中等强度他汀类药物加依折麦布与其他药物的比较高强度他汀类药物用于稳定冠状动脉斑块

Inclusion Criteria:

• Adult men and women aged 18 years or older.

• Patients with coronary artery disease undergoing a coronary intervention procedure using intravascular imaging.

• At least one major native coronary artery ("target vessel") meeting all the following criteria for intracoronary imaging immediately following a qualifying PCI procedure:

  • Angiographic evidence of coronary artery stenosis ≥30% by angiographic visual estimation.
  • Target vessel is accessible to the imaging catheter and suitable for intracoronary imaging in the proximal 50 mm segment.
  • Target vessel is not a bypass graft (saphenous vein or arterial) or a bypassed graft vessel.
  • Target vessel has not undergone PCI within the target segment.
  • Target vessel is not a candidate for PCI at the time of the procedure or for 6 months thereafter (per investigator's judgment).

• Patients who have provided written informed consent to participate in the study.

Exclusion Criteria:

• Left main stem lesion: Left main coronary artery stenosis ≥50% by coronary angiographic visual estimation.

• History of coronary artery bypass graft surgery (CABG).

• Unstable clinical condition (hemodynamic or electrical instability).

• Severe coronary artery calcification or tortuosity interfering with IVUS, NIRS, or evaluation.

• Uncontrolled cardiac arrhythmia (recurrent and symptomatic ventricular tachycardia or atrial fibrillation with rapid ventricular response) not controlled by medication within 3 months prior to screening.

• Active liver disease or liver dysfunction.

• Severe renal dysfunction (eGFR <30 mL/min/1.73m²)

• Known allergy to contrast media, heparin, aspirin, ticagrelor, or prasugrel.

• Active infection or major hematologic, metabolic, or endocrine dysfunction as determined by the investigator.

• Planned surgery within 12 months.

• Currently enrolled in another randomized device study or a drug study involving lipid-lowering therapy.

• Estimated life expectancy of less than 2 years.

• Women of childbearing potential (under 50 years of age) who:

  • Had their last menstrual period within the last 12 months.
  • Have not had tubal ligation, oophorectomy, or hysterectomy.