Study of Intravenous BCX-1777 in Relapsed or Refractory Aggressive T-Cell Leukemias or Lymphomas
Phase I-II Study of Intravenous BCX-1777 in Relapsed or Refractory Aggressive (High Grade) T-Cell Malignancies
調査の概要
詳細な説明
Despite the great strides that have been made in improving the outcome with frontline programs of intensive chemotherapy in patients with aggressive T-cell malignancies, the prognosis with relapsed or refractory T-cell leukemias or lymphomas is poor. BCX-1777 is a purine nucleoside phosphorylase (PNP) inhibitor and a potential T-cell target therapy.
The purpose of the phase I portion of the study is to determine the maximum tolerated dose (MTD) of BCX-1777 and the dose to be studied in the phase II portion of the study.
The purpose of the phase II portion of the study is to determine the safety and efficacy of BCX-1777 in patients with relapsed or refractory aggressive T-cell malignancies.
Patients who respond to BCX-1777 or have stable disease may be eligible to receive an additional course of treatment.
研究の種類
入学
段階
- フェーズ2
- フェーズ 1
連絡先と場所
研究場所
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Texas
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Houston、Texas、アメリカ、77030
- M.D. Anderson Cancer Center
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Previously treated, relapsed or refractory aggressive T-cell malignancies (leukemias and lymphomas) histologically proven with measurable disease.
- Capable of only limited self-care, confined to bed or chair more than 50% of waking hours.
- All ages are eligible. Pediatric patients (<15 years of age) are eligible to be treated at a dose level previously tested in adults.
- Adequate liver and renal function.
- Patients with prior history of stem cell transplant if they meet all other eligibility requirements.
- Negative pregnancy test within 72 hours of study treatment in females of childbearing potential.
- Life expectancy of at least 2 months.
Exclusion:
- Active serious infection not controlled by oral or intravenous antibiotics.
- Treatment with any investigational antileukemic agents or chemotherapy agents in the last 7 days before study entry, unless full recovery from side-effects has occurred or patient has rapidly progressive disease judged to be life-threatening by the investigator.
- Concurrent treatment with other anti-cancer agents.
- Known CNS leukemia or lymphoma requiring intrathecal or craniospinal radiation therapy. Lumbar puncture not required in asymptomatic patients.
- Pregnant and/or lactating women; or fertile men or women not willing to use contraception.
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:処理
- 割り当て:非ランダム化
- 介入モデル:単一グループの割り当て
- マスキング:なし(オープンラベル)
協力者と研究者
スポンサー
捜査官
- 主任研究者:Deborah A. Thomas, M.D.、M.D. Anderson Cancer Center
研究記録日
主要日程の研究
研究開始
研究の完了
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
BCX-1777の臨床試験
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BioCryst Pharmaceuticals完了
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Weijun FuNanjing Legend Biotech Co.積極的、募集していない
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University of Wisconsin, MadisonPepsiCo, Inc.; CIMMYT完了
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Singapore Institute for Clinical SciencesDSM Nutritional Products, Inc.完了