GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial (GMALLregistry)

November 27, 2025 updated by: Nicola Goekbuget, Goethe University

Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult ALL Patients and Related Diseases Associated With a Prospective Collection of Biomaterial

The GMALL registry serves the purpose of ALL research and quality assurance. The Registry collects data about diagnostics, treatment and outcome of Adult ALL Patients in the clinical routine, whether or not the patient is treated within a clinical trial.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

10000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Nicola Gökbuget, Dr. med.
Phone Number: +496963016365
Email: goekbuget@em.uni-frankfurt.de

Study Contact Backup

Name: GMALL Study center
Email: gmall@em.uni-frankfurt.de

Study Locations

Austria
- - Graz, Austria
    - Recruiting
    - Universitätsklinikum Graz
  - Leoben, Austria
    - Recruiting
    - LKH-Hochsteiermark Leoben
  - Vienna, Austria
    - Recruiting
    - Hanusch-Krankenhaus Wien
Germany
- - Aachen, Germany
    - Recruiting
    - Universitätsklinikum Aachen
  - Altenburg, Germany
    - Recruiting
    - Klinikum Altenburger Land
  - Altötting, Germany
    - Recruiting
    - Kreiskliniken Altötting
  - Aschaffenburg, Germany
    - Recruiting
    - Klinikum Aschaffenburg
  - Augsburg, Germany
    - Recruiting
    - Klinikum Augsburg
  - Bad Saarow, Germany
    - Recruiting
    - Helios Klinikum Bad Saarow
  - Bamberg, Germany
    - Recruiting
    - Sozialstiftung Bamberg
  - Bayreuth, Germany
    - Recruiting
    - Klinikum Bayreuth
  - Berlin, Germany
    - Recruiting
    - Charité Universitätsmedizin Berlin
  - Berlin, Germany
    - Recruiting
    - Helios Klinikum Berlin-Buch
  - Berlin, Germany
    - Recruiting
    - Vivantes Klinikum Neukölln
  - Berlin, Germany
    - Recruiting
    - Evangelisches Waldkrankenhaus Spandau
  - Berlin, Germany
    - Recruiting
    - Alexianer St. Hedwig Krankenhaus
  - Berlin, Germany
    - Recruiting
    - Vivantes-Klinikum am Urban
  - Bielefeld, Germany
    - Recruiting
    - Klinikum Bielefeld
  - Bielefeld, Germany
    - Recruiting
    - Evangelisches Krankenhaus Bielefeld
  - Bielefeld, Germany
    - Recruiting
    - Franziskus-Hospital Bielefeld
  - Bochum, Germany
    - Recruiting
    - Universitätsklinikum Knappschaftskrankenhaus Bochum
  - Bochum, Germany
    - Recruiting
    - Katholisches Klinikum Bochum
  - Bochum, Germany
    - Recruiting
    - Augsuta Krankenanstalt Bochum
  - Bonn, Germany
    - Recruiting
    - Universitätsklinikum Bonn
  - Bonn, Germany
    - Recruiting
    - Johanniter-Krankenhaus Bonn
  - Braunschweig, Germany
    - Recruiting
    - Städtisches Klinikum Braunschweig
  - Bremen, Germany
    - Recruiting
    - Klinikum Bremen-Mitte gGmbH
  - Bremen, Germany
    - Recruiting
    - Evangelische Diakonissenanstalt Bremen
  - Chemnitz, Germany
    - Recruiting
    - Klinikum Chemnitz gGmbH
  - Cologne, Germany
    - Recruiting
    - Universitätsklinikum Köln
  - Cottbus, Germany
    - Recruiting
    - Carl-Thiem-Klinikum Cottbus
  - Darmstadt, Germany
    - Recruiting
    - Klinikum Darmstadt
  - Dessau, Germany
    - Recruiting
    - Städtisches Krankenhaus Dessau
  - Dortmund, Germany
    - Recruiting
    - Klinikum Dortmund
  - Dortmund, Germany
    - Recruiting
    - St. Johannes-Hospital Dortmund
  - Dresden, Germany
    - Recruiting
    - Stadtisches Klinikum Dresden
  - Dresden, Germany
    - Recruiting
    - Klinikum Carl-Gustav-Carus
  - Duisburg, Germany
    - Recruiting
    - Helios Klinikum Duisburg
  - Duisburg, Germany
    - Recruiting
    - Johanniter-Krankenhaus Duisburg
  - Düren, Germany
    - Recruiting
    - Krankenhaus Düren
  - Düsseldorf, Germany
    - Recruiting
    - Universitätsklinikum Düsseldorf
  - Düsseldorf, Germany
    - Recruiting
    - Marien-Hospital Düsseldorf
  - Erfurt, Germany
    - Recruiting
    - Helios Klinikum Erfurt
  - Erlangen, Germany
    - Recruiting
    - Universitätsklinikum Erlangen
  - Eschweiler, Germany
    - Recruiting
    - St.-Antonius-Hospital Eschweiler
  - Essen, Germany
    - Recruiting
    - Universitätsklinikum Essen
  - Essen, Germany
    - Recruiting
    - Evang. Krankenhaus Essen-Werden
  - Esslingen am Neckar, Germany
    - Recruiting
    - Klinikum Esslingen
  - Flensburg, Germany
    - Recruiting
    - Malteser Krankenhaus Flensburg
  - Frankfurt, Germany
    - Recruiting
    - Klinikum Frankfurt-Oder
  - Frankfurt, Germany
    - Recruiting
    - Städt. Klinikum Frankfurt-Höchst
  - Freiburg im Breisgau, Germany
    - Recruiting
    - Universitätsklinikum Freiburg
  - Freising, Germany
    - Recruiting
    - Klinikum Freising
  - Fulda, Germany
    - Recruiting
    - Klinikum Fulda
  - Georgsmarienhütte, Germany
    - Recruiting
    - Niels-Stensen-Kliniken Georgsmarienhütte
  - Giessen, Germany
    - Recruiting
    - Klinik der Justus-Liebig-Universität Gießen
  - Goch, Germany
    - Recruiting
    - Wilhelm-Anton-Hospital Goch
  - Greifswald, Germany
    - Recruiting
    - Universitätsklinikum Ernst-Moritz-Arndt-Universität
  - Göttingen, Germany
    - Recruiting
    - Universitätsklinikum Göttingen
  - Gütersloh, Germany
    - Recruiting
    - Städtisches Krankenhaus Gütersloh
  - Hagen, Germany
    - Recruiting
    - Katholisches Krankenhaus Hagen gGmbH
  - Halle, Germany
    - Recruiting
    - Krankenhaus St. Elisabeth und St. Barbara Halle/Saale
  - Halle, Germany
    - Recruiting
    - Martin-Luther-Universität Halle-Wittenberg
  - Hamburg, Germany
    - Recruiting
    - Universitätsklinikum Hamburg-Eppendorf
  - Hamburg, Germany
    - Recruiting
    - Asklepios Klinik Altona Hamburg
  - Hamburg, Germany
    - Recruiting
    - Asklepios Klinik St. Georg Hamburg
  - Hamm, Germany
    - Recruiting
    - Evangelisches Krankenhaus Hamm gGmbH
  - Hamm, Germany
    - Recruiting
    - St. Barbara-Klinik Hamm
  - Hanover, Germany
    - Recruiting
    - Medizinische Hochschule Hannover
  - Hanover, Germany
    - Recruiting
    - Klinikum Siloah Hannover
  - Heidelberg, Germany
    - Recruiting
    - Universitätsklinikum Heidelberg
  - Heilbronn, Germany
    - Recruiting
    - SLK Kliniken Heilbronn
  - Herne, Germany
    - Recruiting
    - Marienhospital Herne
  - Hildesheim, Germany
    - Recruiting
    - St. Bernward Krankenhaus Hildesheim
  - Homburg/Saar, Germany
    - Recruiting
    - Universitätsklinikum des Saarlandes
  - Idar-Oberstein, Germany
    - Recruiting
    - Klinikum Idar-Oberstein
  - Jena, Germany
    - Recruiting
    - Universitätsklinikum Jena
  - Karlsruhe, Germany
    - Recruiting
    - Städt. Klinikum Karlsruhe
  - Karlsruhe, Germany
    - Recruiting
    - St. Vincentius-Kliniken Karlsruhe
  - Kassel, Germany
    - Recruiting
    - Klinikum Kassel Gmbh
  - Kiel, Germany
    - Recruiting
    - Universitätsklinikum Schleswig-Holstein
  - Kiel, Germany
    - Recruiting
    - Städtisches Krankenhaus Kiel
  - Koblenz, Germany
    - Recruiting
    - Gemeinschaftsklinikum Mittelrhein Koblenz
  - Krefeld, Germany
    - Recruiting
    - Helios Klinikum Krefeld
  - Kulmbach, Germany
    - Recruiting
    - Klinikum Kulmbach
  - Landshut, Germany
    - Recruiting
    - Klinikum Landshut
  - Leipzig, Germany
    - Recruiting
    - Universitatsklinikum Leipzig
  - Leipzig, Germany
    - Recruiting
    - Städtisches Klinikum St. Georg Leipzig
  - Leverkusen, Germany
    - Recruiting
    - Klinikum Leverkusen
  - Lingen, Germany
    - Recruiting
    - Bonifatius Hospital Lingen
  - Lippe, Germany
    - Recruiting
    - Klinikum Lippe-Lemgo
  - Ludwigshafen, Germany
    - Recruiting
    - Klinikum der Stadt Ludwigshafen
  - Lübeck, Germany
    - Recruiting
    - Universitatsklinikum Schleswig-Holstein - Campus Lubeck
  - Lübeck, Germany
    - Recruiting
    - Sana Kliniken Lübeck
  - Lüdenscheid, Germany
    - Recruiting
    - Märkische Kliniken Lüdenscheid
  - Magdeburg, Germany
    - Recruiting
    - Universitätsklinikum Magdeburg
  - Magdeburg, Germany
    - Recruiting
    - Gemeinschaftspraxis Magdeburg
  - Mainz, Germany
    - Recruiting
    - Universitätsklinikum Mainz
  - Mannheim, Germany
    - Recruiting
    - Klinikum Mannheim
  - Marburg, Germany
    - Recruiting
    - Universitätsklinikum Marburg
  - Meschede, Germany
    - Recruiting
    - Klinikum Hochsauerland Meschede
  - Minden, Germany
    - Recruiting
    - Johannes Wesling Klinikum Minden
  - Mutlangen, Germany
    - Recruiting
    - Stauferklinikum Mutlangen
  - Mönchengladbach, Germany
    - Recruiting
    - Kliniken Maria Hilf Mönchengladbach
  - München, Germany
    - Recruiting
    - Rotkreuzklinikum München
  - München, Germany
    - Recruiting
    - Klinikum rechts der Isar der TU München
  - München, Germany
    - Recruiting
    - Klinikum München-Bogenhausen
  - München, Germany
    - Recruiting
    - Städtisches Krankenhaus München-Neuperlach
  - München, Germany
    - Recruiting
    - Universitätsklinikum München-Großhadern
  - Münster, Germany
    - Recruiting
    - Universitätsklinikum Münster
  - Neubrandenburg, Germany
    - Recruiting
    - Dietrich-Bonhoeffer-Klinikum Neubrandenburg
  - Nuremberg, Germany
    - Recruiting
    - Klinikum Nurnberg Nord
  - Offenburg, Germany
    - Recruiting
    - Ortenau Klinikum Offenburg
  - Oldenburg, Germany
    - Recruiting
    - Klinikum Oldenburg
  - Oldenburg, Germany
    - Recruiting
    - Pius-Hospital Oldenburg
  - Osnabrück, Germany
    - Recruiting
    - Klinikum Osnabrück
  - Paderborn, Germany
    - Recruiting
    - Brüderkrankenhaus St. Josef Paderborn
  - Passau, Germany
    - Recruiting
    - Klinikum Passau
  - Potsdam, Germany
    - Recruiting
    - Klinikum Ernst von Bergmann
  - Recklinghausen, Germany
    - Recruiting
    - Kliniken Vest Recklinghausen
  - Regensburg, Germany
    - Recruiting
    - Krankenhaus Barmherzige Brüder Regensburg
  - Regensburg, Germany
    - Recruiting
    - Universitätsklinikum Regensburg
  - Reutlingen, Germany
    - Recruiting
    - Kreiskliniken Reutlingen
  - Riesa, Germany
    - Recruiting
    - Elblandklinikum Riesa
  - Rostock, Germany
    - Recruiting
    - Universitätsklinikum Rostock
  - Rostock, Germany
    - Recruiting
    - Klinikum Südstadt Rostock
  - Rotenburg (Wümme), Germany
    - Recruiting
    - Diakoniekrankenhaus Rotenburg
  - Saarlouis, Germany
    - Recruiting
    - Marienhaus Klinikum Saarlouis
  - Sande, Germany
    - Recruiting
    - Nordwest-Krankenhaus Sanderbusch
  - Schwerin, Germany
    - Recruiting
    - HELIOS Klinikum Schwerin
  - Schwäbisch Hall, Germany
    - Recruiting
    - Diakonie-Krankenhaus
  - Siegen, Germany
    - Recruiting
    - Ev. Jung-Stilling Krankenhaus Siegen
  - Siegen, Germany
    - Recruiting
    - St. Marienkrankenhaus Siegen
  - Sindelfingen, Germany
    - Recruiting
    - Klinikum Südwest Sindelfingen
  - Stuttgart, Germany
    - Recruiting
    - Marienhospital Stuttgart
  - Stuttgart, Germany
    - Recruiting
    - Robert-Bosch-Krankenhaus
  - Stuttgart, Germany
    - Recruiting
    - Diakonie-Klinikum Stuttgart
  - Stuttgart, Germany
    - Recruiting
    - Klinikum Stuttgart Katharinenhospital
  - Traunstein, Germany
    - Recruiting
    - Klinikum Traunstein
  - Trier, Germany
    - Recruiting
    - Krankenhaus der Barmherzigen Brüder
  - Trier, Germany
    - Recruiting
    - Mutterhaus der Borromäerinnen Trier
  - Tübingen, Germany
    - Recruiting
    - Universitätsklinikum Tübingen
  - Ulm, Germany
    - Recruiting
    - Bundeswehrkrankenhaus Ulm
  - Ulm, Germany
    - Recruiting
    - Medizinische Universitätsklinikum Ulm
  - Villingen-Schwenningen, Germany
    - Recruiting
    - Klinikum Schwarzwald-Baar Villingen
  - Wiesbaden, Germany
    - Recruiting
    - Helios Dr. Horst Schmidt Kliniken Wiesbaden
  - Winnenden, Germany
    - Recruiting
    - Rems-Murr-Kliniken Winnenden
  - Wolfsburg, Germany
    - Recruiting
    - Klinikum der Stadt Wolfsburg
  - Wuppertal, Germany
    - Recruiting
    - Helios Klinikum Wuppertal
  - Würzburg, Germany
    - Recruiting
    - Universitätsklinikum Würzburg
  - Zwickau, Germany
    - Recruiting
    - Heinrich-Braun-Klinikum Zwickau
- Hesse
  - Frankfurt am Main, Hesse, Germany, 60590
    - Recruiting
    - University Hospital of Frankfurt (Main)
    - Contact:
      
      GMALL Study Center
      
      Phone Number: +496963016366
      
      Email: gmall@em.uni-frankfurt.de
    - Principal Investigator:
      
      Nicola Gökbuget, Dr. med.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Sampling Method

Probability Sample

Study Population

Acute Lymphoblastic Leukemia or seleted NHL

Description

Inclusion Criteria:

Acute Lymphoblastic Leukemia (All Subtypes) if treated according to ALL protocols
Other Types of Leukemia (NK Cell Lymphoma/Leukemia, Biphenotypic Acute Leukemia) if treated according to ALL protocols
Non-Hodgkin's Lymphoma of Following Subtypes: Burkitt Lymphoma, B Cell Lymphoma, B- or T-lineage Lymphoblastic Lymphoma, Anaplastic Large Cell Lymphoma, Other NHL) if treated according to B-ALL protocols
Age minimum 18 yrs

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort
B-ALL/NHL
ALL/ Lymphoblastic Lymphoma (LBL)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Overall survival Time Frame: up to 10 years	up to 10 years

Secondary Outcome Measures

Outcome Measure	Time Frame
Disease free survival Time Frame: up to 10 years	up to 10 years
Remission duration Time Frame: up to 10 years	up to 10 years
Relapse rate Time Frame: up to 10 years	up to 10 years
Event free survival Time Frame: up to 10 years	up to 10 years
Hematologic remission rate Time Frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis	after induction and consolidation, approximately 6 - 8 weeks from diagnosis
Molecular remission rate Time Frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis	after induction and consolidation, approximately 6 - 8 weeks from diagnosis
Positron Emission Tomography (PET) based remission evaluation Time Frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis	after induction and consolidation, approximately 6 - 8 weeks from diagnosis
Early mortality Time Frame: during induction therapy with a duration of approximately 6 - 8 weeks	during induction therapy with a duration of approximately 6 - 8 weeks
Mortality in Clinical Remission (CR) Time Frame: up to 10 years	up to 10 years
Comorbidities Time Frame: Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified	Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified
Quality of life assessed by Quality of Life Questionnaire (QLQ-C30) Time Frame: after treatment which is approximately 2.5 years from diagnosis	after treatment which is approximately 2.5 years from diagnosis
Eastern Cooperative Oncology Group (ECOG) status Time Frame: Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified	Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified
Toxicities assessed by CTCAE v4.03 Time Frame: during treatment with an approximate duration of 2.5 years from diagnosis	during treatment with an approximate duration of 2.5 years from diagnosis

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Goethe University

Investigators

Principal Investigator: Nicola Gökbuget, Dr. med., University Hospital of Frankfurt (Main)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2009

Primary Completion (Estimated)

December 1, 2030

Study Completion (Estimated)

December 1, 2035

Study Registration Dates

First Submitted

August 4, 2016

First Submitted That Met QC Criteria

August 16, 2016

First Posted (Estimated)

August 19, 2016

Study Record Updates

Last Update Posted (Estimated)

December 5, 2025

Last Update Submitted That Met QC Criteria

November 27, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

GMALL_Registry

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial (GMALLregistry)

Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult ALL Patients and Related Diseases Associated With a Prospective Collection of Biomaterial

Study Overview

Status

Conditions

Study Type

Enrollment (Estimated)

Contacts and Locations

Study Contact

Study Contact Backup

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Sampling Method

Study Population

Description

Study Plan

How is the study designed?

Design Details

Number of groups / cohorts

Cohorts and Interventions

Group / Cohort

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Time Frame

Secondary Outcome Measures

Outcome Measure

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Study record dates

Study Major Dates

Study Start

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimated)

Study Record Updates

Last Update Posted (Estimated)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

Clinical Trials on Leukemia

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in India

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations