GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial (GMALLregistry)

August 3, 2026 updated by: Nicola Goekbuget, Goethe University

Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult ALL Patients and Related Diseases Associated With a Prospective Collection of Biomaterial

The GMALL registry serves the purpose of ALL research and quality assurance. The Registry collects data about diagnostics, treatment and outcome of Adult ALL Patients in the clinical routine, whether or not the patient is treated within a clinical trial.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
10000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Contact Backup

Study Locations

  • Austria
      • Graz, Austria
        • Recruiting
        • Universitätsklinikum Graz
      • Leoben, Austria
        • Recruiting
        • LKH-Hochsteiermark Leoben
      • Linz, Austria
        • Recruiting
        • Ordensklinikum Linz Elisabethinen
      • Sankt Pölten, Austria
        • Recruiting
        • Universitätsklinikum St. Pölten
      • Vienna, Austria
        • Recruiting
        • Hanusch-Krankenhaus Wien
  • Germany
      • Aachen, Germany
        • Recruiting
        • Universitätsklinikum Aachen
      • Altenburg, Germany
        • Recruiting
        • Klinikum Altenburger Land
      • Altötting, Germany
        • Recruiting
        • Kreiskliniken Altötting
      • Aschaffenburg, Germany
        • Recruiting
        • Klinikum Aschaffenburg
      • Augsburg, Germany
        • Recruiting
        • Klinikum Augsburg
      • Bad Saarow, Germany
        • Recruiting
        • HELIOS Klinikum Bad Saarow
      • Bamberg, Germany
        • Recruiting
        • Sozialstiftung Bamberg
      • Bayreuth, Germany
        • Recruiting
        • Klinikum Bayreuth
      • Berlin, Germany
        • Recruiting
        • Charité Universitätsmedizin Berlin
      • Berlin, Germany
        • Recruiting
        • Helios Klinikum Berlin-Buch
      • Berlin, Germany
        • Recruiting
        • Vivantes Klinikum Neukölln
      • Berlin, Germany
        • Recruiting
        • Evangelisches Waldkrankenhaus Spandau
      • Berlin, Germany
        • Recruiting
        • Vivantes-Klinikum am Urban
      • Bielefeld, Germany
        • Recruiting
        • Klinikum Bielefeld
      • Bielefeld, Germany
        • Recruiting
        • Evangelisches Krankenhaus Bielefeld
      • Bochum, Germany
        • Recruiting
        • Universitätsklinikum Knappschaftskrankenhaus Bochum
      • Bochum, Germany
        • Recruiting
        • Katholisches Klinikum Bochum
      • Bochum, Germany
        • Recruiting
        • Augsuta Krankenanstalt Bochum
      • Bonn, Germany
        • Recruiting
        • Universitatsklinikum Bonn
      • Bonn, Germany
        • Recruiting
        • Johanniter-Krankenhaus Bonn
      • Braunschweig, Germany
        • Recruiting
        • Städtisches Klinikum Braunschweig
      • Bremen, Germany
        • Recruiting
        • Klinikum Bremen-Mitte gGmbH
      • Bremen, Germany
        • Recruiting
        • Evangelische Diakonissenanstalt Bremen
      • Chemnitz, Germany
        • Recruiting
        • Klinikum Chemnitz gGmbH
      • Cologne, Germany
        • Recruiting
        • Universitätsklinikum Köln
      • Cottbus, Germany
        • Recruiting
        • Carl-Thiem-Klinikum Cottbus
      • Darmstadt, Germany
        • Recruiting
        • Klinikum Darmstadt
      • Dessau, Germany
        • Recruiting
        • Städtisches Krankenhaus Dessau
      • Dortmund, Germany
        • Recruiting
        • Klinikum Dortmund
      • Dortmund, Germany
        • Recruiting
        • St. Johannes-Hospital Dortmund
      • Dresden, Germany
        • Recruiting
        • Städtisches Klinikum Dresden
      • Dresden, Germany
        • Recruiting
        • Klinikum Carl-Gustav-Carus
      • Duisburg, Germany
        • Recruiting
        • Helios Klinikum Duisburg
      • Duisburg, Germany
        • Recruiting
        • Johanniter-Krankenhaus Duisburg
      • Düren, Germany
        • Recruiting
        • Krankenhaus Düren
      • Düsseldorf, Germany
        • Recruiting
        • Universitätsklinikum Düsseldorf
      • Düsseldorf, Germany
        • Recruiting
        • Marien-Hospital Düsseldorf
      • Erfurt, Germany
        • Recruiting
        • Helios Klinikum Erfurt
      • Erlangen, Germany
        • Recruiting
        • Universitätsklinikum Erlangen
      • Eschweiler, Germany
        • Recruiting
        • St.-Antonius-Hospital Eschweiler
      • Essen, Germany
        • Recruiting
        • Universitätsklinikum Essen
      • Essen, Germany
        • Recruiting
        • Evang. Krankenhaus Essen-Werden
      • Flensburg, Germany
        • Recruiting
        • Malteser Krankenhaus Flensburg
      • Frankfurt, Germany
        • Recruiting
        • Klinikum Frankfurt-Oder
      • Frankfurt, Germany
        • Recruiting
        • Städt. Klinikum Frankfurt-Höchst
      • Freiburg im Breisgau, Germany
        • Recruiting
        • Universitatsklinikum Freiburg
      • Fulda, Germany
        • Recruiting
        • Klinikum Fulda
      • Georgsmarienhütte, Germany
        • Recruiting
        • Niels-Stensen-Kliniken Georgsmarienhütte
      • Giessen, Germany
        • Recruiting
        • Klinik der Justus-Liebig-Universität Gießen
      • Goch, Germany
        • Recruiting
        • Wilhelm-Anton-Hospital Goch
      • Greifswald, Germany
        • Recruiting
        • Universitätsklinikum Ernst-Moritz-Arndt-Universität
      • Göttingen, Germany
        • Recruiting
        • Universitätsklinikum Göttingen
      • Gütersloh, Germany
        • Recruiting
        • Städtisches Krankenhaus Gütersloh
      • Hagen, Germany
        • Recruiting
        • Katholisches Krankenhaus Hagen gGmbH
      • Halle, Germany
        • Recruiting
        • Krankenhaus St. Elisabeth und St. Barbara Halle/Saale
      • Halle, Germany
        • Recruiting
        • Martin-Luther-Universität Halle-Wittenberg
      • Hamburg, Germany
        • Recruiting
        • Universitätsklinikum Hamburg-Eppendorf
      • Hamburg, Germany
        • Recruiting
        • Asklepios Klinik Altona Hamburg
      • Hamburg, Germany
        • Recruiting
        • Asklepios Klinik St. Georg Hamburg
      • Hamm, Germany
        • Recruiting
        • Evangelisches Krankenhaus Hamm gGmbH
      • Hamm, Germany
        • Recruiting
        • St. Barbara-Klinik Hamm
      • Hanover, Germany
        • Recruiting
        • Medizinische Hochschule Hannover
      • Hanover, Germany
        • Recruiting
        • Klinikum Siloah Hannover
      • Heidelberg, Germany
        • Recruiting
        • Universitatsklinikum Heidelberg
      • Heilbronn, Germany
        • Recruiting
        • SLK Kliniken Heilbronn
      • Herne, Germany
        • Recruiting
        • Marienhospital Herne
      • Hildesheim, Germany
        • Recruiting
        • St. Bernward Krankenhaus Hildesheim
      • Homburg/Saar, Germany
        • Recruiting
        • Universitatsklinikum des Saarlandes
      • Idar-Oberstein, Germany
        • Recruiting
        • Klinikum Idar-Oberstein
      • Jena, Germany
        • Recruiting
        • Universitatsklinikum Jena
      • Karlsruhe, Germany
        • Recruiting
        • Städt. Klinikum Karlsruhe
      • Karlsruhe, Germany
        • Recruiting
        • St. Vincentius-Kliniken Karlsruhe
      • Kassel, Germany
        • Recruiting
        • Klinikum Kassel Gmbh
      • Kiel, Germany
        • Recruiting
        • Universitatsklinikum Schleswig-Holstein
      • Kiel, Germany
        • Recruiting
        • Stadtisches Krankenhaus Kiel
      • Koblenz, Germany
        • Recruiting
        • Gemeinschaftsklinikum Mittelrhein Koblenz
      • Krefeld, Germany
        • Recruiting
        • Helios Klinikum Krefeld
      • Kulmbach, Germany
        • Recruiting
        • Klinikum Kulmbach
      • Landshut, Germany
        • Recruiting
        • Klinikum Landshut
      • Leipzig, Germany
        • Recruiting
        • Universitatsklinikum Leipzig
      • Lippe, Germany
        • Recruiting
        • Klinikum Lippe-Lemgo
      • Ludwigshafen, Germany
        • Recruiting
        • Klinikum der Stadt Ludwigshafen
      • Lübeck, Germany
        • Recruiting
        • Universitätsklinikum Schleswig-Holstein - Campus Lübeck
      • Lübeck, Germany
        • Recruiting
        • Sana Kliniken Lubeck
      • Lüdenscheid, Germany
        • Recruiting
        • Märkische Kliniken Lüdenscheid
      • Magdeburg, Germany
        • Recruiting
        • Universitätsklinikum Magdeburg
      • Mainz, Germany
        • Recruiting
        • Universitätsklinikum Mainz
      • Mannheim, Germany
        • Recruiting
        • Klinikum Mannheim
      • Marburg, Germany
        • Recruiting
        • Universitätsklinikum Marburg
      • Meschede, Germany
        • Recruiting
        • Klinikum Hochsauerland Meschede
      • Minden, Germany
        • Recruiting
        • Johannes Wesling Klinikum Minden
      • Mutlangen, Germany
        • Recruiting
        • Stauferklinikum Mutlangen
      • Mönchengladbach, Germany
        • Recruiting
        • Kliniken Maria Hilf Mönchengladbach
      • München, Germany
        • Recruiting
        • Rotkreuzklinikum München
      • München, Germany
        • Recruiting
        • Klinikum rechts der Isar der TU Munchen
      • München, Germany
        • Recruiting
        • Klinikum München-Bogenhausen
      • München, Germany
        • Recruiting
        • Städtisches Krankenhaus München-Neuperlach
      • München, Germany
        • Recruiting
        • Universitätsklinikum München-Großhadern
      • Münster, Germany
        • Recruiting
        • Universitätsklinikum Münster
      • Neubrandenburg, Germany
        • Recruiting
        • Dietrich-Bonhoeffer-Klinikum Neubrandenburg
      • Nordhausen, Germany
        • Recruiting
        • Südharz Klinikum Nordhausen
      • Nuremberg, Germany
        • Recruiting
        • Klinikum Nürnberg Nord
      • Offenburg, Germany
        • Recruiting
        • Ortenau Klinikum Offenburg
      • Oldenburg, Germany
        • Recruiting
        • Klinikum Oldenburg
      • Oldenburg, Germany
        • Recruiting
        • Pius-Hospital Oldenburg
      • Osnabrück, Germany
        • Recruiting
        • Klinikum Osnabrück
      • Paderborn, Germany
        • Recruiting
        • Brüderkrankenhaus St. Josef Paderborn
      • Passau, Germany
        • Recruiting
        • Klinikum Passau
      • Potsdam, Germany
        • Recruiting
        • Klinikum Ernst von Bergmann
      • Recklinghausen, Germany
        • Recruiting
        • Kliniken Vest Recklinghausen
      • Regensburg, Germany
        • Recruiting
        • Krankenhaus Barmherzige Brüder Regensburg
      • Regensburg, Germany
        • Recruiting
        • Universitätsklinikum Regensburg
      • Reutlingen, Germany
        • Recruiting
        • Kreiskliniken Reutlingen
      • Riesa, Germany
        • Recruiting
        • Elblandklinikum Riesa
      • Rostock, Germany
        • Recruiting
        • Universitätsklinikum Rostock
      • Rostock, Germany
        • Recruiting
        • Klinikum Südstadt Rostock
      • Rotenburg (Wümme), Germany
        • Recruiting
        • Diakoniekrankenhaus Rotenburg
      • Saarlouis, Germany
        • Recruiting
        • Marienhaus Klinikum Saarlouis
      • Sande, Germany
        • Recruiting
        • Nordwest-Krankenhaus Sanderbusch
      • Schwerin, Germany
        • Recruiting
        • HELIOS Klinikum Schwerin
      • Schwäbisch Hall, Germany
        • Recruiting
        • Diakonie-Krankenhaus
      • Siegen, Germany
        • Recruiting
        • Ev. Jung-Stilling Krankenhaus Siegen
      • Siegen, Germany
        • Recruiting
        • St. Marienkrankenhaus Siegen
      • Sindelfingen, Germany
        • Recruiting
        • Klinikum Südwest Sindelfingen
      • Speyer, Germany
        • Recruiting
        • Diakonissen-Stiftungs-Krankenhaus Speyer
      • Stuttgart, Germany
        • Recruiting
        • Marienhospital Stuttgart
      • Stuttgart, Germany
        • Recruiting
        • Robert-Bosch-Krankenhaus
      • Stuttgart, Germany
        • Recruiting
        • Diakonie-Klinikum Stuttgart
      • Stuttgart, Germany
        • Recruiting
        • Klinikum Stuttgart Katharinenhospital
      • Traunstein, Germany
        • Recruiting
        • Klinikum Traunstein
      • Trier, Germany
        • Recruiting
        • Krankenhaus der Barmherzigen Brüder
      • Trier, Germany
        • Recruiting
        • Mutterhaus der Borromäerinnen Trier
      • Tübingen, Germany
        • Recruiting
        • Universitatsklinikum Tubingen
      • Ulm, Germany
        • Recruiting
        • Medizinische Universitätsklinikum Ulm
      • Villingen-Schwenningen, Germany
        • Recruiting
        • Klinikum Schwarzwald-Baar Villingen
      • Wiesbaden, Germany
        • Recruiting
        • Helios Dr. Horst Schmidt Kliniken Wiesbaden
      • Winnenden, Germany
        • Recruiting
        • Rems-Murr-Kliniken Winnenden
      • Wolfsburg, Germany
        • Recruiting
        • Klinikum der Stadt Wolfsburg
      • Wuppertal, Germany
        • Recruiting
        • Helios Klinikum Wuppertal
      • Würzburg, Germany
        • Recruiting
        • Universitätsklinikum Würzburg
      • Zwickau, Germany
        • Recruiting
        • Heinrich-Braun-Klinikum Zwickau
    • Hesse
      • Frankfurt am Main, Hesse, Germany, 60590
        • Recruiting
        • University Hospital of Frankfurt (Main)
        • Contact:
        • Principal Investigator:
          • Nicola Gökbuget, Dr. med.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

Acute Lymphoblastic Leukemia or seleted NHL

Description

Inclusion Criteria:

  • Acute Lymphoblastic Leukemia (All Subtypes) if treated according to ALL protocols
  • Other Types of Leukemia (NK Cell Lymphoma/Leukemia, Biphenotypic Acute Leukemia) if treated according to ALL protocols
  • Non-Hodgkin's Lymphoma of Following Subtypes: Burkitt Lymphoma, B Cell Lymphoma, B- or T-lineage Lymphoblastic Lymphoma, Anaplastic Large Cell Lymphoma, Other NHL) if treated according to B-ALL protocols
  • Age minimum 18 yrs

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort

Group / Cohort

A group or subgroup of participants in an observational study that is assessed for biomedical or health outcomes.
B-ALL/NHL
ALL/ Lymphoblastic Lymphoma (LBL)

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Time Frame
Overall survival
Time Frame: up to 10 years
up to 10 years

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Time Frame
Disease free survival
Time Frame: up to 10 years
up to 10 years
Remission duration
Time Frame: up to 10 years
up to 10 years
Relapse rate
Time Frame: up to 10 years
up to 10 years
Event free survival
Time Frame: up to 10 years
up to 10 years
Hematologic remission rate
Time Frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis
after induction and consolidation, approximately 6 - 8 weeks from diagnosis
Molecular remission rate
Time Frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis
after induction and consolidation, approximately 6 - 8 weeks from diagnosis
Positron Emission Tomography (PET) based remission evaluation
Time Frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis
after induction and consolidation, approximately 6 - 8 weeks from diagnosis
Early mortality
Time Frame: during induction therapy with a duration of approximately 6 - 8 weeks
during induction therapy with a duration of approximately 6 - 8 weeks
Mortality in Clinical Remission (CR)
Time Frame: up to 10 years
up to 10 years
Comorbidities
Time Frame: Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified
Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified
Quality of life assessed by Quality of Life Questionnaire (QLQ-C30)
Time Frame: after treatment which is approximately 2.5 years from diagnosis
after treatment which is approximately 2.5 years from diagnosis
Eastern Cooperative Oncology Group (ECOG) status
Time Frame: Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified
Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified
Toxicities assessed by CTCAE v4.03
Time Frame: during treatment with an approximate duration of 2.5 years from diagnosis
during treatment with an approximate duration of 2.5 years from diagnosis

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Goethe University

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Principal Investigator: Nicola Gökbuget, Dr. med., University Hospital of Frankfurt (Main)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
February 1, 2009

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
December 1, 2030

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
December 1, 2035

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
August 4, 2016

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
August 16, 2016

First Posted (Estimated)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
August 19, 2016

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
August 5, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
August 3, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
November 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • GMALL_Registry

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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