此页面是自动翻译的，不保证翻译的准确性。请参阅 英文版 对于源文本。

全身振动的健康益处 (VIBE-Rx)

2026年11月3日 更新者：Ryan Harris、Augusta University

亚急性（12 周）全身振动训练对健康益处的试点调查

The overall goals of this pilot investigation are to determine 1) the feasibility of conducting home based WBV studies, and 2) to determine if sub-acute home based WBV can improve a) exercise capacity, b) conduit- and micro- vascular function, and c) skeletal muscle function.

研究概览

地位

主动，不招人

条件

干预/治疗

详细说明

Cardiovascular disease (CVD) is the leading cause of death in the world and many comorbid conditions (i.e. diabetes, obesity) can affect overall CVD risk. There is increasing interest into the role that skeletal muscle health plays in mediating CVD risk, particularly in metabolic disease states (ie. obesity and diabetes). Whole body vibration (WBV) has emerged as an exercise mimetic that may be more tolerable than traditional modes of exercise, such as treadmill walking/running or cycling. Similar to traditional exercise modalities, WBV can elicit beneficial metabolic effects. In fact, a single bout of WBV increases circulating concentrations of IL-6, which correspond with the normalization of glucose and insulin in obese individuals. The proposed pilot investigation will provide the foundation to begin understanding the molecular and physiological mechanisms of how sub-acute WBV can improve overall CVD risk. We hypothesize that home based WBV will decrease CVD risk by improving skeletal muscle and vascular function via a decrease in systemic inflammation.

研究类型

介入性

注册 (估计的)

40

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 美国
    • Georgia
      • Augusta、Georgia、美国、30912
        • Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 及以上 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

全部

描述

Inclusion Criteria:

  • Men and women (> 18 yrs old)
  • All races

Exclusion Criteria:

  • <18 years old
  • Clinical diagnosis of hepatic, cardiovascular, or renal disease
  • Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
  • Pregnancy
  • Direct vasoactive medications (i.e. nitrates)

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：不适用
  • 介入模型：单组作业
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：亚急性（12 周）全身训练
其他：Sub Acute Whole Body Vibration Training

Participants will be given a personal vibration plate to take home with them for training which will last for 12 weeks. For the first four weeks, participants will be asked to complete 10 minutes of WBV per day (1 minute on and up to 1 minute of rest), at least 3-4 days per week. At least 24 hours will be recommended in between sessions during weeks 1-4. Beginning at week 5, participants will be asked to increase WBV time to up to 14 minutes and/or reduce the duration of rest. Beginning at week 9, participants will be asked to increase WBV time to up to 20 minutes and/or reduce the duration of rest.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Change in VO2 Peak
大体时间：pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

change from baseline relative (mL/kg/min) peak oxygen consumption (VO2) during maximal exercise test at 12 weeks
pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
Change in Flow-Mediated Dilation (FMD)
大体时间：pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

change from baseline brachial artery flow mediated dilation at 12 weeks.
pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
Change in Skeletal Muscle Mitochondrial Function
大体时间：pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

change from baseline skeletal muscle mitochondrial function at 12 weeks. Measured using Near Infrared Spectroscopy (NIRS). Values are an index of phosphocreatine recovery expressed as a rate constant (min-1)
pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
Change in Pulse Wave Velocity (PWV)
大体时间：pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

Change from baseline PWV at 12 weeks. Measured by Shygmocor Xcel in m/s.
pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
Change in Post Occlusive Reactive Hyperemia (PORH)
大体时间：pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

Change from baseline PORH at 12 weeks. Measured by Laser Speckle Contrast Imager (Moor FLPI).
pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
Change in IL-6
大体时间：pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

change from baseline concentrations of Interleukin 6 (IL-6) obtained via blood draw at 12 weeks.
pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Augusta University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2022年2月28日

初级完成 (估计的)

2028年1月1日

研究完成 (估计的)

2029年1月1日

研究注册日期

首次提交

2021年10月15日

首先提交符合 QC 标准的

2021年10月27日

首次发布 (实际的)

2021年10月28日

研究记录更新

最后更新发布 (实际的)

2026年11月4日

上次提交的符合 QC 标准的更新

2026年11月3日

最后验证

2026年11月1日

更多信息

与本研究相关的术语

其他研究编号

  • 1818010

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

订阅