- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00412685
Myocardial Contrast Echocardiography in Congenital Heart Disease
June 15, 2015 updated by: University Hospital Inselspital, Berne
Quantification of the Myocardial Microcirculation by Contrast Echocardiography In Adult Patients With Congenital Heart Disease
Patients with congenital heart disease in whom the right ventricle is exposed to pressure or volume overload show progressive systolic dysfunction of the right ventricle, the fact of which conveys substantial morbidity and mortality.
The aim of this study is to investigate the myocardial perfusion in these patients by myocardial contrast echocardiography (MCE) in order to determine whether disturbed blood flow plays a role in the development of right ventricular systolic dysfunction.
Study Overview
Status
Completed
Study Type
Observational
Enrollment (Actual)
45
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Bern, Switzerland, 3010
- University Hospital Inselspital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
The study population is divided in three groups, which are all age- and gender-matched.
The TGA group consists of 15 patients treated withMustard or Senning procedures for surgical repaired of D-TGA atrial switch operation.
The TOF group consists of 15 patients with surgically corrected TOF.
The control group C consists of 15 control subjects (AH) with normal Doppler Echocardiographic echocardiographic examinations.
Description
Inclusion Criteria:
- D-TGA or Fallot-Tetralogy or Healthy person
- written informed consent
- Age >= 18 years
Exclusion Criteria:
- Anaemia
- Pregnancy and breast feeding
- Diabetes mellitus
- Contraindications to stress testing (ergometry or adenosine)
- Known adverse reaction or hypersensitivity against V08DA (SonoVue) or its components or against adenosine
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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TGA group
The TGA group consists of 15 patients treated withMustard or Senning procedures for surgical repaired of D-TGA atrial switch operation.
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TOF group
The TOF group consists of 15 patients with surgically corrected TOF.
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Control group
The control group C consists of 15 control subjects (AH) with normal Doppler Echocardiographic echocardiographic examinations.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Christian Seiler, Prof., University Hospital Berne, Switzerland
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2006
Primary Completion (Actual)
December 1, 2008
Study Completion (Actual)
December 1, 2008
Study Registration Dates
First Submitted
December 15, 2006
First Submitted That Met QC Criteria
December 15, 2006
First Posted (Estimate)
December 18, 2006
Study Record Updates
Last Update Posted (Estimate)
June 16, 2015
Last Update Submitted That Met QC Criteria
June 15, 2015
Last Verified
June 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 70/06
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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