두개내혈관죽상동맥협착-자기공명영상에서 항응고 및 항혈소판 요법의 비교 (CAPTIVA-MRI)
2024년 4월 8일 업데이트: Yale University
CAPTIVA-MRI는 CAPTIVA 시험[약 115개의 StrokeNet 사이트에서 수행된 3군, 이중 맹검 3상 시험으로 70-99% 두개내 죽상경화성 협착증(ICAS ) 아스피린 + 티카그렐러, 클로피도그렐 또는 리바록사반.]
이 보조 연구의 주요 목표는 MRI 바이오마커가 최상의 의료 관리에 실패한 ICAS 환자를 잠재적으로 식별할 수 있는지 확인하는 것입니다.
CAPTIVA-MRI 연구는 CAPTIVA 시험 설계 및 구현을 활용하여 차세대 ICAS 시험 및 ICAS 환자 관리를 알리고 촉진할 정보를 수집합니다.
연구 개요
연구 유형
관찰
등록 (추정된)
300
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 연락처
- 이름: Adam H. de Havenon, MD
- 전화번호: 203-785-4085
- 이메일: adam.dehavenon@yale.edu
연구 연락처 백업
- 이름: Ka-Ho Wong, MBA
- 전화번호: 801-585-7575
- 이메일: ka-ho.wong@hsc.utah.edu
연구 장소
-
-
Alabama
-
Birmingham, Alabama, 미국, 35233
- University of Alabama Hospital
-
수석 연구원:
- Ekaterina Bakradze
-
연락하다:
- Tammy Davis
- 전화번호: 205-975-8572
- 이메일: trdavis@uabmc.edu
-
-
Florida
-
Jacksonville, Florida, 미국, 32207
- Baptist Medical Center Jacksonville
-
Miami, Florida, 미국, 33136
- Jackson Memorial Hospital, Miami
-
수석 연구원:
- Victor Del Brutto
-
연락하다:
- Erick Lopez
- 전화번호: 305-243-6542
- 이메일: exl758@med.miami.edu
-
연락하다:
- Iszet Campo-Bustillo
- 이메일: lIcampo@med.miami.edu
-
-
Illinois
-
Chicago, Illinois, 미국, 60637
- University of Chicago Medical Center
-
수석 연구원:
- Tareq Kass-Hout
-
연락하다:
- Eric Kaplan
- 전화번호: 773-702-1848
- 이메일: Eric.Kaplan@bsd.uchicago.edu
-
연락하다:
- Elida Romo
- 전화번호: 773-702-2039
- 이메일: eromo1@bsd.uchicago.edu
-
Chicago, Illinois, 미국, 60612
- University of Illinois Hospital
-
수석 연구원:
- Ali Alaraj, MD
-
연락하다:
- Christine Maley
- 전화번호: 312-996-2949
- 이메일: cmaley@uic.edu
-
연락하다:
- Linda Rose-Finnell
- 전화번호: 312-355-2050
- 이메일: lfinnell@uic.edu
-
-
Missouri
-
Saint Louis, Missouri, 미국, 63108
- Barnes Jewish Hospital
-
연락하다:
- Jill Newgent
- 이메일: newgentj@wustl.edu
-
수석 연구원:
- Yan Wang, MD
-
연락하다:
- Jenny Babka
- 이메일: babkaj@wustl.edu
-
-
New York
-
Buffalo, New York, 미국, 14203
- Buffalo General Medical Center
-
연락하다:
- Annemarie Crumlish
- 이메일: ac35@buffalo.edu
-
수석 연구원:
- Amit Kandel
-
Manhasset, New York, 미국, 11030
- North Shore University Hospita
-
연락하다:
- Kirendra Pasram
- 이메일: kpasram1@northwell.edu
-
수석 연구원:
- Rohan Arora
-
-
참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
아니
샘플링 방법
비확률 샘플
연구 인구
최근 뇌졸중이 있고 CAPTIVA에 등록된 ICAS 환자.
설명
포함 기준:
- CAPTIVA 시험 등록: 두개내 ICA, MCA, BA 또는 VA의 70-99% 협착증에 이차적으로 30일 이내에 비장애 증상성 허혈성 경색 뇌졸중
- CAPTIVA 등록 후 14일 이내에 기본 연구 MRI를 얻을 수 있는 능력
제외 기준:
- American College of Radiology 가이드라인62에 따른 심박 조율기 또는 기타 MRI 금기 사항을 포함하여 MRI를 받을 수 없거나 받을 의사가 없는 사람
- eGFR<30 ml/min/1.73m2인 가돌리늄 조영제 알레르기 또는 급성 또는 만성 신장 질환
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
개입 / 치료 |
|---|---|
|
CAPTIVA-MRI 그룹
아스피린 + 티카그렐로, 클로피도그렐 또는 리바록사반에 대한 70-99% 두개내 죽상경화성 협착증(ICAS)에 기인한 뇌졸중이 있는 CAPTIVA 환자.
|
기준선 및 12개월 추적 조사에서 CAPTIVA 연구에 대한 추가 MRI
|
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
인덱스 뇌졸중의 혈관 영역에서 재발성 허혈성 뇌졸중의 신뢰할 수 있는 예측인자로 ICAS 혈역학 및 플라크 MRI 바이오마커를 설정합니다.
기간: 12 개월
|
인덱스 뇌졸중 동맥의 혈관 영역에서 증상이 있는 경색으로 정의되는 재발성 허혈성 뇌졸중.
이 결과는 허혈성 뇌졸중에 대한 American Heart Association의 정의를 사용하여 CAPTIVA에서 중심적으로 판정됩니다.
|
12 개월
|
공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
스폰서
수사관
- 수석 연구원: David Liebeskind, MD, University of California, Los Angeles
- 수석 연구원: Sepideh Amin-Hanjani, MD, University Hospitals
- 수석 연구원: Rano Chatterjee, MD, Washington University School of Medicine
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Mossa-Basha M, Hwang WD, De Havenon A, Hippe D, Balu N, Becker KJ, Tirschwell DT, Hatsukami T, Anzai Y, Yuan C. Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes. Stroke. 2015 Jun;46(6):1567-73. doi: 10.1161/STROKEAHA.115.009037. Epub 2015 May 7.
- Holmstedt CA, Turan TN, Chimowitz MI. Atherosclerotic intracranial arterial stenosis: risk factors, diagnosis, and treatment. Lancet Neurol. 2013 Nov;12(11):1106-14. doi: 10.1016/S1474-4422(13)70195-9.
- Chimowitz MI, Lynn MJ, Derdeyn CP, Turan TN, Fiorella D, Lane BF, Janis LS, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Torbey MT, Zaidat OO, Rumboldt Z, Cloft HJ; SAMMPRIS Trial Investigators. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med. 2011 Sep 15;365(11):993-1003. doi: 10.1056/NEJMoa1105335. Epub 2011 Sep 7. Erratum In: N Engl J Med. 2012 Jul 5;367(1):93.
- Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. Lancet. 2014 Jan 25;383(9914):333-41. doi: 10.1016/S0140-6736(13)62038-3. Epub 2013 Oct 26.
- Chimowitz MI, Lynn MJ, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, Levine SR, Chaturvedi S, Kasner SE, Benesch CG, Sila CA, Jovin TG, Romano JG; Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. N Engl J Med. 2005 Mar 31;352(13):1305-16. doi: 10.1056/NEJMoa043033.
- Amin-Hanjani S, Pandey DK, Rose-Finnell L, Du X, Richardson D, Thulborn KR, Elkind MS, Zipfel GJ, Liebeskind DS, Silver FL, Kasner SE, Aletich VA, Caplan LR, Derdeyn CP, Gorelick PB, Charbel FT; Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke Study Group. Effect of Hemodynamics on Stroke Risk in Symptomatic Atherosclerotic Vertebrobasilar Occlusive Disease. JAMA Neurol. 2016 Feb;73(2):178-85. doi: 10.1001/jamaneurol.2015.3772.
- Saba L, Saam T, Jager HR, Yuan C, Hatsukami TS, Saloner D, Wasserman BA, Bonati LH, Wintermark M. Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications. Lancet Neurol. 2019 Jun;18(6):559-572. doi: 10.1016/S1474-4422(19)30035-3. Epub 2019 Apr 4.
- Hosmer DW, Hosmer T, Le Cessie S, Lemeshow S. A comparison of goodness-of-fit tests for the logistic regression model. Stat Med. 1997 May 15;16(9):965-80. doi: 10.1002/(sici)1097-0258(19970515)16:93.0.co;2-o.
- Suri MF, Johnston SC. Epidemiology of intracranial stenosis. J Neuroimaging. 2009 Oct;19 Suppl 1:11S-6S. doi: 10.1111/j.1552-6569.2009.00415.x.
- Arenillas JF. Intracranial atherosclerosis: current concepts. Stroke. 2011 Jan;42(1 Suppl):S20-3. doi: 10.1161/STROKEAHA.110.597278. Epub 2010 Dec 16.
- Bang OY. Intracranial atherosclerosis: current understanding and perspectives. J Stroke. 2014 Jan;16(1):27-35. doi: 10.5853/jos.2014.16.1.27. Epub 2014 Jan 31.
- Koo J. The Latest Information on Intracranial Atherosclerosis: Diagnosis and Treatment. Interv Neurol. 2015 Oct;4(1-2):48-50. doi: 10.1159/000438779. Epub 2015 Sep 18.
- Banerjee C, Chimowitz MI. Stroke Caused by Atherosclerosis of the Major Intracranial Arteries. Circ Res. 2017 Feb 3;120(3):502-513. doi: 10.1161/CIRCRESAHA.116.308441.
- Wang A, Wu L, Wang X, Zhao X, Wang C, Liu L, Zheng H, Cao Y, Wang Y, Wang Y; China National Stroke Registry investigators. Effect of recurrent stroke on poor functional outcome in transient ischemic attack or minor stroke. Int J Stroke. 2016 Oct;11(7):NP80. doi: 10.1177/1747493016641954. Epub 2016 Mar 24. No abstract available.
- Wang YL, Pan YS, Zhao XQ, Wang D, Johnston SC, Liu LP, Meng X, Wang AX, Wang CX, Wang YJ; CHANCE investigators. Recurrent stroke was associated with poor quality of life in patients with transient ischemic attack or minor stroke: finding from the CHANCE trial. CNS Neurosci Ther. 2014 Dec;20(12):1029-35. doi: 10.1111/cns.12329. Epub 2014 Oct 13.
- Albright KC, Huang L, Blackburn J, Howard G, Mullen M, Bittner V, Muntner P, Howard V. Racial differences in recurrent ischemic stroke risk and recurrent stroke case fatality. Neurology. 2018 Nov 6;91(19):e1741-e1750. doi: 10.1212/WNL.0000000000006467. Epub 2018 Oct 3.
- Eriksson SE, Olsson JE. Survival and recurrent strokes in patients with different subtypes of stroke: a fourteen-year follow-up study. Cerebrovasc Dis. 2001;12(3):171-80. doi: 10.1159/000047700.
- Hong KS, Yegiaian S, Lee M, Lee J, Saver JL. Declining stroke and vascular event recurrence rates in secondary prevention trials over the past 50 years and consequences for current trial design. Circulation. 2011 May 17;123(19):2111-9. doi: 10.1161/CIRCULATIONAHA.109.934786. Epub 2011 May 2.
- Chaturvedi S, Sacco RL. How recent data have impacted the treatment of internal carotid artery stenosis. J Am Coll Cardiol. 2015 Mar 24;65(11):1134-43. doi: 10.1016/j.jacc.2014.12.045.
- Bonati LH, Dobson J, Featherstone RL, Ederle J, van der Worp HB, de Borst GJ, Mali WP, Beard JD, Cleveland T, Engelter ST, Lyrer PA, Ford GA, Dorman PJ, Brown MM; International Carotid Stenting Study investigators. Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial. Lancet. 2015 Feb 7;385(9967):529-38. doi: 10.1016/S0140-6736(14)61184-3. Epub 2014 Oct 14.
- Brott TG, Howard G, Roubin GS, Meschia JF, Mackey A, Brooks W, Moore WS, Hill MD, Mantese VA, Clark WM, Timaran CH, Heck D, Leimgruber PP, Sheffet AJ, Howard VJ, Chaturvedi S, Lal BK, Voeks JH, Hobson RW 2nd; CREST Investigators. Long-Term Results of Stenting versus Endarterectomy for Carotid-Artery Stenosis. N Engl J Med. 2016 Mar 17;374(11):1021-31. doi: 10.1056/NEJMoa1505215. Epub 2016 Feb 18.
- Paraskevas KI, Mikhailidis DP, Veith FJ, Spence JD. Definition of Best Medical Treatment in Asymptomatic and Symptomatic Carotid Artery Stenosis. Angiology. 2016 May;67(5):411-9. doi: 10.1177/0003319715624526. Epub 2015 Dec 31.
- Marler JR. NINDS clinical trials in stroke: lessons learned and future directions. Stroke. 2007 Dec;38(12):3302-7. doi: 10.1161/STROKEAHA.107.485144. Epub 2007 Oct 25.
- Mandell DM, Mossa-Basha M, Qiao Y, Hess CP, Hui F, Matouk C, Johnson MH, Daemen MJ, Vossough A, Edjlali M, Saloner D, Ansari SA, Wasserman BA, Mikulis DJ; Vessel Wall Imaging Study Group of the American Society of Neuroradiology. Intracranial Vessel Wall MRI: Principles and Expert Consensus Recommendations of the American Society of Neuroradiology. AJNR Am J Neuroradiol. 2017 Feb;38(2):218-229. doi: 10.3174/ajnr.A4893. Epub 2016 Jul 28.
- Leng X, Wong KS, Liebeskind DS. Evaluating intracranial atherosclerosis rather than intracranial stenosis. Stroke. 2014 Feb;45(2):645-51. doi: 10.1161/STROKEAHA.113.002491. Epub 2014 Jan 7. No abstract available.
- Romano JG, Prabhakaran S, Nizam A, Feldmann E, Sangha R, Cotsonis G, Campo-Bustillo I, Koch S, Rundek T, Chimowitz MI, Liebeskind DS; MyRIAD Investigators. Infarct Recurrence in Intracranial Atherosclerosis: Results from the MyRIAD Study. J Stroke Cerebrovasc Dis. 2021 Feb;30(2):105504. doi: 10.1016/j.jstrokecerebrovasdis.2020.105504. Epub 2020 Dec 1.
- de Havenon A, Khatri P, Prabhakaran S, Yeatts SD, Peterson C, Sacchetti D, Alexander M, Cutting S, Grory BM, Furie K, Liebeskind DS, Yaghi S. Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke. J Neuroimaging. 2020 Jul;30(4):468-470. doi: 10.1111/jon.12710. Epub 2020 Jun 24.
- Feldmann E, Wilterdink JL, Kosinski A, Lynn M, Chimowitz MI, Sarafin J, Smith HH, Nichols F, Rogg J, Cloft HJ, Wechsler L, Saver J, Levine SR, Tegeler C, Adams R, Sloan M; Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial Investigators. The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) trial. Neurology. 2007 Jun 12;68(24):2099-106. doi: 10.1212/01.wnl.0000261488.05906.c1. Epub 2007 Apr 4.
- O'Donnell M. NMR blood flow imaging using multiecho, phase contrast sequences. Med Phys. 1985 Jan-Feb;12(1):59-64. doi: 10.1118/1.595736.
- Marks MP, Pelc NJ, Ross MR, Enzmann DR. Determination of cerebral blood flow with a phase-contrast cine MR imaging technique: evaluation of normal subjects and patients with arteriovenous malformations. Radiology. 1992 Feb;182(2):467-76. doi: 10.1148/radiology.182.2.1732966.
- Amin-Hanjani S, Du X, Zhao M, Walsh K, Malisch TW, Charbel FT. Use of quantitative magnetic resonance angiography to stratify stroke risk in symptomatic vertebrobasilar disease. Stroke. 2005 Jun;36(6):1140-5. doi: 10.1161/01.STR.0000166195.63276.7c. Epub 2005 May 12.
- Timmins LH, Molony DS, Eshtehardi P, McDaniel MC, Oshinski JN, Samady H, Giddens DP. Focal association between wall shear stress and clinical coronary artery disease progression. Ann Biomed Eng. 2015 Jan;43(1):94-106. doi: 10.1007/s10439-014-1155-9. Epub 2014 Oct 15.
- Eshtehardi P, Brown AJ, Bhargava A, Costopoulos C, Hung OY, Corban MT, Hosseini H, Gogas BD, Giddens DP, Samady H. High wall shear stress and high-risk plaque: an emerging concept. Int J Cardiovasc Imaging. 2017 Jul;33(7):1089-1099. doi: 10.1007/s10554-016-1055-1. Epub 2017 Jan 10.
- Jeong SK, Lee JY, Rosenson RS. Association between Ischemic Stroke and Vascular Shear Stress in the Carotid Artery. J Clin Neurol. 2014 Apr;10(2):133-9. doi: 10.3988/jcn.2014.10.2.133. Epub 2014 Apr 23.
- Mutsaerts HJ, Palm-Meinders IH, de Craen AJ, Reiber JH, Blauw GJ, van Buchem MA, van der Grond J, Box FM; PROSPER Study Group. Diastolic carotid artery wall shear stress is associated with cerebral infarcts and periventricular white matter lesions. Stroke. 2011 Dec;42(12):3497-501. doi: 10.1161/STROKEAHA.111.614453. Epub 2011 Sep 8.
- Chen Z, Qin H, Liu J, Wu B, Cheng Z, Jiang Y, Liu L, Jing L, Leng X, Jing J, Wang Y, Wang Y. Characteristics of Wall Shear Stress and Pressure of Intracranial Atherosclerosis Analyzed by a Computational Fluid Dynamics Model: A Pilot Study. Front Neurol. 2020 Jan 17;10:1372. doi: 10.3389/fneur.2019.01372. eCollection 2019.
- Wu J, Wang P, Zhou L, Zhang D, Chen Q, Mao C, Su W, Huo Y, Peng J, Yin X, Chen G. Hemodynamics derived from computational fluid dynamics based on magnetic resonance angiography is associated with functional outcomes in atherosclerotic middle cerebral artery stenosis. Quant Imaging Med Surg. 2022 Jan;12(1):688-698. doi: 10.21037/qims-21-337.
- Leng X, Lan L, Ip HL, Abrigo J, Scalzo F, Liu H, Feng X, Chan KL, Fan FSY, Ma SH, Fang H, Xu Y, Li J, Zhang B, Xu Y, Soo YOY, Mok VCT, Yu SCH, Liebeskind DS, Wong KS, Leung TW. Hemodynamics and stroke risk in intracranial atherosclerotic disease. Ann Neurol. 2019 May;85(5):752-764. doi: 10.1002/ana.25456. Epub 2019 Apr 3.
- de Havenon, A., Chung, L., Park, M. et al. Intracranial vessel wall MRI: a review of current indications and future applications. Neurovasc Imaging 2, 10 (2016). https://doi.org/10.1186/s40809-016-0021-6
- de Havenon A, Yuan C, Tirschwell D, Hatsukami T, Anzai Y, Becker K, Sultan-Qurraie A, Mossa-Basha M. Nonstenotic Culprit Plaque: The Utility of High-Resolution Vessel Wall MRI of Intracranial Vessels after Ischemic Stroke. Case Rep Radiol. 2015;2015:356582. doi: 10.1155/2015/356582. Epub 2015 Aug 6.
- Li Y, Turan TN, Chaudry I, Spiotta AM, Turk AS, Turner RD, Chatterjee AR. High-Resolution Magnetic Resonance Imaging Evidence for Intracranial Vessel Wall Inflammation Following Endovascular Thrombectomy. J Stroke Cerebrovasc Dis. 2017 May;26(5):e96-e98. doi: 10.1016/j.jstrokecerebrovasdis.2017.02.006. Epub 2017 Feb 27.
- Kang N, Qiao Y, Wasserman BA. Essentials for Interpreting Intracranial Vessel Wall MRI Results: State of the Art. Radiology. 2021 Sep;300(3):492-505. doi: 10.1148/radiol.2021204096. Epub 2021 Jul 27.
- Song JW, Pavlou A, Xiao J, Kasner SE, Fan Z, Messe SR. Vessel Wall Magnetic Resonance Imaging Biomarkers of Symptomatic Intracranial Atherosclerosis: A Meta-Analysis. Stroke. 2021 Jan;52(1):193-202. doi: 10.1161/STROKEAHA.120.031480. Epub 2020 Dec 2.
- Gupta A, Baradaran H, Al-Dasuqi K, Knight-Greenfield A, Giambrone AE, Delgado D, Wright D, Teng Z, Min JK, Navi BB, Iadecola C, Kamel H. Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2016 Aug 15;5(8):e003816. doi: 10.1161/JAHA.116.003816.
- Lee HN, Ryu CW, Yun SJ. Vessel-Wall Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis. Front Neurol. 2018 Dec 3;9:1032. doi: 10.3389/fneur.2018.01032. eCollection 2018.
- Kim JM, Jung KH, Sohn CH, Moon J, Shin JH, Park J, Lee SH, Han MH, Roh JK. Intracranial plaque enhancement from high resolution vessel wall magnetic resonance imaging predicts stroke recurrence. Int J Stroke. 2016 Feb;11(2):171-9. doi: 10.1177/1747493015609775.
- Song X, Zhao X, Liebeskind DS, Wang L, Xu W, Xu Y, Hou D, Zheng Z, Wu J. Incremental value of plaque enhancement in predicting stroke recurrence in symptomatic intracranial atherosclerosis. Neuroradiology. 2020 Sep;62(9):1123-1131. doi: 10.1007/s00234-020-02418-8. Epub 2020 Apr 17.
- Qureshi AI, Feldmann E, Gomez CR, Johnston SC, Kasner SE, Quick DC, Rasmussen PA, Suri MF, Taylor RA, Zaidat OO. Consensus conference on intracranial atherosclerotic disease: rationale, methodology, and results. J Neuroimaging. 2009 Oct;19 Suppl 1:1S-10S. doi: 10.1111/j.1552-6569.2009.00414.x.
- Kauw F, Greving JP, Takx RAP, de Jong HWAM, Schonewille WJ, Vos JA, Wermer MJH, van Walderveen MAA, Kappelle LJ, Velthuis BK, Dankbaar JW; Dutch acute stroke study (DUST) investigators. Prediction of long-term recurrent ischemic stroke: the added value of non-contrast CT, CT perfusion, and CT angiography. Neuroradiology. 2021 Apr;63(4):483-490. doi: 10.1007/s00234-020-02526-5. Epub 2020 Aug 28.
- Wong KS, Li H, Chan YL, Ahuja A, Lam WW, Wong A, Kay R. Use of transcranial Doppler ultrasound to predict outcome in patients with intracranial large-artery occlusive disease. Stroke. 2000 Nov;31(11):2641-7. doi: 10.1161/01.str.31.11.2641.
- Shaban S, Huasen B, Haridas A, Killingsworth M, Worthington J, Jabbour P, Bhaskar SMM. Digital subtraction angiography in cerebrovascular disease: current practice and perspectives on diagnosis, acute treatment and prognosis. Acta Neurol Belg. 2022 Jun;122(3):763-780. doi: 10.1007/s13760-021-01805-z. Epub 2021 Sep 22.
- Wang Y, Alkasab TK, Narin O, Nazarian RM, Kaewlai R, Kay J, Abujudeh HH. Incidence of nephrogenic systemic fibrosis after adoption of restrictive gadolinium-based contrast agent guidelines. Radiology. 2011 Jul;260(1):105-11. doi: 10.1148/radiol.11102340. Epub 2011 May 17.
- Lavie J, Vellimana AK, Chatterjee AR. Endovascular Thrombectomy Treatment: Beyond Early Time Windows and Small Core. Top Magn Reson Imaging. 2021 Aug 1;30(4):173-180. doi: 10.1097/RMR.0000000000000291.
- Saba L, Yuan C, Hatsukami TS, Balu N, Qiao Y, DeMarco JK, Saam T, Moody AR, Li D, Matouk CC, Johnson MH, Jager HR, Mossa-Basha M, Kooi ME, Fan Z, Saloner D, Wintermark M, Mikulis DJ, Wasserman BA; Vessel Wall Imaging Study Group of the American Society of Neuroradiology. Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology. AJNR Am J Neuroradiol. 2018 Feb;39(2):E9-E31. doi: 10.3174/ajnr.A5488. Epub 2018 Jan 11.
- Wright CB, Bosetti F, Janis LS, Koenig JI, Moy CS. Organizational Update: NINDS Stroke Research Strategies for Large Vessel Occlusion and Neuroprotection. Stroke. 2021 Jan;52(1):e1-e2. doi: 10.1161/STROKEAHA.120.029977. Epub 2020 Dec 28. No abstract available.
- Liebeskind DS, Albers GW, Crawford K, Derdeyn CP, George MS, Palesch YY, Toga AW, Warach S, Zhao W, Brott TG, Sacco RL, Khatri P, Saver JL, Cramer SC, Wolf SL, Broderick JP, Wintermark M. Imaging in StrokeNet: Realizing the Potential of Big Data. Stroke. 2015 Jul;46(7):2000-6. doi: 10.1161/STROKEAHA.115.009479. Epub 2015 Jun 4. No abstract available.
- Recovery and Rehabilitation Trials [Internet]. [cited 2022 Jan 2]. Available from: https://www.nihstrokenet.org/clinical-trials/recovery-rehab-trials
- Warach Steven J., Luby Marie, Albers Gregory W., Bammer Roland, Bivard Andrew, Campbell Bruce C.V., Derdeyn Colin, Heit Jeremy J., Khatri Pooja, Lansberg Maarten G., Liebeskind David S., Majoie Charles B.L.M., Marks Michael P., Menon Bijoy K., Muir Keith W., Parsons Mark W., Vagal Achala, Yoo Albert J., Alexandrov Andrei V., Baron Jean-Claude, Fiorella David J., Furlan Anthony J., Puig Josep, Schellinger Peter D., Wintermark Max, null null, Ansari Sameer A., Aviv Richard I., Barreto Andrew D., Broderick Joseph P., Christensen Søren, Davis Stephen M., Demchuk Andrew M., Dippel Diederik W., Donnan Geoffrey A., Fiebach Jochen B., Fiehler Jens, Houser Gary, Grotta James C., Hacke Werner, Hill Michael D., Hsia Amie W., Jovin Tudor G., Köhrmann Martin, Latour Lawrence L., Leigh Richard, Lees Kennedy R., Lev Michael D., Marshall Randolph S., Mocco J, Nadareishvili Zurab, Nogueira Raul G., Olivot Jean Marc, Palesch Yuko, PedrazaProtocol Version 1.0 Page 23 Salvador, Sasaki Makoto, Saver Jeffrey L., Savitz Sean I., Schwamm Lee H., Simpkins Alexis, Smith Wade S., Thijs Vincent, Thomalla Götz, Wechsler Lawrence R., Wu Ona, Zaharchuk Greg, Zaidat Osama O. Acute Stroke Imaging Research Roadmap III Imaging Selection and Outcomes in Acute Stroke Reperfusion Clinical Trials. Stroke. American Heart Association; 2016 May 1;47(5):1389-1398
- Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003 Mar 27;348(13):1215-22. doi: 10.1056/NEJMoa022066.
- Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J, Wright C, Beiser AS, Seshadri S, Pandya A, Kamel H. Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis. Stroke. 2016 Mar;47(3):719-25. doi: 10.1161/STROKEAHA.115.011889.
- Smith EE, Saposnik G, Biessels GJ, Doubal FN, Fornage M, Gorelick PB, Greenberg SM, Higashida RT, Kasner SE, Seshadri S; American Heart Association Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Functional Genomics and Translational Biology; and Council on Hypertension. Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2017 Feb;48(2):e44-e71. doi: 10.1161/STR.0000000000000116. Epub 2016 Dec 15.
- Kim JS, Nah HW, Park SM, Kim SK, Cho KH, Lee J, Lee YS, Kim J, Ha SW, Kim EG, Kim DE, Kang DW, Kwon SU, Yu KH, Lee BC. Risk factors and stroke mechanisms in atherosclerotic stroke: intracranial compared with extracranial and anterior compared with posterior circulation disease. Stroke. 2012 Dec;43(12):3313-8. doi: 10.1161/STROKEAHA.112.658500. Epub 2012 Nov 15.
- Diagnostic Radiology: Magnetic Resonance Imaging (MRI) Practice Parameters and Technical Standards - American College of Radiology [Internet]. [cited 2015 Jan 30]. Available from: http://www.acr.org/Quality- Safety/Standards-Guidelines/Practice-Guidelines-by-Modality/MRI
- Song C, Kuo L, Derby CA, Lipton RB, Hall CB. Multi-stage transitional models with random effects and their application to the Einstein aging study. Biom J. 2011 Nov;53(6):938-55. doi: 10.1002/bimj.200900259. Epub 2011 Oct 21.
- de Rooij M. Transitional modeling of experimental longitudinal data with missing values. Adv Data Anal Classif. 2018 Mar 1;12(1):107-130.
- Waters MF, Hoh BL, Lynn MJ, Kwon HM, Turan TN, Derdeyn CP, Fiorella D, Khanna A, Sheehan TO, Lane BF, Janis S, Montgomery J, Chimowitz MI; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial Investigators. Factors Associated With Recurrent Ischemic Stroke in the Medical Group of the SAMMPRIS Trial. JAMA Neurol. 2016 Mar;73(3):308-15. doi: 10.1001/jamaneurol.2015.4315. Erratum In: JAMA Neurol. 2016 Apr;73(4):481.
- Schmidt R, Berghold A, Jokinen H, Gouw AA, van der Flier WM, Barkhof F, Scheltens P, Petrovic K, Madureira S, Verdelho A, Ferro JM, Waldemar G, Wallin A, Wahlund LO, Poggesi A, Pantoni L, Inzitari D, Fazekas F, Erkinjuntti T; LADIS Study Group. White matter lesion progression in LADIS: frequency, clinical effects, and sample size calculations. Stroke. 2012 Oct;43(10):2643-7. doi: 10.1161/STROKEAHA.112.662593. Epub 2012 Aug 9.
- Sheibani N, Wong KH, Turan TN, Yeatts SD, Gottesman RF, Prabhakaran S, Rost NS, de Havenon A. White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial. J Stroke Cerebrovasc Dis. 2021 Jun;30(6):105764. doi: 10.1016/j.jstrokecerebrovasdis.2021.105764. Epub 2021 Apr 3.
- Howard VJ, Meschia JF, Lal BK, Turan TN, Roubin GS, Brown RD Jr, Voeks JH, Barrett KM, Demaerschalk BM, Huston J 3rd, Lazar RM, Moore WS, Wadley VG, Chaturvedi S, Moy CS, Chimowitz M, Howard G, Brott TG; CREST-2 study investigators. Carotid revascularization and medical management for asymptomatic carotid stenosis: Protocol of the CREST-2 clinical trials. Int J Stroke. 2017 Oct;12(7):770-778. doi: 10.1177/1747493017706238. Epub 2017 May 2.
- Gordon NF. Clinical effectiveness of lifestyle management programs: importance of the class effect paradox. Curr Treat Options Cardiovasc Med. 2013 Dec;15(6):675-80. doi: 10.1007/s11936-013-0271-4.
- Gordon NF, Salmon RD, Franklin BA, Sperling LS, Hall L, Leighton RF, Haskell WL. Effectiveness of therapeutic lifestyle changes in patients with hypertension, hyperlipidemia, and/or hyperglycemia. Am J Cardiol. 2004 Dec 15;94(12):1558-61. doi: 10.1016/j.amjcard.2004.08.039.
- Sangha RS, Naidech AM, Corado C, Ansari SA, Prabhakaran S. Challenges in the Medical Management of Symptomatic Intracranial Stenosis in an Urban Setting. Stroke. 2017 Aug;48(8):2158-2163. doi: 10.1161/STROKEAHA.116.016254. Epub 2017 Jul 5.
- Song Y, Liu X, Zhu X, Zhao B, Hu B, Sheng X, Chen L, Yu M, Yang T, Zhao J. Increasing trend of diabetes combined with hypertension or hypercholesterolemia: NHANES data analysis 1999-2012. Sci Rep. 2016 Nov 2;6:36093. doi: 10.1038/srep36093.
- Prince MR, Zhang H, Zou Z, Staron RB, Brill PW. Incidence of immediate gadolinium contrast media reactions. AJR Am J Roentgenol. 2011 Feb;196(2):W138-43. doi: 10.2214/AJR.10.4885.
- Amin-Hanjani S, Rose-Finnell L, Richardson D, Ruland S, Pandey D, Thulborn KR, Liebeskind DS, Zipfel GJ, Elkind MS, Kramer J, Silver FL, Kasner SE, Caplan LR, Derdeyn CP, Gorelick PB, Charbel FT; VERiTAS Study Group. Vertebrobasilar Flow Evaluation and Risk of Transient Ischaemic Attack and Stroke study (VERiTAS): rationale and design. Int J Stroke. 2010 Dec;5(6):499-505. doi: 10.1111/j.1747-4949.2010.00528.x.
- Ryu CW, Lee DH, Kim HS, Lee JH, Choi CG, Kim SJ, Suh DC. Acquisition of MR perfusion images and contrast-enhanced MR angiography in acute ischaemic stroke patients: which procedure should be done first? Br J Radiol. 2006 Dec;79(948):962-7. doi: 10.1259/bjr/23219572. Epub 2006 Aug 2.
- Welker K, Boxerman J, Kalnin A, Kaufmann T, Shiroishi M, Wintermark M; American Society of Functional Neuroradiology MR Perfusion Standards and Practice Subcommittee of the ASFNR Clinical Practice Committee. ASFNR recommendations for clinical performance of MR dynamic susceptibility contrast perfusion imaging of the brain. AJNR Am J Neuroradiol. 2015 Jun;36(6):E41-51. doi: 10.3174/ajnr.A4341. Epub 2015 Apr 23.
- Vakil P, Elmokadem AH, Syed FH, Cantrell CG, Dehkordi FH, Carroll TJ, Ansari SA. Quantifying Intracranial Plaque Permeability with Dynamic Contrast-Enhanced MRI: A Pilot Study. AJNR Am J Neuroradiol. 2017 Feb;38(2):243-249. doi: 10.3174/ajnr.A4998. Epub 2016 Nov 17.
- See AP, Pandey DK, Du X, Rose-Finnell L, Charbel FT, Derdeyn CP, Amin-Hanjani S, Richardson D, Xie H, Thulborn K, Flanner MP, Ganin H, Ruland S, Grysiewicz R, Khaja A, Pedelty L, Testai F, Ong A, Epstein N, Muqtadar H, Watson K, Mlinarevich N, Hillmann M, Elkind MSV, Hirsch J, Dashnaw S, Meyers PM, Willey JZ, McNeill-Simaan E, Perez V, Canaan A, Paulino-Hernandez W, Zipfel GJ, Vo K, Foster G, Ford A, Nassief A, Bradley A, Serna-Northway J, Kraus K, Shiwani L, Hantler N, Liebeskind DS, Alger J, Godinez S, Saver JL, Ali L, Kim D, Tenser M, Froehler M, Raychev R, Song S, Ovbiagele B, Abcede H, Adamczyk P, Rao N, Yallapragada A, Modir R, Hinman J, Tansy A, Calderon-Arnulphi M, Sheth S, Noorian A, Ng K, Liang C, Gadhia J, Smith H, Avila G, Avelar J, Silver FL, Mikulis D, Fierstra J, Hlasny E, Casaubon LK, Vergouwen M, Martin del Campo JC, Jaigobin CS, Astorga C, Kalman L, Kramer J, Vaughan S, Owens L, Richardson D, Thulborn KR, Caplan LR, Gorelick PB, Kasner SE, Kissela B, Turan TN, Aletich V, Jacobs TP, Janis S. Optimized Hemodynamic Assessment to Predict Stroke Risk in Vertebrobasilar Disease: Analysis From the VERiTAS Study. J Am Heart Assoc. American Heart Association; 2020 Jun 16;9(12):e016406.
- Lan L, Liu H, Ip V, Soo Y, Abrigo J, Fan F, Ma SH, Ma K, Ip B, Liu J, Fan Y, Zeng J, Mok V, Wong L, Liebeskind D, Leung T, Leng X. Regional High Wall Shear Stress Associated With Stenosis Regression in Symptomatic Intracranial Atherosclerotic Disease. Stroke. 2020 Oct;51(10):3064-3073. doi: 10.1161/STROKEAHA.120.030615. Epub 2020 Sep 4.
- Leng X, Lan L, Ip VHL, Liu H, Abrigo J, Liebeskind DS, Wong LKS, Leung TW. Noninvasive fractional flow in intracranial atherosclerotic stenosis: Reproducibility, limitations, and perspectives. J Neurol Sci. 2017 Oct 15;381:150-152. doi: 10.1016/j.jns.2017.08.3239. Epub 2017 Aug 24. No abstract available.
- Leng X, Scalzo F, Ip HL, Johnson M, Fong AK, Fan FS, Chen X, Soo YO, Miao Z, Liu L, Feldmann E, Leung TW, Liebeskind DS, Wong KS. Computational fluid dynamics modeling of symptomatic intracranial atherosclerosis may predict risk of stroke recurrence. PLoS One. 2014 May 12;9(5):e97531. doi: 10.1371/journal.pone.0097531. eCollection 2014.
- Leng X, Scalzo F, Fong AK, Johnson M, Ip HL, Soo Y, Leung T, Liu L, Feldmann E, Wong KS, Liebeskind DS. Computational fluid dynamics of computed tomography angiography to detect the hemodynamic impact of intracranial atherosclerotic stenosis. Neurovascular Imaging. 2015 Oct 21;1(1):1.
- Ghaffari M, Tangen K, Alaraj A, Du X, Charbel FT, Linninger AA. Large-scale subject-specific cerebral arterial tree modeling using automated parametric mesh generation for blood flow simulation. Comput Biol Med. 2017 Dec 1;91:353-365. doi: 10.1016/j.compbiomed.2017.10.028. Epub 2017 Oct 24.
- Ren Y, Chen GZ, Liu Z, Cai Y, Lu GM, Li ZY. Reproducibility of image-based computational models of intracranial aneurysm: a comparison between 3D rotational angiography, CT angiography and MR angiography. Biomed Eng Online. 2016 May 6;15(1):50. doi: 10.1186/s12938-016-0163-4.
- Yoneyama Y, Isoda H, Ishiguro K, Terada M, Kamiya M, Otsubo K, Perera R, Mizuno T, Fukuyama A, Takiguchi K, Watanabe T, Kosugi T, Komori Y, Naganawa S. Evaluation of magnetic resonance angiography as a possible alternative to rotational angiography or computed tomography angiography for assessing cerebrovascular computational fluid dynamics. Phys Eng Sci Med. 2020 Dec;43(4):1327-1337. doi: 10.1007/s13246-020-00936-6. Epub 2020 Oct 12.
- Alexander MD, de Havenon A, Kim SE, Parker DL, McNally JS. Assessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis. Neuroradiology. 2019 Jun;61(6):643-650. doi: 10.1007/s00234-019-02167-3. Epub 2019 Jan 24.
- Kasab SA, Bathla G, Varon A, Roa JA, Sabotin R, Raghuram A, Chaorong W, Hasan DM, Turan TN, Chatterjee R, Samaniego EA. High-resolution vessel wall imaging after mechanical thrombectomy. Neuroradiol J. 2021 Dec;34(6):593-599. doi: 10.1177/19714009211017782. Epub 2021 May 20.
- Roa JA, Zanaty M, Osorno-Cruz C, Ishii D, Bathla G, Ortega-Gutierrez S, Hasan DM, Samaniego EA. Objective quantification of contrast enhancement of unruptured intracranial aneurysms: a high-resolution vessel wall imaging validation study. J Neurosurg. 2020 Feb 7;134(3):862-869. doi: 10.3171/2019.12.JNS192746.
- Liebeskind DS, Prabhakaran S, Azhar N, Feldmann E, Campo-Bustillo I, Sangha R, Koch S, Rundek T, Ostergren L, Chimowitz MI, Romano JG; MyRIAD Investigators. Mechanisms of early Recurrence in Intracranial Atherosclerotic Disease (MyRIAD): Rationale and design. J Stroke Cerebrovasc Dis. 2020 Oct;29(10):105051. doi: 10.1016/j.jstrokecerebrovasdis.2020.105051. Epub 2020 Jul 11.
- Vargas J, Spiotta A, Chatterjee AR. Initial Experiences with Artificial Neural Networks in the Detection of Computed Tomography Perfusion Deficits. World Neurosurg. 2018 Oct 24:S1878-8750(18)32382-9. doi: 10.1016/j.wneu.2018.10.084. Online ahead of print.
- Khademi A, Gibicar A, Arezza G, DiGregorio J, Tyrrell PN, Moody AR. Segmentation of white matter lesions in multicentre FLAIR MRI. Neuroimage Rep. 2021 Dec 1;1(4):100044.
- Caligiuri ME, Perrotta P, Augimeri A, Rocca F, Quattrone A, Cherubini A. Automatic Detection of White Matter Hyperintensities in Healthy Aging and Pathology Using Magnetic Resonance Imaging: A Review. Neuroinformatics. 2015 Jul;13(3):261-76. doi: 10.1007/s12021-015-9260-y.
- Wabnitz AM, Derdeyn CP, Fiorella DJ, Lynn MJ, Cotsonis GA, Liebeskind DS, Waters MF, Lutsep H, Lopez-Cancio E, Turan TN, Montgomery J, Janis LS, Lane B, Chimowitz MI; SAMMPRIS Investigators. Hemodynamic Markers in the Anterior Circulation as Predictors of Recurrent Stroke in Patients With Intracranial Stenosis. Stroke. 2019 Jan;50(1):143-147. doi: 10.1161/STROKEAHA.118.020840. Epub 2018 Dec 11.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (추정된)
2024년 4월 1일
기본 완료 (추정된)
2029년 3월 31일
연구 완료 (추정된)
2029년 3월 31일
연구 등록 날짜
최초 제출
2023년 6월 7일
QC 기준을 충족하는 최초 제출
2023년 6월 7일
처음 게시됨 (실제)
2023년 6월 18일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2024년 4월 9일
QC 기준을 충족하는 마지막 업데이트 제출
2024년 4월 8일
마지막으로 확인됨
2024년 4월 1일
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- Pro00050939
- 1UG3NS130228-01 (미국 NIH 보조금/계약)
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
미정
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
아니
미국 FDA 규제 기기 제품 연구
아니
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
MRI에 대한 임상 시험
-
Assistance Publique Hopitaux De Marseille모집하지 않고 적극적으로
-
Cambridge University Hospitals NHS Foundation Trust모병
-
Vanderbilt-Ingram Cancer CenterNational Cancer Institute (NCI)종료됨성인 역형성 성상세포종 | 성인 역형성 뇌실막종 | 성인 역형성 핍지교종 | 성인 거대 세포 교모세포종 | 성인 교모세포종 | 성인 교육종 | 재발성 성인 뇌종양미국
-
Vanderbilt-Ingram Cancer CenterNational Cancer Institute (NCI)종료됨
-
Assistance Publique - Hôpitaux de Paris알려지지 않은