Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers

Phase I Evaluation of Sodium Stibogluconate in Combination With Interferon α-2b Followed by Cisplatin, Vinblastine and Dacarbazine for Patients With Melanoma or Malignancies Potentially Responsive to SSG and/or Interferons

RATIONALE: Sodium stibogluconate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Interferon alfa-2b may interfere with the growth of tumor cells and slow the growth of melanoma and other cancers. Drugs used in chemotherapy, such as cisplatin, vinblastine, and dacarbazine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sodium stibogluconate and interferon alfa-2b together with combination chemotherapy may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of sodium stibogluconate when given together with interferon alfa-2b, cisplatin, vinblastine, and dacarbazine in treating patients with advanced melanoma or other cancer.

Study Overview

• Status: Completed
• Conditions: Stage IV Melanoma
• Intervention / Treatment: Biological: recombinant interferon alfa-2b; Drug: cisplatin; Drug: sodium stibogluconate; Drug: dacarbazine; Drug: vinblastine

Detailed Description

OBJECTIVES:

Primary

• To determine the safety of the combination of sodium stibogluconate and interferon alfa-2b with chemotherapy.
• To confirm the activity of sodium stibogluconate in augmenting cytokine effects.

Secondary

• To quantify the effects of sodium stibogluconate on interferon alfa-2b induced gene modulation and signal transduction pathways by measuring the serum soluble gene products.
• To define the effectiveness of sodium stibogluconate in inhibiting the protein tyrosine phosphatases SHP-1 and SHP-2 assayed from peripheral blood leukocytes of patients receiving sodium stibogluconate in combination with interferon alfa-2b.
• To define the pharmacokinetics of sodium stibogluconate in serum at escalating doses.
• To assess clinical response to the combination of sodium stibogluconate and interferon alfa-2b as priming for combination chemotherapy.

OUTLINE:

• Course 1: Patients receive sodium stibogluconate IV over 15 minutes on day 1 and days 15-18; interferon alfa-2b subcutaneously (SC) on days 8-12 and 15-18; cisplatin IV over 30-60 minutes and vinblastine IV on days 19 and 20; and dacarbazine. After a 2-week rest period, patients proceed to course 2.
• Course 2 and all subsequent courses: Patients receive sodium stibogluconate IV over 15 minutes and interferon alfa-2b SC on days 1-4; cisplatin IV over 30-60 minutes and vinblastine IV on days 5 and 6; dacarbazine. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.* NOTE: *Patients with stage IV disease who have no evidence of disease [NED} receive only 4 courses of therapy.

Cohorts of 6 patients receive escalating doses of sodium stibogluconate until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which dose-limiting toxicity occurs (i.e., no more than 1 patient at a given dose experiences DLT).

Patients undergo blood sample collection periodically for immunological and pharmacokinetic studies. Samples are analyzed for serum soluble gene products and protein tyrosine phosphatase inhibition.

• Study Type: Interventional
• Enrollment (Actual): 22
• Phase: Phase 1

Contacts and Locations

Study Locations

• United States
  • Ohio
    • Cleveland, Ohio, United States, 44195
      • Cleveland Clinic Taussig Institute, Case Comprehensive Cancer Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

DISEASE CHARACTERISTICS:

• Histologically confirmed melanoma or other malignancies

  • Must be refractory or resistant to established treatments OR have metastatic disease for which no effective therapy has been established

  • Gliomas or controlled CNS metastasis allowed

    • A CT scan or MRI must confirm stable brain metastases within 28 days of study entry
    • Patients with primary CNS malignancies refractory to other therapies are eligible
• Malignancy potentially responsive to sodium stibogluconate and/or interferon alfa-2b and combination chemotherapy

• Patients must have measurable or evaluable disease

  • Evaluable disease can include clinically or radiographically nonmeasurable tumor, specific tumor markers, or stage IV patients with no evidence of disease (NED)

PATIENT CHARACTERISTICS:

• Inclusion criteria:

  • ECOG performance status 0-2
  • Granulocytes > 1,500/μl
  • Platelets > 100,000/μl
  • Creatinine < 1.5 x upper limit of normal (ULN)
  • Bilirubin < 1.5 x ULN
  • AST and ALT < 1.5 x ULN (unless due to hepatic metastases)
  • Potassium ≤ 5.0 mmol/L
  • Magnesium ≤ 2.4 mg/dL
  • Creatinine clearance ≥ 60 cc/min
  • Ejection fraction ≥ 50%

• Exclusion criteria:

  • Pregnant or lactating women and fertile women or men unless surgically sterile or using effective contraception

    • All female patients of childbearing potential or less than 1 year postmenopausal must have a negative β-HCG pregnancy test at baseline and practice a medically acceptable method of birth control (i.e., oral contraceptives for at least 3 months, implantation of an intrauterine device for at least 2 months, or barrier methods [e.g., vaginal diaphragm, vaginal sponge, or condom with spermicidal jelly]) during and for 3 months after study initiation
  • History of atrial fibrillation, flutter, or other serious arrhythmia (excluding asymptomatic atrial or ventricular premature complexes) in the past 24 months
  • History of congestive heart failure currently requiring treatment; angina pectoris; or other severe cardiovascular disease (i.e., New York Heart Association class III or IV heart disease)
  • Baseline ECG abnormalities suggestive of cardiac conduction delay (i.e., first degree or greater atrio-ventricular block and/or complete or incomplete [QRS > 120 ms] bundle branch block)
  • Baseline ECG abnormalities suggestive of repolarization abnormalities (i.e., QTc ≥ 0.48 sec)

  • Culture positive acute infections requiring antibiotics within the past 14 days

    • Patients on long term suppressive antibiotic therapies are eligible
  • Known to be positive for HBsAg
  • Patients judged to not be psychologically prepared to understand informed consent or comply with an investigational study

PRIOR CONCURRENT THERAPY:

• Inclusion criteria:

  • Prior interferon therapy is allowed if administered ≥ 4 months ago
  • At least 3 weeks since prior major surgery, radiation therapy, or chemotherapy

• Exclusion criteria:

  • No prior treatment with interferon, sodium stibogluconate, cisplatin, vinblastine, or dacarbazine, except if given in an adjuvant setting
  • Patients with a prior history of solid organ allografts or allogeneic bone marrow transplant

  • Patients taking the following medications will not be eligible:

    • Amiodarone (Cordarone)
    • Disopyramide (Norpace)
    • Dofetilide (Tikosyn)
    • Procainamide (Procanbid or Pronestyl)
    • Quinidine (Quinaglute)
    • Sotalol (Betapace)
    • Erythromycin
    • Azithromycin (Z-pack)
    • Clarithromycin (Biaxin)
    • Pentamidine (Pentacarinat)
    • Trimethoprim-sulfamethoxazole (Bactrim)
    • Bepridil (Vascor)
    • Phenothiazines (e.g., prochlorperazine [Compazine], promethazine [Phenergan], or chlorpromazine [Thorazine])
    • Butyrophenones (e.g., Haloperidol [Haldol])
    • Risperidone (Risperdal)
    • Any other antipsychotic medication
    • Tricyclic or tetracyclic antidepressants (e.g., imipramine [Tofranil], amitriptyline [Elavil], desipramine [Norpramin], or nortriptyline [Pamelor])
    • Monoamine oxidase inhibitors
    • High-dose methadone
    • Arsenic trioxide
    • Dolasetron (Anzemet)
    • Any herbal preparations
  • Use of daily glucocorticoids except for physiological replacement

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: recombinant interferon alfa-2b	Biological: recombinant interferon alfa-2b; recombinant interferon alfa-2b; Other Names: IFN 2b; Drug: cisplatin; recombinant interferon alfa-2b; Other Names: CDDP; Drug: sodium stibogluconate; sodium stibogluconate; Drug: dacarbazine; dacarbazine; Other Names: DTIC; Drug: vinblastine; vinblastine; Other Names: VBL

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Safety of the combination of sodium stibogluconate and interferon alfa-2b with chemotherapy	2 years

Secondary Outcome Measures

Outcome Measure	Time Frame
Effects of sodium stibogluconate on interferon alfa-2b induced gene modulation and signal transduction pathways by measuring the serum soluble gene product	2 years
Effectiveness of sodium stibogluconate in inhibiting the protein tyrosine phosphatases SHP-1 and SHP-2 assayed from peripheral blood leukocytes	2 years
Pharmacokinetics of sodium stibogluconate in serum at escalating doses	2 years
Clinical response to the combination of sodium stibogluconate and interferon alfa-2b as priming for combination chemotherapy	2 years

Collaborators and Investigators

• Sponsor: Case Comprehensive Cancer Center
• Collaborators: National Cancer Institute (NCI)
• Investigators: Principal Investigator: Ernest C. Borden, MD, Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center

Study record dates

Study Major Dates

• Study Start: May 1, 2007
• Primary Completion (Actual): May 1, 2010
• Study Completion (Actual): January 1, 2012

Study Registration Dates

• First Submitted: July 10, 2007
• First Submitted That Met QC Criteria: July 10, 2007
• First Posted (Estimate): July 11, 2007

Study Record Updates

• Last Update Posted (Actual): July 24, 2020
• Last Update Submitted That Met QC Criteria: July 22, 2020
• Last Verified: July 1, 2020

More Information

Terms related to this study

• Keywords: adult glioblastoma; adult giant cell glioblastoma; adult gliosarcoma; recurrent adult brain tumor; adult anaplastic astrocytoma; recurrent melanoma; stage IV melanoma; adult anaplastic ependymoma; adult anaplastic oligodendroglioma; adult brain stem glioma; adult diffuse astrocytoma; adult ependymoma; adult myxopapillary ependymoma; adult oligodendroglioma; adult subependymoma; adult pilocytic astrocytoma; mixed gliomas; adult subependymal giant cell astrocytoma; adult pineal gland astrocytoma
• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue; Neuroendocrine Tumors; Nevi and Melanomas; Melanoma; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Anti-Infective Agents; Antiviral Agents; Antineoplastic Agents; Immunologic Factors; Tubulin Modulators; Antimitotic Agents; Mitosis Modulators; Antineoplastic Agents, Alkylating; Alkylating Agents; Antineoplastic Agents, Phytogenic; Antiprotozoal Agents; Antiparasitic Agents; Anthelmintics; Schistosomicides; Antiplatyhelmintic Agents; Interferons; Interferon-alpha; Cisplatin; Interferon alpha-2; Dacarbazine; Vinblastine; Antimony Sodium Gluconate
• Other Study ID Numbers: CASE3Y06

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No