Omega Tots 長期フォローアップ

実験的：ドコサヘキサエン酸＋アラキドン酸

ドコサヘキサエン酸＋アラキドン酸（DHA＋AA）

薬：ドコサヘキサエン酸＋アラキドン酸（DHA＋AA）

6 か月間、1 日あたり 200 mg の DHA + 200 mg の AA

プラセボコンパレーター：プラセボ

コーン油サプリ

ダイエットサプリメント：プラセボ

1日あたり400mgのコーン油を6ヶ月間

General Cognitive Ability Score (Differential Ability Scales, Second Edition-DAS-II)

Differential Ability Scales-II General Conceptual Ability Assessment は、一般的な認知能力の尺度であり、子供の認知の長所と短所を評価および識別するために使用されます。 一般的な認知能力スコアの範囲は 30 ～ 170 (平均 = 100、SD = 15) です。 低いスコアはパフォーマンスが低いことを示し、高いスコアは最高のパフォーマンスを示します。

実行機能 (NIH ツールボックス)

NIH Toolbox Cognition Battery は、認知機能を評価する簡単な尺度の多次元セットです。 フランカー、次元カードソート、およびパターン比較サブテストは、実行機能、処理速度、および注意力を測定します。 標準スコアの範囲は 30 ～ 170 (平均 = 100、SD = 15) です。 低いスコアはパフォーマンスが低いことを示し、高いスコアは最高のパフォーマンスを示します。

Core Language Score (Clinical Evaluation of Language Fundamentals, Fifth Edition-CELF-5)

Clinical evaluation of Language Fundamentals, 5th edition core tests is a comprehensive measure of language and can assess children's written and oral language skills, as well as their reading comprehension. The core language score has a range from 30 to 170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

溝付きペグボード タスク

溝付きペグボード タスクは、子供たちにペグをボードに挿入することで、目と手の協調と運動速度を測定します。 スコアは、ペグを配置する時間です。 子供が 3 分の制限時間に達した場合、スコアは配置されたペグの数です。 より速い時間とより少ない数のペグを落とすことは、より良いパフォーマンスを示しています。

人体測定学 - 肥満症

子供の肥満度を評価するには、生体電気インピーダンスを使用して体脂肪率を測定します。 お子様の身長と体重を合わせて BMI (kg/m^2) を報告します。 これらの測定値は、世界保健機関の子どもの成長基準に基づいて、年齢と性別の z スコアに変換されます。 z スコアは、平均から離れた標準偏差の数を示します。 z スコア 0 は、参照母集団 (同じ年齢で同じ性別の子供) の平均に等しくなります。 0 未満の値は参照母集団よりも低い値を示し、0 より大きい値は参照母集団よりも高い値を示します。

NIH ツールボックス フレンドシップ定型フォーム

NIH Toolbox Friendship (Age 8-17) Fixed Form は、過去 1 か月間の仲間関係を測定し、友人や他の知人との関係の質を評価する 5 項目のアンケートです。 スコアは t スコア (範囲 = [16-68]; 平均 = 50; SD=10) として表され、スコアが高いほどピア関係が強いことを示します。

NIH ツールボックス ポジティブ ピア インタラクション 親レポート 定型フォーム

NIH ツールボックス ポジティブ ピア インタラクション フォーム (3 ～ 12 歳) は、親レポートを介して子ピア関係を測定する 4 項目のアンケートです。 スコアは t スコア (範囲 = [-8-63] ; 平均 = 50; SD=10) として表され、スコアが高いほどピア関係が強いことを示します。

Select Subtest From the Wechsler Intelligence Scales for Children, Fifth Edition (WISC-V)

The Weschler Intelligence Scales for Children-V Digit Span and Picture Span subtests assess working memory. The working memory index composite score has a range from 30-170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Select Subtests From the Kaufman Test of Educational Achievement, Third Edition (KTEA-3)

The Kaufman Test of Educational Achievement-3 is an assessment of key academic skills. The Letter and Word Recognition, Math Computation, Object Naming Facility, and Associative Fluency Subtests measure children's reading, math, and written language skills. The standard score has a range from 30-170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Anthropometrics-Body Composition (Height)

To assess children's body composition, height (in centimeters) is measured. This is converted to a z score for age and sex based on Child Growth Standards from the World Health Organization. The z score indicates the number of standard deviations away from the mean. A z score of 0 is equal to the mean of a reference population (children the same age and sex). Values less than 0 indicate values lower than the reference population, while values greater than 0 indicate values higher than the reference population.

Anthropometrics-Body Composition (Weight)

To assess children's body composition, weight (in kilograms) is measured. This is converted to a z score for age and sex based on Child Growth Standards from the World Health Organization. The z score indicates the number of standard deviations away from the mean. A z score of 0 is equal to the mean of a reference population (children the same age and sex). Values less than 0 indicate values lower than the reference population, while values greater than 0 indicate values higher than the reference population.

Behavior Rating Inventory of Executive Function, 2nd Edition (BRIEF-2)

The Behavior Rating Inventory of Executive Function, 2nd ed., is completed by the child's caregiver and teacher to measure a range of executive functioning capabilities in children. The BRIEF-2 yields nine clinical scales that measure various aspects of executive function plus three broad indices: behavioral regulation, emotion regulation, and cognitive regulation. Scores are summed to obtain a Global Executive Composite Score that will be expressed as a t score (range= [35-90]; (mean=50; SD=10), where a higher score indicates greater dysregulation .

Select Subscales From the Teacher Report Form 6-18

The Teacher Report Form (syndrome and DSM-Oriented subscales) is completed by the child's teacher to reflect on the child's behavior in the previous six months. Scores are summed to provide a total problems score. Scores are also computed to measure the following subscales: internalizing problems, externalizing problems, anxious/depressed, withdrawn/depressed, somatic complaints, social problems, thought problems, attention problems, rule-breaking behavior, aggression behavior, affective problems, anxiety problems, somatic problems, attention deficit/hyperactivity problems, oppositional defiant problems, conduct problems. Scores will be expressed as a t-score (range= [33-100]; mean=50; SD=10), where a lower score indicates a more optimal outcome.

Child Behavior Checklist 6-18 (CBCL) - Competence

The Child Behavior Checklist is completed by the child' caregiver to reflect their child's behavior in the previous six months. Scores were summed to provide total competence score. Total competence scores will be expressed as a t-score (range= [20-100]; mean=50; SD=10), where a higher score reflects a more optimal outcome.

National Survey of Children's Health Module - Learning Disability

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

Emotion Regulation Checklist - Emotion Regulation

The Emotion Regulation Checklist is completed by the child's caregiver to measure child's ability to manage their emotions. Scores are grouped and summed to yield Emotion Regulation scale (range=10-40). Higher scores on the Emotion Regulation scale indicates more ability to regulate

Child Sleep Habits Questionnaire-abbreviated Measure

The Child Sleep Habits Questionnaire-abbreviated measures child sleep pattern and behaviors via parent report. Parents are asked to report on the child's bedtime behavior, sleep duration, and behavior during sleep. Scores are summed to give the total sleep disturbance score (range 33-99). Scores are also grouped and summed to yield eight subscales that measure different aspects of sleep. A higher score is indicative of more sleep problems .

Child Behavior Checklist 6-18 (CBCL) - Problems

The Child Behavior Checklist is completed by the child' caregiver to reflect their child's behavior in the previous six months. Scores were summed to provide problem scores. T Problem scores will be expressed as a t-score (range= [25,100]; mean=50; SD=10), where a lower score reflects a more optimal outcome.

National Survey of Children's Health Module - Developmental Delay

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - INtellectual Disability

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - Speech or Other Language Disorder

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - Behavioral or Conduct Problems

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

Emotion Regulation Checklist - Lability/Negativity

The Emotion Regulation Checklist is completed by the child's caregiver to measure child's ability to manage their emotions. Scores are grouped and summed to yield a Lability/Negativity (range=14-56) scale. Higher scores on the Lability/Negativity scale reflect greater dysregulation .