Suivi à long terme Omega Tots

Expérimental: Acide docosahexaénoïque + acide arachidonique

Acide docosahexaénoïque + acide arachidonique (DHA+AA)

Médicament: Acide docosahexaénoïque + acide arachidonique (DHA+AA)

200 mg DHA + 200 mg AA par jour pendant 6 mois

Comparateur placebo: Placebo

Supplément d'huile de maïs

Complément alimentaire: Placebo

400 mg d'huile de maïs par jour pendant 6 mois

Score d'aptitude cognitive générale (échelles d'aptitude différentielles, deuxième édition-DAS-II)

Échelles d'aptitudes différentielles-II L'évaluation des capacités conceptuelles générales est une mesure de la capacité cognitive générale et est utilisée pour évaluer et identifier les forces et les faiblesses cognitives des enfants. Le score général des capacités cognitives varie de 30 à 170 (moyenne = 100 ; SD = 15). Un score faible indique une mauvaise performance et un score élevé indique une meilleure performance.

Fonction exécutive (boîte à outils NIH)

La NIH Toolbox Cognition Battery est un ensemble multidimensionnel de brèves mesures évaluant la fonction cognitive. Les sous-tests Flanker, Tri dimensionnel des cartes et Comparaison de modèles mesurent la fonction exécutive, la vitesse de traitement et l'attention. Les scores standard vont de 30 à 170 (moyenne = 100 ; SD = 15). Un score faible indique une mauvaise performance et un score élevé indique une meilleure performance.

Core Language Score (Clinical Evaluation of Language Fundamentals, Fifth Edition-CELF-5)

Clinical evaluation of Language Fundamentals, 5th edition core tests is a comprehensive measure of language and can assess children's written and oral language skills, as well as their reading comprehension. The core language score has a range from 30 to 170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Tâche de panneau perforé rainuré

La tâche Grooved Pegboard mesure la coordination œil-main et la vitesse motrice en demandant aux enfants d'insérer des chevilles dans une planche. Le score est le temps de placer les chevilles. Si l'enfant atteint le temps limite de 3 minutes, le score correspond au nombre de piquets placés. Un temps plus rapide et un nombre inférieur de piquets lâchés indiquent de meilleures performances.

Anthropométrie-Adiposité

Pour évaluer l'adiposité des enfants, une impédance bioélectrique est utilisée pour mesurer le pourcentage de graisse corporelle. La taille et le poids de l'enfant seront combinés pour indiquer l'IMC (kg/m^2). Ces mesures sont converties en un score z pour l'âge et le sexe basé sur les normes de croissance de l'enfant de l'Organisation mondiale de la santé. Le score z indique le nombre d'écarts types par rapport à la moyenne. Un score z de 0 est égal à la moyenne d'une population de référence (enfants du même âge et du même sexe). Les valeurs inférieures à 0 indiquent des valeurs inférieures à la population de référence, tandis que les valeurs supérieures à 0 indiquent des valeurs supérieures à la population de référence.

Formulaire fixe d'amitié de la boîte à outils NIH

Le formulaire fixe NIH Toolbox Friendship (Ages 8-17) est un questionnaire en 5 points qui mesure les relations avec les pairs et évalue la qualité des relations avec les amis et autres connaissances au cours du mois écoulé. Les scores seront exprimés sous forme de score t (plage = [16-68] ; moyenne = 50 ; SD = 10), où un score plus élevé indique des relations plus fortes avec les pairs.

NIH Toolbox Positive Peer Interaction Parent Report Formulaire fixe

Le formulaire NIH Toolbox Positive Peer Interaction (3-12 ans) est un questionnaire en 4 points qui mesure les relations entre les enfants et les pairs via le rapport des parents. Les scores seront exprimés sous forme de score t (plage = [-8-63] ; moyenne = 50 ; SD = 10), où un score plus élevé indique des relations plus fortes avec les pairs.

Select Subtest From the Wechsler Intelligence Scales for Children, Fifth Edition (WISC-V)

The Weschler Intelligence Scales for Children-V Digit Span and Picture Span subtests assess working memory. The working memory index composite score has a range from 30-170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Select Subtests From the Kaufman Test of Educational Achievement, Third Edition (KTEA-3)

The Kaufman Test of Educational Achievement-3 is an assessment of key academic skills. The Letter and Word Recognition, Math Computation, Object Naming Facility, and Associative Fluency Subtests measure children's reading, math, and written language skills. The standard score has a range from 30-170 (mean=100; SD=15). A low score indicates poor performance, and a high score indicates best performance.

Anthropometrics-Body Composition (Height)

To assess children's body composition, height (in centimeters) is measured. This is converted to a z score for age and sex based on Child Growth Standards from the World Health Organization. The z score indicates the number of standard deviations away from the mean. A z score of 0 is equal to the mean of a reference population (children the same age and sex). Values less than 0 indicate values lower than the reference population, while values greater than 0 indicate values higher than the reference population.

Anthropometrics-Body Composition (Weight)

To assess children's body composition, weight (in kilograms) is measured. This is converted to a z score for age and sex based on Child Growth Standards from the World Health Organization. The z score indicates the number of standard deviations away from the mean. A z score of 0 is equal to the mean of a reference population (children the same age and sex). Values less than 0 indicate values lower than the reference population, while values greater than 0 indicate values higher than the reference population.

Behavior Rating Inventory of Executive Function, 2nd Edition (BRIEF-2)

The Behavior Rating Inventory of Executive Function, 2nd ed., is completed by the child's caregiver and teacher to measure a range of executive functioning capabilities in children. The BRIEF-2 yields nine clinical scales that measure various aspects of executive function plus three broad indices: behavioral regulation, emotion regulation, and cognitive regulation. Scores are summed to obtain a Global Executive Composite Score that will be expressed as a t score (range= [35-90]; (mean=50; SD=10), where a higher score indicates greater dysregulation .

Select Subscales From the Teacher Report Form 6-18

The Teacher Report Form (syndrome and DSM-Oriented subscales) is completed by the child's teacher to reflect on the child's behavior in the previous six months. Scores are summed to provide a total problems score. Scores are also computed to measure the following subscales: internalizing problems, externalizing problems, anxious/depressed, withdrawn/depressed, somatic complaints, social problems, thought problems, attention problems, rule-breaking behavior, aggression behavior, affective problems, anxiety problems, somatic problems, attention deficit/hyperactivity problems, oppositional defiant problems, conduct problems. Scores will be expressed as a t-score (range= [33-100]; mean=50; SD=10), where a lower score indicates a more optimal outcome.

Child Behavior Checklist 6-18 (CBCL) - Competence

The Child Behavior Checklist is completed by the child' caregiver to reflect their child's behavior in the previous six months. Scores were summed to provide total competence score. Total competence scores will be expressed as a t-score (range= [20-100]; mean=50; SD=10), where a higher score reflects a more optimal outcome.

National Survey of Children's Health Module - Learning Disability

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

Emotion Regulation Checklist - Emotion Regulation

The Emotion Regulation Checklist is completed by the child's caregiver to measure child's ability to manage their emotions. Scores are grouped and summed to yield Emotion Regulation scale (range=10-40). Higher scores on the Emotion Regulation scale indicates more ability to regulate

Child Sleep Habits Questionnaire-abbreviated Measure

The Child Sleep Habits Questionnaire-abbreviated measures child sleep pattern and behaviors via parent report. Parents are asked to report on the child's bedtime behavior, sleep duration, and behavior during sleep. Scores are summed to give the total sleep disturbance score (range 33-99). Scores are also grouped and summed to yield eight subscales that measure different aspects of sleep. A higher score is indicative of more sleep problems .

Child Behavior Checklist 6-18 (CBCL) - Problems

The Child Behavior Checklist is completed by the child' caregiver to reflect their child's behavior in the previous six months. Scores were summed to provide problem scores. T Problem scores will be expressed as a t-score (range= [25,100]; mean=50; SD=10), where a lower score reflects a more optimal outcome.

National Survey of Children's Health Module - Developmental Delay

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - INtellectual Disability

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - Speech or Other Language Disorder

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

National Survey of Children's Health Module - Behavioral or Conduct Problems

The National Survey of Children's Health module captures child developmental and behavioral diagnoses and other major diagnoses via parent report . A binary variable will be formed to indicate if a child has been diagnosed with each condition or not (yes, no).

Emotion Regulation Checklist - Lability/Negativity

The Emotion Regulation Checklist is completed by the child's caregiver to measure child's ability to manage their emotions. Scores are grouped and summed to yield a Lability/Negativity (range=14-56) scale. Higher scores on the Lability/Negativity scale reflect greater dysregulation .