- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT02117271
The Treatment of Obstructive Sleep Apnea With Continuous Positive Airway Pressure on Appearance and Age
"BEAUTY CPAP": The Impact of the Treatment of Obstructive Sleep Apnea With Continuous Positive Airway Pressure on Appearance and Age: a Randomized Crossover Placebo-controlled Study
The investigators hypothesized that the treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) will positively affect the appearance of the patient. The purpose of this study was to compare effects of one month of treatment of CPAP and placebo on appearance of patient with OSA in a randomized and crossover study.
Consecutive sleepy patients with severe OSA were included. The patients underwent three polysomnograms (PSG): first one to confirm OSA and two additional ones using placebo (nasal dilator) and for CPAP titration before starting each treatment period. All patients were randomly included into two treatment groups: 1) placebo use and 2) CPAP use. After one month with the first treatment and 15 days of washout, patients were crossed-over for the second treatment. Photographs from the patients' faces were obtained in the three experimental moments. The photographs were presented in a random order by the Qualtrics Survey Software, and were evaluated online by 704 observers for quantifying healthy appearance (unhealthy to extremely healthy), attractive (unattractive to extremely attractive) and tired (not tired to extremely tired). Apparent age was also rated for each observer. Quantitative evaluations of the skin characteristics of the patients' faces were also carried out at each experimental moment, including the presence of acne, patches, porosity, wrinkles, texture, and skin tone uniformity, through the capture of images by VISIATM System equipment.
During treatment period, the 30 patients (age = 46±9 years, 21 men) wearing placebo intervention on 98% of the nights and adherence to CPAP was 94%, with a mean of 6.0 ± 1.7 hours of use per day of treatment. Observational assessment of the photographs showed that patients were evaluated as being younger after using CPAP (P <0.001), but no quantitative changes in face skin characteristics were observed compared to the baseline and after the use of placebo.
Sleepy patients with severe OSA had a younger appearance after one month of CPAP treatment.
연구 개요
상세 설명
Introduction: A previous study showed that sleep deprived people were perceived as less healthy, less attractive, and more tired than after a normal night's sleep (Axelsson et al., Beauty sleep: experimental study on the perceived health and attractiveness of sleep deprived people. BMJ 2010;341:c6614). The investigators believe that likewise sleep deprivation, patients with OSA also are perceived as less attractive, tired, healthy and look older than your age. the investigators therefore hypothesized that the treatment of OSA with continuous positive airway pressure (CPAP) positively affect the appearance of the patient. The purpose of this study was to compare effects of one month of treatment of CPAP and placebo on appearance of patient with OSA in a randomized and crossover study.
Methods:The investigators included 30 consecutive patients of both genders, aged between 30 and 60 years, referred to the sleep clinic of the Heart Institute (InCor) of University of Sao Paulo, with a history of snoring, excessive sleepiness, and with severe OSA confirmed by polysomnography. Patients were excluded if presenting previous treatment for sleep-disordered breathing, previous diagnosis of chronic diseases that interfere with sleep patterns and history the chronic use of alcohol, sedatives or drugs of abuse, in the last month.
Patients were randomized into two treatment groups: 1) Placebo arm - use of nasal dilator strip; and 2) CPAP arm - use of CPAP. At the first night of each treatment the patients were submitted to a polysomnography with nasal strip (placebo arm) or to CPAP titration (CPAP arm). After one month of treatment in the first randomized arm, patients were submitted to two weeks without treatment (washout period). After washout period, patients were assigned to the treatment crossover, i.e., patients in group 1) receiving CPAP therapy and patients in Group 2) receiving placebo treatment, during a period of one additional month. Excessive sleepiness (Epworth Sleepiness Scale) and quality of life (Functional Outcomes of Sleep Questionnaire - FOSQ) were evaluated in the three experimental times: baseline (immediately before treatment), one month (after one month of treatment defined at baseline), and 2 months (after one month of treatment crossover).
During the study period, the patients were followed by trained professionals and received all the necessary information about the use of each treatment. After three days of treatment, patients were contacted by phone to ensure the adherence treatment and to solve potential doubts. After each week of treatment, patients returned to the sleep clinic to management of the adherence data from the memory card (CPAP group) and data from the full filled sleep log (Placebo group), and also to had reinforced the information about the study protocol. Any issues or concerns about the treatment were also solved by phone calls.
All patients were photographed in the three experimental times: baseline (immediately before treatment), one month (after one month of treatment defined at baseline) and 2 months (after one month of treatment crossover). Photographs were taken by a trained photographer in a standardized manner. The photographer was blind to the experimental condition of patients. The photographs were displayed in a randomized order for 704 observers (general population, both genders, similar socioeconomic status and education), who were unaware of the conditions of the study. The observers rated the faces for attractiveness (very unattractive to very attractive), health (very sick to very healthy), and tiredness (not at all tired to very tired). Perceived age was also rated by the observers' evaluation by the Qualtrics Survey Software.
The high-resolution analyzing system VISIA TM (Canfield Scientific Inc. Fairfield USA) was used for computer analysis to precisely measure presence of porphyrins (P. acnes), coloration/evenness, vascular features, porosity, wrinkles and skin texture of the patient's face. The photographs from VISIA TM were taken after standard skin preparation and were analyzed by a specific analysis algorithm. Collection of dermatological assessments was conducted in three experimental sampling times.
During treatment period, the patients wearing placebo intervention on 98% of the nights and adherence to CPAP was 94%, with a mean of 6.0 ± 1.7 hours of use per day of treatment. After CPAP treatment, compared to baseline and after placebo treatment, improvement in the objective sleep quality, sleepiness, quality of life and depressive symptoms were observed (P <0.05). Observational assessment of the photographs showed that patients were evaluated as being younger after using CPAP (P <0.001), but no quantitative changes in face skin characteristics were observed compared to the baseline and after the use of placebo. Linear regression analysis identified the number of days with CPAP treatment, total sleep time and percentage of total sleep time with oxyhemoglobin saturation below 90% were predictors of decreasing of rated age after CPAP treatment.
In conclusion, sleepy patients with severe OSA had a younger appearance after one month of CPAP treatment.
연구 유형
등록 (실제)
단계
- 해당 없음
연락처 및 위치
연구 장소
-
-
SP
-
Sao Paulo, SP, 브라질, 05401-000
- Núcleo Interdisciplinar Da Ciencia Do Sono
-
-
참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- severe sleep apnea (apnea-hypopnea index > 30)
- Epworth Sleepiness Scale score > 10
Exclusion Criteria:
- previous treatment for sleep-disordered breathing
- previous diagnosis of chronic diseases that interfere with sleep patterns
- history the chronic use of alcohol, sedatives or drugs of abuse, in the last month.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
---|---|
위약 비교기: nasal dilator strip
Breathe Right ® nasal dilator strip used during sleep
|
Nasal dilator strip treatment used during sleep to open the nasal airway
다른 이름들:
|
실험적: continuous positive airway pressure
nasal continuous positive airway pressure used during sleep
|
device to treat obstructive sleep apnea using positive airway pressure with a nasal mask
다른 이름들:
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
---|---|---|
appearance
기간: 1 month
|
Patients will be rated for attractiveness (very unattractive to very attractive), health (very sick to very healthy), tiredness (not at all tired to very tired) and age
|
1 month
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
---|---|---|
skin quality
기간: 1 month
|
Computer analysis of face image to measure presence of porphyrins (P.
acnes), coloration/evenness, vascular features, porosity, wrinkles and skin texture.
|
1 month
|
공동 작업자 및 조사자
수사관
- 수석 연구원: GERALDO L FILHO, MD, PHD, University of Sao Paulo
간행물 및 유용한 링크
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
키워드
추가 관련 MeSH 약관
기타 연구 ID 번호
- 0068
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
미국에서 제조되어 미국에서 수출되는 제품
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
Breathe Right ®에 대한 임상 시험
-
Brigham and Women's HospitalBeth Israel Deaconess Medical Center완전한
-
Columbia UniversityNational Institute of Nursing Research (NINR)모병
-
Brown UniversityNational Institute on Aging (NIA)완전한
-
The George InstituteNational Health and Medical Research Council, Australia; Medical University of South Carolina 그리고 다른 협력자들모병
-
Medical Research Council, South AfricaAga Khan University; Texas Woman's University알려지지 않은
-
Jena University HospitalThe German Heart Foundation알려지지 않은