Omega Totsin pitkäaikainen seuranta

Kokeellinen: Dokosaheksaeenihappo + arakidonihappo

Dokosaheksaeenihappo + arakidonihappo (DHA + AA)

Lääke: Dokosaheksaeenihappo + arakidonihappo (DHA + AA)

200 mg DHA + 200 mg AA päivässä 6 kuukauden ajan

Placebo Comparator: Plasebo

Maissiöljyn lisäaine

Ravintolisä: Plasebo

400 mg maissiöljyä päivässä 6 kuukauden ajan

Yleiset kognitiiviset kyvyt (Differential Ability Scales, Second Edition-DAS-II)

Differential Ability Scales-II Yleisten käsitteellisten kykyjen arviointi on yleisen kognitiivisen kyvyn mitta, ja sitä käytetään arvioimaan ja tunnistamaan lasten kognitiivisia vahvuuksia ja heikkouksia. Yleinen kognitiivisten kykyjen pistemäärä on 30-170 (keskiarvo = 100; SD = 15). Matala pistemäärä tarkoittaa huonoa suorituskykyä ja korkea pistemäärä parasta suorituskykyä.

Executive Function (NIH Toolbox)

NIH Toolbox Cognition Battery on moniulotteinen sarja lyhyitä mittareita, jotka arvioivat kognitiivisia toimintoja. Flanker-, Dimensional Card Sort- ja Pattern Comparison -alitestit mittaavat toimeenpanotoimintoa, käsittelynopeutta ja tarkkaavaisuutta. Vakiopisteet ovat 30-170 (keskiarvo = 100; SD = 15). Matala pistemäärä tarkoittaa huonoa suorituskykyä ja korkea pistemäärä parasta suorituskykyä.

Core Language Score (Clinical Evaluation of Language Fundamentals, Fifth Edition-CELF-5)

Clinical evaluation of Language Fundamentals, 5th edition core tests is a comprehensive measure of language and can assess children's written and oral language skills, as well as their reading comprehension. The core language score has a range from 30 to 170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Uritettu Pegboard-tehtävä

Grooved Pegboard -tehtävä mittaa silmän ja käden koordinaatiota ja moottorin nopeutta vaatimalla lapsia työntämään tappeja tauluun. Pisteet on aika asettaa tapit. Jos lapsi saavuttaa 3 minuutin aikarajan, pistemäärä on asetettujen tappien määrä. Nopeampi aika ja pienempi pudotettujen tappien määrä ovat osoitus paremmasta suorituskyvystä.

Antropometria-rasvaisuus

Lasten rasvaisuuden arvioimiseksi käytetään biosähköistä impedanssia mittaamaan kehon rasvaprosenttia. Lapsen pituus ja paino yhdistetään ilmoittamaan BMI (kg/m^2). Nämä mittaukset muunnetaan iän ja sukupuolen z-pisteiksi Maailman terveysjärjestön lasten kasvustandardien perusteella. Z-pisteet osoittavat keskihajonnan keskiarvosta poispäin. Z-pistemäärä 0 on yhtä suuri kuin vertailupopulaation (saman ikäiset ja samaa sukupuolta olevat lapset) keskiarvo. Arvot, jotka ovat pienempiä kuin 0, osoittavat arvoja, jotka ovat pienempiä kuin vertailupopulaatio, kun taas arvot, jotka ovat suurempia kuin 0, osoittavat arvoja, jotka ovat korkeampia kuin vertailupopulaatio.

NIH Toolbox ystävyyden kiinteä lomake

NIH Toolbox Friendship (8–17-vuotiaat) kiinteä lomake on 5-kohdan kyselylomake, joka mittaa vertaissuhteita ja arvioi suhteiden laatua ystäviin ja muihin tuttuihin viimeisen kuukauden aikana. Pisteet ilmaistaan ​​t-pisteinä (alue = [16-68]; keskiarvo = 50; SD = 10), jossa korkeampi pistemäärä osoittaa vahvemman vertaissuhteen.

NIH Toolbox Positive Peer Interaction Parent Report Kiinteä lomake

NIH Toolbox Positive Peer Interaction Form (3–12-vuotiaat) on neljän kohdan kyselylomake, joka mittaa lasten vertaissuhteita vanhempainraportin kautta. Pisteet ilmaistaan ​​t-pisteinä (alue = [-8-63] ; keskiarvo = 50; SD = 10), jossa korkeampi pistemäärä osoittaa vahvemmat vertaissuhteet.

Select Subtest From the Wechsler Intelligence Scales for Children, Fifth Edition (WISC-V)

The Weschler Intelligence Scales for Children-V Digit Span and Picture Span subtests assess working memory. The working memory index composite score has a range from 30-170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Select Subtests From the Kaufman Test of Educational Achievement, Third Edition (KTEA-3)

The Kaufman Test of Educational Achievement-3 is an assessment of key academic skills. The Letter and Word Recognition, Math Computation, Object Naming Facility, and Associative Fluency Subtests measure children's reading, math, and written language skills. The standard score has a range from 30-170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Anthropometrics-Body Composition (Height)

To assess children's body composition, height (in centimeters) is measured. This is converted to a z score for age and sex based on Child Growth Standards from the World Health Organization. The z score indicates the number of standard deviations away from the mean. A z score of 0 is equal to the mean of a reference population (children the same age and sex). Values less than 0 indicate values lower than the reference population, while values greater than 0 indicate values higher than the reference population.

Anthropometrics-Body Composition (Weight)

To assess children's body composition, weight (in kilograms) is measured. This is converted to a z score for age and sex based on Child Growth Standards from the World Health Organization. The z score indicates the number of standard deviations away from the mean. A z score of 0 is equal to the mean of a reference population (children the same age and sex). Values less than 0 indicate values lower than the reference population, while values greater than 0 indicate values higher than the reference population.

Behavior Rating Inventory of Executive Function, 2nd Edition (BRIEF-2)

The Behavior Rating Inventory of Executive Function, 2nd ed., is completed by the child's caregiver and teacher to measure a range of executive functioning capabilities in children. The BRIEF-2 yields nine clinical scales that measure various aspects of executive function plus three broad indices: behavioral regulation, emotion regulation, and cognitive regulation. Scores are summed to obtain a Global Executive Composite Score that will be expressed as a t score (range= [35-90]; (mean=50; SD=10), where a higher score indicates greater dysregulation .

Select Subscales From the Teacher Report Form 6-18

The Teacher Report Form (syndrome and DSM-Oriented subscales) is completed by the child's teacher to reflect on the child's behavior in the previous six months. Scores are summed to provide a total problems score. Scores are also computed to measure the following subscales: internalizing problems, externalizing problems, anxious/depressed, withdrawn/depressed, somatic complaints, social problems, thought problems, attention problems, rule-breaking behavior, aggression behavior, affective problems, anxiety problems, somatic problems, attention deficit/hyperactivity problems, oppositional defiant problems, conduct problems. Scores will be expressed as a t-score (range= [33-100]; mean=50; SD=10), where a lower score indicates a more optimal outcome.

Child Behavior Checklist 6-18 (CBCL) - Competence

The Child Behavior Checklist is completed by the child' caregiver to reflect their child's behavior in the previous six months. Scores were summed to provide total competence score. Total competence scores will be expressed as a t-score (range= [20-100]; mean=50; SD=10), where a higher score reflects a more optimal outcome.

National Survey of Children's Health Module - Learning Disability

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

Emotion Regulation Checklist - Emotion Regulation

The Emotion Regulation Checklist is completed by the child's caregiver to measure child's ability to manage their emotions. Scores are grouped and summed to yield Emotion Regulation scale (range=10-40). Higher scores on the Emotion Regulation scale indicates more ability to regulate

Child Sleep Habits Questionnaire-abbreviated Measure

The Child Sleep Habits Questionnaire-abbreviated measures child sleep pattern and behaviors via parent report. Parents are asked to report on the child's bedtime behavior, sleep duration, and behavior during sleep. Scores are summed to give the total sleep disturbance score (range 33-99). Scores are also grouped and summed to yield eight subscales that measure different aspects of sleep. A higher score is indicative of more sleep problems .

Child Behavior Checklist 6-18 (CBCL) - Problems

The Child Behavior Checklist is completed by the child' caregiver to reflect their child's behavior in the previous six months. Scores were summed to provide problem scores. T Problem scores will be expressed as a t-score (range= [25,100]; mean=50; SD=10), where a lower score reflects a more optimal outcome.

National Survey of Children's Health Module - Developmental Delay

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - INtellectual Disability

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - Speech or Other Language Disorder

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - Behavioral or Conduct Problems

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

Emotion Regulation Checklist - Lability/Negativity

The Emotion Regulation Checklist is completed by the child's caregiver to measure child's ability to manage their emotions. Scores are grouped and summed to yield a Lability/Negativity (range=14-56) scale. Higher scores on the Lability/Negativity scale reflect greater dysregulation .