Weight-Bearing Magnetic Resonance Imaging (MRI) for Analysis of Knee Osteoarthritis (OA)

Inclusion Criteria:

• Female
• 40 years and older
• Subjects who are willing and able to comply with x-ray and MRI procedures
• Evidence of a personally signed and dated consent document

Additional inclusion for normal controls:

• Infrequent knee pain, aching, or stiffness during the past year or infrequent use of medication for treatment of knee pain during the past year
• No evidence of OA on either knee (i.e. K-L grade = 0 diagnosed by knee radiography)

Additional inclusion for OA patients:

• Pain, aching, or stiffness on most days of a month during the past year; or use of medication for treatment of knee pain on most days of a month during the past year
• Kellgren-Lawrence Grade 2 or 3 of the study knee obtained on a Standard knee radiograph (with either the same or less severe OA, or no OA in the contralateral knee)

Exclusion Criteria:

• Subject is unable to undergo MRI because of contraindication
• Women at risk of pregnancy
• Weight greater than 250 lbs
• History of surgery in the study knee
• History of other diseases involving the study knee joint including inflammatory joint diseases, crystalline disease, and infection of the study knee