- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00478400
Awareness of Deficit After Combat-related Brain Injury
Study Overview
Status
Conditions
Detailed Description
The extent of recovery from brain injury is often difficult to predict because of our limited understanding of how the brain changes as it heals. New brain imaging methods may help in this regard. One imaging technique called functional magnetic resonance imaging (fMRI) has made it possible to study the brain "at work"; that is, we can see regions of the brain that are active during particular tasks such as focusing attention, making decisions, or remembering words and pictures. Another MRI method called diffusion tensor imaging provides information on the pathways between brain regions that may be altered with brain injury.
The goals of this research are to 1) determine the brain regions involved in making accurate judgments about one's abilities and disabilities after a brain injury and whether damage to these brain areas affects outcome; and 2) examine how recovery of cognitive and physical abilities relates to changes in brain function over time. In order to accomplish the first goal we will recruit Veterans who have sustained a head injury and matched control subjects. For the second goal, we are asking patients and controls who have previously participated in brain injury research with our lab to come back for another visit at three years post-injury.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Wisconsin
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Madison, Wisconsin, United States, 53705
- William S. Middleton Memorial Veterans Hospital, Madison, WI
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- History of traumatic brain injury at least 12 months prior to enrollment
- Control Group: No history of traumatic brain injury
Exclusion Criteria:
- Claustrophobia
- Metallic or electronic implants or devices that are not MRI-safe
- Foreign metal, such as shrapnel, in the body
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Participants who have had a TBI
(recruited by invitation only)
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Participants with No history of TBI
(Recruited by invitation only)
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Veterans with History of TBI
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US Veterans with No history of TBI
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cognition change at study endpoint between TBI and controls
Time Frame: Greater than 3 years post-injury
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Greater than 3 years post-injury
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Longitudinal change in white matter
Time Frame: 2 months, 1 year, and greater than 3 years post-injury
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Participants will include post-TBI in survivors the investigators have studied previously
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2 months, 1 year, and greater than 3 years post-injury
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Longitudinal change in whole brain morphology
Time Frame: 2 months, 1 year, and greater than 3 years post-injury
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Participants will include post-TBI in survivors the investigators have studied previously
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2 months, 1 year, and greater than 3 years post-injury
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Sterling C Johnson, PhD, William S. Middleton Memorial Veterans Hospital, Madison, WI
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NEUC-029-06S
- H-2006-0256 (Other Grant/Funding Number: University of Wisconsin, Madison)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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