午前と午後のエクササイズトレーニング
高血圧のある閉経後女性の血圧と血管の健康に対する午前と午後の運動トレーニングの影響
The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise training performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.
調査の概要
状態
条件
詳細な説明
Blood pressure has an internal rhythm associated with the 24-hr clock. Nocturnal blood pressure (BP) is a key contributor to cardiovascular health and may be improved by exercise. Moreover, the time of day of the exercise may be a key factor. This study aims to evaluate the effects of morning and evening exercise training on BP and other measures of vascular function in older females with hypertension.
研究の種類
入学 (推定)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前：Katharine Currie, PhD
- 電話番号：517-432-4073
- メール：curriek4@msu.edu
研究連絡先のバックアップ
- 名前：Jill Slade, PhD
- 電話番号：5178843351
- メール：jslade@msu.edu
研究場所
-
-
Michigan
-
East Lansing、Michigan、アメリカ、48824
- 募集
- Michigan State University
-
コンタクト：
- Jill Slade, PhD
- 電話番号：517-884-3351
- メール：jslade@msu.edu
-
コンタクト：
- Katharine Currie, PhD
- 電話番号：517-432-4073
- メール：curriek4@msu.edu
-
-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Systolic BP equal to or greater than 130 mmHg without BP medication or greater than 120 mmHg with medication and diastolic blood pressure equal to and greater than 80 mmHg
- 55-80 years old
- Post-menopausal female
- Able to walk without assistance
Exclusion Criteria:
- Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week
- Overt pulmonary disease/condition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension
- Cardiometabolic disease/condition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months
- Cancer within last 5 years
- Body mass index >39 kg/m2
- Current smoking or vape
- Evening shift work
- uncontrolled thyroid disorder
- 2 or more falls in the last year
- Anemia within 3 months of enrollment
- Parkinson's disease
- Dementia
- Unstable angina
- Acute pulmonary embolus or infarction
- Acute myocarditis or pericarditis
- Acute aortic dissection
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：独身
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
実験的：Morning (AM)
Exercise starting before 10:01 AM |
handgrip and treadmill walking 4 days per week handgrip and treadmill walking 4 days per week |
|
実験的：Evening (PM)
Exercise starting after 3:59 PM |
handgrip and treadmill walking 4 days per week handgrip and treadmill walking 4 days per week |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Nocturnal systolic blood pressure (BP)
時間枠：6 weeks
|
Change in systolic nocturnal BP (Pre-training - Post-training) |
6 weeks
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Endothelial function
時間枠：6 weeks
|
Change in flow mediated dilation of the brachial artery (Post-training - Pre-training) |
6 weeks
|
|
Microvascular function
時間枠：6 weeks
|
Change in rapid onset vasodilation of the popliteal artery |
6 weeks
|
|
Ambulatory blood pressure
時間枠：6 weeks
|
Change in systolic and diastolic BPs over a 24-hr period (Pre-training - Post-training) |
6 weeks
|
|
Arterial stiffness
時間枠：6 weeks
|
Change in carotid femoral pulse wave velocity (Pre-training - Post-training) |
6 weeks
|
協力者と研究者
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。