sessions per week; 2 sets per session for weeks 1-4, 3 sets per session for weeks 5-8).

Participants complete an 8-week supervised circuit training intervention consisting of 20 total sessions (2 sessions per week). Each session begins with a 5-minute warm-up, followed by 10 exercise stations targeting both upper-body and lower-body muscle groups using body weight, resistance bands, and dumbbells.

The 10 stations include: heel raises with dumbbells, lateral raises with resistance bands, leg abductions with resistance bands, shoulder extensions and flexions with resistance bands, jump rope, triceps extensions with dumbbells, half squats with resistance bands, standing chest fly with dumbbells, leg curls with resistance bands, and bicep curls with dumbbells.

Each exercise station is performed for 30 seconds with a 1-minute rest interval between stations, and a 5-minute rest interval between complete sets. Training volume progresses from 2 sets per session in Weeks 1-4 (8 sessions) to 3 sets per session in Weeks 5-8 (12 sessions)

Altri nomi:
  • Progressive Circuit Training Protocol

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Change in Low-Frequency (LF) Power in Normalized Units (LF n.u.)
Lasso di tempo: Measured at Baseline (Week 0), Post-10 minutes (Week 8), and Post-24 hours (Week 8).

Frequency-domain heart rate variability metric reflecting combined sympathetic and parasympathetic autonomic modulation (measured in normalized units, n.u.).

Measured at Baseline (Week 0), Post-10 minutes (Week 8), and Post-24 hours (Week 8).
Change in High-Frequency (HF) Power in Normalized Units (HF n.u.)
Lasso di tempo: Measured at Baseline (Week 0), Post-10 minutes (Week 8), and Post-24 hours (Week 8).

Frequency-domain heart rate variability metric reflecting parasympathetic (vagal) autonomic modulation (measured in normalized units, n.u.)

Measured at Baseline (Week 0), Post-10 minutes (Week 8), and Post-24 hours (Week 8).
Change in Low-Frequency to High-Frequency Ratio (LF/HF Ratio)
Lasso di tempo: Measured at Baseline (Week 0), Post-10 minutes (Week 8), and Post-24 hours (Week 8).

Ratio of LF power to HF power, used as an index of sympathovagal balance during recovery.

Measured at Baseline (Week 0), Post-10 minutes (Week 8), and Post-24 hours (Week 8).

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Investigatori

  • Investigatore principale: Marilyn Li Yin Ong, PhD, Universiti Sains Malaysia

Pubblicazioni e link utili

La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

6 marzo 2025

Completamento primario (Effettivo)

5 marzo 2026

Completamento dello studio (Effettivo)

5 marzo 2026

Date di iscrizione allo studio

Primo inviato

28 settembre 2026

Primo inviato che soddisfa i criteri di controllo qualità

28 settembre 2026

Primo Inserito (Effettivo)

2 ottobre 2026

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

7 ottobre 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

3 ottobre 2026

Ultimo verificato

1 ottobre 2026

Maggiori informazioni

Termini relativi a questo studio

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • USM/JEPeM/KK/25010089

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

NO

Descrizione del piano IPD

Individual participant data (IPD) will not be shared to maintain participant privacy and confidentiality. All relevant aggregated datasets generated and analyzed during the current study are provided within the results section of the published article.

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .