Gene Function in Bone Marrow Cells From Patients With Fanconi Anemia and From Healthy Participants
Analysis of Fanconi Anemia Gene Function by Microarray Analysis of Bone Marrow Cells
RATIONALE: Studying samples of bone marrow from patients with Fanconi anemia and from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to Fanconi anemia.
PURPOSE: This laboratory study is evaluating gene function in bone marrow cells from patients with Fanconi anemia and from healthy participants.
研究概览
详细说明
OBJECTIVES:
- Describe the complete hematopoietic transcriptomes of Fanconi cells of every common complementation group (e.g., A, C, G, and F) as well as transcriptomes of neoplastic cells derived from bone marrow of patients with Fanconi anemia.
- Define large-scale dynamic gene expression data in these patients.
OUTLINE: This is a multicenter study.
Patients and healthy volunteers undergo bone marrow aspiration or biopsy for biological studies. Samples are analyzed for gene expression profiles using microarray assays.
PROJECTED ACCRUAL: A total of 80 patients and 10 healthy volunteers will be accrued for this study.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Oregon
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Portland、Oregon、美国、97239-3098
- Knight Cancer Institute At Oregon Health and Science University
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
DISEASE CHARACTERISTICS:
Meets 1 of the following criteria:
Diagnosis of Fanconi anemia
- Requires bone marrow aspiration or biopsy for clinical purposes
Healthy volunteer
- Over 18 years of age
- No known blood abnormality
PATIENT CHARACTERISTICS:
- Platelet count > 150,000/mm^3
- White Blood Cell(WBC) > 4,000/mm^3
- Hemoglobin > 13 g/dL
- No clinical signs or symptoms of acute or subacute infection (e.g., viral, bacterial, or fungal)
- No allergies to lidocaine or xylocaine
PRIOR CONCURRENT THERAPY:
- Not specified
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
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Comparison of Fanconi anemia (FA) hematopoietic cells vs normal hematopoietic cells
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Comparison of FA hematopoietic cells from children with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) vs children (siblings) with FA but without MDS/AML
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Comparison of FA cells from different complementation groups
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他相关的 MeSH 术语
其他研究编号
- IRB00000713
- OHSU-HEM-01079-L
- CDR0000445212 (其他标识符：NCI PDQ)
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
范可尼贫血的临床试验
活检的临床试验
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Cliniques universitaires Saint-Luc- Université...Université de Liège招聘中