Sleep Quality in CHIMES (MF101)

Menopausal women often complain of difficulty sleeping and the transition from pre- to postmenopausal status is associated with an incresase in self-reported sleep disturbance. Hot flashes have been associated with self-reported measures of sleep disturbance and changes in sleep pattern as measured by plysomnography, including an increase in stage 4 and a latency or shortened time in rapid-eye movement sleep. Although there are some data on the effect of hormone replacement therapy on self-reported sleep measures in symptomatic postmenopausal women, there are no data on the effect of herbal extracts on subjective or objective measures of sleep quality in this population group. Actigraphy, the use of a device to record movement generally placed on the wrist, has been used over 20 years to provide objective data concerning sleep/wake patterns. The advantage of actigraphy over traditional polysomnography is that actigraphy can conveniently record continuously for 24-hours a day for longer periods of time.

Study Overview

• Status: Completed
• Conditions: Sleep Quality; Menopausal Symptoms
• Intervention / Treatment: Drug: MF101

Detailed Description

Specific Aims:

1. To determine the effect of MF101 (a combination of Chinese herbs) compared to placebo on change in sleep quality utilizing baseline and follow-up actigraphy obtained from a subset of approximately 90 women enrolled in the randomized, double-blind, placebo-controlled Chinese Herbs for Menopausal Symptoms (CHIMES) trial.
2. TO identify the correlates of sleep quality as assessed by actigraphy in women with frequent hot flashes. We will evaluate demographic, lifestyle, anthropometric, medical and gynecologic history and hormonal factors that may relate to the actigraphic measures of sleep quality, including self-reported measures of sleep.

• Study Type: Interventional
• Enrollment: 180
• Phase: Phase 2

Contacts and Locations

Study Locations

• United States
  • California
    • San Francisco, California, United States
      • University of California, San Francisco
  • Minnesota
    • Minneapolis, Minnesota, United States, 55415
      • University of Minnesota Twin Cities Campus

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 40 years to 60 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Women between the ages of 40 to 60.
• Currently receiving medical care from a health care provider.
• Self-report 5 hot flashes per day or 35 hot flashes per week.
• Postmenopausal as defined by 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum FSH levels > 30mlU/ml or 6 weeks post-surgical bilateral oophorectomy with or without hysterectomy or hysterectomy with FSH levels > 30 mlU/ml.
• Agree not to start new herbal or dietary supplements and not to change the dose of any currently used herbal or dietary supplements for the duration of the trial.
• Successful completion of a Hot Flash Diary, a Daily Study Medication Diary and a Bleeding Diary, tolerates placebo, and 80% compliant at run-in.
• Must have had a mammogram within the last 9 months.
• Have access to a phone.
• Provide informed consent.

Exclusion Criteria:

• Inability to sign an informed consent or fill out questionnaires.
• History of breast, uterine or ovarian cancer or melanoma.
• Abnormal mammogram or breast examination within the last 9 months suggestive of cancer.
• Abnormal Pap smear or pelvic examination within the last 9 months suggestive of cancer.
• Double-wall endometrial thickness that exceeds 5 mm measured on transvaginal ultrasound.
• Unexplained abnormal uterine bleeding within six months of enrollment.
• Pregnancy or lactating.
• Clinical evidence of active ischemic cardiovascular disease or a history of cardiovascular disease.
• History of deep vein thrombosis or pulmonary embolism requiring anticoagulation.
• Active liver or gallbladder disease.
• Use of medications, herbal or dietary supplements known to possibly be effective for the treatment of hot flashes within three months of enrollment for oral or transdermal drugs, or within 6 months of enrollment for implanted or injected drugs.
• Use of raloxifene or tamoxifen within three months of enrollment.
• Use of another investigational agent within 3 months of enrollment.
• History of multiple or severe food or medicine allergies.
• Any medical or psychiatric condition that, in the investigator's opinion, would preclude the participant from adhering to the protocol or completing the trial, including severe illness, plans to move, substance abuse, significant problems, or dementia.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Single Group Assignment
• Masking: Double

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Actigraph watch (SleepWatch-O, Ambulatory Monitoring, Inc., Ardsley, NY)

Collaborators and Investigators

• Sponsor: Bionovo
• Investigators: Principal Investigator: Kristine Ensrud, MD, MPH, University of Minnesota Twin Cities Campus

Study record dates

Study Major Dates

• Study Start: February 1, 2006
• Study Completion (Actual): February 1, 2007

Study Registration Dates

• First Submitted: March 28, 2007
• First Submitted That Met QC Criteria: March 29, 2007
• First Posted (Estimate): March 30, 2007

Study Record Updates

• Last Update Posted (Estimate): March 30, 2007
• Last Update Submitted That Met QC Criteria: March 29, 2007
• Last Verified: March 1, 2007

More Information

Terms related to this study

• Keywords: Sleep Quality; Actigraph; Menopausal Symptoms; Bionovo; MF101
• Other Study ID Numbers: MF101 Ancillary Study