Social-software iMproving wARfarin Therapy (SMART)
Randomized Evaluation of Social-software Improving Warfarin Therapy in Patients With Mechanical Heart Valve Replacement
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
Social software is becoming a necessary of life. Wechat, powered by Tencent company, is the most popular social software in China. People can chat with others no matter how far away from each other.
Anticoagulation Quality is very important for patients receiving warfarin anticoagulation therapy, which is usually evaluated Time in therapeutic range (TTR). It is reported that TTR is very low (38.8%) in China patients. So we are planning to introduce the social software to set up a bridge for clinicians and their patients, to instruct warfarin therapy. We aim to investigate whether social software could be used to improve warfarin anticoagulation quality of Chinese patients.
We planned to enrol enough eligible patients receiving warfarin therapy due to the mechanical valves in a randomized controlled trial. Warfarin-treated patients were assigned to social software management group ( in which warfarin therapy was guided via the social platform by experienced clinicians) or to the traditional management control group (in which warfarin therapy was managed with traditional model). The primary outcomes the first time to bleeding or thrombotic events, the secondary outcomes were an elevation in time in therapeutic range (TTR) of international normalized ratio (INR), reduction in INR variation and number of extremely high INR results during 18 months.
Studietype
Registrering (Faktiske)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiesteder
-
-
Hubei
-
Wuhan, Hubei, Kina, 430000
- WAHH
-
-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- Received mechanical valve replacement;
- Receiving warfarin anticoagulation therapy;
- Have smartphone and Know how to use wechat application and our mini-program;
- be expected to survive for the duration of the study;
- not be suffering from intracranial bleeding (intracranial haemorrhage, subarachnoid haemorrhage, hemorrhagic stroke) or any other contraindication described in the warfarin package insert;
- be willing to be randomized;
- sign the informed consent form;
- not be enrolled in another randomized clinical trial that involves a drug or device intervention.
Exclusion Criteria:
- subject has had an intracranial haemorrhage, subarachnoid haemorrhage, hemorrhagic stroke, or any other absolute/major contraindication described in the warfarin package insert within the last month
- subject enrolled in another randomized clinical trial that involves a drug or device intervention
- subject is not able to follow the protocol and all related instructions and does not have a caregiver with these skills
- Patients were considered being not suitable for this study
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Social-software management group
We set up a mini-program based on wechat application.
We instruct warfarin therapy via social-software including dose adjustment, answer questions, remind monitoring INR et.al.
|
Using Wechat application, a social platform, to manage warfarin therapy in patients with mechanical valve replacement.
|
|
Ingen inngripen: Routine management group
This is the control group, Warfarin therapy was managed via traditional style without social software intervention.
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Time to First Event
Tidsramme: Up to 18 months
|
Thrombotic events, such as Valve thrombosis, Stroke, Peripheral embolism; Major bleeding, such as cerebral hemorrhage，gastrointestinal bleeding etc.
|
Up to 18 months
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Time in therapeutic range
Tidsramme: Up to 18 months
|
Time in target range (TTR) based on Prothrombin Time standardized to the International Normalized Ratio
|
Up to 18 months
|
|
Individual variation of International Normalized Ratio (INR)
Tidsramme: Up to 18 months
|
Standard deviation (SD) of individual INR results
|
Up to 18 months
|
|
Times of extremely high International Normalized Ratio (INR) values
Tidsramme: Up to 18 months
|
Times of INR results above 4.0; Times of INR results above 12.0
|
Up to 18 months
|
Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Studieleder: Zhenlu ZHANG, MD,PhD, Wuhan Asia Heart Hospital
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Andre studie-ID-numre
- 2017-P-033
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
IPD-planbeskrivelse
IPD-deling Støtteinformasjonstype
- STUDY_PROTOCOL
- SEVJE
- ICF
- CSR
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Studerer et amerikansk FDA-regulert enhetsprodukt
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .
Kliniske studier på Social-software management
-
Hugo W. Moser Research Institute at Kennedy Krieger...Autism SpeaksFullført
-
University of ConnecticutNational Cancer Institute (NCI)Fullført
-
University of North Carolina, Chapel HillNational Institute on Drug Abuse (NIDA); RTI InternationalRekruttering
-
University of WashingtonFullførtDemensForente stater
-
University of MichiganFullført
-
Medipol UniversityYeditepe UniversityHar ikke rekruttert ennå
-
University of PennsylvaniaNational Institute on Aging (NIA)Aktiv, ikke rekrutterendeHjertefeil | Hypertensjon | Diabetes | Mobilitetsbegrensning | Ambulatorisk vanskelighetsgradForente stater
-
University of ChicagoUniversity of Alabama at Birmingham; Tulane University; Birmingham AIDS Outreach og andre samarbeidspartnereRekrutteringHIV seropositivitetForente stater
-
Indiana UniversityFullførtStillesittende atferd | CVDForente stater
-
University of MinhoPåmelding etter invitasjonOvervekt | OvervektigPortugal