Establishment of a Database of Patients Suffering From Obesity With a Medical Treatment (Elodie Cohort)
Establishment of a Database of Patients Suffering From Obesity With a Medical Treatment in the Framework of The Specialized Obesity Center Languedoc-Roussillon CHU Montpellier
Obesity is a public health problem, given its prevalence (15% in France in 2012, Obépi survey) but also by the complications that it generates. We were firstly, intersted in bone mineral density during obesity.
We were able to confirm in an observational study that BMD (Z-score)was augmented. We also showed, for the first time, that this increase in Z-score was dependent on sex, severity of obesity and age but also bone site. If the increase in BMD at the level of the bearing zones seems logically to be explained by the hypothesis that the mechanical stresses have an osteogenic effect on the bone tissue, the latter can not in any way respond to the concomitant increase in BMD at non-bearing areas such as the radius.These results suggest that changes in certain systemic compounds induced by obesity may interfere with bone metabolism. recent data also suggest a change in the concentration of pro-glucagon peptides (GLP-1, glicentin, glucagon, etc.) in obese subjects and in bariatric surgery). Although body composition and its variation after surgery could be largely involved in the modification of these peptides, no data on these potential relationships is currently available. However, no data are available for baseline body composition and weight loss data. Finally, 80% of obesity is associated with insulin resistance, a key mechanism in the pathophysiology of type 2 diabetes. A metabolically healthy obesity phenotype is described, although the definition criteria are not consensual.The evolution of this phenotype with aging and with the duration of evolution of obesity is not well described.
Our goal is to create a database of weight-bearing patients in the care setting and to determine the "hormonal dialogue" between peripheral (muscular and adipose) and bone tissues, which may be associated with changes in body composition during obesity and aging, and that according to sex.
研究概览
地位
研究类型
注册 (预期的)
联系人和位置
学习地点
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Montpellier、法国、34295
- 招聘中
- UHMontpellier
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接触:
- Ariane SULTAN, PR
- 电话号码:33 467338402
- 邮箱:a-sultan@chu-montpellier.fr
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion criteria:
- obese patients age above 18 years old
Exclusion criteria:
- non agreement of inclusion
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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identify the determinants of body composition
大体时间:1 day
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Compile a comprehensive database of all patients who are weight-bearing as part of the care to identify the determinants of body composition (lean mass, bone mass, muscle mass) in the obese subject according to sex and age, and the link with the complications of obesity.
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1 day
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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Measured plasma concentration
大体时间:1 day
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Measured plasma concentration of myokines, adipokines, markers of bone remodeling, incretin-glucagon
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1 day
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measurement of muscle strength
大体时间:1 day
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the measurement of muscle strength by hand-grip and performance by 6-minute walk test.
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1 day
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合作者和调查者
调查人员
- 研究主任:Ariane SULTAN, PR、University Hospital, Montpellier
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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BMI Greater Than 30的临床试验
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University Hospital, Strasbourg, France未知
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Lille Catholic UniversityCentre Hospitalier Arras招聘中
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Rennes University Hospital招聘中慢性阻塞性肺疾病 (COPD) | BMI 大于 30 的肥胖症 | 成人重症监护中的急性呼吸窘迫法国