Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial (CLASP IID/IIF)
Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial (CLASP IID/IIF): A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Mitral Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System Compared to Abbott MitraClip in Patients With Mitral Regurgitation
Study Overview
Status
Status
Conditions
Conditions
Intervention / Treatment
Intervention / Treatment
Detailed Description
A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Valve Repair System compared to Abbott MitraClip in patients with degenerative mitral regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)
Patients will be seen for follow-up visits at discharge, 30 days, 6 months, and annually through 5 years.
Study Type
Study Type
Enrollment (Estimated)
Enrollment
Phase
Phase
- Not Applicable
Contacts and Locations
Study Contact
Study Contact
- Name: Edwards TMTT Clinical Affairs
- Phone Number: (949) 250-2500
- Email: TMTT_Clinical@edwards.com
Study Locations
-
-
-
Québec, Canada, G1V 4G5
- Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ) ULaval
-
-
British Columbia
-
Vancouver, British Columbia, Canada, V6E 1M7
- St. Pauls Hospital
-
-
Ontario
-
Hamilton, Ontario, Canada, L8L 2X2
- Hamilton Health Sciences
-
Toronto, Ontario, Canada, M5B 1W8
- St. Michael's Hospital
-
-
Quebec
-
Montreal, Quebec, Canada, H1T 1C8
- Montreal Heart Institute
-
-
-
-
-
Bad Oeynhausen, Germany, 32545
- Klinik für Allgemeine und Interventionelle Kardiologie/Angiologie, Herz- und Diabeteszentrum NRW, Universitätsklinik der Ruhr-Universität Bochum
-
Cologne, Germany, 50937
- Herzzentrum Universitätsklinikum Koln
-
Dresden, Germany, 01307
- Herrzentrum Dresden GmbH Universitätklinik an der Technischen Universität Dresden
-
Essen, Germany, 45174
- Universitätsklinikum Essen (AöR) Klinik für Kardiologie und Angiologie am Westdeutschen Herz- und Gefäßzentrum
-
Giessen, Germany, 35392
- Universitätsklinikum Gießen Medizinische Klinik I, Innere Medizin/ Kardiologie
-
Hamburg, Germany, 20246
- Universitäres Herzzentrum Hamburg GmbH (UHZ) Klinik und Poliklinik für Allgemeneine und Interventionelle Kardiologie
-
Heidelberg, Germany, 69120
- Universitätsklinikum Heidelberg Klinik für Kardiologie, Angiologie, Pneumologie
-
Leipzig, Germany, 04289
- Herzzentrum Leipzig Universitätsklinik für Kardiologie
-
Mainz, Germany, 55131
- Zentrum für Kardiologie - Kardiologie I Universitätsmedizin der Johannes Gutenberg Universität Mainz
-
München, Germany, 81377
- Medizinische Klinik I LMU München Campus Grosshadern
-
Siegburg, Germany, 53721
- Helios Klinikum Siegburg
-
Ulm, Germany, 89081
- ULM University Zentrum für Innere Medizin Klinik für Innere Medizin II
-
-
-
-
-
Bern, Switzerland, 3010
- University Hospital Bern
-
-
-
-
Arizona
-
Phoenix, Arizona, United States, 85006
- Banner University Medical Center
-
Phoenix, Arizona, United States, 85016
- Abrazo Arizona Heart Hospital
-
Tucson, Arizona, United States, 85712
- TMC HealthCare
-
-
California
-
La Jolla, California, United States, 92071
- Scripps Memorial Hospital La Jolla
-
Los Angeles, California, United States, 90048
- Cedars Sinai Medical Center
-
Orange, California, United States, 92868
- UC Irvine
-
Sacramento, California, United States, 95618
- Sutter Medical Center-Sacramento
-
San Francisco, California, United States, 94143
- University of California, San Francisco
-
San Francisco, California, United States, 94118
- Kaiser Permanente San Francisco
-
San Francisco, California, United States, 94109
- Sutter Bay Area
-
Stanford, California, United States, 94305
- Stanford University
-
Thousand Oaks, California, United States, 91360
- Los Robles Hospital and Medical Center
-
-
Colorado
-
Loveland, Colorado, United States, 80538
- Medical Center of the Rockies
-
-
District of Columbia
-
Washington D.C., District of Columbia, United States, 20010
- Medstar Washington Hospital Center
-
-
Florida
-
Gainesville, Florida, United States, 32605
- The Cardiac and Vascular Institute Research Foundation
-
Miami Beach, Florida, United States, 33140
- Mount Sinai
-
Naples, Florida, United States, 34102
- NCH Rooney Heart Institute
-
Orlando, Florida, United States, 32803
- AdventHealth Orlando
-
-
Georgia
-
Atlanta, Georgia, United States, 30309
- Piedmont HealthCare
-
Atlanta, Georgia, United States, 30322
- Emory University Hospital and Emory University Hospital Midtown
-
-
Illinois
-
Chicago, Illinois, United States, 60611
- Northwestern University
-
-
Indiana
-
Carmel, Indiana, United States, 46290
- St. Vincent Heart Center
-
-
Iowa
-
Iowa City, Iowa, United States, 52242
- University of Iowa Hospitals & Clinics
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, United States, 02114
- Massachusetts General Hospital
-
Boston, Massachusetts, United States, 02115
- Brigham and Woman's Hospital
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48109
- University of Michigan
-
Detroit, Michigan, United States, 48202
- Henry Ford Hospital
-
-
Minnesota
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic
-
Saint Cloud, Minnesota, United States, 56303
- CentraCare Heart and Vascular Center
-
-
Missouri
-
Kansas City, Missouri, United States, 64111
- St.Luke's Hospital of Kansas City
-
St Louis, Missouri, United States, 63110
- Washington University/Barnes Jewish Hospital
-
-
New Jersey
-
Morristown, New Jersey, United States, 07960
- Morristown Medical Center
-
New Brunswick, New Jersey, United States, 08901
- Rutgers-RWJMS
-
-
New York
-
Albany, New York, United States, 12208
- Albany Medical College
-
Buffalo, New York, United States, 14203
- State University of New York at Buffalo
-
Mineola, New York, United States, 11501
- NYU Langone Hospital - Long Island
-
New York, New York, United States, 10016
- NYU Langone Health
-
New York, New York, United States, 10032
- Columbia University Medical Center/New York Presbyterian Hospital
-
New York, New York, United States, 10075
- Lenox Hill Hospital and North Shore University
-
Rochester, New York, United States, 14621
- Rochester General Hospital
-
Roslyn, New York, United States, 11576
- St. Francis Hospital
-
The Bronx, New York, United States, 10467
- Montefiore Medical Center
-
-
Ohio
-
Cincinnati, Ohio, United States, 45219-2906
- The Christ Hospital
-
Cleveland, Ohio, United States, 44195
- Cleveland Clinic Foundation
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States, 73120
- Oklahoma Cardiovascular
-
Tulsa, Oklahoma, United States, 74104
- Oklahoma Heart Institute
-
-
Oregon
-
Portland, Oregon, United States, 97239
- Oregon Health & Science University
-
-
Pennsylvania
-
Philadelphia, Pennsylvania, United States, 19104
- Hospital of the University of Pennsylvania/Penn Presbyterian Medical Center
-
Pittsburgh, Pennsylvania, United States, 15212
- Allegheny General Hospital
-
Wormleysburg, Pennsylvania, United States, 17043
- Pinnacle Health Cardiovascular Institute/ UPMC Pinnacle Harrisburg
-
Wynnewood, Pennsylvania, United States, 19096
- Lankenau Medical Center
-
York, Pennsylvania, United States, 17405
- Wellspan York Hospital
-
-
Tennessee
-
Kingsport, Tennessee, United States, 37660
- CVA Heart Institute Kingsport
-
Memphis, Tennessee, United States, 38138
- Baptist Memorial Hospital Memphis
-
Nashville, Tennessee, United States, 37232
- Vanderbilt University Medical Center
-
Nashville, Tennessee, United States, 37203
- Centennial Medical Center
-
Nashville, Tennessee, United States, 37205
- Saint Thomas Heart at Saint Thomas West
-
-
Texas
-
Houston, Texas, United States, 77030
- Baylor College of Medicine
-
Houston, Texas, United States, 77030
- Houston Methodist Hospital
-
Houston, Texas, United States, 77030
- The University of Texas Health Science Center at Houston
-
Houston, Texas, United States, 77004
- HCA Houston Healthcare Medical Center
-
Plano, Texas, United States, 75093
- The Heart Hospital Baylor Plano
-
-
Utah
-
Salt Lake City, Utah, United States, 84107
- Intermountain Medical Center
-
-
Virginia
-
Charlottesville, Virginia, United States, 22908
- University of Virginia
-
Norfolk, Virginia, United States, 23507
- Sentara Norfolk General Hospital
-
-
Washington
-
Seattle, Washington, United States, 98122
- Swedish Medical Center
-
-
Wisconsin
-
Milwaukee, Wisconsin, United States, 53215
- Aurora St. Luke's Medical Center
-
-
Participation Criteria
Eligibility Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Eighteen (18) years of age or older
- Patient is able and willing to give informed consent and follow protocol procedures, and comply with follow-up visit requirements.
- Patient is determined to be at prohibitive risk for mitral valve surgery by the heart team (CLASP IID cohort only).
- Patient is on stable heart failure medications/Guideline Directed Medical Therapy (CLASP IIF cohort only)
- Patient is determined to be a candidate for transcatheter mitral valve repair by the heart team for both PASCAL and MitraClip
- Mitral regurgitation (3+ to 4+) by echo
- Suitable valve and regurgitant jet morphology
- Elevated corrected BNP > 400 pg/ml or corrected NT-pro BNP of > 900 pg/ml or heart failure hospitalization within the past 12 months (CLASP IIF cohort only)
- LVEF ≥ 20% (and ≤ 50%; CLASP IIF cohort only)
Exclusion Criteria:
- Patient in whom a TEE is contraindicated or screening TEE is unsuccessful
- Mitral valve anatomy which may preclude proper PASCAL or MitraClip access, use and/or deployment or sufficient reduction in mitral regurgitation
- Patient with refractory heart failure requiring advanced intervention (i.e. left ventricular assist device, Status ≤5 heart transplantation) (ACC/AHA Stage D heart failure)
- Clinically significant, untreated coronary artery disease
- Recent stroke
- Other severe valve disorders requiring intervention
- Need for emergent or urgent surgery for any reason or any planned cardiac surgery within the next 12 months
- Any prior mitral valve surgery or transcatheter mitral valve procedure (excluding chordal replacement or surgical annuloplasty repair)
- Severe tricuspid regurgitation or tricuspid valve disease requiring surgery
- Active rheumatic heart disease or rheumatic etiology for MR
- Severe aortic stenosis or regurgitation
- Known history of untreated, severe carotid stenosis
- Recent deep vein thrombosis (DVT) or pulmonary embolism (PE)
- Severe COPD
- Pregnant or planning pregnancy within next 12 months. Note: Female patients of childbearing potential need to have a negative pregnancy test performed within 14 days prior to intervention and be adherent to an accepted method of contraception
- Concurrent medical condition with a life expectancy of less than 12 months in the judgment of the Investigator
- Patient is currently participating in another investigational biologic, drug or device clinical study where the primary study endpoint was not reached at time of enrollment
- Other medical, social, or psychological conditions that preclude appropriate consent and follow-up, including patients under guardianship
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Number of Arms
Arms and Interventions
Participant Group / ArmParticipant Group / Arm |
Intervention / TreatmentIntervention / Treatment |
|---|---|
|
Experimental: Edwards PASCAL System - CLASP IID
Transcatheter mitral valve repair with the Edwards PASCAL System in patients with degenerative mitral regurgitation
|
Transcatheter mitral valve repair with the Edwards PASCAL System
Other Names:
|
|
Active Comparator: Abbott Mitraclip System - CLASP IID
Transcatheter mitral valve repair with the Abbott Mitraclip System in patients with degenerative mitral regurgitation
|
Transcatheter mitral valve repair with the Abbott Mitraclip System
Other Names:
|
|
Experimental: Edwards PASCAL System - CLASP IIF
Transcatheter mitral valve repair with the Edwards PASCAL System in patients on guideline directed medical therapy with functional mitral regurgitation
|
Transcatheter mitral valve repair with the Edwards PASCAL System
Other Names:
|
|
Active Comparator: Abbott Mitraclip System - CLASP IIF
Transcatheter mitral valve repair with the Abbott Mitraclip System in patients on guideline directed medical therapy with functional mitral regurgitation
|
Transcatheter mitral valve repair with the Abbott Mitraclip System
Other Names:
|
|
Experimental: Edwards PASCAL System - Single-Arm Registry
Transcatheter mitral valve repair with the Edwards PASCAL System in patients with mitral regurgitation who were deemed non-randomizable by a central screening committee (CSC) due to complex anatomical features described in the current MitraClip Instructions for Use (IFU) but were considered suitable for the PASCAL system.
|
Transcatheter mitral valve repair with the Edwards PASCAL System
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Primary Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
|
PASCAL is not inferior to MitraClip with respect to the proportion of patients with major adverse events (MAE). The primary safety endpoint is a composite of Major Adverse Events (MAEs).
Time Frame: 30 days.
|
30 days.
|
|
PASCAL is not inferior to Mitraclip with respect to the proportion of patients with MR severity reduction as measured by echocardiography using a scale of 0-4+ for the CLASP IID Cohort.
Time Frame: 6 months
|
6 months
|
|
PASCAL is not inferior to Mitraclip with respect to the time to first heart failure hospitalization or death for the CLASP IIF Cohort only.
Time Frame: From date of randomization until date of first heart failure hospitalization or death, through 5 year follow-up
|
From date of randomization until date of first heart failure hospitalization or death, through 5 year follow-up
|
Secondary Outcome Measures
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Rates of various adverse events
Time Frame: 6 months; 12 months
|
Rates of various adverse events at 6 and 12 months
|
6 months; 12 months
|
|
Functional Improvement (increase in 6 minute walk test in meters)
Time Frame: 30 days , 6 months, 1 year
|
Increase in 6 minute walk test in meters
|
30 days , 6 months, 1 year
|
|
Functional improvement (quality of life) as assessed using the Kansas City Cardiomyopathy Questionnaire through 2 years
Time Frame: 30 days , 6 months, 1 year, 2 year
|
Number of points of improvement on a scale of 0-100 in Kansas City Cardiomyopathy Questionnaire, with higher scores associated with higher Quality of Life
|
30 days , 6 months, 1 year, 2 year
|
|
Functional improvement (quality of life) as assessed by number of points of improvement on the Short Form Health Survey (SF-36) questionnaire through 2 years
Time Frame: 30 days, 6 months, 1 year, 2 year
|
Number of points of improvement on a scale of 0-100 in Short Form Health Survey (SF-36) questionnaire, with higher totals associated with higher Quality of Life
|
30 days, 6 months, 1 year, 2 year
|
|
Functional improvement (quality of life) as assessed by number of points of improvement on the Short Form Health Survey (EQ-5D-5L) questionnaire through
Time Frame: 30 days, 6 months, 1 year, 2 year
|
Number of points of improvement on a scale of 1-100 in Short Form Health Survey (EQ-5D-5L) questionnaire, with higher totals associated with higher Quality of Life
|
30 days, 6 months, 1 year, 2 year
|
Collaborators and Investigators
Sponsor
Sponsor
Investigators
Investigators
- Principal Investigator: Scott Lim, MD, University of Virginia
- Principal Investigator: Robert Smith, MD, The Heart Hospital Baylor Plano
- Principal Investigator: Linda Gillam, MD, Morristown Medical Center
- Principal Investigator: Vinod Thourani, MD, Piedmont HealthCare
- Principal Investigator: Paul Grayburn, MD, The Heart Hospital Baylor Plano
- Principal Investigator: Brian K Whisenant, MD, Intermountain Medical Center
- Principal Investigator: Jörg Hausleiter, MD, LMU München, Campus Gorsshadern
- Principal Investigator: Ralph Stephan von Bardeleben, MD, / Universitätsmedizin Mainz- Zentrum für Kardiologie
Publications and helpful links
General Publications
- Marcoff L, Koulogiannis K, Aldaia L, Mediratta A, Chadderdon SM, Makar MM, Ruf TF, Gossler T, Zaroff JG, Leung GK, Ku IA, Nabauer M, Grayburn PA, Wang Z, Hawthorne KM, Fowler DE, Dal-Bianco JP, Vannan MA, Bevilacqua C, Meineri M, Ender J, Forner AF, Puthumana JJ, Mansoor AH, Lloyd DJ, Voskanian SJ, Ghobrial A, Hahn RT, Mahmood F, Haeffele C, Ong G, Schneider LM, Wang DD, Sekaran NK, Koss E, Mehla P, Harb S, Miyasaka R, Ivannikova M, Stewart-Dehner T, Mitchel L, Raissi SR, Kalbacher D, Biswas S, Ho EC, Goldberg Y, Smith RL, Hausleiter J, Lim DS, Gillam LD; CLASP IID Pivotal Trial Investigators. Echocardiographic Outcomes With Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in Prohibitive Surgical Risk Patients. JACC Cardiovasc Imaging. 2024 May;17(5):471-485. doi: 10.1016/j.jcmg.2023.09.015. Epub 2023 Dec 13.
- Hausleiter J, Lim DS, Gillam LD, Zahr F, Chadderdon S, Rassi AN, Makkar R, Goldman S, Rudolph V, Hermiller J, Kipperman RM, Dhoble A, Smalling R, Latib A, Kodali SK, Lazkani M, Choo J, Lurz P, O'Neill WW, Laham R, Rodes-Cabau J, Kar S, Schofer N, Whisenant B, Inglessis-Azuaje I, Baldus S, Kapadia S, Koulogiannis K, Marcoff L, Smith RL; PASCAL IID Registry Investigators. Transcatheter Edge-to-Edge Repair in Patients With Anatomically Complex Degenerative Mitral Regurgitation. J Am Coll Cardiol. 2023 Feb 7;81(5):431-442. doi: 10.1016/j.jacc.2022.11.034.
- Lim DS, Smith RL, Gillam LD, Zahr F, Chadderdon S, Makkar R, von Bardeleben RS, Kipperman RM, Rassi AN, Szerlip M, Goldman S, Inglessis-Azuaje I, Yadav P, Lurz P, Davidson CJ, Mumtaz M, Gada H, Kar S, Kodali SK, Laham R, Hiesinger W, Fam NP, Kessler M, O'Neill WW, Whisenant B, Kliger C, Kapadia S, Rudolph V, Choo J, Hermiller J, Morse MA, Schofer N, Gafoor S, Latib A, Koulogiannis K, Marcoff L, Hausleiter J; CLASP IID Pivotal Trial Investigators. Randomized Comparison of Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in Prohibitive Surgical Risk Patients. JACC Cardiovasc Interv. 2022 Dec 26;15(24):2523-2536. doi: 10.1016/j.jcin.2022.09.005. Epub 2022 Sep 17.
Study record dates
Study Major Dates
Study Start (Actual)
Study Start
Primary Completion (Estimated)
Primary Completion
Study Completion (Estimated)
Study Completion
Study Registration Dates
First Submitted
First Submitted
First Submitted That Met QC Criteria
First Submitted That Met QC Criteria
First Posted (Actual)
First Posted
Study Record Updates
Last Update Posted (Actual)
Last Update Posted
Last Update Submitted That Met QC Criteria
Last Update Submitted That Met QC Criteria
Last Verified
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
Other Study ID Numbers
- 2018-07
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Mitral Regurgitation
-
NCT04350372CompletedFunctional Mitral Regurgitation | Degenerrative Mitral Regurgitation
-
NCT00800046CompletedMitral Regurgitation | Mitral Valve Regurgitation | Functional Mitral Regurgitation
-
NCT06814210Not yet recruitingMitral Regurgitation | Functional Mitral Regurgitation | Degenerative Mitral Valve Regurgitation
-
NCT05865938CompletedMitral Regurgitation | Functional Mitral Regurgitation | Degenerative Mitral Valve Regurgitation
-
NCT07227675CompletedMitral Regurgitation | Mitral Valve Regurgitation
-
NCT04396379Not yet recruitingIschemic Mitral Regurgitation | Functional Mitral Regurgitation
-
NCT02520310CompletedMitral Valve Regurgitation | Mitral Valve Incompetence | Mitral Insufficiency | Functional Mitral Regurgitation | Mitral Stenosis With Insufficiency
-
NCT06876883RecruitingMitral Insufficiency | Mitral Regurgitation (MR)
-
NCT02592889UnknownMITRAL REGURGITATION
-
NCT01626079Active, not recruitingHeart Failure | Mitral Regurgitation | Mitral Valve Regurgitation | Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects
Clinical Trials on Edwards PASCAL System
-
NCT04430075RecruitingMitral Regurgitation | Mitral Insufficiency
-
NCT04614402Active, not recruitingTricuspid Valve Insufficiency
-
NCT04443218CompletedMitral Valve Insufficiency
-
NCT04097145RecruitingTricuspid Valve Insufficiency | Tricuspid Regurgitation | Tricuspid Valve Disease
-
NCT05628779Enrolling by invitationCardiac Catheterization | Tricuspid Valve Regurgitation, Nonrheumatic | Heart Failure, Right Sided | Valve Regurgitation, Tricuspid
-
NCT05328284RecruitingTricuspid Regurgitation
-
NCT02309502WithdrawnSevere Non-proliferative Diabetic Retinopathy
-
NCT03600688Active, not recruitingMitral Regurgitation | Mitral Insufficiency | Mitral Repair | Mitral Valve | Annuloplasty | Edwards Cardioband
-
NCT02214277CompletedSevere Symptomatic Calcified Native Aortic Valve Stenosis