Long-term COVID-19 Immune Response in a Vulnerable Neighbourhood in Argentina
Long-term Persistence of Immunoglobulin G Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 in a Vulnerable Neighbourhood in Buenos Aires, Argentina
研究概览
详细说明
Background Between June 10t h and July 1st, a cross-sectional design study was carried out in an Argentina slum over people, selected from a probabilistic sample of households showed a prevalence based on IgG-class antibodies against SARS-CoV-2 of 53.4%. In regarding to the persistence of these antibodies, the early data brought hope that acquired immunity was possible. But some subsequent studies have suggested that immune protection might be short-lived. The new findings show that people who survive a COVID-19 infection continue to produce protective antibodies against key parts of the virus for at least three to four months after developing their first symptoms. In contrast, some other antibody types decline more quickly.
It remains unanswered whether natural infection produces a sustained immunity that is capable of establishing herd immunity. The other health problem that Latin America faces is dengue, whose transmission, like SARS-CoV-2, is greater in areas with high population density such as vulnerable neighborhoods. In this context, the occurrence of the two diseases implies a risk, particularly in regions with several dengue serotypes where secondary and tertiary infections have been demonstrated and dengue epidemiological surveillance has been affected by the saturation of health system.
Objectives The aim of this study is to evaluate the presence of IgG antibodies for COVID-19 after 5 months in inhabitants of this slum who consented the Seroprevalence Study for COVID-19, and to evaluate those factors associated with the persistence of positive antibodies. As a secondary objective, the presence of positive IgG for dengue will be evaluated.
Methods Cross sectional study. Population of the study were inhabitants of the slum: men and women form 14 years of age or older were included. People will be invited to participated and detection of antibodies will be performed with ta serological tests, an enzyme linked immunosorbent assay (ELISA) developed and validated in Argentina which detects antibodies against two viral antigens, trimeric spike and the receptor binding domain (RBD) of the spike protein. Blood sample will be collected in a capillary tube from a finger prick taken at the doorstep of each person. Samples will be processed and analyzed at the "Hospital de Niños Doctor Ricardo Gutierrez" Virology laboratory.
Blood sample collection and epidemiological data were collected, and entered in a secure database.
Sample Size The first seroprevalence study included 426 inhabitants of 14 years or more. Considering a persistence of antibodies of 30% with a precision of 5% for a confidence interval of 95% 184 inhabitants should be included. This sample will be selected by a proportionate stratified random sampling, considering the ten sectors in which the slum is divided.
Statistical analysis Descriptive statistics of the data will be carried out according to the variables obtained. Continuous variables will be expressed as mean and standard deviation, and categorical variables as proportions. A multiple logistic regression model will be performed to evaluate the factors associated with the persistence of positive antibodies for SARS-CoV-2.
Dengue seroprevalence is determined globally and by geographic sector. R software version 4.0.2 will be used.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Ciudad De Buenos Aires
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Buenos Aires、Ciudad De Buenos Aires、阿根廷、C1425EFD
- Hospital de Niños Ricardo Gutiérrez
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Men and women form 14 years of age or older who were included in the seroprevalence study and who have positive antibodies against severe acute respiratory syndrome coronavirus 2
Exclusion Criteria:
- deny consent
学习计划
研究是如何设计的?
设计细节
- 观测模型:队列
- 时间观点:横截面
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
to estimate the proportion of people with positive IgG antibodies for COVID-19 who have positive IgG antibodies after 5 month of the first measurement
大体时间:up to 20 weeks
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to estimate the proportion of people with positive IgG antibodies for COVID-19 who have positive IgG antibodies after 5 month of the first measurement
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up to 20 weeks
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
to estimate the proportion of people with positive IgG antibodies for dengue
大体时间:up to 20 weeks
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to estimate the proportion of people with positive IgG antibodies for dengue
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up to 20 weeks
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合作者和调查者
调查人员
- 学习椅:Vanina Pagotto, MD MG、Hospital Italiano de Buenos Aires
- 首席研究员:Alicia Mistchenko, Phd、Hospital de Niños Ricardo Gutiérrez
- 学习椅:Silvana Figar, MD MG、Hospital Italiano de Buenos Aires
- 学习椅:Andrea Gamarnick, Phd、National Council of Scientific and Technical Research, Argentina
- 学习椅:Ana Maria Gomez Saldaño, MD MG、Salud Comunitaria Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires
- 学习椅:Lorena Luna、Salud Comunitaria Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires
- 学习椅:Julieta Salto、Salud Comunitaria Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires
- 学习椅:Magdalena Wagner Manslau、Salud Comunitaria Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires
- 研究主任:Fernan Quiroz, MD MG、Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires
出版物和有用的链接
一般刊物
- Jordan RE, Adab P, Cheng KK. Covid-19: risk factors for severe disease and death. BMJ. 2020 Mar 26;368:m1198. doi: 10.1136/bmj.m1198. No abstract available.
- Long QX, Tang XJ, Shi QL, Li Q, Deng HJ, Yuan J, Hu JL, Xu W, Zhang Y, Lv FJ, Su K, Zhang F, Gong J, Wu B, Liu XM, Li JJ, Qiu JF, Chen J, Huang AL. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med. 2020 Aug;26(8):1200-1204. doi: 10.1038/s41591-020-0965-6. Epub 2020 Jun 18.
- Kellam P, Barclay W. The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection. J Gen Virol. 2020 Aug;101(8):791-797. doi: 10.1099/jgv.0.001439. Review.
- Wilder-Smith A, Tissera H, Ooi EE, Coloma J, Scott TW, Gubler DJ. Preventing Dengue Epidemics during the COVID-19 Pandemic. Am J Trop Med Hyg. 2020 Aug;103(2):570-571. doi: 10.4269/ajtmh.20-0480. Epub 2020 Jun 15.
- Cardoso MR, Cousens SN, de Góes Siqueira LF, Alves FM, D'Angelo LA. Crowding: risk factor or protective factor for lower respiratory disease in young children? BMC Public Health. 2004 Jun 3;4:19.
有用的网址
- 2019 Novel Coronavirus (COVID-19) Pneumonia with Hemoptysis as the Initial Symptom: CT and Clinical Features
- SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
- Community-level SARS-CoV-2 Seroprevalence Survey in urban slum dwellers of Buenos Aires City, Argentina: a participatory research.
- Reductions in commuting mobility correlate with geographic differences in SARS-CoV-2 prevalence in New York City
- The COVID-19 pandemic should not jeopardize dengue control
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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