Effekten av oral cannabisadministration och samadministration av alkohol på funktionsnedsättning
29 juli 2026 uppdaterad av: Johns Hopkins University
Denna studie kommer att utvärdera de individuella och interaktiva effekterna av oral cannabis och alkohol på subjektiva och beteendemässiga mått på funktionsnedsättning.
Studieöversikt
Status
Avslutad
Betingelser
Intervention / Behandling
Detaljerad beskrivning
Denna kliniska laboratoriestudie kommer att vara dubbelblind, placebokontrollerad och kommer att använda en experimentell design inom försökspersonerna.
Deltagarna kommer att genomföra 7 polikliniska läkemedelsadministrationssessioner som kommer att bestå av självadministrering av oral cannabis (0, 10 eller 25 mg THC) och alkohol (antingen placebo eller aktiv; BAC på 0,05 procent); deltagarna kommer alltid att få både en alkoholdryck (aktiv eller placebo) och dos av cannabis (aktiv eller placebo).
Deltagarna kommer också att slutföra ett tillstånd där de administrerar alkohol (BAC: 0,08 procent) med placebo cannabis, som en positiv kontroll.
Primära resultat inkluderar prestation på nykterhetstest i fält, kognitiv och psykomotorisk funktionsnedsättning, subjektiva drogeffekter och simulerad körprestanda.
Blodkoncentrationer av THC och THC-metaboliter kommer också att bestämmas.
Studietyp
Interventionell
Inskrivning (Faktisk)
70
Fas
- Fas 1
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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Maryland
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Baltimore, Maryland, Förenta staterna, 21224
- Johns Hopkins Behavioral Pharmacology Research Unit
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
21 år till 55 år (Vuxen)
Tar emot friska volontärer
Ja
Beskrivning
Inklusionskriterier:
- Har lämnat skriftligt informerat samtycke
- Var mellan 21 och 50 år
- Var vid god allmän hälsa baserat på en fysisk undersökning, medicinsk historia, vitala tecken och screening av urin och blodprov
- Inte vara gravid eller ammande (om kvinna). Alla kvinnor måste ha ett negativt serumgraviditetstest vid screeningbesöket och ett negativt uringraviditetstest vid varje studiebesök.
- Har ett kroppsmassaindex (BMI) i intervallet 19 till 36 kg/m2
- Blodtrycket vid screeningbesök överstiger inte ett systoliskt blodtryck (SBP) på 150 mmHg eller ett diastoliskt blodtryck (DBP) på 90 mmHg
- Har inte donerat blod under de senaste 30 dagarna.
- Rapportera minst 2 dagars hetskonsumtion under de senaste 90 dagarna (fler än 4 eller 5 drinkar vid ett enstaka tillfälle för kvinnor respektive män)
- Rapportera ≥ 5 användningar av cannabis under det senaste året
- Ge negativt urintest för olaglig droganvändning (exklusive THC) och negativt utandningsalkoholtest (0 % BAC) vid screening och före studietillfällen
- Rapportera minst 1 fall av samtidig alkohol och användning under det senaste året.
Exklusions kriterier:
- Psykoaktiv droganvändning (bortsett från cannabis, nikotin, alkohol eller koffein) den senaste månaden
- Nuvarande användning av receptfria (OTC) läkemedel, kosttillskott/vitaminer eller receptbelagda läkemedel som, enligt utredarens eller medicinsk personals åsikt, kommer att påverka deltagarens säkerhet
- Historik eller aktuella bevis på betydande medicinskt tillstånd
- Bevis på aktuellt psykiatriskt tillstånd [(MINI for Diagnostic and Statistical Manual (DSM)-V)]
- Uppfyll kriterierna för allvarlig alkoholmissbruksstörning (MINI för DSM-V)
- Clinical Institute Abstinensbedömning för alkoholskala (CIWA-Ar) poäng > 9
- Har tidigare varit i behandling för alkohol- eller cannabismissbruk
- Användning av cannabis i genomsnitt mer än 2 gånger/vecka under de senaste 3 månaderna
- Leverfunktionstester mer än 2x normalområdet
- Inskrivning i en annan klinisk prövning eller mottagande av något läkemedel som en del av forskning inom de senaste 30 dagarna
- Shipley vokabulärpoäng <18 (motsvarar läsnivå i 5:e klass).
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Grundläggande vetenskap
- Tilldelning: Randomiserad
- Interventionsmodell: Crossover tilldelning
- Maskning: Dubbel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
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Placebo-jämförare: Placebo cannabis + placebo alkohol
Deltagarna administrerar oral cannabis som innehåller 0 mg THC i kombination med en placebo alkoholdryck.
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Cannabis kommer att intas oralt via en brownie
Alkohol kommer att intas oralt via en smaksatt dryck
|
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Experimentell: lågdos cannabis med placebo alkohol
Deltagarna administrerar oral cannabis som innehåller 10 mg THC i kombination med en placebo alkoholdryck.
|
Cannabis kommer att intas oralt via en brownie
Alkohol kommer att intas oralt via en smaksatt dryck
|
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Experimentell: hög dos cannabis med placebo alkohol
Deltagarna administrerar oral cannabis som innehåller 25 mg THC i kombination med en placebo alkoholdryck.
|
Cannabis kommer att intas oralt via en brownie
Alkohol kommer att intas oralt via en smaksatt dryck
|
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Experimentell: låg dos cannabis med låg dos alkohol
Deltagarna administrerar oral cannabis som innehåller 10 mg THC i kombination med en alkoholdryck (0,05 procent BAC).
|
Cannabis kommer att intas oralt via en brownie
Alkohol kommer att intas oralt via en smaksatt dryck
|
|
Experimentell: hög dos cannabis med låg dos alkohol
Deltagarna administrerar oral cannabis som innehåller 25 mg THC i kombination med en alkoholdryck (0,05 procent BAC).
|
Cannabis kommer att intas oralt via en brownie
Alkohol kommer att intas oralt via en smaksatt dryck
|
|
Experimentell: Placebo cannabis + låg dos alkohol
Deltagarna administrerar oral cannabis som innehåller 0 mg THC i kombination med en alkoholdryck (0,05 procent BAC).
|
Cannabis kommer att intas oralt via en brownie
Alkohol kommer att intas oralt via en smaksatt dryck
|
|
Experimentell: Placebo cannabis + hög dos alkohol
Deltagarna administrerar oral cannabis som innehåller 0 mg THC i kombination med en alkoholdryck (0,08 procent BAC).
|
Cannabis kommer att intas oralt via en brownie
Alkohol kommer att intas oralt via en smaksatt dryck
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Mean Peak Change From Baseline DRUID Application Global Impairment Score
Tidsram: 7.5 hours, assessed at baseline (prior to drug administration) and again 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours after oral cannabis ingestion.
|
Acute cognitive and behavioral impairment will be assessed with global impairment score (range 0-100) on the DRUID app (higher scores indicate greater impairment).
Results are mean change from baseline.
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7.5 hours, assessed at baseline (prior to drug administration) and again 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours after oral cannabis ingestion.
|
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Cumulative Score on Field Sobriety Tests
Tidsram: 7.5 hours
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Impairment will be assessed using a battery of standard field sobriety tests including: the Horizontal Gaze Nystagmus Test (HGN), the Walk and Turn, the One Leg Stand, and the Modified Romberg Balance.
We will report the cumulative amount of clues observed across these tasks (out of a possible 0-22 clues).
Higher scores indicate greater/worse impairment.
These assessments were completed once after 7.5 hours.
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7.5 hours
|
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Mean Peak Change From Baseline Scores on the Drug Effect Questionnaire (DEQ) - Feel Drug Effect
Tidsram: 7.5 hours, assessed at baseline (prior to drug administration) and again 0.5, 1, 1.25, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours after oral cannabis ingestion
|
The DEQ will be used to obtain subjective ratings of "feel drug effects".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Results are mean change from baseline and a higher score indicates a more extreme/worse drug effect.
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7.5 hours, assessed at baseline (prior to drug administration) and again 0.5, 1, 1.25, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours after oral cannabis ingestion
|
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Drug Effect Questionnaire - Feel High
Tidsram: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "feel high".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher score greater "feel high" rating.
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7.5 hours
|
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Drug Effect Questionnaire - Confidence to Drive (Change From Baseline)
Tidsram: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "confidence to drive".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher scores indicate higher confidence to drive.
Results expressed as change from baseline
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7.5 hours
|
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Drug Effect Questionnaire - Willingness to Drive
Tidsram: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "willingness to drive".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher score indicates higher willingness to drive.
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7.5 hours
|
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Biphasic Alcohol Effects Scale (BAES) - Sedative Score
Tidsram: Baseline, 7.5 hours
|
The BAES is used to assess sedative and stimulant subjective effects of alcohol.
There are 7 sedative-related questionnaire items, each presented on a scale of 0 (not at all) to 10 (extremely), which are integrated to produce an overall sedative score (0-70).
Higher scores indicating greater sedative effects of alcohol.
Scores presented show the change from baseline to 7.5 hours.
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Baseline, 7.5 hours
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Biphasic Alcohol Effects Scale (BAES) - Stimulant Score
Tidsram: 7.5 hours
|
The BAES is used to assess sedative and stimulant subjective effects of alcohol.
There are 7 stimulant-related questionnaire items, each presented on a scale of 0 (not at all) to 10 (extremely), which are integrated to produce an overall stimulant score (0-70).
Higher scores indicating greater stimulant effects of alcohol.
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7.5 hours
|
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Subjective High Assessment Scale (SHAS)
Tidsram: 7.5 hours
|
For the SHAS, participants are presented with 13 questionnaire items, displayed on a visual analog scale anchored from 0 (normal) to 10 (extremely), which assess subjective effects of alcohol.
These items are integrated to produce an overall SHAS score (0-130).
Higher score indicates greater effects of alcohol.
|
7.5 hours
|
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Driving Performance as Assessed by Standard Deviation of Lateral Position (SDLP)
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
SDLP (measured in cm) was calculated across all drives to get a composite index of lateral control and reported as peak change from baseline.
SDLP is the gold standard of quantifying the magnitude of driving impairment from drugs and alcohol and has excellent predictive validity to actual driving.
Scores range from 0 to no upper limit.
Higher scores represent higher magnitude of driving impairment.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
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Driving Performance as Assessed by Composite Drive Score
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Driving impairment will be assessed via a composite drive score.
The composite drive score is derived by integrating various driving outcomes (see primary and secondary driving outcomes).
Higher z-score indicates worse performance.
The score is on a z-score scale, meaning a score of 1 equates to 1 standard deviation outside of the participants' mean baseline performance and a Z-score of 0 represents the mean baseline performance.
This was calculated across all drives and reported as peak change from baseline.
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Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Driving Performance as Assessed by Standard Deviation of Speed (SDSP)
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
SDSP will be calculated across all drives to get a composite index of the variability in speed (measured in MPH) and is reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent higher magnitude of driving impairment.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
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Total Run Length
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Total run length will be calculated across all drives and measured as peak change from baseline score (in seconds).
Higher scores represent higher magnitude of driving impairment.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
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Driving Performance (Number of Speed Exceedances)
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Driving performance will be calculated across all drives to get a cumulative number of times participants exceed the allowable speed limit and reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent higher numbers of speed exceedances.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
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Driving Performance (Number of Accidents)
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Driving performance will be calculated across all drives to get a cumulative number of accidents (including car collisions, pedestrians hit, etc.) and reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent higher numbers of accidents.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Driving Performance (Total Rule Violations)
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Driving performance will be calculated across all drives to get a cumulative number of total rule violations (including number of missed stop signs, illegal turns, speed exceedances, etc.) and reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent higher numbers of rule violations.
All scores reported are relative to baseline, thus negative values represent a lower number of rule violations than at baseline.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Driving Performance (Distance to Lead Vehicles)
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Driving performance will be calculated across all drives to get the mean distance (in meters) maintained to lead vehicles during car-following segments and reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent greater distance maintained to lead vehicles.
All scores reported are relative to baseline, thus negative values represent a shorter distance maintained than at baseline.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Change in Field Sobriety Test - Score on Horizontal Gaze Nystagmus Test
Tidsram: Baseline, 7.5 hours
|
Impairment will be assessed using performance on the Horizontal Gaze Nystagmus Test (HGN).
Total score will be recorded (out of possible 0-6 clues) with higher scores indicating higher impairment.
Assessed at baseline and 7.5 hours, change from baseline to 7.5 hours reported
|
Baseline, 7.5 hours
|
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Change in Field Sobriety Test - Score on Walk and Turn Test
Tidsram: Baseline, 7.5 hours
|
Impairment will be assessed using performance on the the Walk and Turn.
Total score will be recorded (out of a possible 0-8 clues) with higher scores indicating higher impairment.
Assessed at baseline and 7.5 hours, change from baseline to 7.5 hours reported
|
Baseline, 7.5 hours
|
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Change in Field Sobriety Test - Score on One Leg Stand
Tidsram: Baseline, 7.5 hours
|
Impairment will be assessed using performance on the One Leg Stand test.
Total score will be recorded (out of a possible 0-4 clues) with higher scores indicating higher impairment.
Assessed at baseline and 7.5 hours, change from baseline to 7.5 hours reported
|
Baseline, 7.5 hours
|
|
Change in Field Sobriety Test - Score on Modified Romberg Balance
Tidsram: Baseline, 7.5 hours
|
Impairment will be assessed using performance on the Modified Romberg Balance test.
Total score will be recorded (out of a possible 0-4 clues) with higher scores indicating higher impairment.
Assessed at baseline and 7.5 hours, change from baseline to 7.5 hours reported
|
Baseline, 7.5 hours
|
|
Drug Effect Questionnaire - Like Drug Effect
Tidsram: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "like drug effect".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher score indicating greater "liked drug effect" rating.
|
7.5 hours
|
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Drug Effect Questionnaire - Dislike Drug Effect
Tidsram: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "dislike drug effect".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher score indicating greater "dislike drug effect" rating.
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7.5 hours
|
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Pharmacokinetics - CMax for THC and THC Metabolites
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Whole blood concentrations of THC, 11-OH-THC, and THCCOOH will be measured using quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS) analysis.
The maximum concentration (Cmax) is determined as the highest concentration reached for each individual (ng/mL) across all timepoints.
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Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
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Pharmacokinetics - AUC for THC and THC Metabolites
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Whole blood concentrations of THC, 11-OH-THC, and THCCOOH will be measured using quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS) analysis.
The area under the curve (AUC) is calculated cumulative across all timepoints.
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Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
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Pharmacokinetics - CMax for Alcohol
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
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BAC will be measured using the Alco-Sensor IV.
Measuring BAC is needed to confirm that participants reached the targeted BAC for a given session and to confirm adherence to pre-session alcohol abstinence requirements (g/210L).
The maximum concentration (Cmax) is determined as the highest concentration reached for each individual (ng/mL) across all timepoints.
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Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
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Pharmacokinetics - AUC for Alcohol
Tidsram: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Whole blood concentrations of Alcohol will be measured using quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS) analysis.
The area under the curve (AUC) is calculated cumulative across all timepoints.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Samarbetspartners
Utredare
- Huvudutredare: Tory Spindle, PhD, Johns Hopkins University
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
17 februari 2022
Primärt slutförande (Faktisk)
15 augusti 2025
Avslutad studie (Faktisk)
15 augusti 2025
Studieregistreringsdatum
Först inskickad
11 juni 2021
Först inskickad som uppfyllde QC-kriterierna
11 juni 2021
Första postat (Faktisk)
18 juni 2021
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
3 augusti 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
29 juli 2026
Senast verifierad
1 juli 2026
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- IRB00290015
- 1R01DA052295-01 (U.S.S. NIH-anslag/kontrakt)
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
NEJ
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Ja
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .