Strength Training for Obesity Prevention
Recent obesity prevalence increases have made obesity prevention a clear and pressing public health issue.
The average US.
woman gains about 0.5 kg per year.
Overweight women aged 25 to 44 have a higher prevalence of significant weight gains (BMI increases of > 5 kg/m2) than men or older or thinner women.
The difficulty in successfully losing weight and maintaining weight loss has resulted in recommendations from several expert panels to advise overweight and mildly obese individuals free of co-morbidities to avoid weight gains rather than to lose weight.
Physical activity is observed to decline with age while caloric intake remains stable or declines slightly.
There is strong observational evidence that physical activity could prevent or attenuate age associated fat gains.
This randomized, controlled behavioral intervention trial will test the hypothesis that regular participation in a twice weekly strength training program over 2 years, can prevent age associated body fat increases (total and abdominal fat) in 80 overweight to mildly obese premenopausal women between the ages of 25 and 44 years, compared to a 'standard care' group (n=80).
The overall aim of the study is to prevent body fat gains and to reduce health risks associated with obesity.
Treatment effects will be assessed for insulin sensitivity, blood pressure, blood lipids, muscle strength, and psychosocial predictors of strength training adherence.
The innovation of this approach rests in its simplicity and the minimal time requirement for full participation (2 exercise sessions weekly).
A preliminary study of this innovative approach resulted in 88% exercise session attendance over 12 months and maintenance of treatment effects on total body fat percentage to the end of pilot study measurements (9 months).
This supports the feasibility and potential for long term efficacy of the proposed intervention approach.
The long-term implication of success in this efficacy trial would be that this modest behavior change could prevent the fat gains and associated co-morbidities commonly observed in midlife women.
研究概览
详细说明
Recent obesity prevalence increases have made obesity prevention a clear and pressing public health issue.
The average US.
woman gains about 0.5 kg per year, 60 to 80% of which can be assumed to be fat.
Overweight women aged 25 to 44 have a higher prevalence of significant weight gains (BMI increases of > 5 kg/m2) than men or older or thinner women.
Total and visceral abdominal fat gains are associated with a variety of obesity co-morbidities, including insulin resistance, hypertension, and dyslipidemia.
The difficulty in successfully losing weight and maintaining weight loss has resulted in recommendations from several expert panels to advise overweight and mildly obese individuals free of co-morbidities to avoid weight gains rather than to lose weight.
Physical activity is observed to decline with age while caloric intake remains stable or declines slightly.
There is strong observational evidence that physical activity could prevent or attenuate age associated fat gains.
This randomized, controlled behavioral intervention trial will test the hypothesis that regular participation in a twice weekly strength training program over 2 years, can prevent age associated body fat increases (total and visceral abdominal fat) in 80 overweight to mildly obese premenopausal women (BMI 25-35 kg/m2) between the ages of 25 and 44 years, compared to a 'standard care' group (n=80).
The overall aim of the study is to prevent body fat gains and to reduce health risks associated with obesity.
Treatment effects will be assessed for insulin sensitivity, blood pressure, blood lipids, muscle strength, and psychosocial predictors of strength training adherence.
The innovation of this approach rests in its simplicity and the minimal time requirement for full participation (2 exercise sessions weekly).
A preliminary study of this innovative approach resulted in 88% exercise session attendance over 12 months and maintenance of treatment effects on total body fat percentage to the end of pilot study measurements (9 months).
This supports the feasibility and potential for long term efficacy of the proposed intervention approach.
The long-term implication of success in this efficacy trial would be that this modest behavior change could prevent the fat gains and associated co-morbidities commonly observed in midlife women.
研究类型
介入性
注册
160
阶段
- 阶段2
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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Minnesota
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Minneapolis、Minnesota、美国、55454
- University of Minnesota, Division of Epidemiology
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
25年 至 44年 (成人)
接受健康志愿者
是的
有资格学习的性别
女性
描述
Eligible participants will include women between the ages of 25 and 44, BMI between 25 and 35 (inclusive).
Other inclusion/exclusion criteria:
- Weight stable (<5% body weight change over past year)
- No medical conditions or medications that would prohibit participation in an exercise program or would negatively impact our ability to test our primary aims (e.g. fibromyalgia, chronic fatigue syndrome, metabolic disorders, recent cardiovascular event, orthopedic limitations, any drug expected to impact body weight, psychiatric disorders requiring anti-psychotic drugs)
- Uncontrolled hypertension (systolic blood pressure over 160 and/or diastolic blood pressure over 99)
- No history of cancer within the past 5 years, excepting non-melanoma skin cancers
- Not currently or recently (past 6 months) pregnant
- Not planning to become pregnant during the study period
- Not currently or recently (past 2 months) lactating
- No history of physician diagnosed menstrual irregularities or significant gynecologic conditions (e.g. fibroids, endometriosis)
- Pre-menopausal
- Current non-smokers (for at least the past 2 years)
- Sedentary to modestly physically active (up to 3 sessions weekly of physical activity of no greater intensity than brisk walking) with no history of strength training within the past 6 months
- Not planning to move away from the Twin Cities area over the next 2 years
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:预防
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:单身的
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2002年4月1日
研究完成
2005年7月1日
研究注册日期
首次提交
2002年2月7日
首先提交符合 QC 标准的
2002年2月7日
首次发布 (估计)
2002年2月8日
研究记录更新
最后更新发布 (估计)
2010年1月13日
上次提交的符合 QC 标准的更新
2010年1月12日
最后验证
2010年1月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
Strength Training的临床试验
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Karolinska InstitutetMinistry of Health and Social Affairs, Sweden完全的
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Mental Health Services in the Capital Region, DenmarkCopenhagen Trial Unit, Center for Clinical Intervention Research; Center for Clinical Intervention...完全的
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University of RochesterNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University of Virginia 和其他合作者招聘中