허혈성 뇌졸중 환자에서 ILIB 후 치료 효과 및 혈소판 활성도 조사

실험적: 치료군

치료 그룹은 정맥 내 헬륨-네온 레이저 광선 요법을 받습니다. 팔꿈치 위쪽에 위치한 정맥에 정맥 내주 바늘을 삽입하고 내주 캐뉼라를 통해 레이저 섬유 카테터를 삽입합니다. 레이저 출력은 2.5 ~ 3.0Mw, 매회 60분, 1일 1회 연속 주 5일, 2주간 설정(1코스 총 10회)

장치: 혈액의 혈관 내 레이저 조사

혈액 광선 요법의 저강도 레이저 정맥 조사는 632.8nm의 적색광이 섬유를 통해 정맥에 침투하는 방식으로 밝기는 태양의 100배입니다. 빛은 인체의 혈액과 세포 순환을 가속화하여 단백질 분자 구조가 변화를 촉진합니다.

가짜 비교기: 대조군

제어 그룹의 단계는 출력 전력이 0 강도로 조정된다는 점을 제외하면 처리 그룹과 동일합니다.

장치: 혈액의 혈관 내 레이저 조사

혈액 광선 요법의 저강도 레이저 정맥 조사는 632.8nm의 적색광이 섬유를 통해 정맥에 침투하는 방식으로 밝기는 태양의 100배입니다. 빛은 인체의 혈액과 세포 순환을 가속화하여 단백질 분자 구조가 변화를 촉진합니다.

Modified Rankin Scale (mRS)

The Modified Rankin Scale (mRS) is used to measure the degree of disability or dependence in the daily activities in patients who have had a stroke 0: No symptoms at all

1. No significant disability despite symptoms; able to carry out all usual duties and activities
2. Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance
3. Moderate disability; requiring some help, but able to walk without assistance
4. Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance
5. Severe disability; bedridden, incontinent and requiring constant nursing care and attention
6. Dead Measure before intravenous laser irradiation, three days, one month, and three months after the therapy.

National Institutes of Health Stroke Scale (NIHSS)

NIHSS is a measure of the severity of symptoms associated with ischemic stroke and is used as a quantitative measure of neurological deficit post stroke. NIHSS score is composed of 11 items, including consciousness, eye movement, visual fields, muscle power of four limbs, limbs ataxia, sensation, language, dysarthria and extinction. Each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. Total score are between 0-42.

Measure before intravenous laser irradiation, three days, one month, and three months after the therapy.

Stroke Impact Scale(SIS)

The Stroke Impact Scale (SIS) is a newly developed comprehensive outcome measure consists of items measuring 8 domains- strength (0-20), hand function (0-25), activities of daily living (ADL) and instrumental ADL (0-50), mobility (0-45), communication (0-35), emotion (0-45), memory and thinking (0-35), and participation (0-40). It was based on feedback from patients and their caregivers. The total score is 0-295. The higher scores indicating better function or less impact from stroke.

The Fugl-Meyer Assessment-Motor Function

The Fugl-Meyer Assessment - Motor Function (FMA-MF) subscale evaluates movement, reflexes, and coordination of the upper and lower extremities post-stroke. It is widely used as a standardized measure of motor recovery.Upper extremity subscale: 33 items, maximum score = 66.Lower extremity subscale: 17 items, maximum score = 34.

Total motor domain score: Sum of upper and lower extremity subscales, maximum score = 100. Higher scores indicate better motor function and less impairment. Reported values in this study represent the total motor domain score (0-100).

The 6-minute Walk Test

is a widely used functional evaluation tool that quantifies the distance an individual can walk over a flat surface within 6 minutes.