佛蒙特州牛津网络极低出生体重数据库 (VON VLBW)
2024年11月19日 更新者：Vermont Oxford Network
佛蒙特州牛津网络极低出生体重婴儿数据库 401 至 1500 克或出生胎龄 22 至 29 周
Vermont Oxford Network 为体重 401 至 1500 克或胎龄 22 至 29 周的活产婴儿维护一个数据库，这些婴儿在参与医院出生或在出生后 28 天内入院，无论婴儿在医院的哪个地方接受护理。
研究概览
详细说明
该数据库收集关于母亲和婴儿的观察性基线数据，以及婴儿使用的疗法和结果。 所收集的信息并非特定于某种疾病或治疗。 收集的数据包括以下信息：
- 母婴人口统计
- 母亲的健康、分娩和分娩
- 入院时婴儿的健康状况、程序和干预措施以及医疗结果
这些数据用于： 向会员中心提供用于质量改进的报告；检查基线特征、治疗和结果之间的关联；并跟踪疾病发病率和治疗效果的趋势。
研究类型
观察性的
注册 (估计的)
60000
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Peter Pelaia
- 电话号码：802-865-4814
- 邮箱：mail@vtoxford.org
学习地点
-
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Vermont
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Burlington、Vermont、美国、05401
- 招聘中
- Vermont Oxford Network
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接触：
- Jeffrey D Horbar, MD
- 电话号码：802-865-4814
- 邮箱：mail@vtoxford.org
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
不超过 3年 (孩子)
接受健康志愿者
不
取样方法
非概率样本
研究人群
出生体重 401 至 1500 克或胎龄 22 至 29 周且在出生后 28 天内入住佛蒙特牛津网络成员中心且未先回家的婴儿
描述
纳入标准：
- 任何活产且出生体重在 401 至 1500 克或 22 周 0 天和 29 周 6 天胎龄（含）且出生后 28 天内在佛蒙特州牛津网络成员中心出生或入院的婴儿第一个回家，无论婴儿在哪里接受护理
排除标准：
- 死产婴儿
- 在进入会员中心之前出院的婴儿
- 28 天后入院的婴儿
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 观测模型：队列
- 时间观点：预期
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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极低出生体重婴儿
出生后 28 天内入住佛蒙特州牛津网络成员中心的 <=1500 克或胎龄 <=29 周的婴儿
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
以统一方式收集的极低出生体重婴儿基线和结果数据的登记
大体时间：长达 1 年
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数据项包括婴儿和产妇特征、产房干预、呼吸护理和结果、手术、感染、其他严重并发症和住院时间。
数据收集的时间范围包括： 出生特征；第 28 天；和出院时。
跟踪在出院回家（包括转出的婴儿）或一年后结束。
|
长达 1 年
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 学习椅：Jeffrey D Horbar, MD、Vermont Oxford Network
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Horbar JD, Ehrenkranz RA, Badger GJ, Edwards EM, Morrow KA, Soll RF, Buzas JS, Bertino E, Gagliardi L, Bellu R. Weight Growth Velocity and Postnatal Growth Failure in Infants 501 to 1500 Grams: 2000-2013. Pediatrics. 2015 Jul;136(1):e84-92. doi: 10.1542/peds.2015-0129.
- Prakalapakorn SG, Greenberg L, Edwards EM, Ehret DEY. Trends in Retinopathy of Prematurity Screening and Treatment: 2008-2018. Pediatrics. 2021 Jun;147(6):e2020039966. doi: 10.1542/peds.2020-039966. Epub 2021 May 11.
- Jensen EA, Edwards EM, Greenberg LT, Soll RF, Ehret DEY, Horbar JD. Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States. Pediatrics. 2021 Jul;148(1):e2020030007. doi: 10.1542/peds.2020-030007. Epub 2021 Jun 2.
- Edwards EM, Greenberg LT, Profit J, Draper D, Helkey D, Horbar JD. Quality of Care in US NICUs by Race and Ethnicity. Pediatrics. 2021 Aug;148(2):e2020037622. doi: 10.1542/peds.2020-037622. Epub 2021 Jul 22.
- Flannery DD, Edwards EM, Puopolo KM, Horbar JD. Early-Onset Sepsis Among Very Preterm Infants. Pediatrics. 2021 Oct;148(4):e2021052456. doi: 10.1542/peds.2021-052456. Epub 2021 Sep 7. Erratum In: Pediatrics. 2022 Oct 1;150(4):e2022059058. doi: 10.1542/peds.2022-059058.
- Boghossian NS, Geraci M, Edwards EM, Horbar JD. Changes in hospital quality at hospitals serving black and hispanic newborns below 30 weeks' gestation. J Perinatol. 2022 Feb;42(2):187-194. doi: 10.1038/s41372-021-01222-3. Epub 2021 Oct 2.
- Runte KE, Flyer JN, Edwards EM, Soll RF, Horbar JD, Yeager SB. Variation of Patent Ductus Arteriosus Treatment in Very Low Birth Weight Infants. Pediatrics. 2021 Nov;148(5):e2021052874. doi: 10.1542/peds.2021-052874. Epub 2021 Oct 21.
- Edwards EM, Greenberg LT, Ehret DEY, Soll RF, Lanzieri TM, Horbar JD. STORCH Infections Among Very Low Birth Weight and Preterm Infants: 2018-2020. Pediatrics. 2022 Jan 1;149(1):e2021053655. doi: 10.1542/peds.2021-053655. No abstract available.
- Keefe G, Culbreath K, Edwards EM, Morrow KA, Soll RF, Modi BP, Horbar JD, Jaksic T. Current outcomes of infants with esophageal atresia and tracheoesophageal fistula: A multicenter analysis. J Pediatr Surg. 2022 Jun;57(6):970-974. doi: 10.1016/j.jpedsurg.2022.01.060. Epub 2022 Feb 14.
- Culbreath K, Keefe G, Edwards EM, Morrow KA, Soll RF, Jaksic T, Horbar JD, Modi BP. Morbidity associated with laparotomy-confirmed spontaneous intestinal perforation: A prospective multicenter analysis. J Pediatr Surg. 2022 Jun;57(6):981-985. doi: 10.1016/j.jpedsurg.2022.01.058. Epub 2022 Feb 14.
- Salazar EG, Handley SC, Greenberg LT, Edwards EM, Lorch SA. Measuring quality of care in moderate and late preterm infants. J Perinatol. 2022 Oct;42(10):1294-1300. doi: 10.1038/s41372-022-01377-7. Epub 2022 Mar 30.
- Boghossian NS, Greenberg LT, Edwards EM, Horbar JD. Transfer Patterns of Very Low Birth Weight Infants for Convalescent Care. Pediatrics. 2022 Jun 1;149(6):e2021054866. doi: 10.1542/peds.2021-054866.
- Culbreath K, Knell J, Keefe G, Nes E, Han SM, Edwards EM, Morrow KA, Soll RF, Jaksic T, Horbar JD, Modi BP. Impact of concomitant necrotizing enterocolitis on mortality in very low birth weight infants with intraventricular hemorrhage. J Perinatol. 2023 Jan;43(1):91-96. doi: 10.1038/s41372-022-01434-1. Epub 2022 Jun 17.
- Handley SC, Salazar EG, Greenberg LT, Foglia EE, Lorch SA, Edwards EM. Variation and Temporal Trends in Delivery Room Management of Moderate and Late Preterm Infants. Pediatrics. 2022 Aug 1;150(2):e2021055994. doi: 10.1542/peds.2021-055994.
- Mangiza M, Ehret DEY, Edwards EM, Rhoda N, Tooke L. Morbidity and mortality in small for gestational age very preterm infants in a middle-income country. Front Pediatr. 2022 Aug 9;10:915796. doi: 10.3389/fped.2022.915796. eCollection 2022.
- Flannery DD, Edwards EM, Coggins SA, Horbar JD, Puopolo KM. Late-Onset Sepsis Among Very Preterm Infants. Pediatrics. 2022 Dec 1;150(6):e2022058813. doi: 10.1542/peds.2022-058813.
- Fraiman YS, Edwards EM, Horbar JD, Mercier CE, Soll RF, Litt JS. Racial Inequity in High-Risk Infant Follow-Up Among Extremely Low Birth Weight Infants. Pediatrics. 2023 Feb 1;151(2):e2022057865. doi: 10.1542/peds.2022-057865.
- Salazar EG, Handley SC, Greenberg LT, Edwards EM, Lorch SA. Association Between Neonatal Intensive Care Unit Type and Quality of Care in Moderate and Late Preterm Infants. JAMA Pediatr. 2023 Mar 1;177(3):278-285. doi: 10.1001/jamapediatrics.2022.5213.
- Edwards EM, Greenberg LT, Horbar JD, Gagliardi L, Adams M, Berger A, Leitao S, Luyt K, Ehret DEY, Rogowski JA. Discharge Age and Weight for Very Preterm Infants in Six Countries: 2012-2020. Neonatology. 2023;120(2):208-216. doi: 10.1159/000528013. Epub 2023 Jan 17.
- Coggins SA, Edwards EM, Flannery DD, Gerber JS, Horbar JD, Puopolo KM. Serratia Infection Epidemiology Among Very Preterm Infants in the Neonatal Intensive Care Unit. Pediatr Infect Dis J. 2023 Feb 1;42(2):152-158. doi: 10.1097/INF.0000000000003736. Epub 2022 Nov 2.
- Boghossian NS, Geraci M, Phibbs CS, Lorch SA, Edwards EM, Horbar JD. Trends in Resources for Neonatal Intensive Care at Delivery Hospitals for Infants Born Younger Than 30 Weeks' Gestation, 2009-2020. JAMA Netw Open. 2023 May 1;6(5):e2312107. doi: 10.1001/jamanetworkopen.2023.12107.
- Agha L, Staiger D, Brown C, Soll RF, Horbar JD, Edwards EM. Association of Hospital Adoption of Probiotics With Outcomes Among Neonates With Very Low Birth Weight. JAMA Health Forum. 2023 May 5;4(5):e230960. doi: 10.1001/jamahealthforum.2023.0960.
- Frade Garcia A, Edwards EM, de Andrade Lopes JM, Tooke L, Assenga E, Ehret DEY, Hansen A. Neonatal Admission Temperature in Middle- and High-Income Countries. Pediatrics. 2023 Sep 1;152(3):e2023061607. doi: 10.1542/peds.2023-061607.
- Rogowski J, Greenberg L, Edwards E, Ehret D, Horbar J. Horizontally integrated health systems and neonatal intensive care unit (NICU) care for very preterm infants. Health Aff Sch. 2023 Sep 11;1(3):qxad042. doi: 10.1093/haschl/qxad042. eCollection 2023 Sep.
- Culbreath K, Keefe G, Nes E, Edwards EM, Knell J, Morrow KA, Soll RF, Jaksic T, Horbar JD, Modi BP. Association between neurodevelopmental outcomes and concomitant presence of NEC and IVH in extremely low birth weight infants. J Perinatol. 2024 Jan;44(1):108-115. doi: 10.1038/s41372-023-01780-8. Epub 2023 Sep 21.
- Munoz FA, Carter EH, Edwards EM, Jerome M, Litt JS. Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia? J Perinatol. 2024 Feb;44(2):301-306. doi: 10.1038/s41372-023-01808-z. Epub 2023 Oct 28.
- Horbar JD, Greenberg LT, Buzas JS, Ehret DEY, Soll RF, Edwards EM. Trends in Mortality and Morbidities for Infants Born 24 to 28 Weeks in the US: 1997-2021. Pediatrics. 2024 Jan 1;153(1):e2023064153. doi: 10.1542/peds.2023-064153. Erratum In: Pediatrics. 2024 May 1;153(5):e2024066036. doi: 10.1542/peds.2024-066036.
- Handley SC, Salazar EG, Kunz SN, Lorch SA, Edwards EM. Transfer Patterns Among Infants Born at 28 to 34 Weeks' Gestation. Pediatrics. 2024 Jan 1;153(2):e2023063118. doi: 10.1542/peds.2023-063118.
- Nes E, Chugh PV, Keefe G, Culbreath K, Morrow KA, Ehret DEY, Soll RF, Horbar JD, Harting MT, Lally KP, Modi BP, Jaksic T, Edwards EM. Predictors of Mortality in Very Low Birth Weight Neonates With Congenital Diaphragmatic Hernia. J Pediatr Surg. 2024 May;59(5):818-824. doi: 10.1016/j.jpedsurg.2024.01.032. Epub 2024 Feb 1.
- Chugh PV, Nes E, Culbreath K, Keefe G, Edwards EM, Morrow KA, Ehret D, Soll RF, Modi BP, Horbar JD, Jaksic T. Comparing Healthcare Needs in Extremely Low Birth Weight Infants With NEC and Spontaneous Intestinal Perforation. J Pediatr Surg. 2024 Sep;59(9):1759-1764. doi: 10.1016/j.jpedsurg.2024.03.006. Epub 2024 Mar 16.
- Edwards EM, Ehret DEY, Horbar JD. Potentially Better Practices for Follow Through in Neonatal Intensive Care Units. Pediatrics. 2024 Jul 1;154(1):e2023065530. doi: 10.1542/peds.2023-065530.
- Leahy BF, Edwards EM, Ehret DEY, Soll RF, Yeager SB, Flyer JN. Transcatheter and Surgical Ductus Arteriosus Closure in Very Low Birth Weight Infants: 2018-2022. Pediatrics. 2024 Aug 1;154(2):e2024065905. doi: 10.1542/peds.2024-065905.
- Edwards EM, Ehret DEY, Soll RF, Horbar JD. Survival of Infants Born at 22 to 25 Weeks' Gestation Receiving Care in the NICU: 2020-2022. Pediatrics. 2024 Oct 1;154(4):e2024065963. doi: 10.1542/peds.2024-065963.
- Lake ET, Staiger D, Horbar J, Cheung R, Kenny MJ, Patrick T, Rogowski JA. Association between hospital recognition for nursing excellence and outcomes of very low-birth-weight infants. JAMA. 2012 Apr 25;307(16):1709-16. doi: 10.1001/jama.2012.504.
- Fitzgibbons SC, Ching Y, Yu D, Carpenter J, Kenny M, Weldon C, Lillehei C, Valim C, Horbar JD, Jaksic T. Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg. 2009 Jun;44(6):1072-5; discussion 1075-6. doi: 10.1016/j.jpedsurg.2009.02.013.
- Zupancic JA, Richardson DK, Horbar JD, Carpenter JH, Lee SK, Escobar GJ; Vermont Oxford Network SNAP Pilot Project Participants. Revalidation of the Score for Neonatal Acute Physiology in the Vermont Oxford Network. Pediatrics. 2007 Jan;119(1):e156-63. doi: 10.1542/peds.2005-2957. Epub 2006 Dec 11.
- Walsh MC, Yao Q, Horbar JD, Carpenter JH, Lee SK, Ohlsson A. Changes in the use of postnatal steroids for bronchopulmonary dysplasia in 3 large neonatal networks. Pediatrics. 2006 Nov;118(5):e1328-35. doi: 10.1542/peds.2006-0359.
- Morales LS, Staiger D, Horbar JD, Carpenter J, Kenny M, Geppert J, Rogowski J. Mortality among very low-birthweight infants in hospitals serving minority populations. Am J Public Health. 2005 Dec;95(12):2206-12. doi: 10.2105/AJPH.2004.046730.
- Rogowski JA, Staiger DO, Horbar JD. Variations in the quality of care for very-low-birthweight infants: implications for policy. Health Aff (Millwood). 2004 Sep-Oct;23(5):88-97. doi: 10.1377/hlthaff.23.5.88.
- Lucey JF, Rowan CA, Shiono P, Wilkinson AR, Kilpatrick S, Payne NR, Horbar J, Carpenter J, Rogowski J, Soll RF. Fetal infants: the fate of 4172 infants with birth weights of 401 to 500 grams--the Vermont Oxford Network experience (1996-2000). Pediatrics. 2004 Jun;113(6):1559-66. doi: 10.1542/peds.113.6.1559.
- Rogowski JA, Horbar JD, Staiger DO, Kenny M, Carpenter J, Geppert J. Indirect vs direct hospital quality indicators for very low-birth-weight infants. JAMA. 2004 Jan 14;291(2):202-9. doi: 10.1001/jama.291.2.202.
- Suresh GK, Horbar JD, Kenny M, Carpenter JH; Vermont Oxford Network. Major birth defects in very low birth weight infants in the Vermont Oxford Network. J Pediatr. 2001 Sep;139(3):366-73. doi: 10.1067/mpd.2001.117072.
- Horbar JD, Badger GJ, Lewit EM, Rogowski J, Shiono PH. Hospital and patient characteristics associated with variation in 28-day mortality rates for very low birth weight infants. Vermont Oxford Network. Pediatrics. 1997 Feb;99(2):149-56. doi: 10.1542/peds.99.2.149.
- Horbar JD. Increasing use of antenatal corticosteroid therapy between 1990 and 1993 in Vermont Oxford Network. J Perinatol. 1997 Jul-Aug;17(4):309-13.
- De Nisi G, Berti M, Malossi R, Pederzini F, Pedrotti A, Valente A. Comparison of neonatal intensive care: Trento area versus Vermont Oxford Network. Ital J Pediatr. 2009 Mar 14;35(1):5. doi: 10.1186/1824-7288-35-5.
- Hull MA, Fisher JG, Gutierrez IM, Jones BA, Kang KH, Kenny M, Zurakowski D, Modi BP, Horbar JD, Jaksic T. Mortality and management of surgical necrotizing enterocolitis in very low birth weight neonates: a prospective cohort study. J Am Coll Surg. 2014 Jun;218(6):1148-55. doi: 10.1016/j.jamcollsurg.2013.11.015. Epub 2013 Nov 27.
- Fisher JG, Jones BA, Gutierrez IM, Hull MA, Kang KH, Kenny M, Zurakowski D, Modi BP, Horbar JD, Jaksic T. Mortality associated with laparotomy-confirmed neonatal spontaneous intestinal perforation: a prospective 5-year multicenter analysis. J Pediatr Surg. 2014 Aug;49(8):1215-9. doi: 10.1016/j.jpedsurg.2013.11.051. Epub 2013 Nov 15.
- Lake ET, Staiger D, Horbar J, Kenny MJ, Patrick T, Rogowski JA. Disparities in perinatal quality outcomes for very low birth weight infants in neonatal intensive care. Health Serv Res. 2015 Apr;50(2):374-97. doi: 10.1111/1475-6773.12225. Epub 2014 Sep 22.
- Fisher JG, Bairdain S, Sparks EA, Khan FA, Archer JM, Kenny M, Edwards EM, Soll RF, Modi BP, Yeager S, Horbar JD, Jaksic T. Serious congenital heart disease and necrotizing enterocolitis in very low birth weight neonates. J Am Coll Surg. 2015 Jun;220(6):1018-1026.e14. doi: 10.1016/j.jamcollsurg.2014.11.026. Epub 2014 Dec 9.
- Fullerton BS, Sparks EA, Morrow KA, Edwards EM, Soll RF, Jaksic T, Horbar JD, Modi BP. Hospital transfers and patterns of mortality in very low birth weight neonates with surgical necrotizing enterocolitis. J Pediatr Surg. 2016 Jun;51(6):932-5. doi: 10.1016/j.jpedsurg.2016.02.051. Epub 2016 Mar 3.
- McBride CA, Bernstein IM, Badger GJ, Horbar JD, Soll RF. The effect of maternal hypertension on mortality in infants 22, 29weeks gestation. Pregnancy Hypertens. 2015 Oct;5(4):362-6. doi: 10.1016/j.preghy.2015.10.002. Epub 2015 Oct 27.
- Hallowell SG, Rogowski JA, Spatz DL, Hanlon AL, Kenny M, Lake ET. Factors associated with infant feeding of human milk at discharge from neonatal intensive care: Cross-sectional analysis of nurse survey and infant outcomes data. Int J Nurs Stud. 2016 Jan;53:190-203. doi: 10.1016/j.ijnurstu.2015.09.016. Epub 2015 Oct 9.
- Horbar JD, Edwards EM, Greenberg LT, Morrow KA, Soll RF, Buus-Frank ME, Buzas JS. Variation in Performance of Neonatal Intensive Care Units in the United States. JAMA Pediatr. 2017 Mar 6;171(3):e164396. doi: 10.1001/jamapediatrics.2016.4396. Epub 2017 Mar 6. Erratum In: JAMA Pediatr. 2017 Mar 1;171(3):306. doi: 10.1001/jamapediatrics.2017.0158.
- Fullerton BS, Hong CR, Velazco CS, Mercier CE, Morrow KA, Edwards EM, Ferrelli KR, Soll RF, Modi BP, Horbar JD, Jaksic T. Severe neurodevelopmental disability and healthcare needs among survivors of medical and surgical necrotizing enterocolitis: A prospective cohort study. J Pediatr Surg. 2017 Oct 12:S0022-3468(17)30651-6. doi: 10.1016/j.jpedsurg.2017.10.029. Online ahead of print.
- Boghossian NS, Geraci M, Edwards EM, Morrow KA, Horbar JD. Anthropometric Charts for Infants Born Between 22 and 29 Weeks' Gestation. Pediatrics. 2016 Dec;138(6):e20161641. doi: 10.1542/peds.2016-1641. Epub 2016 Nov 18.
- Horbar JD, Edwards EM, Greenberg LT, Profit J, Draper D, Helkey D, Lorch SA, Lee HC, Phibbs CS, Rogowski J, Gould JB, Firebaugh G. Racial Segregation and Inequality in the Neonatal Intensive Care Unit for Very Low-Birth-Weight and Very Preterm Infants. JAMA Pediatr. 2019 May 1;173(5):455-461. doi: 10.1001/jamapediatrics.2019.0241.
- Belfort MB, Edwards EM, Greenberg LT, Parker MG, Ehret DY, Horbar JD. Diet, weight gain, and head growth in hospitalized US very preterm infants: a 10-year observational study. Am J Clin Nutr. 2019 May 1;109(5):1373-1379. doi: 10.1093/ajcn/nqz008.
- Smith BJ, Flyer JN, Edwards EM, Soll RF, Horbar JD, Yeager SB. Outcomes for Ectopia Cordis. J Pediatr. 2020 Jan;216:67-72. doi: 10.1016/j.jpeds.2019.09.014. Epub 2019 Oct 24.
- Han SM, Watters KF, Hong CR, Edwards EM, Knell J, Morrow KA, Soll RF, Jaksic T, Horbar JD, Modi BP. Tracheostomy in Very Low Birth Weight Infants: A Prospective Multicenter Study. Pediatrics. 2020 Mar;145(3):e20192371. doi: 10.1542/peds.2019-2371. Epub 2020 Feb 25.
- Gray MM, Edwards EM, Ehret DEY, Brei BK, Greenberg LT, Umoren RA, Ringer S, Horbar J. Resuscitation Opportunities for Fellows of Very Low Birth Weight Infants in the Vermont Oxford Network. Pediatrics. 2020 Jul;146(1):e20193641. doi: 10.1542/peds.2019-3641. Epub 2020 Jun 12.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
1990年1月1日
初级完成 (估计的)
2040年12月1日
研究完成 (估计的)
2040年12月1日
研究注册日期
首次提交
2013年3月27日
首先提交符合 QC 标准的
2013年4月4日
首次发布 (估计的)
2013年4月5日
研究记录更新
最后更新发布 (实际的)
2024年11月22日
上次提交的符合 QC 标准的更新
2024年11月19日
最后验证
2024年11月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.