中強度のスタチンとエゼチミブの比較冠状動脈プラーク安定化のための高強度スタチン

Inclusion Criteria:

• Adult men and women aged 18 years or older.

• Patients with coronary artery disease undergoing a coronary intervention procedure using intravascular imaging.

• At least one major native coronary artery ("target vessel") meeting all the following criteria for intracoronary imaging immediately following a qualifying PCI procedure:

  • Angiographic evidence of coronary artery stenosis ≥30% by angiographic visual estimation.
  • Target vessel is accessible to the imaging catheter and suitable for intracoronary imaging in the proximal 50 mm segment.
  • Target vessel is not a bypass graft (saphenous vein or arterial) or a bypassed graft vessel.
  • Target vessel has not undergone PCI within the target segment.
  • Target vessel is not a candidate for PCI at the time of the procedure or for 6 months thereafter (per investigator's judgment).

• Patients who have provided written informed consent to participate in the study.

Exclusion Criteria:

• Left main stem lesion: Left main coronary artery stenosis ≥50% by coronary angiographic visual estimation.

• History of coronary artery bypass graft surgery (CABG).

• Unstable clinical condition (hemodynamic or electrical instability).

• Severe coronary artery calcification or tortuosity interfering with IVUS, NIRS, or evaluation.

• Uncontrolled cardiac arrhythmia (recurrent and symptomatic ventricular tachycardia or atrial fibrillation with rapid ventricular response) not controlled by medication within 3 months prior to screening.

• Active liver disease or liver dysfunction.

• Severe renal dysfunction (eGFR <30 mL/min/1.73m²)

• Known allergy to contrast media, heparin, aspirin, ticagrelor, or prasugrel.

• Active infection or major hematologic, metabolic, or endocrine dysfunction as determined by the investigator.

• Planned surgery within 12 months.

• Currently enrolled in another randomized device study or a drug study involving lipid-lowering therapy.

• Estimated life expectancy of less than 2 years.

• Women of childbearing potential (under 50 years of age) who:

  • Had their last menstrual period within the last 12 months.
  • Have not had tubal ligation, oophorectomy, or hysterectomy.