Drug Resistance Factors In Healthcare-associated Pneumonia (DEFINE)
A Multicenter Study to Evaluate Predictive Factors for Multidrug Resistant Healthcare Associated Pneumonia in Critically Ill Patients
研究概览
详细说明
Pneumonia is one of the leading causes of death in the United States and is associated with significant costs to the healthcare system. Recent treatment guidelines describe a new subtype of pneumonia, healthcare-associated pneumonia (HCAP), to identify those patients who present to a hospital from the community and are thought to be at greater risk for developing pneumonia due to multidrug resistant organisms (MDRO).
The HCAP categorization scheme is intended to improve the prescription of initial appropriate empiric antibacterial agents and minimize the morbidity and mortality associated with inappropriate empiric selection.However, one of the chief criticisms of the guideline recommendations is that the criteria used to define HCAP is overly broad, which may result in greater use of broad-spectrum antibiotics.
The prevailing notion is that many patients in the community will be at the lowest risk for experiencing MDR pneumonia and can be treated with a less broad anti-infective regimen. Patients with increasing exposure to the healthcare system will receive initial anti-infective therapy that is more broad in an effort to target MDROs. The investigator group believes that it is not simply exposure to the healthcare system that predicts the incidence of MDR pneumonia (i.e., criteria for HCAP), but rather, the "intensity" of exposure to the healthcare system that is predictive of MDR pneumonia. The aim of this study is to identify risk factors for MDR HCAP pneumonia in critically ill patients. .
研究类型
注册 (实际的)
联系人和位置
学习地点
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Riyahd、沙特阿拉伯、1515
- Ministry of of National Guard-Health Affaires
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Arkansas
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Little Rock、Arkansas、美国、72205
- University of Arkansas for Medical Sciences
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Connecticut
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Hartford、Connecticut、美国、06102
- Hartford Healthcare
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Florida
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Jacksonville、Florida、美国、32209
- University of Florida - Jacksonville Hospital
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Weston、Florida、美国、33331
- Cleveland Clinic - Florida
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Georgia
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Savannah、Georgia、美国、31401
- Memorial University Medical Center
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Illinois
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Chicago、Illinois、美国、60612
- Rush University Medical Center
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Chicago、Illinois、美国、60037
- University of Chicago Medical Center
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Indiana
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Indianapolis、Indiana、美国、46202
- Roudebush - Indianapolis Veterans Administration Hospital
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Kentucky
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Lexington、Kentucky、美国、40506
- University of Kentucky Healthcare - Chandler Medical Center
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Louisiana
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New Orleans、Louisiana、美国、70121
- Ochsner Clinic Foundation
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Massachusetts
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Boston、Massachusetts、美国、02116
- Brigham and Women's Hospital
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Boston、Massachusetts、美国、02116
- Massachusetts General Hospital
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Michigan
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Detroit、Michigan、美国、48201
- Detroit Medical Center
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Grand Rapids、Michigan、美国、49503
- Spectrum Health
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Royal Oak、Michigan、美国、48073
- Beaumont Health System
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Minnesota
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Minneapolis、Minnesota、美国、55454
- University of Minnesota - Fairview Health Services
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Missouri
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Kirksville、Missouri、美国、63501
- Northeast Regional Medical Center
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New Hampshire
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Laconia、New Hampshire、美国、03246
- Lakes Regional General Healthcare
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New Jersey
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Hackensack、New Jersey、美国、07601
- Hackensack University Medical Center
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New York
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Rochester、New York、美国、14642
- University of Rochester Medical Center
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Ohio
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Canton、Ohio、美国、44708
- Mercy Medical Center
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Cleveland、Ohio、美国、44195
- Cleveland Clinic - Cleveland
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Pennsylvania
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Pittsburgh、Pennsylvania、美国、15212
- Allegheny Health Network
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South Carolina
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Charleston、South Carolina、美国、29401
- Roper St. Francis Healthcare
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Tennessee
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Nashville、Tennessee、美国、37232
- Vanderbilt University Medical Center
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Texas
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Austin、Texas、美国、78701
- Seton Healthcare Family
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Houston、Texas、美国、77030
- Memorial Hermann Healthcare System
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Wisconsin
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Madison、Wisconsin、美国、53792
- University of Wisconsin Hospital
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Milwaukee、Wisconsin、美国
- Medical College of Wisconsin/ Froedtert Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Age ≥ 18 years old
- ICU admission
- Empiric or directed anti-infective treatment for pneumonia for ≥ 5 days
Exclusion Criteria:
- Patient stay in ICU for < 24 hours
- Patient transfer to the ICU from a hospital floor following prescription for anti-infective therapy in the previous 24 hours of ICU admission
- Diagnosis of cystic fibrosis or bronchiectasis
- Fungal pneumonia
学习计划
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
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Incidence of multidrug resistant pneumonia pathogen
大体时间：30 days
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30 days
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次要结果测量
结果测量 |
大体时间 |
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Incidence of pneumonia subtypes
大体时间：30 days
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30 days
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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