缺血性脑卒中患者ILIB治疗效果及血小板活性的研究

实验性的：治疗组

治疗组接受静脉内氦氖激光光疗。 静脉留置针将被放置在他们位于上肘部的静脉中，激光纤维导管将通过留置套管被引入。 激光功率设置在2.5~3.0Mw之间，每次60分钟，每天一次，每周连续5天，连续2周（一疗程共10次）

设备：血液的血管内激光照射

低强度静脉内激光照射血液光疗是一种632.8nm的红光通过光纤进入静脉的方法，亮度是太阳的100倍。 光加速人体内的血液和细胞循环，使蛋白质分子结构发生变化。

假比较器：控制组

对照组步骤与治疗组相同，只是将输出功率调整为零强度。

设备：血液的血管内激光照射

低强度静脉内激光照射血液光疗是一种632.8nm的红光通过光纤进入静脉的方法，亮度是太阳的100倍。 光加速人体内的血液和细胞循环，使蛋白质分子结构发生变化。

Modified Rankin Scale (mRS)

The Modified Rankin Scale (mRS) is used to measure the degree of disability or dependence in the daily activities in patients who have had a stroke 0: No symptoms at all

1. No significant disability despite symptoms; able to carry out all usual duties and activities
2. Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance
3. Moderate disability; requiring some help, but able to walk without assistance
4. Moderately severe disability; unable to walk without assistance and unable to attend to own bodily needs without assistance
5. Severe disability; bedridden, incontinent and requiring constant nursing care and attention
6. Dead Measure before intravenous laser irradiation, three days, one month, and three months after the therapy.

National Institutes of Health Stroke Scale (NIHSS)

NIHSS is a measure of the severity of symptoms associated with ischemic stroke and is used as a quantitative measure of neurological deficit post stroke. NIHSS score is composed of 11 items, including consciousness, eye movement, visual fields, muscle power of four limbs, limbs ataxia, sensation, language, dysarthria and extinction. Each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. Total score are between 0-42.

Measure before intravenous laser irradiation, three days, one month, and three months after the therapy.

Stroke Impact Scale(SIS)

The Stroke Impact Scale (SIS) is a newly developed comprehensive outcome measure consists of items measuring 8 domains- strength (0-20), hand function (0-25), activities of daily living (ADL) and instrumental ADL (0-50), mobility (0-45), communication (0-35), emotion (0-45), memory and thinking (0-35), and participation (0-40). It was based on feedback from patients and their caregivers. The total score is 0-295. The higher scores indicating better function or less impact from stroke.

The Fugl-Meyer Assessment-Motor Function

The Fugl-Meyer Assessment - Motor Function (FMA-MF) subscale evaluates movement, reflexes, and coordination of the upper and lower extremities post-stroke. It is widely used as a standardized measure of motor recovery.Upper extremity subscale: 33 items, maximum score = 66.Lower extremity subscale: 17 items, maximum score = 34.

Total motor domain score: Sum of upper and lower extremity subscales, maximum score = 100. Higher scores indicate better motor function and less impairment. Reported values in this study represent the total motor domain score (0-100).

The 6-minute Walk Test

is a widely used functional evaluation tool that quantifies the distance an individual can walk over a flat surface within 6 minutes.