Omega Tots Долгосрочное наблюдение

Экспериментальный: Докозагексаеновая кислота + арахидоновая кислота

Докозагексаеновая кислота + арахидоновая кислота (DHA+AA)

Лекарство: Докозагексаеновая кислота + арахидоновая кислота (DHA+AA)

200 мг ДГК + 200 мг АК в день в течение 6 месяцев

Плацебо Компаратор: Плацебо

Добавка кукурузного масла

Диетическая добавка: Плацебо

400 мг кукурузного масла в день в течение 6 месяцев

Общая оценка когнитивных способностей (шкалы дифференциальных способностей, второе издание-DAS-II)

Шкалы дифференциальных способностей-II Оценка общих концептуальных способностей является мерой общих когнитивных способностей и используется для оценки и выявления сильных и слабых сторон когнитивных способностей детей. Общая оценка когнитивных способностей имеет диапазон от 30 до 170 (среднее значение = 100; SD = 15). Низкий балл указывает на низкую производительность, а высокий балл указывает на лучшую производительность.

Исполнительная функция (Инструментарий NIH)

Батарея когнитивных функций NIH Toolbox представляет собой многомерный набор кратких показателей, оценивающих когнитивные функции. Подтесты Flanker, Dimension Card Sort и Pattern Comparison измеряют исполнительную функцию, скорость обработки и внимание. Стандартные оценки имеют диапазон от 30 до 170 (среднее значение = 100; SD = 15). Низкий балл указывает на плохую производительность, а высокий балл указывает на лучшую производительность.

Core Language Score (Clinical Evaluation of Language Fundamentals, Fifth Edition-CELF-5)

Clinical evaluation of Language Fundamentals, 5th edition core tests is a comprehensive measure of language and can assess children's written and oral language skills, as well as their reading comprehension. The core language score has a range from 30 to 170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Рифленая задача Pegboard

Задание с рифленой доской измеряет зрительно-моторную координацию и скорость моторики, требуя от детей вставлять колышки в доску. Счет - это время, чтобы разместить колышки. Если ребенок достигает лимита времени в 3 минуты, то счет определяется количеством поставленных прищепок. Более быстрое время и меньшее количество сброшенных колышков свидетельствует о лучшей производительности.

Антропометрия-Ожирение

Для оценки ожирения у детей используется биоэлектрический импеданс для измерения процента жира в организме. Рост и вес ребенка будут объединены для определения ИМТ (кг/м^2). Эти измерения преобразуются в z-показатель для возраста и пола на основе Стандартов роста детей Всемирной организации здравоохранения. Показатель z указывает количество стандартных отклонений от среднего значения. Показатель z, равный 0, равен среднему значению контрольной группы (дети того же возраста и пола). Значения меньше 0 указывают на значения ниже эталонной совокупности, а значения больше 0 указывают на значения выше эталонной совокупности.

Фиксированная форма дружбы NIH Toolbox

Фиксированная форма NIH Toolbox Friendship (Ages 8-17) представляет собой анкету из 5 пунктов, которая измеряет отношения со сверстниками и оценивает качество отношений с друзьями и другими знакомыми за последний месяц. Баллы будут выражены в виде t-балла (диапазон = [16–68]; среднее значение = 50; SD = 10), где более высокий балл указывает на более сильные отношения со сверстниками.

NIH Toolbox Фиксированная форма родительского отчета о положительном взаимодействии сверстников

Форма положительного взаимодействия со сверстниками NIH Toolbox (возраст 3–12 лет) представляет собой анкету из 4 пунктов, которая измеряет отношения детей со сверстниками с помощью родительского отчета. Баллы будут выражены в виде t-балла (диапазон = [-8-63]; среднее = 50; SD = 10), где более высокий балл указывает на более сильные отношения со сверстниками.

Select Subtest From the Wechsler Intelligence Scales for Children, Fifth Edition (WISC-V)

The Weschler Intelligence Scales for Children-V Digit Span and Picture Span subtests assess working memory. The working memory index composite score has a range from 30-170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Select Subtests From the Kaufman Test of Educational Achievement, Third Edition (KTEA-3)

The Kaufman Test of Educational Achievement-3 is an assessment of key academic skills. The Letter and Word Recognition, Math Computation, Object Naming Facility, and Associative Fluency Subtests measure children's reading, math, and written language skills. The standard score has a range from 30-170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Anthropometrics-Body Composition (Height)

To assess children's body composition, height (in centimeters) is measured. This is converted to a z score for age and sex based on Child Growth Standards from the World Health Organization. The z score indicates the number of standard deviations away from the mean. A z score of 0 is equal to the mean of a reference population (children the same age and sex). Values less than 0 indicate values lower than the reference population, while values greater than 0 indicate values higher than the reference population.

Anthropometrics-Body Composition (Weight)

To assess children's body composition, weight (in kilograms) is measured. This is converted to a z score for age and sex based on Child Growth Standards from the World Health Organization. The z score indicates the number of standard deviations away from the mean. A z score of 0 is equal to the mean of a reference population (children the same age and sex). Values less than 0 indicate values lower than the reference population, while values greater than 0 indicate values higher than the reference population.

Behavior Rating Inventory of Executive Function, 2nd Edition (BRIEF-2)

The Behavior Rating Inventory of Executive Function, 2nd ed., is completed by the child's caregiver and teacher to measure a range of executive functioning capabilities in children. The BRIEF-2 yields nine clinical scales that measure various aspects of executive function plus three broad indices: behavioral regulation, emotion regulation, and cognitive regulation. Scores are summed to obtain a Global Executive Composite Score that will be expressed as a t score (range= [35-90]; (mean=50; SD=10), where a higher score indicates greater dysregulation .

Select Subscales From the Teacher Report Form 6-18

The Teacher Report Form (syndrome and DSM-Oriented subscales) is completed by the child's teacher to reflect on the child's behavior in the previous six months. Scores are summed to provide a total problems score. Scores are also computed to measure the following subscales: internalizing problems, externalizing problems, anxious/depressed, withdrawn/depressed, somatic complaints, social problems, thought problems, attention problems, rule-breaking behavior, aggression behavior, affective problems, anxiety problems, somatic problems, attention deficit/hyperactivity problems, oppositional defiant problems, conduct problems. Scores will be expressed as a t-score (range= [33-100]; mean=50; SD=10), where a lower score indicates a more optimal outcome.

Child Behavior Checklist 6-18 (CBCL) - Competence

The Child Behavior Checklist is completed by the child' caregiver to reflect their child's behavior in the previous six months. Scores were summed to provide total competence score. Total competence scores will be expressed as a t-score (range= [20-100]; mean=50; SD=10), where a higher score reflects a more optimal outcome.

National Survey of Children's Health Module - Learning Disability

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

Emotion Regulation Checklist - Emotion Regulation

The Emotion Regulation Checklist is completed by the child's caregiver to measure child's ability to manage their emotions. Scores are grouped and summed to yield Emotion Regulation scale (range=10-40). Higher scores on the Emotion Regulation scale indicates more ability to regulate

Child Sleep Habits Questionnaire-abbreviated Measure

The Child Sleep Habits Questionnaire-abbreviated measures child sleep pattern and behaviors via parent report. Parents are asked to report on the child's bedtime behavior, sleep duration, and behavior during sleep. Scores are summed to give the total sleep disturbance score (range 33-99). Scores are also grouped and summed to yield eight subscales that measure different aspects of sleep. A higher score is indicative of more sleep problems .

Child Behavior Checklist 6-18 (CBCL) - Problems

The Child Behavior Checklist is completed by the child' caregiver to reflect their child's behavior in the previous six months. Scores were summed to provide problem scores. T Problem scores will be expressed as a t-score (range= [25,100]; mean=50; SD=10), where a lower score reflects a more optimal outcome.

National Survey of Children's Health Module - Developmental Delay

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - INtellectual Disability

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - Speech or Other Language Disorder

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - Behavioral or Conduct Problems

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

Emotion Regulation Checklist - Lability/Negativity

The Emotion Regulation Checklist is completed by the child's caregiver to measure child's ability to manage their emotions. Scores are grouped and summed to yield a Lability/Negativity (range=14-56) scale. Higher scores on the Lability/Negativity scale reflect greater dysregulation .