Moderate or Extensive Carbohydrate Reduction in Risk Patients (LOWinCHIP)
To Lower Glucose Levels and Reduce Weight by Exclusion of Carbohydrates and Inclusion of Psychological Behavioral Support
Risk-patients for diabetes or patients that are diagnosed with this condition but who are not treated with insulin are randomized two times, according to diet and according to the type of support:
Randomization with regard to carbohydrate restriction (25-30 E% or < 10E%). Randomization with regard to type of psychological support. Either according to Acceptance and Commitment Therapy or to traditional cognitive behavioral therapy. Both kinds of psychological support is given as group therapy.
Two-hundred patients are recruited and each patient is followed for two years.
연구 개요
상세 설명
The organizers will recruit 200 patients in the study "To lower glucose levels and reduce weight by exclusion of carbohydrates and inclusion of psychological behavioral support" (LOWinCHIP) at the primary care health center "Cithyhälsan Centrum" in Norrköping. Each patient will be followed for 2 years. Patients are eligible if they have are above 18 years of age and have a BMI above 28 kg/m2 and also belong to one or more of the following groups: 1) type 2 diabetes that is not treated with insulin. 2) Patients that have had gestational diabetes or who have 3) first grade relative with type 2 diabetes. Finally 4) pre-diabetic individuals with impaired fasting glucose (6.1-6.9 mmol) or impaired glucose tolerance (capillary plasma glucose 8.9-12-1 after glucose challenge) are also potential participants. Patients must not have insulin therapy or severe kidney failure (GFR< 30). They can also not have severe physical restrictions for activity and they must not have difficulties with understanding written Swedish texts.
The participants are randomized two times (two by two factorial):
Randomization with regard to carbohydrate restriction (25-30 E% or < 10E%). Randomization with regard to type of psychological support. Either according to Acceptance and Commitment Therapy (ACT) or to traditional cognitive behavioral therapy. Each group will have three group sessions with approximately 8 participants followed by a telephone call by the therapist. Each session will be held by the psychologists that are part of the Cityhälsan Centrum staff.
The study has > 95% power to demonstrate 5% HbA1c (mmol/mol) difference between groups with a drop out of 25%.
연구 유형
등록 (예상)
단계
- 해당 없음
연락처 및 위치
연구 장소
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Linkoping, 스웨덴, 58185
- 모병
- University Hospital of Linkoping
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연락하다:
- Fredrik H Nystrom, MD, prof.
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수석 연구원:
- Fredrik H Nystrom, MD PhD prof
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Diabetes without insulin. Patients at high risk for developing diabetes.
Exclusion Criteria:
- Severe kidney failure. Insulin therapy. Inability to understand instructions.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
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활성 비교기: Moderate carbohydrate restriction and traditional support
Moderate carbohydrate restriction and traditional support with group meetings
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Randomization to moderate or extreme low-carbohydrate Mediterranean diet advice.
Randomization to group-based psychological support according to ACT or to traditional cognitive behavioral therapy
|
|
활성 비교기: Extreme low carbohydrate diet and traditional support
Extreme carbohydrate restriction and traditional support with group meetings
|
Randomization to moderate or extreme low-carbohydrate Mediterranean diet advice.
Randomization to group-based psychological support according to ACT or to traditional cognitive behavioral therapy
|
|
활성 비교기: Moderate carbohydrate restriction and ACT support
Moderate carbohydrate restriction and psychological support based on acceptance and commitment therapy
|
Randomization to moderate or extreme low-carbohydrate Mediterranean diet advice.
Randomization to group-based psychological support according to ACT or to traditional cognitive behavioral therapy
|
|
활성 비교기: Extreme carbohydrate restriction and ACT support
Extreme carbohydrate restriction and psychological support based on acceptance and commitment therapy
|
Randomization to moderate or extreme low-carbohydrate Mediterranean diet advice.
Randomization to group-based psychological support according to ACT or to traditional cognitive behavioral therapy
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Long-term glucose levels
기간: 2 years
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HbA1c levels
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2 years
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Quality of Life
기간: 2 years
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Quality of Life by questionnaires
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2 years
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Cardiovascular risk factors
기간: 2 years
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Lipids, body weight, glucose, ketones
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2 years
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공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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