The Effect Of Multimodal Analgesia On Chronic Pain
Tramadol、Metamizol 和 Dexketoprofen 组合对心脏手术后慢性疼痛发展的影响
This study aimed to show the characteristics and predictors of chronic pain after a mini-thoracotomy. Non-Coronary Heart Surgery patients were scheduled for the study. In patients with acute postoperative period use of tramadol retard, metamizole, and dexketoprofen the effects on the development of chronic pain and its character have been analyzed.
研究概览
地位
条件
详细说明
This prospective study analyzed surgical thoracotomy patients treated with analgesic drugs with pain levels equal to or higher than four on the Douleur Neuropathique scale. The screening test for neuropathic pain is the Douleur Neuropathique 4 (DN4). Postoperative 3rd-month DN4 questionnaires are used to predict persistent postoperative neuropathic pain. Patients were separated into two groups with those who developed chronic pain and those who did not on the 3rd-month of post-operation. Demographical characteristics and clinical findings regarding the situation of post-operation 3rd-month pain include but are not limited to; gender, body mass index (BMI), preoperative and postoperative clinical examination status (EUROSCORE), changes in the average VAS scores during hospitalization, neuropathic pain scores, duration of chest drains, duration of cardiopulmonary bypass, cross-clamp time, time under anesthesia, duration of stay in the ICU (hours), duration of pain after being discharged (days), additional drug requests by the patient, and any possible complications that arise. In addition, the presence and distribution of somatic (throbbing, tingling, spasm, tautening, stabbing, scouring), neuropathic (electric shock, burning, numbness, prickling, loss of sense), as well as other symptoms such as allodynia and hyperalgesia experienced by chronic patients three months post-operation were also analyzed and compared non-chronic patients.
研究类型
注册 (实际的)
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Both female and male participants are taking part in the study.
描述
Inclusion Criteria:
- Patients included between 20-70 years
- ASA 1-4
- Euroscore value lower than 7
- Undergoned non coronary heart surgery (minithoracotomy)
- Intensive care has been discharged from the service in 24 hours , with patients given tramadol retard , metamizol, Dexketoprofen on postoperatif first day to discharged from the hospital.
Exclusion Criteria:
- Diabetes mellitus
- Chronic renal failure
- COPD
- Uncontrolled hypertension
- Epilepsy
- Psychiatric disease
- Malignancy
- Patients with a history of cerebrovascular disease
- Patients with ischemia
- Patients suffering from chronic pain and analgesic use
- Patients taking antidepressants and antiepileptic drug
- Off-pump technique used or redo undergo cases
- Ongoing postoperative time thoracic or mediastinal drains more than 48 hours remaining patients, bleeding or patients who received repeated revisions due to infection
- More than 24 hours remaining in intensive care patients
- Patients with long discharge duration 1 week
- Patients who discontinued due to side effects of tramadol may begin after medicines.
- Postoperative wound infection.
学习计划
研究是如何设计的?
设计细节
- 观测模型:CASE_CONTROL
- 时间观点:PROSPECTIVE
研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
|---|---|
|
neuropathic pain assesement by DN4 score after minithoracotomy
大体时间:outcome measure assessed 3 months after the surgery
|
outcome measure assessed 3 months after the surgery
|
合作者和调查者
调查人员
- 首席研究员:H. Gul Baytan Yildiz, MD、republic of turkey ministry of health
出版物和有用的链接
有用的网址
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2015-PMS-41
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